نتائج البحث - "Pietilä, Mika"

1

دورية أكاديمية

Sortilin-related receptor is a druggable therapeutic target in breast cancer

المؤلفون: Al-Akhrass, Hussein, Pietilä, Mika, Lilja, Johanna, Vesilahti, Ella-Maria, Anttila, Johanna M., Haikala, Heidi M., Munne, Pauliina M., Klefström, Juha, Peuhu, Emilia, Ivaska, Johanna

المساهمون: HUS Comprehensive Cancer Center, Faculty of Medicine, CAN-PRO - Translational Cancer Medicine Program, University Management

مصطلحات موضوعية: breast cancer, HER2, HER3, receptor trafficking, SorLA, trastuzumab, AMYLOID PRECURSOR PROTEIN, PHOSPHORYLATION, LAPATINIB, ANTIBODY, DOMAIN, CELLS, ERBB2, 3122 Cancers

وصف الملف: application/pdf

العلاقة: We thank J. Siivonen and P. Laasola for technical assistance. H. Hamidi is acknowledged for illustrations and editing the manuscript. The Cell Imaging and Cytometry and Genome Editing core facilities (Turku Bioscience Centre, University of Turku, and Abo Akademi University and Biocenter Finland) and the EuroBioimaging node in Turku (Turku Bioscience Centre, University of Turku, and Abo Akademi University) are acknowledged for services, instrumentation, and expertise. This study was supported by an ERC Proof of Concept grant (SaveHER 790274, JI), K. Albin Johansson Foundation (JI), the Finnish Cancer Organizations (JI, JK), the Academy of Finland (JK), Business Finland (JK, PM), EU Horizon 2020 RESCUER (JK), the Finnish Cancer Institute (JI and JK), iCAN Flagship (JK, PM), Jane and Aatos Erkko Foundation (JK), and Sigrid Juselius Foundation (JI, JK). H. Al-Akhrass has been supported by the Finnish Cultural Foundation Central Fund 190150.; Al-Akhrass , H , Pietilä , M , Lilja , J , Vesilahti , E-M , Anttila , J M , Haikala , H M , Munne , P M , Klefström , J , Peuhu , E & Ivaska , J 2022 , ' Sortilin-related receptor is a druggable therapeutic target in breast cancer ' , Molecular oncology , vol. 16 , no. 1 , pp. 116-129 . https://doi.org/10.1002/1878-0261.13106Test; ORCID: /0000-0002-9720-9964/work/156645867; http://hdl.handle.net/10138/353147Test; f5324e01-c143-432d-960e-a4f5632e4151; 000705565000001

الإتاحة: http://hdl.handle.net/10138/353147Test

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2

دورية أكاديمية

MASTL is enriched in cancerous and pluripotent stem cells and influences OCT1/OCT4 levels

المؤلفون: Närvä, Elisa, Taskinen, Maria E., Lilla, Sergio, Isomursu, Aleksi, Pietilä, Mika, Weltner, Jere, Isola, Jorma, Sihto, Harri, Joensuu, Heikki, Zanivan, Sara, Norman, Jim, Ivaska, Johanna

المساهمون: STEMM - Stem Cells and Metabolism Research Program, Centre of Excellence in Stem Cell Metabolism, Department of Pathology, Doctoral Programme in Clinical Research, Doctoral Programme in Biomedicine, Research Programs Unit, Department of Oncology, Heikki Joensuu / Principal Investigator, HUS Comprehensive Cancer Center

مصطلحات موضوعية: Cancer, Cell biology, Proteomics, Stem cells research, 3122 Cancers

