Two groups of rhinoviruses revealed by a panel of antiviral compounds present sequence divergence and differential pathogenicity
| العنوان: | Two groups of rhinoviruses revealed by a panel of antiviral compounds present sequence divergence and differential pathogenicity |
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| المؤلفون: | Henri Moereels, J. Snoeks, P. A. J. Janssen, Leo Wouters, Pj Lewi, B. Dewindt, Koenraad Jozef Lodewijk Marcel Andries |
| المصدر: | Journal of Virology. 64:1117-1123 |
| بيانات النشر: | American Society for Microbiology, 1990. |
| سنة النشر: | 1990 |
| مصطلحات موضوعية: | Serotype, Rhinovirus, viruses, Molecular Sequence Data, Immunology, Sequence alignment, Biology, medicine.disease_cause, Antiviral Agents, Microbiology, Group A, Virus, Capsid, stomatognathic system, Sequence Homology, Nucleic Acid, Virology, medicine, Amino Acid Sequence, Binding site, Peptide sequence, chemistry.chemical_classification, Analysis of Variance, Binding Sites, Virulence, virus diseases, Amino acid, Poliovirus, chemistry, Insect Science, Research Article |
| الوصف: | A variety of chemically different compounds inhibit the replication of several serotypes of rhinoviruses (common-cold viruses). We noticed that one of these antiviral compounds, WIN 51711, had an antiviral spectrum clearly distinctive from a consensus spectrum or other capsid-binding compounds, although all of them were shown to share the same binding site. A systematic evaluation of all known rhinovirus capsid-binding compounds against all serotyped rhinoviruses was therefore initiated. Multivariate analysis of the results revealed the existence of two groups of rhinoviruses, which we will call antiviral groups A and B. The differential sensitivity of members of these groups to antiviral compounds suggests the existence of a dimorphic binding site. The antiviral groups turned out to be a reflection of a divergence of rhinovirus serotypes on a much broader level. Similarities in antiviral spectra were highly correlated with sequence similarities, not only of amino acids lining the antiviral compound-binding-site, but also of amino acids of the whole VP1 protein. Furthermore, analysis of epidemiological data indicated that group B rhinoviruses produced more than twice as many clinical infections per serotype than group A rhinoviruses did. Rhinoviruses belonging to the minor receptor group were without exception all computed to lie in the same region of antiviral group B. |
| تدمد: | 1098-5514 0022-538X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6409f629807f930f36c444b5e943a695Test https://doi.org/10.1128/jvi.64.3.1117-1123.1990Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6409f629807f930f36c444b5e943a695 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10985514 0022538X |
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