Genetic and Environmental Influences on Retinopathy of Prematurity
| العنوان: | Genetic and Environmental Influences on Retinopathy of Prematurity |
|---|---|
| المؤلفون: | J. M. Ortega-Molina, J. L. García-Serrano, R. Piñar-Molina, J. Uberos-Fernández, M. J. Chaves-Samaniego, R. Anaya-Alaminos, A. Solans-Pérez de Larraya, A. Jerez-Calero, A.D. Salgado-Miranda |
| المساهمون: | [Ortega-Molina,JM, Anaya-Alaminos,R, Solans-Pérez de Larraya,A, Chaves-Samaniego,MJ, Salgado-Miranda,A, García-Serrano,JL] Department of Ophthalmology, San Cecilio University Hospital, Granada, Spain. [Uberos-Fernández,J, Jerez-Calero,A] Department of Paediatrics, San Cecilio University Hospital, Granada, Spain. [Piñar-Molina,R] Retinopathy of Prematurity Programme, San Cecilio University Hospital, Granada, Spain. |
| المصدر: | Mediators of Inflammation, Vol 2015 (2015) Mediators of Inflammation |
| بيانات النشر: | Hindawi Publishing Corporation, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Pediatrics, medicine.medical_specialty, Article Subject, Genotype, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Prospective Studies [Medical Subject Headings], Immunology, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors [Medical Subject Headings], Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Phenomena and Processes::Genetic Phenomena::Phenotype::Gene-Environment Interaction [Medical Subject Headings], Risk Factors, Recién nacido, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Models, Theoretical::Models, Statistical::Logistic Models [Medical Subject Headings], Estudios prospectivos, medicine, Genetic predisposition, lcsh:Pathology, Humans, Retinopathy of Prematurity, Prospective Studies, Gene–environment interaction, Interacción gen-ambiente, Prospective cohort study, Retrospective Studies, business.industry, Infant, Newborn, Gestational age, Retrospective cohort study, Retinopathy of prematurity, Cell Biology, Heritability, medicine.disease, eye diseases, Modelos logísticos, Humanos, Logistic Models, Clinical Study, Gene-Environment Interaction, Phenomena and Processes::Genetic Phenomena::Genotype [Medical Subject Headings], medicine.symptom, business, Weight gain, Genotipo, lcsh:RB1-214, Factores de riesgo |
| الوصف: | Objective. The goals were to isolate and study the genetic susceptibility to retinopathy of prematurity (ROP), as well as the gene-environment interaction established in this disease.Methods. A retrospective study (2000–2014) was performed about the heritability of retinopathy of prematurity in 257 infants who were born at a gestational age of ≤32 weeks. The ROP was studied and treated by a single pediatric ophthalmologist. A binary logistic regression analysis was completed between the presence or absence of ROP and the predictor variables.Results. Data obtained from 38 monozygotic twins, 66 dizygotic twins, and 153 of simple birth were analyzed. The clinical features of the cohorts of monozygotic and dizygotic twins were not significantly different. Genetic factors represented 72.8% of the variability in the stage of ROP, environmental factors 23.08%, and random factors 4.12%. The environmental variables representing the highest risk of ROP were the number of days of tracheal intubation (p< 0.001), postnatal weight gain (p= 0.001), and development of sepsis (p= 0.0014).Conclusion. The heritability of ROP was found to be 0.73. The environmental factors regulate and modify the expression of the genetic code. |
| وصف الملف: | application/pdf; text/xhtml |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcc29589e0a6d7ee392abf278a06d36aTest https://hdl.handle.net/10668/2519Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....fcc29589e0a6d7ee392abf278a06d36a |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |