المؤلفون: Bay, Yasmin, Egeberg Jeppesen, Mie, Frydenvang, Karla, Francotte, Pierre, Pirotte, Bernard, Pickering, Darryl S., Kristensen, Anders Skov, Kastrup, Jette Sandholm

المصدر: Bay , Y , Egeberg Jeppesen , M , Frydenvang , K , Francotte , P , Pirotte , B , Pickering , D S , Kristensen , A S & Kastrup , J S 2024 , ' The positive allosteric modulator BPAM344 and L-glutamate introduce an active-like structure of the ligand-binding domain of GluK2 ' , FEBS Letters , vol. 598 , no. 7 , pp. 743-757 . https://doi.org/10.1002/1873-3468.14824Test

مصطلحات موضوعية: BPAM344 binding mode, calcium-sensitive fluorescence-based assay, dimer interface, GluK2 mutations, positive allosteric modulation, X-ray crystallography

وصف الملف: application/pdf

الإتاحة: https://doi.org/10.1002/1873-3468.14824Test
https://curis.ku.dk/portal/da/publications/the-positive-allosteric-modulator-bpam344-and-lglutamate-introduce-an-activelike-structure-of-the-ligandbinding-domain-of-gluk2Test(edc0b943-651d-4436-ac37-82f7e06d37e7).html
https://curis.ku.dk/ws/files/387737935/FEBS_Letters_2024_Bay_The_positive_allosteric_modulator_BPAM344_and_L_glutamate_introduce_an_active_like_structure_of.pdfTest

المؤلفون: Chałupnik, Paulina, Marek, Aleš, Hovah, Marie Emilie Leiticia, Pickering, Darryl S., Temperini, Piero, Donbosco, Stephanie, Szymańska, Ewa, Johansen, Tommy N.

المصدر: Chałupnik , P , Marek , A , Hovah , M E L , Pickering , D S , Temperini , P , Donbosco , S , Szymańska , E & Johansen , T N 2024 , ' Tritium and deuterium labelling of a kainate receptor antagonist and evaluation as a radioligand ' , Journal of Labelled Compounds and Radiopharmaceuticals , vol. 67 , no. 4 , pp. 120-130 . https://doi.org/10.1002/jlcr.4087Test

مصطلحات موضوعية: ionotropic glutamate receptors, quinoxaline-2,3-diones, tritium labelling

وصف الملف: application/pdf

الإتاحة: https://doi.org/10.1002/jlcr.4087Test
https://curis.ku.dk/portal/da/publications/tritium-and-deuterium-labelling-of-a-kainate-receptor-antagonist-and-evaluation-as-a-radioligandTest(a7bef4d5-a37d-4f23-aab6-80e54e840dd9).html
https://curis.ku.dk/ws/files/390514826/Labelled_Comp_Radiopharmac_2024_Cha_upnik_Tritium_and_deuterium_labelling_of_a_kainate_receptor_antagonist_and.pdfTest

المؤلفون: Warfvinge, Karin, Edvinsson, Lars, Pickering, Darryl S., Sheykhzade, Majid

المصدر: Pharmacology. 104(5-6):332-341

مصطلحات موضوعية: Medicin och hälsovetenskap, Medicinska och farmaceutiska grundvetenskaper, Farmakologi och toxikologi, Medical and Health Sciences, Basic Medicine, Pharmacology and Toxicology

الوصول الحر: https://lup.lub.lu.se/record/becabe2b-efde-47af-834f-75977dd38fa7Test
http://dx.doi.org/10.1159/000502471Test

المؤلفون: Bay, Yasmin, Venskutonytė, Raminta, Frantsen, Stine M., Thorsen, Thor S., Musgaard, Maria, Frydenvang, Karla, Francotte, Pierre, Pirotte, Bernard, Biggin, Philip C., Kristensen, Anders S., Boesen, Thomas, Pickering, Darryl S., Gajhede, Michael, Kastrup, Jette S.

