دورية أكاديمية
Processes involved in biochemical response to pesticides by lizard Podarcis siculus (Rafinesque-Schmaltz, 1810) – A field study
| العنوان: | Processes involved in biochemical response to pesticides by lizard Podarcis siculus (Rafinesque-Schmaltz, 1810) – A field study |
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| المؤلفون: | Moltedo G., Catalano B., Martuccio G., Sesta G., Romanelli G., Lauria A., Berducci M. T., Parravano R., Maggi C., Simbula G., Vignoli L., Onorati F., D'Antoni S. |
| المساهمون: | Moltedo, G., Catalano, B., Martuccio, G., Sesta, G., Romanelli, G., Lauria, A., Berducci, M. T., Parravano, R., Maggi, C., Simbula, G., Vignoli, L., Onorati, F., D'Antoni, S. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Bioaccumulation, Cytochrome P450, Field Study, Oxidative Stre, Pesticide, Reptiles |
| الوصف: | Although reptiles are non-target organisms of pesticide applications, their ecological niche and trophic role suggest that the use of these compounds in agriculture can have toxicological effects on them. Our recent field study on Italian wall lizard Podarcis siculus in hazelnut orchards evidenced that the use of pesticides-mixtures, consisting of thiophanate-methyl (TM), tebuconazole (TEB), deltamethrin (DM), lambda-cyhalothrin (LCT), besides copper sulphate, induced an increase of the total antioxidant capacity toward hydroxyl radicals and caused DNA damage; however, it did not cause neurotoxicity, and did not induce the glutathione-S-transferases' activities. These results raised some questions which were answered in this study by carrying out analyses on 4 biomarkers and 5 chemical substances in the tissues of non-target organisms coming from treated fields: cytochrome P450, catalase, total glutathione, and malondialdehyde, TM, TEB, DM, LCT and Cu. Our results highlighted a partial accumulation of different chemicals, the involvement of two important mechanisms of defence, and some cellular damages after exposure to the considered pesticides. In details, 1) LCT and DM were not accumulated in lizard muscle, copper remained at basal levels, whereas TM and TEB were uptaken with a partial metabolization of TM; 2) the cytochrome P450 and the catalase were involved in lizard biochemical responses to pesticides-mixtures used for “conventional” farming treatment; 3) “conventional” treatment with pesticides caused damage to lipids, besides DNA, probably related to the excess of hydroxyl radicals. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/wos/WOS:000976727900001; volume:467; journal:TOXICOLOGY AND APPLIED PHARMACOLOGY; https://hdl.handle.net/11590/475271Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85151513163 |
| DOI: | 10.1016/j.taap.2023.116491 |
| الإتاحة: | https://doi.org/10.1016/j.taap.2023.116491Test https://hdl.handle.net/11590/475271Test |
| رقم الانضمام: | edsbas.C521EA96 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.taap.2023.116491 |
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