نتائج البحث - "Prashant B. Nigade"

1

Dual PI3Kδγ inhibition demonstrates potent anticancer effects in diffuse large B-cell lymphoma models: Discovery and preclinical characterization of LL-00084282

المصدر: Biochemical and Biophysical Research Communications. 637:267-275

مصطلحات موضوعية: B-Lymphocytes, Phosphatidylinositol 3-Kinases, Cell Line, Tumor, Biophysics, Humans, Lymphoma, Large B-Cell, Diffuse, Cell Biology, Leukemia, Lymphocytic, Chronic, B-Cell, Molecular Biology, Biochemistry, Phosphoinositide-3 Kinase Inhibitors

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4587d39fd2411d176cb38bbd74a04caeTest
https://doi.org/10.1016/j.bbrc.2022.11.038Test

2

Discovery of a Novel Potent and Selective Calcium Release-Activated Calcium Channel Inhibitor: 2,6-Difluoro-N-(2′-methyl-3′-(4-methyl-5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)-[1,1′-biphenyl]-4-yl)benzamide. Structure–Activity Relationship and Preclinical Characterization

المؤلفون: Shashikant Pawar, Vinod Patil, Rajender Kumar Kamboj, Milind Sindkhedkar, Trupti Bhankhede, Venkata P. Palle, Jaysagar Gundu, Spinvin Venugopal, Dhananjay Bakhle, Praveenkumar Anidil Kizhakinagath, Kumar Naik, Sanjay Bokan, Zubair Shaikh, Sagar Budhe, Vikas Shinde, Dipak Modi, M. K. Singh, Maneesh Mehta, Kamlesh J Padiya, Gururaj Vishwase, Akshaya Wagh, Rajesh Gupta, Sharad Sharma, Hemant Kumar, Sandip Kuldharan, Sadanand Mallurwar, Neelima Sinha, Gokul Deshmukh, Kaustubh Tamane, Himani Pareek, Rajesh Yeshodharan, Prashant B. Nigade, Milind Gholve, Kumar V S Nemmani, Santosh Jachak, Dilip Pandey, Nidhi Sharma, Vijay Karche, Lakshmi Narasimham, Nageswara Rao Irlapatti, Jagadeesh Daler, Rajesh Shankar, Nilesh Raghunath Khedkar, Mandar Bhonde, Vijay Kanoje, Prabakaran Kamalakannan, Chirag Shah, Shaji K George, Sachin Ingawale, Prajakta Ahirrao, Disha Dadke, Harshal Narendra Nemade, Anil Kalia, Amit Patil, Samiron Phukan, Swaroop Kumar

المصدر: Journal of Medicinal Chemistry. 64:17004-17030

مصطلحات موضوعية: Calcium channel, chemistry.chemical_element, Pharmacology, Calcium, chemistry.chemical_compound, chemistry, Pharmacokinetics, In vivo, Oral administration, Drug Discovery, Lipophilicity, Molecular Medicine, Structure–activity relationship, Benzamide

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::fc2c7afc213cb2f010008814556ab51cTest
https://doi.org/10.1021/acs.jmedchem.1c01403Test

3

Discovery of a Potent and Selective PI3Kδ Inhibitor (S)-2,4-Diamino-6-((1-(7-fluoro-1-(4-fluorophenyl)-4-oxo-3-phenyl-4H-quinolizin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile with Improved Pharmacokinetic Profile and Superior Efficacy in Hematological Cancer Models