المصدر: Bay , Y , Venskutonytė , R , Frantsen , S M , Thorsen , T S , Musgaard , M , Frydenvang , K , Francotte , P , Pirotte , B , Biggin , P C , Kristensen , A S , Boesen , T , Pickering , D S , Gajhede , M & Kastrup , J S 2024 , ' Small-molecule positive allosteric modulation of homomeric kainate receptors GluK1-3 : development of screening assays and insight into GluK3 structure ' , FEBS journal , vol. 291 , no. 7 , pp. 1506-1529 . https://doi.org/10.1111/febs.17046Test

مصطلحات موضوعية: calcium-sensitive fluorescence-based assays, electron microscopy, kainate receptors, molecular dynamics simulations, X-ray crystallography

العلاقة: https://pure.au.dk/portal/en/publications/ed55e272-6246-4232-af77-692cd51146c8Test

الإتاحة: https://doi.org/10.1111/febs.17046Test
https://pure.au.dk/portal/en/publications/ed55e272-6246-4232-af77-692cd51146c8Test
http://www.scopus.com/inward/record.url?scp=85185918937&partnerID=8YFLogxKTest

المؤلفون: Francotte, Pierre, Bay, Yasmin, Goffin, Eric, Colson, Thomas, Lesenfants, Cindy, Dorosz, Jerzy, Laulumaa, Saara, Fraikin, Pierre, de Tullio, Pascal, Beaufour, Caroline, Botez, Iuliana, Pickering, Darryl S., Frydenvang, Karla, Danober, Laurence, Kristensen, Anders Skov, Kastrup, Jette Sandholm, Pirotte, Bernard

المصدر: Francotte , P , Bay , Y , Goffin , E , Colson , T , Lesenfants , C , Dorosz , J , Laulumaa , S , Fraikin , P , de Tullio , P , Beaufour , C , Botez , I , Pickering , D S , Frydenvang , K , Danober , L , Kristensen , A S , Kastrup , J S & Pirotte , B 2024 , ' Exploring thienothiadiazine dioxides as isosteric analogues of benzo- and pyridothiadiazine dioxides in the search of new AMPA and kainate receptor positive allosteric modulators ' , ....

مصطلحات موضوعية: 1,2,4-Benzothiadiazine 1,1-dioxides, Calcium-sensitive fluorescence-based assay, Ionotropic glutamate receptors, Positive allosteric modulators, thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxides, X-ray crystallography

الإتاحة: https://doi.org/10.1016/j.ejmech.2023.116036Test
https://curis.ku.dk/portal/da/publications/exploring-thienothiadiazine-dioxides-as-isosteric-analogues-of-benzo-and-pyridothiadiazine-dioxides-in-the-search-of-new-ampa-and-kainate-receptor-positive-allosteric-modulatorsTest(4ff101cd-50ac-44e4-8b8c-dfcfe8ce4852).html

المؤلفون: Bay, Yasmin, Venskutonytė, Raminta, Frantsen, Stine M., Thorsen, Thor S., Musgaard, Maria, Frydenvang, Karla, Francotte, Pierre, Pirotte, Bernard, Biggin, Philip C., Kristensen, Anders S., Boesen, Thomas, Pickering, Darryl S., Gajhede, Michael, Kastrup, Jette S.

المصدر: FEBS Journal; Apr2024, Vol. 291 Issue 7, p1506-1529, 24p

مصطلحات موضوعية: ALLOSTERIC regulation, MOLECULAR dynamics, X-ray crystallography, GLUTAMATE receptors, ZINC-finger proteins, ZINC ions, G protein coupled receptors, CALCIUM channels

المؤلفون: Bay, Yasmin, Venskutonytė, Raminta, Frantsen, Stine M, Thorsen, Thor S, Musgaard, Maria, Frydenvang, Karla, Francotte, Pierre, Pirotte, Bernard, Biggin, Philip C, Kristensen, Anders S, Boesen, Thomas, Pickering, Darryl S, Gajhede, Michael, Kastrup, Jette S

المصدر: FEBS Journal (2023-12-25)

مصطلحات موضوعية: Kainate receptors, X-ray crystallography, calcium-sensitive fluorescence-based assays, electron microscopy, molecular dynamics simulations, Cell Biology, Molecular Biology, Biochemistry, Human health sciences, Pharmacy, pharmacology & toxicology, Sciences de la santé humaine, Pharmacie, pharmacologie & toxicologie

