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FoxM1 repression during human aging leads to mitotic decline and aneuploidy-driven full senescence

التفاصيل البيبلوغرافية
العنوان: FoxM1 repression during human aging leads to mitotic decline and aneuploidy-driven full senescence
المؤلفون: Joana Catarina Macedo, Sara Vaz, Bjorn Bakker, Rui Ribeiro, Petra Lammigje Bakker, Jose Miguel Escandell, Miguel Godinho Ferreira, René Medema, Floris Foijer, Elsa Logarinho
المصدر: Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
بيانات النشر: Nature Portfolio, 2018.
سنة النشر: 2018
المجموعة: LCC:Science
مصطلحات موضوعية: Science
الوصف: Evidence for mitotic decline in aged cells and for aneuploidy-driven progression into full senescence is limited. Here, the authors find that in aged cells, mitotic gene repression leads to increased chromosome mis-segregation and aneuploidy that triggers permanent cell cycle arrest and full senescence.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2041-1723
العلاقة: https://doaj.org/toc/2041-1723Test
DOI: 10.1038/s41467-018-05258-6
الوصول الحر: https://doaj.org/article/bfcab92a173641ca9b7e59b64b8285c9Test
رقم الانضمام: edsdoj.bfcab92a173641ca9b7e59b64b8285c9
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20411723
DOI:10.1038/s41467-018-05258-6