المؤلفون: Anand Tarage, Gopal Gole, Mandar Bhonde, Madhusudhan Reddy, Sharad Sharma, Harish Volam, Sudeep Sabde, Sanjeev Anant Kulkarni, Sadanand Mallurwar, Brahmam Sunkara, Ramesh Dattatraya Phadtare, Manoj Dandekar, Hemant Goyal, Samiron Phukan, Gayathri Sadasivam, Rupesh Kanhere, Maneesh Mehta, Nirmal Jana, Murthy Cheemala, Prashant Vidhate, Lal Dinchhana, Prashant B. Nigade, Bernstein Peter Robert, Prajakta Ahirrao, Rajan Goel, Aditya Naik, Vipul Pachpute, Sukanya Patra, Rajender Kumar Kamboj, Nilesh Mahajan, Kaustubh Tamane, Sneha Trivedi, M. K. Singh, Ajit Kumar Marisetti, Shankar Bhagwat, Mahip Verma, Atul Akarte, Dipak Lagad, Charudatt Samant, Venkata P. Palle, Vinod Patil, Anand Bokare, Dipak Modi, Chaitanya A. Kulkarni, Lakshmi Narasimham, Neetinkumar Reddy, Majid Bashir Sayyed, Sarita Koul, Shukla Manojkumar Ramprasad, Milind Gholve, Swati Tota, Vinod D. Chaudhari, Jayasagar Gundu, Manisha Shingare, Sachin J Mahangare, Shashikant Pawar

المصدر: Journal of Medicinal Chemistry. 63:14700-14723

مصطلحات موضوعية: Gene isoform, chemistry.chemical_compound, Pyrimidine, Pharmacokinetics, Chemistry, Cell culture, Drug discovery, Stereochemistry, Drug Discovery, Molecular Medicine, Germinal center, Structure–activity relationship, Potency

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::c4614f9af4bf378b9f2f87f030837f97Test
https://doi.org/10.1021/acs.jmedchem.0c01264Test

4

Discovery of Potent, Selective, and State-Dependent NaV1.7 Inhibitors with Robust Oral Efficacy in Pain Models: Structure–Activity Relationship and Optimization of Chroman and Indane Aryl Sulfonamides

المؤلفون: Shreyas Deshpande, Rashmi Talwar, Ganesh Navinchandra Gote, Jayasagar Gundu, Rupali Vyawahare, Shashikant Pawar, Akshaya Wagh, Talha Khan, Anil Kalia, Venkata P. Palle, Usha Dhayagude, M. K. Singh, Pradeep Patil, Ganesh Chaure, Praveen Kumar Gupta, Amit Das, Vijay Kanoje, Sharad Sharma, Vidya Ramdas, Vinod Patil, Rajesh Yeshodharan, Prashant B. Nigade, Dipak Modi, Dnyaneshwar Warude, Dilip Pandey, Jagadeesh Daler, Mahammad Azhar, Arun Nayak, Sneha Joshi, Sudipto Das, Rajender Kumar Kamboj, Javed S Shaikh, Maneesh Mehta, Deepak Sahebrao Walke, Rajesh V. Gupta, Himani Pareek, Kumar V S Nemmani, Parag Joshi, Mahip Verma, Vinod Mali, Laxmikant Datrange, Santosh Parkale, Rajesh Loriya, Vaibhav Kalhapure, Geetika Sharma, Ravindra R. Pal, Sagar Budhe, Gautam Agarwal, Sachin Suravase, Sagar Darekar, Mark G. Bock, Advait Arun Joshi, Moloy Banerjee, Smita Bhoskar, Amitesh Kishore, Dhananjay Bakhle

المصدر: Journal of Medicinal Chemistry. 63:6107-6133

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::086c900f1a53e7be6872ad0b9e12f6e4Test
https://doi.org/10.1021/acs.jmedchem.0c00361Test

5

Discovery of Novel, Potent, Brain-Permeable, and Orally Efficacious Positive Allosteric Modulator of α7 Nicotinic Acetylcholine Receptor [4-(5-(4-Chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)benzenesulfonamide]: Structure–Activity Relationship and Preclinical Characterization

المؤلفون: Sagar J. Desai, Sameer S. Walunj, Anand M. Bokare, Sharad Sharma, Dhananjay Bakhle, Sachchidanand Sachchidanand, Mahip K. Verma, Rajesh Gupta, Vijaya Mahimane, Jayasagar Gundu, Baban Rupaji Thube, Prashant B. Nigade, Firoj Aftab Raje, Chirag Shah, Sanjay Pralhad Kurhade, M. K. Singh, Lairikyengbam Bikramjit Singh, Girish Dhanraj Hatnapure, Shridhar Keshav Adurkar, Rajender Kumar Kamboj, Vinod Patil, Neelima Sinha, Ajay Ramchandra Tilekar, Sudhakar Maruti Balgude, Sarita Koul, Manavi Chatterjee, Anil Kashiram Hajare, Ruchi Dixit, Yogesh Bhosale, Ganesh Rajaram Jadhav, Manoj P. Dandekar, Navnath Popat Karche, Dnyaneshwar Changdeo Bhanage, Ashish P. Bharne, Rajan Goel, Javed S Shaikh, Gourhari Jana, Dipak Modi, Maneesh Mehta, Venkata P. Palle

