دورية أكاديمية
Mesenchymal Stem Cells Loaded with p5, Derived from CDK5 Activator p35, Inhibit Calcium-Induced CDK5 Activation in Endothelial Cells
| العنوان: | Mesenchymal Stem Cells Loaded with p5, Derived from CDK5 Activator p35, Inhibit Calcium-Induced CDK5 Activation in Endothelial Cells |
|---|---|
| المؤلفون: | Fang, Wen-Hui, Kumar, Shant, McDowell, Garry, Smith, David, Krupinski, Jurek, Olah, Peter, Al-Baradie, Raid Saleem, Al-Rukban, Mohammad Othman, Petcu, Eugene Bogdan, Slevin, Mark |
| المصدر: | Fang , W-H , Kumar , S , McDowell , G , Smith , D , Krupinski , J , Olah , P , Al-Baradie , R S , Al-Rukban , M O , Petcu , E B & Slevin , M 2016 , ' Mesenchymal Stem Cells Loaded with p5, Derived from CDK5 Activator p35, Inhibit Calcium-Induced CDK5 Activation in Endothelial Cells ' , Stem cells international , vol. 2016 , pp. 2165462 . https://doi.org/10.1155/2016/2165462Test |
| سنة النشر: | 2016 |
| المجموعة: | The University of Manchester: Research Explorer - Publications |
| مصطلحات موضوعية: | Journal Article |
| الوصف: | The potential use of stem cells as therapeutics in disease has gained momentum over the last few years and recently phase-I clinical trials have shown favourable results in treatment of a small cohort of acute stroke patients. Similarly, they have been used in preclinical models drug-loaded for the effective treatment of solid tumours. Here we have characterized uptake and release of a novel p5-cyclin-dependent kinase 5 (CDK5) inhibitory peptide by mesenchymal stem cells and showed release levels capable of blocking aberrant cyclin-dependent kinase 5 (CDK5) signaling pathways, through phosphorylation of cyclin-dependent kinase 5 (CDK5) and p53. These pathways represent the major acute mechanism stimulating apoptosis after stroke and hence its modulation could benefit patient recovery. This work indicates a potential use for drug-loaded stem cells as delivery vehicles for stroke therapeutics and in addition as anticancer receptacles particularly, if a targeting and/or holding mechanism can be defined. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1155/2016/2165462 |
| الإتاحة: | https://doi.org/10.1155/2016/2165462Test https://research.manchester.ac.uk/en/publications/af4a07ab-dafd-4287-8e75-d13dcf72b591Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.9E067A9F |
| قاعدة البيانات: | BASE |
| DOI: | 10.1155/2016/2165462 |
|---|