Serum containing Gengnianchun formula suppresses amyloid�β‑induced inflammatory cytokines in BV‑2 microglial cells by inhibiting the NF‑κB and JNK signaling pathways
| العنوان: | Serum containing Gengnianchun formula suppresses amyloid�β‑induced inflammatory cytokines in BV‑2 microglial cells by inhibiting the NF‑κB and JNK signaling pathways |
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| المؤلفون: | Yan‑Qiu Rao, Wenjun Wang, Pin‑Li Chen, Ming‑Jun Cheng, Jun Li |
| المصدر: | Molecular Medicine Reports |
| بيانات النشر: | Spandidos Publications, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Cancer Research, Cell Survival, Inflammation, Pharmacology, Biochemistry, Neuroprotection, Cell Line, Proinflammatory cytokine, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, microglial cells, Genetics, medicine, Animals, Molecular Biology, Neuroinflammation, Amyloid beta-Peptides, Innate immune system, Microglia, JNK Mitogen-Activated Protein Kinases, NF-kappa B, NF-κB, Articles, Alzheimer's disease, Rats, 030104 developmental biology, medicine.anatomical_structure, Oncology, chemistry, Gengnianchun formula, amyloid β, Cytokines, Molecular Medicine, Tumor necrosis factor alpha, Inflammation Mediators, medicine.symptom, 030217 neurology & neurosurgery, Drugs, Chinese Herbal, Signal Transduction |
| الوصف: | As the resident macrophages of the brain's innate immune system, microglial cells are key modulators in the neurodegenerative disease Alzheimer's disease (AD). In particular, the activation and accumulation of microglial cells around amyloid plaques is considered to result in chronic neuroinflammation. Although the pathologic mechanism remains to be fully elucidated, inflammation has been shown to be critical in the pathogenesis of AD. The Gengnianchun (GNC) formula has long been used to treat perimenopausal syndrome clinically, and is particularly effective in improving learning ability and memory. Our previous study demonstrated that GNC formula had an anti-inflammatory effect and offered neuroprotection in animal experiments. In the present study, the anti-inflammatory properties of GNC and its underlying mechanism of action were examined in BV-2 microglial cells. Amyloid-β peptide (Aβ)-stimulated microglial cells were examined for the production of proinflammatory cytokines and the underlying signaling pathways. Compared with the normal control group, the protein expression levels of IL-1β and TNF-α were significantly increased following treatment with Aβ (P |
| تدمد: | 1791-3004 1791-2997 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c249719dd7b56a839d295774378a148eTest https://doi.org/10.3892/mmr.2018.8524Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c249719dd7b56a839d295774378a148e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17913004 17912997 |
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