Attenuation of nociceptive pain and inflammatory disorders by total steroid and terpenoid fraction of Euphorbia tirucalli Linn root in experimental in vitro and in vivo model
| العنوان: | Attenuation of nociceptive pain and inflammatory disorders by total steroid and terpenoid fraction of Euphorbia tirucalli Linn root in experimental in vitro and in vivo model |
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| المؤلفون: | Nahid Ali, Shubhadeep Roychoudhury, Subhash C. Mandal, Dhrubojyoti Mukherjee, Asad, Partha Palit, Poulami Mahanta, Shadab |
| المصدر: | Inflammopharmacology. 26:235-250 |
| بيانات النشر: | Springer Science and Business Media LLC, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Anti-Inflammatory Agents, Arthritis, Pharmacology, Plant Roots, Nociceptive Pain, law.invention, Mice, 0302 clinical medicine, Euphorbia, law, Edema, Medicine, Pharmacology (medical), Acetic Acid, Analgesics, biology, 030220 oncology & carcinogenesis, Neuropathic pain, Cytokines, Female, Steroids, Euphorbia tirucalli, medicine.drug_class, Immunology, Analgesic, Nitric Oxide, Anti-inflammatory, Proinflammatory cytokine, 03 medical and health sciences, Cell Line, Tumor, Animals, Inflammation, Plant Extracts, Terpenes, business.industry, biology.organism_classification, medicine.disease, Rats, RAW 264.7 Cells, 030104 developmental biology, Prostaglandin-Endoperoxide Synthases, biology.protein, Medicine, Traditional, Cyclooxygenase, Nitric Oxide Synthase, Phytotherapy, business |
| الوصف: | The plant Euphorbia tirucalli Linn has been successfully used as a tribal folk medicine in India and Africa for the management of acute inflammatory, arthritic, nociceptive pain and asthmatic symptoms. The present study was conducted to assess the anti-inflammatory, analgesic, anti-asthmatic and anti-arthritic role of the total steroid and terpenoid rich fractions of the hydro-alcoholic extract of E. tirucalli root (STF-HAETR). STF-HAETR fraction demonstrated 71.25 ± 2.5 and 74.25 ± 5.1% protection against acetic acid-induced pain and central neuropathic pain at 75 and 100 mg/kg doses, respectively. It showed 96.97% protection against acute inflammation at 100 mg/kg with 1.6-fold better activity than the standard drug. The fraction exhibited such efficacy via inhibition of proinflammatory cytokines TNF-α, IFN-γ, by 61.12 and 65.18%, respectively, at 100 μg/mL. Inhibition of cyclooxygenase and Nitric oxide synthase in a dose-dependent manner affirms its analgesic and anti-inflammatory activity. The spectrophotometric analysis reveals that STF-HAETR induces ameliorative effect against heat-induced denaturation of Bovine serum albumin (BSA) and exhibits significant anti-proteinase activity. The plant fraction also demonstrated anti-asthmatic activity by displaying 62.45% protection against histamine induced bronchoconstriction or dyspnoea. Our findings suggest that STF-HAETR could be an effective safe therapeutic agent to treat nociceptive pain, acute inflammation, asthma, and arthritis which may authenticate its traditional use. |
| تدمد: | 1568-5608 0925-4692 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9442ddaf92065ac22e068d7db24594c9Test https://doi.org/10.1007/s10787-017-0403-7Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....9442ddaf92065ac22e068d7db24594c9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15685608 09254692 |
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