وصف الملف: application/pdf

العلاقة: We thank Prof. Timo Otonkoski and the Biomedicum Stem Cell Center, University of Helsinki, for providing hiPSC lines HEL11.4 and HEL62.4. We thank Jenni Siivonen and Petra Laasola for technical assistance. The Ivaska laboratory is acknowledged for lively discussions and critical feedback on the project. Hellyeh Hamidi for editing the manuscript. The Cell Imaging and Cytometry core facility (Turku Bioscience Center, University of Turku and Åbo Akademi University and Biocenter Finland), EuroBioimaging node in Turku, and the Mass spectrometry unit of the Beatson Institute for Cancer Research are acknowledged for services, instrumentation, and expertise. This study has been supported by the Academy of Finland (E.N. 297079 and J.I. 312517), Academy of Finland CoE for Translational Cancer Biology (J.I.), an ERC CoG grant 615258 (J.I.), InFLAMES Flagship Programme of the Academy of Finland (decision number: 337530), the Sigrid Jusélius Foundation (J.I.), the Finnish Cancer Organization (J.I. and E.N.), Finnish Cultural Foundation (E.N. M.E.T. and A.I.) and Cancer Research UK, A17196 (S.L.) and Stand Up to Cancer campaign for Cancer Research UK A29800 (S.Z.). We also acknowledge EMBO for a short-time fellowship (E.N.). Conceptualization, E.N. and J.I.; Investigation, E.N. M.E.T. S.L. A.I. M.P. J.W. and H.J.; Formal Analysis, E.N. M.E.T. S.L. A.I. H.S. and H.J.; Writing – Original Draft, E.N. and J.I. Writing-editing; E.N. S.L. M.E.T. J.I. A.I. and H.J.; Visualization, E.N. and M.E.T.; Supervision, J.I. J.C.N. S.Z. and J.Is.; Funding Acquisition, J.I. The authors declare no competing financial interests. We thank Prof. Timo Otonkoski and the Biomedicum Stem Cell Center, University of Helsinki, for providing hiPSC lines HEL11.4 and HEL62.4. We thank Jenni Siivonen and Petra Laasola for technical assistance. The Ivaska laboratory is acknowledged for lively discussions and critical feedback on the project. Hellyeh Hamidi for editing the manuscript. The Cell Imaging and Cytometry core facility (Turku Bioscience Center, University of Turku and Åbo Akademi University and Biocenter Finland), EuroBioimaging node in Turku, and the Mass spectrometry unit of the Beatson Institute for Cancer Research are acknowledged for services, instrumentation, and expertise. This study has been supported by the Academy of Finland (E.N. 297079 and J.I. 312517 ), Academy of Finland CoE for Translational Cancer Biology (J.I.), an ERC CoG grant 615258 (J.I.), InFLAMES Flagship Programme of the Academy of Finland (decision number: 337530 ), the Sigrid Jusélius Foundation (J.I.), the Finnish Cancer Organization (J.I. and E.N.), Finnish Cultural Foundation (E.N., M.E.T., and A.I.) and Cancer Research UK , A17196 (S.L.) and Stand Up to Cancer campaign for Cancer Research UK A29800 (S.Z.). We also acknowledge EMBO for a short-time fellowship (E.N.).; Närvä , E , Taskinen , M E , Lilla , S , Isomursu , A , Pietilä , M , Weltner , J , Isola , J , Sihto , H , Joensuu , H , Zanivan , S , Norman , J & Ivaska , J 2022 , ' MASTL is enriched in cancerous and pluripotent stem cells and influences OCT1/OCT4 levels ' , iScience , vol. 25 , no. 6 , 104459 . https://doi.org/10.1016/j.isci.2022.104459Test; ORCID: /0000-0003-0281-2507/work/129612235; ORCID: /0000-0001-5265-5509/work/129612250; 85132377007; d96d5d33-2b4d-411b-a175-8f9a34e14adb; http://hdl.handle.net/10138/354851Test

الإتاحة: http://hdl.handle.net/10138/354851Test

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3

دورية أكاديمية

Stabilizing vimentin phosphorylation inhibits stem-like cell properties and metastasis of hybrid epithelial/mesenchymal carcinomas

المصدر: Cell Reports ; volume 42, issue 12, page 113470 ; ISSN 2211-1247

مصطلحات موضوعية: General Biochemistry, Genetics and Molecular Biology

الإتاحة: https://doi.org/10.1016/j.celrep.2023.113470Test
https://api.elsevier.com/content/article/PII:S2211124723014821?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2211124723014821?httpAccept=text/plainTest

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4

دورية أكاديمية

MASTL is enriched in cancerous and pluripotent stem cells and influences OCT1/OCT4 levels

المؤلفون: Närvä, Elisa, Taskinen, Maria E., Lilla, Sergio, Isomursu, Aleksi, Pietilä, Mika, Weltner, Jere, Isola, Jorma, Sihto, Harri, Joensuu, Heikki, Zanivan, Sara, Norman, Jim, Ivaska, Johanna

المساهمون: Tampere University, BioMediTech

مصطلحات موضوعية: 318 Medical biotechnology

وصف الملف: fulltext

العلاقة: 104459; 25; https://trepo.tuni.fi/handle/10024/141579Test; URN:NBN:fi:tuni-202208096304

الإتاحة: https://doi.org/10.1016/j.isci.2022.104459Test
https://trepo.tuni.fi/handle/10024/141579Test

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النص الكامل

5

دورية أكاديمية

A vimentin binding small molecule leads to mitotic disruption in mesenchymal cancers

المؤلفون: Bollong, Michael J., Pietilä, Mika, Pearson, Aaron D., Sarkar, Tapasree Roy, Ahmad, Insha, Soundararajan, Rama, Lyssiotis, Costas A., Mani, Sendurai A., Schultz, Peter G., Lairson, Luke L.

المصدر: Proceedings of the National Academy of Sciences of the United States of America, 2017 Nov . 114(46), E9903-E9912.

