التفاصيل البيبلوغرافية
| العنوان: |
Analysis of Side Effects Following Vaccination Against COVID-19 Among Individuals With Multiple Sclerosis Treated With DMTs in Poland |
| المؤلفون: |
Czarnowska, Agata, Tarasiuk, Joanna, Zajkowska, Olga, Wnuk, Marcin, Marona, Monika, Nowak, Klaudia, Słowik, Agnieszka, Jamroz-Wiśniewska, Anna, Rejdak, Konrad, Lech, Beata, Popiel, Małgorzata, Rościszewska-Żukowska, Iwona, Perenc, Adam, Bartosik-Psujek, Halina, Świderek-Matysiak, Mariola, Siger, Małgorzata, Ciach, Agnieszka, Walczak, Agata, Jurewicz, Anna, Stasiołek, Mariusz, Kania, Karolina, Dyczkowska, Klara, Kalinowska-Łyszczarz, Alicja, Galus, Weronika, Walawska-Hrycek, Anna, Krzystanek, Ewa, Chojdak-Łukasiewicz, Justyna, Ubysz, Jakub, Pokryszko-Dragan, Anna, Kapica-Topczewska, Katarzyna, Chorąży, Monika, Bazylewicz, Marcin, Mirończuk, Anna, Kulikowska, Joanna, Kochanowicz, Jan, Białek, Marta, Stolarz, Małgorzata, Kubicka-Bączyk, Katarzyna, Niedziela, Natalia, Warmus, Paweł, Adamczyk-Sowa, Monika, Podlecka-Piçtowska, Aleksandra, Nojszewska, Monika, Zakrzewska-Pniewska, Beata, Jasińska, Elżbieta, Zaborski, Jacek, Milewska-Jȩdrzejczak, Marta, Zwiernik, Jacek, Zwiernik, Beata, Potemkowski, Andrzej |
| المصدر: |
Frontiers in Neurology ; volume 13 ; ISSN 1664-2295 |
| بيانات النشر: |
Frontiers Media SA |
| سنة النشر: |
2022 |
| المجموعة: |
Frontiers (Publisher - via CrossRef) |
| مصطلحات موضوعية: |
Neurology (clinical), Neurology |
| الوصف: |
Background and Objectives Since vaccination against COVID-19 is available for over a year and the population of immunized individuals with autoimmune disorders is higher than several months before, an evaluation of safety and registered adverse events can be made. We conducted a large study of side effects following the COVID-19 vaccine among patients with multiple (MS) sclerosis treated with disease-modifying therapies (DMTs) and analyzed factors predisposing for particular adverse events. Methods We gathered data of individuals with MS treated with DMTs from 19 Polish MS Centers, who reported at least one adverse event following COVID-19 vaccination. The information was obtained by neurologists using a questionnaire. The same questionnaire was used at all MS Centers. To assess the relevance of reported adverse events, we used Fisher's exact test, t -test, and U -Menn-Whutney test. Results A total of 1,668 patients with MS and reports of adverse events after COVID-19 vaccination were finally included in the study. Besides one case marked as “red flag”, all adverse events were classified as mild. Pain at the injection site was the most common adverse event, with a greater frequency after the first dose. Pain at the injection site was significantly more frequent after the first dose among individuals with a lower disability (EDSS ≤2). The reported adverse events following immunization did not differ over sex. According to age, pain at the injection site was more common among individuals between 30 and 40 years old, only after the first vaccination dose. None of the DMTs predisposed for particular side effects. Conclusions According to our findings, vaccination against COVID-19 among patients with MS treated with DMTs is safe. Our study can contribute to reducing hesitancy toward vaccination among patients with MS. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| DOI: |
10.3389/fneur.2022.913283 |
| DOI: |
10.3389/fneur.2022.913283/full |
| الإتاحة: |
https://doi.org/10.3389/fneur.2022.913283Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.D42E0AFA |
| قاعدة البيانات: |
BASE |
