دورية أكاديمية
أعرض في EDS

Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia

التفاصيل البيبلوغرافية
العنوان: Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia
المؤلفون: Sonja I. Berndt, A, Nicola J. Camp, * Nicola J. Camp, Christine F. Skibola, * Christine F. Skibola, Joseph Vijai, *, Zhaoming Wang, *, Jian Gu, *, Alexandra Nieters, *, Rachel S. Kelly, 8 Rachel S. Kelly, Karin E. Smedby, 10 Karin E. Smedby, Alain Monnereau, 11, Wendy Cozen, 14, Angela Cox, 16, Sophia S. Wang, 17 Sophia S. Wang, Qing Lan, 18, Lauren R. Teras, 1 Lauren R. Teras, Moara Machado, 19, Meredith Yeager, 20, Angela R. Brooks Wilson, 6 Angela R. Brooks Wilson, Patricia Hartge, 22, Mark P. Purdue, 1 Mark P. Purdue, Brenda M. Birmann, 23 Brenda M. Birmann, Claire M. Vajdic, 24 Claire M. Vajdic, COCCO, PIER LUIGI, Yawei Zhang, 26, Graham G. Giles, 27 Graham G. Giles, Anne Zeleniuch Jacquotte, 29, Charles Lawrence, 32, Rebecca Montalvan, 33, Laurie Burdett, 33, Amy Hutchinson, 6, Yuanqing Ye, 6, Timothy G. Call, 7 Timothy G. Call, Tait D. Shanafelt, 34 Tait D. Shanafelt, Anne J. Novak, 35 Anne J. Novak, Neil E. Kay, 35 Neil E. Kay, Mark Liebow, 34, Julie M. Cunningham, 35 Julie M. Cunningham, Cristine Allmer, 36, Henrik Hjalgrim, 37, Hans Olov Adami, 38, Mads Melbye, 39, Bengt Glimelius, 40, Ellen T. Chang, 41 Ellen T. Chang, Martha Glenn, 43, Karen Curtin, 44, Lisa A. Cannon Albright, 45 Lisa A. Cannon Albright, Ryan Diver, 46 W, Brian K. Link, 19 Brian K. Link, George J. Weiner, 47 George J. Weiner, Lucia Conde, 47, Paige M. Bracci, 4 Paige M. Bracci, Jacques Riby, 48, Donna K. Arnett, 4 Donna K. Arnett, Degui Zhi, 3, Justin M. Leach, 49 Justin M. Leach, Elizabeth A. Holly, 49 Elizabeth A. Holly, Rebecca D. Jackson, 48 Rebecca D. Jackson, Lesley F. Tinker, 50 Lesley F. Tinker, Yolanda Benavente, 51, Núria Sala, 53, Delphine Casabonne, 55, Nikolaus Becker, 57, Paolo Boffetta, 58, Paul Brennan, 59, Lenka Foretova, 60, Marc Maynadie, 61, James McKay, 62, Anthony Staines, 60, Kari G. Chaffee, 63 Kari G. Chaffee, Sara J. Achenbach, 37 Sara J. Achenbach, Celine M. Vachon, 37 Celine M. Vachon, Lynn R. Goldin, 37 Lynn R. Goldin, Sara S. Strom, 1 Sara S. Strom, Jose F. Leis, 7 Jose F. Leis, Brice Weinberg, 64 J., Neil E. Caporaso, 65 Neil E. Caporaso, Aaron D. Norman, 1 Aaron D. Norman, Anneclaire J. De Roos, 37 Anneclaire J. De Roos, Lindsay M. Morton, 66 Lindsay M. Morton, Richard K. Severson, 1 Richard K. Severson, Elio Riboli, 67, Paolo Vineis, 68, Rudolph Kaaks, 69, Giovanna Masala, 58, Elisabete Weiderpass, 70, María Dolores Chirlaque, 73, Roel C. H. Vermeulen, 74 Roel C. H. Vermeulen, Ruth C. Travis, 76 Ruth C. Travis, Melissa C. Southey, 77 Melissa C. Southey, Roger L. Milne, 78 Roger L. Milne, Demetrius Albanes, 29, Jarmo Virtamo, 