نتائج البحث - "Paul R. J. Davey"

1

Discovery of a Potent and Orally Bioavailable Zwitterionic Series of Selective Estrogen Receptor Degrader-Antagonists

المؤلفون: James S. Scott, Darren Stead, Bernard Barlaam, Jason Breed, Rodrigo J. Carbajo, Elisabetta Chiarparin, Natalie Cureton, Paul R. J. Davey, David I. Fisher, Eric T. Gangl, Tyler Grebe, Ryan D. Greenwood, Sudhir Hande, Holia Hatoum-Mokdad, Samantha J. Hughes, Thomas A. Hunt, Tony Johnson, Stefan L. Kavanagh, Teresa C. M. Klinowska, Carrie J. B. Larner, Mandy Lawson, Andrew S. Lister, David Longmire, Stacey Marden, Thomas M. McGuire, Caroline McMillan, Lindsay McMurray, Christopher J. Morrow, J. Willem M. Nissink, Thomas A. Moss, Daniel H. O’Donovan, Radoslaw Polanski, Stephen Stokes, Kumar Thakur, Dawn Trueman, Caroline Truman, Michael J. Tucker, Haixia Wang, Nicky Whalley, Dedong Wu, Ye Wu, Bin Yang, Wenzhan Yang

المصدر: Journal of Medicinal Chemistry. 66:2918-2945

مصطلحات موضوعية: Drug Discovery, Molecular Medicine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::b2ec7d4c4fb73ee3f4aed9c21a77b1bfTest
https://doi.org/10.1021/acs.jmedchem.2c01964Test

2

Bicyclic β‐Sheet Mimetics that Target the Transcriptional Coactivator β‐Catenin and Inhibit Wnt Signaling

المؤلفون: Alan Gerber, Sven Hennig, Rosa Bellavita, Isabel Everard, Thirza van Ramshorst, Elisabetta Chiarparin, Nina Louisa Efrém, Nicholas M Pearce, Paul R. J. Davey, Tom N. Grossmann, Paolo Grieco, Mathias Wendt, Mercedes Vazquez-Chantada

المساهمون: Organic Chemistry, AIMMS, Wendt, Mathia, Bellavita, Rosa, Gerber, Alan, Efrém, Nina-Louisa, van Ramshorst, Thirza, Pearce, Nicholas M., Davey, Paul R. J., Everard, Isabel, Vazquez-Chantada, Mercede, Chiarpari, Elisabetta, Grieco, Paolo, Hennig, Sven, Grossmann, Tom N., Neurosurgery

المصدر: Angewandte Chemie (International Ed. in English)
Angewandte Chemie-International Edition, 60(25), 13937-13944. Wiley
Wendt, M, Bellavita, R, Gerber, A, Efrém, N L, van Ramshorst, T, Pearce, N M, Davey, P R J, Everard, I, Vazquez-Chantada, M, Chiarparin, E, Grieco, P, Hennig, S & Grossmann, T N 2021, ' Bicyclic β-Sheet Mimetics that Target the Transcriptional Coactivator β-Catenin and Inhibit Wnt Signaling ', Angewandte Chemie-International Edition, vol. 60, no. 25, pp. 13937-13944 . https://doi.org/10.1002/anie.202102082Test
Angewandte Chemie-International Edition, 60(25), 13937-13944. John Wiley and Sons Ltd

مصطلحات موضوعية: cell-penetrating peptides, Models, Molecular, Peptidomimetics | Hot Paper, Peptidomimetic, Beta sheet, protein–protein interactions, 010402 general chemistry, 01 natural sciences, Catalysis, Thioether crosslink, Protein–protein interaction, protein-protein interaction, SDG 17 - Partnerships for the Goals, Transcription factor, thioether crosslinks, Wnt Signaling Pathway, Research Articles, beta Catenin, Bicyclic molecule, Chemistry, 010405 organic chemistry, Wnt signaling pathway, General Chemistry, General Medicine, Bridged Bicyclo Compounds, Heterocyclic, peptidomimetic, Cell biology, 0104 chemical sciences, macrocycles, Catenin, peptidomimetics, Wnt Signaling, macrocycle, Peptides, Intracellular, Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6210eeee6d272df71252f5b2989c6227Test
http://europepmc.org/articles/PMC8252567Test

3

Design, Synthesis, and Analytical Evaluation of Fsp3‐Inspired Raman Probes for Cellular Imaging

المؤلفون: Craig F. Steven, Martin Lee, Gary S. Nichol, Paul R. J. Davey, Elisabetta Chiarparin, Valerie G. Brunton, Alison N. Hulme

