المؤلفون: Cloud P Paweletz, Jannik N Andersen, Roy Pollock, Kumiko Nagashima, Mansuo L Hayashi, Shangshuan U Yu, Hongbo Guo, Ekaterina V Bobkova, Zangwei Xu, Alan Northrup, Peter Blume-Jensen, Ronald C Hendrickson, An Chi

المصدر: PLoS ONE, Vol 6, Iss 10, p e26459 (2011)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

العلاقة: http://europepmc.org/articles/PMC3200335?pdf=renderTest; https://doaj.org/toc/1932-6203Test

الوصول الحر: https://doaj.org/article/ecc88f9d2bf143f09228d27bcd3a4329Test

المؤلفون: Farrukh Vohidov (2072296), Jannik N. Andersen (199563), Kyriakos D. Economides (10332160), Michail V. Shipitsin (10332163), Olga Burenkova (10332166), James C. Ackley (10332169), Bhavatarini Vangamudi (1313319), Hung V.-T. Nguyen (2885066), Nolan M. Gallagher (1795861), Peyton Shieh (1586818), Matthew R. Golder (1678135), Jenny Liu (647696), William K. Dahlberg (2188987), Deborah J. C. Ehrlich (10332172), Julie Kim (10332175), Samantha L. Kristufek (10332178), Sung Jin Huh (2401033), Allison M. Neenan (10332181), Joelle Baddour (10332184), Sattanathan Paramasivan (10332187), Elisa de Stanchina (153061), Gaurab KC (10332190), David J. Turnquist (10332193), Jennifer K. Saucier-Sawyer (10332196), Paul W. Kopesky (10332199), Samantha W. Brady (5211746), Michael J. Jessel (10332202), Lawrence A. Reiter (335508), Donald E. Chickering (4847407), Jeremiah A. Johnson (1316577), Peter Blume-Jensen (199585)

مصطلحات موضوعية: Biochemistry, Medicine, Pharmacology, Biotechnology, Immunology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, drug development, novel BETi prodrugs, protein inhibitors, prodrug design, prodrug activation kinetics, vivo tumor pharmacokinetics, Such approaches, traceless linkers, tissues offer, Superior Efficacy, BET Inhibitor Bottlebrush Prodrugs, dose-limiting toxicities, antitumor efficacies, syngeneic triple-negative breast ca., trial-and-error design, TI, Systemic Toxicities Prodrugs, prodrug platform

العلاقة: https://figshare.com/articles/journal_contribution/Design_of_BET_Inhibitor_Bottlebrush_Prodrugs_with_Superior_Efficacy_and_Devoid_of_Systemic_Toxicities/14251084Test

الإتاحة: https://doi.org/10.1021/jacs.1c00312.s001Test

المؤلفون: Fred Saad, Philip Kantoff, Jonathan I. Epstein, Mathieu Latour, Cristina Magi-Galluzzi, Eric A. Klein, Massimo Loda, James Dunyak, Julie Nardone, Eldar Giladi, Hua Chang, Alex Kaprelyants, Aeron Hurley, Christina Ernst, Louis Coupal, Teresa Capela, Sibgat Choudhury, Clayton Small, Thomas P. Nifong, Mathew Putzi, Michail Shipitsin, David L. Rimm, David M. Berman, Peter Blume-Jensen

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8a1d5ad71950008144484ceac754a37Test
https://doi.org/10.1158/1078-0432.c.6524298Test

المؤلفون: Fred Saad, Philip Kantoff, Jonathan I. Epstein, Mathieu Latour, Cristina Magi-Galluzzi, Eric A. Klein, Massimo Loda, James Dunyak, Julie Nardone, Eldar Giladi, Hua Chang, Alex Kaprelyants, Aeron Hurley, Christina Ernst, Louis Coupal, Teresa Capela, Sibgat Choudhury, Clayton Small, Thomas P. Nifong, Mathew Putzi, Michail Shipitsin, David L. Rimm, David M. Berman, Peter Blume-Jensen