المصدر: Journal of Medicinal Chemistry. 63:944-960

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::5a58527c53cdd9032bedaf222277ce22Test
https://doi.org/10.1021/acs.jmedchem.9b01569Test

6

Discovery and Characterization of Potent Pan-Genotypic HCV NS5A Inhibitors Containing Novel Tricyclic Central Core Leading to Clinical Candidate

المصدر: Journal of Medicinal Chemistry. 62:10563-10582

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df0347f54ddf821889bfcaf5e07c536eTest
https://doi.org/10.1021/acs.jmedchem.9b01562Test

7

LL-00066471, a novel positive allosteric modulator of α7 nicotinic acetylcholine receptor ameliorates cognitive and sensorimotor gating deficits in animal models: Discovery and preclinical characterization

المؤلفون: Anand M. Bokare, Venkata P. Palle, Maneesh Mehta, Sameer S. Walunj, Sarita Koul, Mahip K. Verma, Dipak Modi, Navnath Popat Karche, Rajan Goel, Vinod Patil, Nilendra Singh, Santoshkumar Tota, Neelima Sinha, Jayasagar Gundu, Sagar Desai, Prashant B. Nigade, Rajender Kumar Kamboj, Manoj P. Dandekar

المصدر: European journal of pharmacology. 891

مصطلحات موضوعية: 0301 basic medicine, Male, Reflex, Startle, Allosteric modulator, alpha7 Nicotinic Acetylcholine Receptor, medicine.medical_treatment, Allosteric regulation, Cholinergic Agents, Rats, Sprague-Dawley, 03 medical and health sciences, 0302 clinical medicine, Cognition, Dogs, Cell Line, Tumor, Medicine, Animals, Cognitive Dysfunction, Rats, Wistar, Antipsychotic, Social Behavior, Prepulse inhibition, Gait Disorders, Neurologic, Recognition memory, Ischemic Stroke, Pharmacology, Mice, Inbred BALB C, Behavior, Animal, business.industry, Brain, Sensory Gating, Nicotinic acetylcholine receptor, Disease Models, Animal, Oxidative Stress, 030104 developmental biology, Exploratory Behavior, Cholinergic, business, Neuroscience, Open Field Test, 030217 neurology & neurosurgery, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50dee4d769e8c9421b7d3480a20167f2Test
https://pubmed.ncbi.nlm.nih.gov/33127363Test

8

Discovery of Potent, Selective, and State-Dependent Na

المؤلفون: Vidya, Ramdas, Rashmi, Talwar, Vijay, Kanoje, Rajesh M, Loriya, Moloy, Banerjee, Pradeep, Patil, Advait Arun, Joshi, Laxmikant, Datrange, Amit Kumar, Das, Deepak Sahebrao, Walke, Vaibhav, Kalhapure, Talha, Khan, Ganesh, Gote, Usha, Dhayagude, Shreyas, Deshpande, Javed, Shaikh, Ganesh, Chaure, Ravindra R, Pal, Santosh, Parkale, Sachin, Suravase, Smita, Bhoskar, Rajesh V, Gupta, Anil, Kalia, Rajesh, Yeshodharan, Mahammad, Azhar, Jagadeesh, Daler, Vinod, Mali, Geetika, Sharma, Amitesh, Kishore, Rupali, Vyawahare, Gautam, Agarwal, Himani, Pareek, Sagar, Budhe, Arun, Nayak, Dnyaneshwar, Warude, Praveen Kumar, Gupta, Parag, Joshi, Sneha, Joshi, Sagar, Darekar, Dilip, Pandey, Akshaya, Wagh, Prashant B, Nigade, Maneesh, Mehta, Vinod, Patil, Dipak, Modi, Shashikant, Pawar, Mahip, Verma, Minakshi, Singh, Sudipto, Das, Jayasagar, Gundu, Kumar, Nemmani, Mark G, Bock, Sharad, Sharma, Dhananjay, Bakhle, Rajender Kumar, Kamboj, Venkata P, Palle