1, Stephanie Weinstein, 79, Jacqueline Clavel, 1, Tongzhang Zheng, 13, Theodore R. Holford, 27 Theodore R. Holford, Danylo J. Villano, 80 Danylo J. Villano, Ann Maria, 5, John J. Spinelli, 5 John J. Spinelli, Randy D. Gascoyne, 82 Randy D. Gascoyne, Joseph M. Connors, 84 Joseph M. Connors, Kimberly A. Bertrand, 85 Kimberly A. Bertrand, Edward Giovannucci, 24, Peter Kraft, 86, Anne Kricker, 87, Jenny Turner, 88, ENNAS, MARIA GRAZIA, Giovanni M. Ferri, 91 Giovanni M. Ferri, Lucia Miligi, 92, Liming Liang, 93, Baoshan Ma, 87, Jinyan Huang, 94, Simon Crouch, 9, Ju Hyun Park, 95, Nilanjan Chatterjee, 96, Kari E. North, 1 Kari E. North, John A. Snowden, 98 John A. Snowden, Josh Wright, 99, Joseph F. Fraumeni, 99 Joseph F. Fraumeni, Kenneth Offit, 1, Xifeng Wu, 5, Silvia de Sanjose, †, James R. Cerhan, † James R. Cerhan, Stephen J. Chanock, † Stephen J. Chanock, Nathaniel Rothman, †, Susan L. Slager, †, Susan L. Slager
المساهمون: Sonja I. Berndt, A, Nicola J. Camp, * Nicola J. Camp, Christine F. Skibola, * Christine F. Skibola, Joseph Vijai, *, Zhaoming Wang, *, Jian Gu, *, Alexandra Nieters, *, Rachel S. Kelly, 8 Rachel S. Kelly, Karin E. Smedby, 10 Karin E. Smedby, Alain Monnereau, 11, Wendy Cozen, 14, Angela Cox, 16, Sophia S. Wang, 17 Sophia S. Wang, Qing Lan, 18, Lauren R. Teras, 1 Lauren R. Tera, Moara Machado, 19, Meredith Yeager, 20, Angela R. Brooks Wilson, 6 Angela R. Brooks Wilson, Patricia Hartge, 22, Mark P. Purdue, 1 Mark P. Purdue, Brenda M. Birmann, 23 Brenda M. Birmann, Claire M. Vajdic, 24 Claire M. Vajdic, Cocco, PIER LUIGI, Yawei Zhang, 26, Graham G. Giles, 27 Graham G. Gile, Anne Zeleniuch Jacquotte, 29, Charles Lawrence, 32, Rebecca Montalvan, 33, Laurie Burdett, 33, Amy Hutchinson, 6, Yuanqing Ye, 6, Timothy G. Call, 7 Timothy G. Call, Tait D. Shanafelt, 34 Tait D. Shanafelt, Anne J. Novak, 35 Anne J. Novak, Neil E. Kay, 35 Neil E. Kay, Mark Liebow, 34, Julie M. Cunningham, 35 Julie M. Cunningham, Cristine Allmer, 36, Henrik Hjalgrim, 37, Hans Olov Adami, 38, Mads Melbye, 39, Bengt Glimelius, 40, Ellen T. Chang, 41 Ellen T. Chang, Martha Glenn, 43, Karen Curtin, 44, Lisa A. Cannon Albright, 45 Lisa A. Cannon Albright, Ryan Diver, 46 W, Brian K. Link, 19 Brian K. Link, George J. Weiner, 47 George J. Weiner, Lucia Conde, 47, Paige M. Bracci, 4 Paige M. Bracci, Jacques Riby, 48, Donna K. Arnett, 4 Donna K. Arnett, Degui Zhi, 3, Justin M. Leach, 49 Justin M. Leach, Elizabeth A. Holly, 49 Elizabeth A. Holly, Rebecca D. Jackson, 48 Rebecca D. Jackson, Lesley F. Tinker, 50 Lesley F. Tinker, Yolanda Benavente, 51, Núria Sala, 53, Delphine Casabonne, 55, Nikolaus Becker, 57, Paolo Boffetta, 58, Paul Brennan, 59, Lenka Foretova, 60, Marc Maynadie, 61, James McKay, 62, Anthony Staines, 60, Kari G. Chaffee, 