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a775876007c847964815ceef0082305Test
https://doi.org/10.1158/1078-0432.22459749Test

المؤلفون: Manfred Kraus, Jannik N. Andersen, Peter Blume-Jensen, Nancy Kohl, Victoria Richon, Giulio Draetta, Martin L. Scott, Roderick T. Bronson, Shailaja Kasibhatla, Ekaterina V. Bobkova, Alan Northrup, Thomas F. Vogt, Myung K. Shin, Melissa Hurd, Paula Andrade, Erica Leccese, Minilik Angagaw, Nirah H. Shomer, Diana Gargano, Alessandra Di Bacco, Yusuf Erkul, Erin O'Hare, Kumiko Nagashima, Kun Hu, Yamicia Connor, Brian Dolinski, Kaiko Kunii, Heike Keilhack, Katharine Ellwood-Yen

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::828919a62a5a02040e157eb5ac219fb4Test
https://doi.org/10.1158/0008-5472.22390089Test

المؤلفون: Jeremiah A. Johnson, DeborahJ. C. Ehrlich, MatthewR. Golder, Allison M. Neenan, Peter Blume-Jensen, James C. Ackley, William K. Dahlberg, Kyriakos D. Economides, Jennifer K. Saucier-Sawyer, Lawrence A. Reiter, Paul W. Kopesky, Elisa de Stanchina, Olga Burenkova, David J. Turnquist, Jannik N. Andersen, Sattanathan Paramasivan, Jenny Liu, Bhavatarini Vangamudi, Sung Jin Huh, Nolan M. Gallagher, Samantha W. Brady, Michael J. Jessel, Donald E. Chickering, Peyton Shieh, Farrukh Vohidov, Joelle Baddour, Julie Kim, Michail Shipitsin, Hung V.-T. Nguyen, Gaurab Kc

مصطلحات موضوعية: BET inhibitor, Therapeutic index, Drug development, Tolerability, In vivo, business.industry, medicine.medical_treatment, medicine, Prodrug, Pharmacology, business, Targeted therapy, Bromodomain

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d4231b129eb3966639444cef3e553caTest
https://doi.org/10.26434/chemrxiv.13241966.v1Test

المؤلفون: Sattanathan Paramasivan, Kyriakos D. Economides, Deborah C. Ehrlich, Eric J. Held, Joelle Baddour, Peter Blume-Jensen, Matthew R. Golder, Allison M. Neenan, Jeremiah A. Johnson, Samantha W. Brady, James C. Ackley, Jennifer K. Saucier-Sawyer, Bhavatarini Vangamudi, Farrukh Vohidov, Paul W. Kopesky, Sung Jin Huh, Hung V.-T. Nguyen, Donald E. Chickering, Michail Shipitsin, Jannik N. Andersen, Jenny Liu, Lawrence A. Reiter

المصدر: Nature biomedical engineering

مصطلحات موضوعية: 0301 basic medicine, Liver Cirrhosis, Male, medicine.medical_specialty, medicine.drug_class, Polymers, Biomedical Engineering, Medicine (miscellaneous), Bioengineering, Pharmacology, 010402 general chemistry, 01 natural sciences, Article, Rats, Sprague-Dawley, 03 medical and health sciences, Mice, Medicine, Animals, Prodrugs, Telmisartan, Antihypertensive drug, Carbon Tetrachloride, chemistry.chemical_classification, Mice, Inbred BALB C, business.industry, Prodrug, Molecular medicine, 3. Good health, 0104 chemical sciences, Computer Science Applications, Rats, Disease Models, Animal, 030104 developmental biology, Enzyme, chemistry, Gene Expression Regulation, Liver, Drug Design, Drug delivery, Histopathology, Female, Hepatic fibrosis, business, Angiotensin II Type 1 Receptor Blockers, Biotechnology, medicine.drug, Half-Life

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e98eadcb9d6da5cc80f3eab8653dfa20Test
https://pubmed.ncbi.nlm.nih.gov/31015683Test

المؤلفون: Doi:mol Cell Biol, Zhimin Lu, Guoqiang Jiang, Peter Blume-jensen, Downregulation Of, Tony Hunter

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://mcb.asm.org/content/21/12/4016.full.pdfTest.