العلاقة: https://febs.onlinelibrary.wiley.com/doi/pdf/10.1111/febs.17046Test; urn:issn:1742-464X; urn:issn:1742-4658

الوصول الحر: https://orbi.uliege.be/handle/2268/313465Test

المؤلفون: Chałupnik, Paulina, Vialko, Alina, Pickering, Darryl S, Hinkkanen, Markus, Donbosco, Stephanie, Møller, Thor C, Jensen, Anders A, Nielsen, Birgitte, Bay, Yasmin, Kristensen, Anders S, Johansen, Tommy N, Łątka, Kamil, Bajda, Marek, Szymańska, Ewa

المصدر: Chałupnik , P , Vialko , A , Pickering , D S , Hinkkanen , M , Donbosco , S , Møller , T C , Jensen , A A , Nielsen , B , Bay , Y , Kristensen , A S , Johansen , T N , Łątka , K , Bajda , M & Szymańska , E 2022 , ' Discovery of the First Highly Selective Antagonist of the GluK3 Kainate Receptor Subtype ' , International Journal of Molecular Sciences , vol. 23 , no. 15 , 8797 . https://doi.org/10.3390/ijms23158797Test

وصف الملف: application/pdf

الإتاحة: https://doi.org/10.3390/ijms23158797Test
https://curis.ku.dk/portal/da/publications/discovery-of-the-first-highly-selective-antagonist-of-the-gluk3-kainate-receptor-subtypeTest(1dd1c2f0-5aea-4a68-b87c-cdb85b250a93).html
https://curis.ku.dk/ws/files/319247299/ijms_23_08797.pdfTest

المؤلفون: Frydenvang, Karla, Pickering, Darryl S., Kastrup, Jette Sandholm

المصدر: Frydenvang , K , Pickering , D S & Kastrup , J S 2022 , ' Structural basis for positive allosteric modulation of AMPA and kainate receptors ' , The Journal of Physiology , vol. 600 , no. 2 , pp. 181-200 . https://doi.org/10.1113/JP280873Test

مصطلحات موضوعية: GluA2, GluA3, GluK1, ionotropic glutamate receptors, positive allosteric modulators

وصف الملف: application/pdf

الإتاحة: https://doi.org/10.1113/JP280873Test
https://curis.ku.dk/portal/da/publications/structural-basis-for-positive-allosteric-modulation-of-ampa-and-kainate-receptorsTest(8cdd807d-9f09-44a1-ac4e-f693a2bc67ae).html
https://curis.ku.dk/ws/files/371268250/JP_SR_2021_280873_manuscript_2021.04.22.pdfTest

المؤلفون: Kayser, Silke, Hansen, Jacob C, Staudt, Markus, Moroz, Aleksandra, Larsen, Younes, Temperini, Piero, Yi, Feng, Syrenne, Jed T, Krogsgaard-Larsen, Niels, Iliadis, Stylianos, Nielsen, Birgitte, Hansen, Kasper B, Pickering, Darryl S, Bunch, Lennart

المصدر: Kayser , S , Hansen , J C , Staudt , M , Moroz , A , Larsen , Y , Temperini , P , Yi , F , Syrenne , J T , Krogsgaard-Larsen , N , Iliadis , S , Nielsen , B , Hansen , K B , Pickering , D S & Bunch , L 2020 , ' Stereoselective Synthesis of New (2S,3R)-3-Carboxyphenyl)pyrrolidine-2-carboxylic Acid Analogues Utilizing a C(sp3)-H Activation Strategy and Structure-Activity Relationship Studies at the Ionotropic Glutamate Receptors ' , ACS Chemical Neuroscience , vol. 11 , pp. 674-701 . https://doi.org/10.1021/acschemneuro.0c00003Test

الإتاحة: https://doi.org/10.1021/acschemneuro.0c00003Test
https://curis.ku.dk/portal/da/publications/stereoselective-synthesis-of-new-2s3r3carboxyphenylpyrrolidine2carboxylic-acid-analogues-utilizing-a-csp3h-activation-strategy-and-structureactivity-relationship-studies-at-the-ionotropic-glutamate-receptorsTest(8b6ef517-8c79-4fc3-a63a-de2b0ea0e184).html
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227796/pdf/nihms-1579919.pdfTest