الوصول الحر: https://www.jstor.org/stable/26486596Test

النص الكامل

6

دورية أكاديمية

SORLA regulates endosomal trafficking and oncogenic fitness of HER2

المؤلفون: Pietilä, Mika, Sahgal, Pranshu, Peuhu, Emilia, Jäntti, Niklas Z., Paatero, Ilkka, Närvä, Elisa, Al-Akhrass, Hussein, Lilja, Johanna, Georgiadou, Maria, Andersen, Olav M., Padzik, Artur, Sihto, Harri, Joensuu, Heikki, Blomqvist, Matias, Saarinen, Irena, Boström, Peter J., Taimen, Pekka, Ivaska, Johanna

المساهمون: Department of Pathology, Department of Oncology, CAN-PRO - Translational Cancer Medicine Program, HUS Comprehensive Cancer Center, Research Programs Unit, Heikki Joensuu / Principal Investigator

مصطلحات موضوعية: GROWTH-FACTOR RECEPTOR, HUMAN-BREAST-CANCER, KINASE DOMAIN, SOMATIC MUTATIONS, BLADDER-CANCER, ERBB2, PROTEIN, ENDOCYTOSIS, SURVIVAL, IDENTIFICATION, 3122 Cancers, 3111 Biomedicine

وصف الملف: application/pdf

العلاقة: We thank P. Laasola, J. Siivonen, and S. Collanus for excellent technical assistance, M. Saari for help with the microscopes. The Cell Imaging and Cytometry core facility, University of Turku, Turku Bioscience Centre for technical assistance with imaging. S. Hamalisto for useful suggestions regarding the CAD experiments. H. Hamidi for the scientific illustrations and manuscript editing, J. Westermarck, M. Salmi and the Ivaska lab for critical reading and feedback on the manuscript. This study has been supported by the Academy of Finland (M.P. and J.I.), Academy of Finland CoE for Translational Cancer Research (J.I. and H.J.), an ERC CoG grant 615258 (J.I.), the Sigrid Juselius Foundation, the Orion Research Foundation and the Finnish Cancer Organization (J.I.). P.S. has been supported by the Turku Doctoral Program of Molecular Medicine (TuDMM). E.P. is supported by the Finnish Cultural Foundation.; Pietilä , M , Sahgal , P , Peuhu , E , Jäntti , N Z , Paatero , I , Närvä , E , Al-Akhrass , H , Lilja , J , Georgiadou , M , Andersen , O M , Padzik , A , Sihto , H , Joensuu , H , Blomqvist , M , Saarinen , I , Boström , P J , Taimen , P & Ivaska , J 2019 , ' SORLA regulates endosomal trafficking and oncogenic fitness of HER2 ' , Nature Communications , vol. 10 , 2340 . https://doi.org/10.1038/s41467-019-10275-0Test; ORCID: /0000-0003-0281-2507/work/59442147; ORCID: /0000-0001-5265-5509/work/116549990; daad1012-150f-4afc-9a01-982898572a94; http://hdl.handle.net/10138/303895Test; 000469221900004

الإتاحة: http://hdl.handle.net/10138/303895Test

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7

دورية أكاديمية

GGA2 and RAB13 promote activity-dependent β1-integrin recycling

المؤلفون: Sahgal, Pranshu, Alanko, Jonna H, Icha, Jaroslav, Paatero, Ilkka, Hamidi, Hellyeh, Arjonen, Antti, Pietilä, Mika, Rokka, Anne, Ivaska, Johanna

المصدر: Sahgal P, Alanko JH, Icha J, et al. GGA2 and RAB13 promote activity-dependent β1-integrin recycling. Journal of Cell Science . 2019;132(11). doi: 10.1242/jcs.233387

العلاقة: info:eu-repo/semantics/altIdentifier/issn/0021-9533; info:eu-repo/semantics/altIdentifier/issn/1477-9137; info:eu-repo/semantics/altIdentifier/wos/000473327900017; info:eu-repo/semantics/altIdentifier/pmid/31076515; https://research-explorer.ista.ac.at/record/7420Test

الإتاحة: https://doi.org/10.1242/jcs.233387Test
https://research-explorer.ista.ac.at/record/7420Test

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8

دورية أكاديمية

Notch-Jagged signalling can give rise to clusters of cells exhibiting a hybrid epithelial/mesenchymal phenotype

المؤلفون: Boareto, Marcelo, Jolly, Mohit Kumar, Goldman, Aaron, Pietilä, Mika, Mani, Sendurai A., Sengupta, Shiladitya, Ben-Jacob, Eshel, Levine, Herbert, Onuchic, José Nelson

المساهمون: Center for Theoretical Biological Physics

مصطلحات موضوعية: notch signaling, epithelial–mesenchymal transition, circulating tumour cells, hybrid epithelial/mesenchymal phenotype, multistability, cell–cell communication

وصف الملف: application/pdf

العلاقة: Boareto, Marcelo, Jolly, Mohit Kumar, Goldman, Aaron, et al. "Notch-Jagged signalling can give rise to clusters of cells exhibiting a hybrid epithelial/mesenchymal phenotype." Journal of the Royal Society Interface, 13, no. 118 (2016) Royal Society Publishing: http://dx.doi.org/10.1098/rsif.2015.1106Test.; https://hdl.handle.net/1911/90841Test; http://dx.doi.org/10.1098/rsif.2015.1106Test

الإتاحة: https://doi.org/10.1098/rsif.2015.1106Test
https://hdl.handle.net/1911/90841Test

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