Exposure to thiamethoxam during the larval phase affects synapsin levels in the brain of the honey bee
| العنوان: | Exposure to thiamethoxam during the larval phase affects synapsin levels in the brain of the honey bee |
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| المؤلفون: | Osmar Malaspina, Elaine C.M. Silva-Zacarin, Daiana Antonia Tavares, Roberta Cornélio Ferreira Nocelli, Thaisa Cristina Roat |
| المساهمون: | Universidade Estadual Paulista (Unesp), Universidade Federal de São Carlos (UFSCar) |
| المصدر: | Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| بيانات النشر: | Elsevier BV, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Insecticides, animal structures, Health, Toxicology and Mutagenesis, 0211 other engineering and technologies, Zoology, 02 engineering and technology, 010501 environmental sciences, Biology, 01 natural sciences, Neonicotinoids, chemistry.chemical_compound, Pesticide, mushroom body, antennal lobe, Animals, Nectar, 0105 earth and related environmental sciences, 021110 strategic, defence & security studies, Larva, fungi, Pupa, Public Health, Environmental and Occupational Health, Brain, food and beverages, General Medicine, Honey bee, Synapsin, Bees, Synapsins, Pollution, Honey bee development, Worker bee, chemistry, Bee pollen, Mushroom bodies, behavior and behavior mechanisms, Pollen, Apis mellifera, Thiamethoxam |
| الوصف: | Made available in DSpace on 2019-10-06T16:06:25Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-03-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Thiamethoxam (TMX) is a neurotoxic insecticide widely used for insect pest control. TMX and other neonicotinoids are reported to be potential causes of honey bee decline. Due to its systematic action, TMX may be recovered in pollen, bee bread, nectar, and honey, which make bees likely to be exposed to contaminated diet. In this study, we used immunolabeling to demonstrate that sublethal concentrations of TMX decrease the protein levels of synapsin in the mushroom bodies (MBs) and the antennal lobes (ALs) of pupae and newly emerged worker bees that were exposed through the food to TMX during the larval phase. A decrease in the synapsin level was observed in the MBs of pupae previously exposed to 0.001 and 1.44 ng/µL and in newly emerged bees previously exposed to 1.44 ng/µL and no changes were observed in the optical lobes (OLs). In the ALs, the decrease was observed in pupae and newly emerged bees exposed to 1.44 ng/µL. Because the MBs and ALs are brain structures involved in stimuli reception, learning, and memory consolidation and because synapsin is important for the regulation of neurotransmitter release, we hypothesize that exposure to sublethal concentrations of TMX during the larval stage may cause neurophysiological disorders in honey bees. Universidade Estadual Paulista (UNESP) Centro de Estudos de Insetos Sociais (CEIS) Instituto de Biociências Campus Rio Claro Universidade Federal de São Carlos (UFSCar) Departamento de Biologia Laboratório de Ecotoxicologia e Biomarcadores em Animais (LEBA) Campus Sorocaba Universidade Federal de São Carlos (UFSCar) Departamento de Ciências da Natureza Matemática e Educação Centro de Ciências Agrárias Campus Araras Universidade Estadual Paulista (UNESP) Centro de Estudos de Insetos Sociais (CEIS) Instituto de Biociências Campus Rio Claro FAPESP: 2012/01498-0 FAPESP: 2012/13370-8 FAPESP: 2012/50197-2 |
| تدمد: | 0147-6513 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::304a99fb1ff3d73447ce33967dae91a8Test https://doi.org/10.1016/j.ecoenv.2018.11.048Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....304a99fb1ff3d73447ce33967dae91a8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 01476513 |
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