63 Kari G. Chaffee, Sara J. Achenbach, 37 Sara J. Achenbach, Celine M. Vachon, 37 Celine M. Vachon, Lynn R. Goldin, 37 Lynn R. Goldin, Sara S. Strom, 1 Sara S. Strom, Jose F. Leis, 7 Jose F. Lei, Brice Weinberg, 64 J., Neil E. Caporaso, 65 Neil E. Caporaso, Aaron D. Norman, 1 Aaron D. Norman, Anneclaire J. De Roos, 37 Anneclaire J. De Roo, Lindsay M. Morton, 66 Lindsay M. Morton, Richard K. Severson, 1 Richard K. Severson, Elio Riboli, 67, Paolo Vineis, 68, Rudolph Kaaks, 69, Giovanna Masala, 58, Elisabete Weiderpass, 70, María Dolores Chirlaque, 73, Roel C. H. Vermeulen, 74 Roel C. H. Vermeulen, Ruth C. Travis, 76 Ruth C. Travi, Melissa C. Southey, 77 Melissa C. Southey, Roger L. Milne, 78 Roger L. Milne, Demetrius Albanes, 29, Jarmo Virtamo, 1, Stephanie Weinstein, 79, Jacqueline Clavel, 1, Tongzhang Zheng, 13, Theodore R. Holford, 27 Theodore R. Holford, Danylo J. Villano, 80 Danylo J. Villano, Ann Maria, 5, John J. Spinelli, 5 John J. Spinelli, Randy D. Gascoyne, 82 Randy D. Gascoyne
سنة النشر: 2016
المجموعة: Università degli Studi di Cagliari: UNICA IRIS
مصطلحات موضوعية: Meta-analysi, Genome-wide association studie, Chronic lymphocytic leukemia
الوصف: Chronic lymphocytic leukemia (CLL) is a common lymphoid malignancy with strong heritability. To further understand the genetic susceptibility for CLL and identify common loci associated with risk, we conducted a meta-analysis of four genome-wide association studies (GWAS) composed of 3,100 cases and 7,667 controls with follow-up replication in 1,958 cases and 5,530 controls. Here we report three new loci at 3p24.1 (rs9880772, EOMES, P=2.55 × 10(-11)), 6p25.2 (rs73718779, SERPINB6, P=1.97 × 10(-8)) and 3q28 (rs9815073, LPP, P=3.62 × 10(-8)), as well as a new independent SNP at the known 2q13 locus (rs9308731, BCL2L11, P=1.00 × 10(-11)) in the combined analysis. We find suggestive evidence (P<5 × 10(-7)) for two additional new loci at 4q24 (rs10028805, BANK1, P=7.19 × 10(-8)) and 3p22.2 (rs1274963, CSRNP1, P=2.12 × 10(-7)). Pathway analyses of new and known CLL loci consistently show a strong role for apoptosis, providing further evidence for the importance of this biological pathway in CLL susceptibility.
نوع الوثيقة: article in journal/newspaper
اللغة: English
العلاقة: info:eu-repo/semantics/altIdentifier/pmid/26956414; info:eu-repo/semantics/altIdentifier/wos/WOS:000371729200001; volume:7; numberofpages:9; journal:NATURE COMMUNICATIONS; http://hdl.handle.net/11584/147683Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84960517435
DOI: 10.1038/ncomms10933
الإتاحة: https://doi.org/10.1038/ncomms10933Test
http://hdl.handle.net/11584/147683Test
حقوق: info:eu-repo/semantics/openAccess
رقم الانضمام: edsbas.3A9D157A
قاعدة البيانات: BASE
الوصف
DOI:10.1038/ncomms10933