التفاصيل البيبلوغرافية
| العنوان: |
Survival, Treatment Outcome, and Safety of Multiple and Repeated Courses of Stereotactic Body Radiotherapy for Pulmonary Oligometastases of Head and Neck Squamous Cell Carcinoma. |
| المؤلفون: |
Vorbach, Samuel Moritz, Mangesius, Julian, Dejaco, Daniel, Seppi, Thomas, Santer, Matthias, Zur Nedden, Stephanie, Sarcletti, Manuel Paolo, Pointner, Martin Josef, Hart, Tilmann Jakob, Riechelmann, Herbert, Ganswindt, Ute, Nevinny-Stickel, Meinhard |
| المصدر: |
Cancers; Nov2023, Vol. 15 Issue 21, p5253, 15p |
| مصطلحات موضوعية: |
TREATMENT of lung tumors, TUMOR treatment, HEAD & neck cancer, METASTASIS, RETROSPECTIVE studies, TREATMENT effectiveness, ADJUVANT treatment of cancer, CHEMORADIOTHERAPY, DESCRIPTIVE statistics, RADIOSURGERY, PROGRESSION-free survival, ALTERNATIVE medicine, SQUAMOUS cell carcinoma, OVERALL survival, PATIENT safety, EVALUATION |
| مستخلص: |
Simple Summary: The objective of this retrospective study was to evaluate whether stereotactic body radiotherapy (SBRT) is safe and effective when applied for the treatment of oligometastatic pulmonary metastases (PM) exclusively derived from head and neck squamous cell carcinoma (HNSCC). Excellent local control of 92 treated single and multiple lesions was achieved even after repeated courses of SBRT of newly emerging metastases. Overall survival of the 46 included patients was in the upper range of previously reported results. Toxicities were limited to grade 2 and no functional lung impairment was observed. Based on the presented findings in this largest investigated cohort of exclusively HNSCC-derived PMs to date, SBRT can be recommended as a safe and effective treatment alternative to surgical resection for inoperable and resectable lesions. Current literature regarding survival and treatment outcome of SBRT in patients with pulmonary oligometastatic head and neck squamous cell carcinoma (HNSCC) is limited. Additionally, most of the published studies include metastatic lesions deriving also from primaries with histologies other than SCC when investigating the outcome of SBRT. The aim of the present retrospective study is to explore local control (LC) of treated metastases, progression-free survival (PFS), and overall survival (OS) of exclusively pulmonary oligometastatic HNSCC-patients treated with SBRT. Between 2006 and 2021, a total of 46 patients were treated with SBRT for a maximum of four pulmonary oligometastases (PM) concurrently (mean PM per patient = 2.0; range 1 to 6 PM, total of 92). Of these, 17 patients (37.0%) developed new pulmonary metastases after their first SBRT. Repeated courses of SBRT were required once in 15 patients (88.2%) and twice in 2 patients (11.8%). Median follow-up was 17 months (range, 0–109 months). One year after completion of SBRT, LC rate, PFS, and OS were 98.7%, 37.9%, and 79.5%, respectively. After two years, LC rate, PFS, and OS were 98.7%, 28.7%, and 54.9%; as well as 98.7%, 16.7%, and 31.0% after five years. Radiochemotherapy (HR 2.72, p < 0.001) or radiotherapy as primary treatment (HR 8.60; p = 0.003), as well as reduced patient performance status (HR 48.30, p = 0.002), were associated with lower PFS. Inferior OS correlated with poor performance status (HR 198.51, p < 0.001) and surgery followed by radiochemotherapy (HR 4.18, p = 0.032) as primary treatment, as well as radiotherapy alone (HR 7.11, p = 0.020). Treatment of more than one PM is an independent predictor of impaired OS (HR 3.30, p = 0.016). SBRT of HNSCC-derived PMs results in excellent LC rates and encouraging OS rates of 54.9% at two years along with good tolerability (no more than grade 2 toxicities). Favourable outcome and low toxicity also apply to repeated courses of SBRT of newly emerging PMs. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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