المصدر: Journal of medicinal chemistry. 63(11)

مصطلحات موضوعية: Male, Voltage-Gated Sodium Channel Blockers, Mice, Inbred BALB C, Sulfonamides, NAV1.7 Voltage-Gated Sodium Channel, Drug Evaluation, Preclinical, Disease Models, Animal, Mice, Structure-Activity Relationship, Drug Design, Animals, Cytochrome P-450 CYP3A, Neuralgia, Protein Isoforms, Chromans, Cytochrome P-450 CYP2C9, Half-Life

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::c52c66d3e92a25570d2232b2452b0ca7Test
https://pubmed.ncbi.nlm.nih.gov/32368909Test

9

Prediction of Tissue-to-Plasma Ratios of Basic Compounds in Mice

المؤلفون: Jayasagar Gundu, Kumar V.S. Nemmani, Prashant B. Nigade, K. Sreedhara Pai

المصدر: European Journal of Drug Metabolism and Pharmacokinetics. 42:835-847

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1719a72ccf3e94398e3f2e2d40a1e22bTest
https://doi.org/10.1007/s13318-017-0402-5Test

10

Discovery of isoquinolinone and naphthyridinone-based inhibitors of poly(ADP-ribose) polymerase-1 (PARP1) as anticancer agents: Structure activity relationship and preclinical characterization

المؤلفون: Albi Francis, Javed S. Shaikh, Tariq Bhat, Sanjay P. Kurhade, Nivrutti Kamble, Harish Volam, Sadanand Mallurwar, Pushpak Bora, Prashant B. Nigade, Mandar Bhonde, Hemant Goyal, Gagan Kukreja, Nishant R. Gupta, Nageswara Rao Irlapati, Prajakta Ahirrao, Bernstein Peter Robert, Rajesh B. Shankar, Kumar Ram Naik, Sneha Naidu, Gopal Gole, Yogesh Pawar, Apparao Bommakanti, Vinod Patil, Rajendra G. Powar, V.R. Praveen Kumar, Rakesh Kumar, Prabhakaran Kamalakannan, Anil K. Hajare, Neelima Sinha, Rajender Kumar Kamboj, Jayasagar Gundu, Sharad Sharma, Nilesh Khedkar, Arun R. Jagdale, Navnath P. Karche, Venkata P. Palle, Dipak Modi, Saif Wahid, Vamsi Pagdala, Kochumalayil Shaji George, Ganesh R. Jadhav, Gourhari Jana, Rohan Limaye, Baban Thube, Lakshmi Narasimham, Harshal Khanwalkar, Shashikant Pawar, Kumar V.S. Nemmani, Rajesh Gupta, Minakshi Singh, Ramesh Kale, Ajay R. Tilekar, Samiron Phukan, Dhananjay Bakhle, Pradipta Kumar

المصدر: Bioorganic & Medicinal Chemistry. 28:115819

مصطلحات موضوعية: Cell Survival, Stereochemistry, Poly ADP ribose polymerase, Transplantation, Heterologous, Clinical Biochemistry, Poly (ADP-Ribose) Polymerase-1, Substituent, Pharmaceutical Science, Antineoplastic Agents, Poly(ADP-ribose) Polymerase Inhibitors, Quinolones, 01 natural sciences, Biochemistry, Mice, Structure-Activity Relationship, chemistry.chemical_compound, PARP1, Cell Line, Tumor, Neoplasms, Drug Discovery, Animals, Humans, Potency, Structure–activity relationship, Moiety, Naphthyridines, Molecular Biology, Mice, Inbred BALB C, Binding Sites, Bicyclic molecule, 010405 organic chemistry, Organic Chemistry, 0104 chemical sciences, Molecular Docking Simulation, 010404 medicinal & biomolecular chemistry, chemistry, Molecular Medicine, Linker, Half-Life

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae439561d9cd7678612504a2221cbc22Test
https://doi.org/10.1016/j.bmc.2020.115819Test

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