دورية أكاديمية
Epidural electrical stimulation of the cervical dorsal roots restores voluntary upper limb control in paralyzed monkeys.
| العنوان: | Epidural electrical stimulation of the cervical dorsal roots restores voluntary upper limb control in paralyzed monkeys. |
|---|---|
| المؤلفون: | Barra, B., Conti, S., Perich, M.G., Zhuang, K., Schiavone, G., Fallegger, F., Galan, K., James, N.D., Barraud, Q., Delacombaz, M., Kaeser, M., Rouiller, E.M., Milekovic, T., Lacour, S., Bloch, J., Courtine, G., Capogrosso, M. |
| المصدر: | Nature neuroscience, vol. 25, no. 7, pp. 924-934 |
| سنة النشر: | 2022 |
| المجموعة: | Université de Lausanne (UNIL): Serval - Serveur académique lausannois |
| مصطلحات موضوعية: | Animals, Electric Stimulation, Haplorhini, Humans, Movement/physiology, Paralysis/therapy, Reproducibility of Results, Spinal Cord, Spinal Cord Injuries/therapy, Spinal Nerve Roots, Upper Extremity |
| الوصف: | Regaining arm control is a top priority for people with paralysis. Unfortunately, the complexity of the neural mechanisms underlying arm control has limited the effectiveness of neurotechnology approaches. Here, we exploited the neural function of surviving spinal circuits to restore voluntary arm and hand control in three monkeys with spinal cord injury, using spinal cord stimulation. Our neural interface leverages the functional organization of the dorsal roots to convey artificial excitation via electrical stimulation to relevant spinal segments at appropriate movement phases. Stimulation bursts targeting specific spinal segments produced sustained arm movements, enabling monkeys with arm paralysis to perform an unconstrained reach-and-grasp task. Stimulation specifically improved strength, task performances and movement quality. Electrophysiology suggested that residual descending inputs were necessary to produce coordinated movements. The efficacy and reliability of our approach hold realistic promises of clinical translation. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1097-6256 |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/35773543; info:eu-repo/semantics/altIdentifier/eissn/1546-1726; https://serval.unil.ch/notice/serval:BIB_55C465CF903DTest; urn:issn:1097-6256 |
| DOI: | 10.1038/s41593-022-01106-5 |
| الإتاحة: | https://doi.org/10.1038/s41593-022-01106-5Test https://serval.unil.ch/notice/serval:BIB_55C465CF903DTest |
| رقم الانضمام: | edsbas.9972EC23 |
| قاعدة البيانات: | BASE |
| تدمد: | 10976256 |
|---|---|
| DOI: | 10.1038/s41593-022-01106-5 |