دورية أكاديمية
Synaptic effects of xenon on NMDA receptor-mediated response in rat spinal neuron.
| العنوان: | Synaptic effects of xenon on NMDA receptor-mediated response in rat spinal neuron. |
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| المؤلفون: | Nonaka, Kiku, Nakamura, Michiko, Noda, Mami, Yamaga, Toshitaka, Jang, Il-Sung, Akaike, Norio |
| المصدر: | Neurosci Lett ; ISSN:1872-7972 |
| بيانات النشر: | Elsevier Science |
| سنة النشر: | 2024 |
| المجموعة: | PubMed Central (PMC) |
| مصطلحات موضوعية: | AMPA/KA receptor, NMDA receptor, Pre- and/or postsynaptic action, Whole-cell patch-clamp technique, Xenon, spinal sacral dorsal commissural nucleus (SDCN) neurons |
| الوصف: | To investigate the precise mechanism of xenon (Xe), pharmacologically isolated AMPA/KA and NMDA receptor-mediated spontaneous (s) and evoked (e) excitatory postsynaptic currents (s/eEPSCAMPA/KA and s/eEPSCNMDA) were recorded from mechanically isolated single spinal sacral dorsal commissural nucleus (SDCN) neurons attached with glutamatergic nerve endings (boutons) using conventional whole-cell patch-clamp technique. We analysed kinetic properties of both s/eEPSCAMPA/KA and s/eEPSCNMDA by focal single- and/or paired-pulse electrical stimulation to compare them. The s/eEPSCNMDA showed smaller amplitude, slower rise time, and slower 1/e decay time constant (τDecay) than those of s/eEPSCAMPA/KA. We previously examined how Xe modulates s/eEPSCAMPA/KA, therefore, examined the effects on s/eEPSCNMDA in the present study. Xe decreased the frequency and amplitude of sEPSCNMDA, and decreased the amplitude but increased the failure rate and paired-pulse ratio of eEPSCNMDA without affecting their τDecay. It was concluded that Xe might suppress NMDA receptor-mediated synaptic transmission via both presynaptic and postsynaptic mechanisms. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.1016/j.neulet.2024.137885Test; https://pubmed.ncbi.nlm.nih.gov/38914276Test |
| DOI: | 10.1016/j.neulet.2024.137885 |
| الإتاحة: | https://doi.org/10.1016/j.neulet.2024.137885Test https://pubmed.ncbi.nlm.nih.gov/38914276Test |
| حقوق: | Copyright © 2024. Published by Elsevier B.V. |
| رقم الانضمام: | edsbas.CCDA2C33 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.neulet.2024.137885 |
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