التفاصيل البيبلوغرافية
| العنوان: |
Mitovesicles are a novel population of extracellular vesicles of mitochondrial origin altered in down syndrome |
| المؤلفون: |
D'Acunzo, Pasquale, Pérez-González, Rocío, Kim, Yohan, Hargash, Tal, Miller, Chelsea, Alldred, Melissa J., Erdjument-Bromage, Hediye, Penikalapati, Sai Charan, Pawlik, Monika, Saito, Mitsuo, Saito, Mariko, Ginsberg, Stephen D., Neubert, Thomas A., Goulbourne, Chris N., Levy, Efrat |
| سنة النشر: |
2021 |
| المجموعة: |
Universitat Autònoma de Barcelona: Dipòsit Digital de Documents de la UAB |
| مصطلحات موضوعية: |
Alzheimer's disease, Biological process, Density gradient separation, Diagnostic strategy, Mitochondrial dysfunction, Mitochondrial protein, Neurodegenerative disorders, Selective isolation, Alzheimer Disease, Animals, Down Syndrome, Exosomes, Extracellular Vesicles, Humans, Mice |
| الوصف: |
Altres ajuts: National Institute on Aging (AG017617, AG056732, and AG057517); National Institute on Drug Abuse (DA044489); NIH Instrumentation Grant (S10RR027990). ; Mitochondrial dysfunction is an established hallmark of aging and neurodegenerative disorders such as Down syndrome (DS) and Alzheimer's disease (AD). Using a high-resolution density gradient separation of extracellular vesicles (EVs) isolated from murine and human DS and diploid control brains, we identify and characterize a previously unknown population of double-membraned EVs containing multiple mitochondrial proteins distinct from previously described EV subtypes, including microvesicles and exosomes. We term these newly identified mitochondria-derived EVs "mitovesicles." We demonstrate that brain-derived mitovesicles contain a specific subset of mitochondrial constituents and that their levels and cargo are altered during pathophysiological processes where mitochondrial dysfunction occurs, including in DS. The development of a method for the selective isolation of mitovesicles paves the way for the characterization in vivo of biological processes connecting EV biology and mitochondria dynamics and for innovative therapeutic and diagnostic strategies. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| تدمد: |
23752548 |
| العلاقة: |
Science advances; Vol. 7 Núm. 7 (december 2021), p. eabe5085; https://ddd.uab.cat/record/272125Test; urn:10.1126/sciadv.abe5085; urn:oai:ddd.uab.cat:272125; urn:scopus_id:85100975363; urn:articleid:23752548v7n7eabe5085; urn:pmid:33579698; urn:pmc-uid:7880603; urn:pmcid:PMC7880603; urn:oai:pubmedcentral.nih.gov:7880603 |
| الإتاحة: |
https://ddd.uab.cat/record/272125Test |
| حقوق: |
open access ; Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. ; https://creativecommons.org/licenses/by-nc/4.0Test/ |
| رقم الانضمام: |
edsbas.9B033158 |
| قاعدة البيانات: |
BASE |
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