المصدر: Steven, C F, Lee, M, Nichol, G S, Davey, P R J, Chiarparin, E, Brunton, V G & Hulme, A N 2022, ' Design, Synthesis, and Analytical Evaluation of Fsp3-Inspired Raman Probes for Cellular Imaging ', European Journal of Organic Chemistry . https://doi.org/10.1002/ejoc.202200393Test

مصطلحات موضوعية: Organic Chemistry, Physical and Theoretical Chemistry

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b628c744c874dbb66683f7f772cbcaeTest
https://hdl.handle.net/20.500.11820/4bad3341-53a7-4468-8429-2af89587f01bTest

4

Discovery of a Potent and Selective ATAD2 Bromodomain Inhibitor with Antiproliferative Activity in Breast Cancer Models

المصدر: Journal of medicinal chemistry. 65(4)

مصطلحات موضوعية: Models, Molecular, Antineoplastic Agents, Breast Neoplasms, Crystallography, X-Ray, Substrate Specificity, DNA-Binding Proteins, Small Molecule Libraries, Structure-Activity Relationship, Cell Line, Tumor, Drug Discovery, Molecular Medicine, ATPases Associated with Diverse Cellular Activities, Humans, Female, Drug Screening Assays, Antitumor, Tumor Stem Cell Assay

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a88074865de698d2bc564627346d6bbcTest
https://pubmed.ncbi.nlm.nih.gov/35133824Test

5

Characterization of the Kinetic Mechanism of Human Protein Arginine Methyltransferase 5

المؤلفون: Alice R Eddershaw, Karl Syson, Paul R. J. Davey, Gregory Hamm, Christopher D. Stubbs, Paul Clarkson, Elizabeth Underwood, Lucy V Edwardes

المصدر: Biochemistry. 59:4775-4786

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0c63875119c271f482688a035fe6bfcTest
https://doi.org/10.1021/acs.biochem.0c00554Test

6

Addition of Fluorine and a Late-Stage Functionalization (LSF) of the Oral SERD AZD9833

المؤلفون: Michael J. Tucker, Thomas A. Moss, James S. Scott, Barlaam Bernard Christophe, Paul R. J. Davey, Ryan Greenwood, Stephen Stokes, Gary Fairley, Radoslaw Polanski, Holia Hatoum-Mokdad, David Longmire, Eric Gangl, Bin Yang, Andrew Lister, Jeffrey G. Varnes

المصدر: ACS Med Chem Lett

مصطلحات موضوعية: Chemistry, Organic Chemistry, Drug Discovery, Advanced stage, Lipophilicity, Late stage, Fluorine, Surface modification, chemistry.chemical_element, Biochemistry, Combinatorial chemistry

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55625bf7244588708149a96a259a8b3eTest
https://doi.org/10.1021/acsmedchemlett.0c00505Test

7

A protein tertiary structure mimetic modulator of the Hippo signalling pathway

المساهمون: Organic Chemistry, AIMMS

المصدر: Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Adihou, H, Gopalakrishnan, R, Förster, T, Guéret, S M, Gasper, R, Geschwindner, S, Carrillo García, C, Karatas, H, Pobbati, A V, Vazquez-Chantada, M, Davey, P, Wassvik, C M, Pang, J K S, Soh, B S, Hong, W, Chiarparin, E, Schade, D, Plowright, A T, Valeur, E, Lemurell, M, Grossmann, T N & Waldmann, H 2020, ' A protein tertiary structure mimetic modulator of the Hippo signalling pathway ', Nature Communications, vol. 11, no. 1, 5425 . https://doi.org/10.1038/s41467-020-19224-8Test
Nature Communications, 11(1):5425. Nature Publishing Group
Nature Communications

مصطلحات موضوعية: 0301 basic medicine, Solid-phase synthesis, Science, General Physics and Astronomy, Plasma protein binding, Protein Serine-Threonine Kinases, 010402 general chemistry, 01 natural sciences, Article, HIPPO signalling, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Protein structure, SDG 3 - Good Health and Well-being, Humans, Hippo Signaling Pathway, lcsh:Science, Transcription factor, X-ray crystallography, Hippo signaling pathway, Multidisciplinary, Drug discovery, Effector, Chemistry, Nuclear Proteins, TEA Domain Transcription Factors, General Chemistry, Protein tertiary structure, Hedgehog signaling pathway, Protein Structure, Tertiary, 0104 chemical sciences, Cell biology, DNA-Binding Proteins, 030104 developmental biology, lcsh:Q, Peptidomimetics, Peptides, Protein Binding, Signal Transduction, Transcription Factors