دورية أكاديمية
Role of succinyl substituents in the mannose-capping of lipoarabinomannan and control of inflammation in Mycobacterium tuberculosis infection
| العنوان: | Role of succinyl substituents in the mannose-capping of lipoarabinomannan and control of inflammation in Mycobacterium tuberculosis infection |
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| المؤلفون: | Palčeková, Zuzana, Obregón-Henao, Andrés, De, Kavita, Walz, Amanda, Lam, Ha, Philp, Jamie, Angala, Shiva, Kumar, Patterson, Johnathan, Pearce, Camron, Zuberogoitia, Sophie, Avanzi, Charlotte, Nigou, Jérôme, Mcneil, Michael, Muñoz Gutiérrez, Juan, F, Gilleron, Martine, Wheat, William, H, Gonzalez-Juarrero, Mercedes, Jackson, Mary |
| المساهمون: | Mycobacteria Research Laboratories, Colorado State University Fort Collins (CSU), Biomolécules : Conception, Isolement, Synthèse (BioCIS), Institut de Chimie - CNRS Chimie (INC-CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-CY Cergy Paris Université (CY), Institut de pharmacologie et de biologie structurale (IPBS), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Ecole Polytechnique Fédérale de Lausanne (EPFL), Mycobacteria Research Laboratories Fort Collins, CO, États-Unis, Department of Microbiology, Immunology and Pathology Fort Collins, CO, États-Unis, Colorado State University Fort Collins (CSU)-Colorado State University Fort Collins (CSU) |
| المصدر: | ISSN: 1553-7366. |
| بيانات النشر: | HAL CCSD Public Library of Science |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | [SDV]Life Sciences [q-bio] |
| الوصف: | International audience ; The covalent modification of bacterial (lipo)polysaccharides with discrete substituents may impact their biosynthesis, export and/or biological activity. Whether mycobacteria use a similar strategy to control the biogenesis of its cell envelope polysaccharides and modulate their interaction with the host during infection is unknown despite the report of a number of tailoring substituents modifying the structure of these glycans. Here, we show that discrete succinyl substituents strategically positioned on Mycobacterium tuberculosis (Mtb) lipoarabinomannan govern the mannose-capping of this lipoglycan and, thus, much of the biological activity of the entire molecule. We further show that the absence of succinyl substituents on the two main cell envelope glycans of Mtb, arabinogalactan and lipoarabinomannan, leads to a significant increase of pro-inflammatory cytokines and chemokines in infected murine and human macrophages. Collectively, our results validate polysaccharide succinylation as a critical mechanism by which Mtb controls inflammation. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | hal-04238654; https://hal.science/hal-04238654Test; https://hal.science/hal-04238654/documentTest; https://hal.science/hal-04238654/file/Palcekova_Plos%20Pathogen_2023.pdfTest |
| DOI: | 10.1371/journal.ppat.1011636 |
| الإتاحة: | https://doi.org/10.1371/journal.ppat.1011636Test https://hal.science/hal-04238654Test https://hal.science/hal-04238654/documentTest https://hal.science/hal-04238654/file/Palcekova_Plos%20Pathogen_2023.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.CE763560 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1371/journal.ppat.1011636 |
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