Cryo-EM demonstrates the in vitro proliferation of an ex vivo amyloid fibril morphology by seeding

التفاصيل البيبلوغرافية
العنوان:	Cryo-EM demonstrates the in vitro proliferation of an ex vivo amyloid fibril morphology by seeding
المؤلفون:	Thomas Heerde, Matthies Rennegarbe, Alexander Biedermann, Dilan Savran, Peter B. Pfeiffer, Manuel Hitzenberger, Julian Baur, Ioana Puscalau-Girtu, Martin Zacharias, Nadine Schwierz, Christian Haupt, Matthias Schmidt, Marcus Fändrich
المصدر:	Nature Communications, Vol 13, Iss 1, Pp 1-8 (2022)
بيانات النشر:	Nature Portfolio, 2022.
سنة النشر:	2022
المجموعة:	LCC:Science
مصطلحات موضوعية:	Science
الوصف:	Here, the authors present the cryo-EM structure of in vitro amyloid fibrils from recombinant SAA1.1 protein that were formed by seeding with fibrils purified from systemic AA amyloidosis tissue. This in vitro fibril structure resembles the structure of the ex vivo fibrils but differs from unseeded in vitro fibrils. These findings show that fibril morphologies can be propagated in vitro by seeding.
نوع الوثيقة:	article
وصف الملف:	electronic resource
اللغة:	English
تدمد:	2041-1723
العلاقة:	https://doaj.org/toc/2041-1723Test
DOI:	10.1038/s41467-021-27688-5
الوصول الحر:	https://doaj.org/article/1dc8229b0dcb4b2fa12efbe783d6a181Test
رقم الانضمام:	edsdoj.1dc8229b0dcb4b2fa12efbe783d6a181
قاعدة البيانات:	Directory of Open Access Journals

الوصف
تدمد:	20411723
DOI:	10.1038/s41467-021-27688-5