مصطلحات موضوعية: of Focal Adhesion Kinase

وصف الملف: application/pdf

العلاقة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.547.7023Test; http://mcb.asm.org/content/21/12/4016.full.pdfTest

الإتاحة: http://mcb.asm.org/content/21/12/4016.full.pdfTest

المؤلفون: Sibgat Choudhury, J. Dunyak, David M. Berman, Aeron D. Hurley, Eric A. Klein, Julie Nardone, Louis Coupal, Thomas P. Nifong, Fred Saad, Peter Blume-Jensen, David L. Rimm, Teresa Capela, Massimo Loda, Philip W. Kantoff, Hua Chang, Mathieu Latour, Christina Ernst, Cristina Magi-Galluzzi, Mathew Putzi, Clayton Small, Alex Kaprelyants, Michail Shipitsin, Jonathan I. Epstein, Eldar Giladi

المصدر: Clinical Cancer Research. 21:2591-2600

مصطلحات موضوعية: Male, Proteomics, Oncology, Cancer Research, medicine.medical_specialty, Prostate biopsy, medicine.medical_treatment, Risk Assessment, Prostate cancer, Internal medicine, Biopsy, Biomarkers, Tumor, Humans, Medicine, Aged, Prostatectomy, Gynecology, Framingham Risk Score, medicine.diagnostic_test, business.industry, Prostatic Neoplasms, Odds ratio, Middle Aged, Prostate-Specific Antigen, Prognosis, medicine.disease, Gene Expression Regulation, Neoplastic, Biomarker (medicine), Neoplasm Recurrence, Local, business, Risk assessment

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31eb2c1aa00338ec8a958933a4326487Test
https://doi.org/10.1158/1078-0432.ccr-14-2603Test

المؤلفون: Julie Nardone, Peter Blume-Jensen, Massimo Loda, Christina Ernst, Shaun A. Hussain, Thomas P. Nifong, David L. Rimm, S Friedlander, Sibgat Choudhury, Y E Huang, Michail Shipitsin, Catherine B. Small, David M. Berman, H. Chang, Aeron D. Hurley, J. Dunyak, Eldar Giladi

المصدر: British Journal of Cancer

مصطلحات موضوعية: Oncology, Male, Proteomics, Cancer Research, Pathology, sampling error, Smad2 Protein, Prostate cancer, Prostate, Image Processing, Computer-Assisted, Actinin, Phosphorylation, Smad4 Protein, Ribosomal Protein S6, medicine.diagnostic_test, Middle Aged, prostate cancer, Cullin Proteins, DNA-Binding Proteins, medicine.anatomical_structure, Area Under Curve, Identification (biology), medicine.medical_specialty, Tumour heterogeneity, Biopsy, Fine-Needle, Mitochondrial Proteins, Internal medicine, Biopsy, medicine, Biomarkers, Tumor, Humans, biopsy, HSP70 Heat-Shock Proteins, Molecular Diagnostics, Selection Bias, Aged, Neoplasm Staging, Neoplasm Grading, Alkyl and Aryl Transferases, business.industry, Voltage-Dependent Anion Channel 1, biomarkers, Membrane Proteins, Prostatic Neoplasms, medicine.disease, ROC Curve, Tissue Array Analysis, RNA-Binding Protein FUS, Lethality, prognosis, tumour heterogeneity, Y-Box-Binding Protein 1, business, Follow-Up Studies

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ef42de7cd2594c8dbcc3bd61e5370a8Test
http://europepmc.org/articles/PMC4453845Test