دورية أكاديمية
TH1/TH2 pattern of renal tissues in acute and chronic animal models treated with mesenchymal stem cells
| العنوان: | TH1/TH2 pattern of renal tissues in acute and chronic animal models treated with mesenchymal stem cells |
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| المؤلفون: | Patricia Semedo, Carolina Gardini Palasio, Cassiano Donizetti Oliveira, Carla Quarim Feitoza, Giselle Martins Gonçalves, Pamella Mei Wang, Marcos Antonio Cenedeze, Alvaro Pacheco-Silva, Vicente de Paula Teixeira, Marlene Antônia dos Reis, Niels Olsen Saraiva Câmara |
| المصدر: | Brazilian Journal of Transplantation, Vol 10, Iss 2 (2007) |
| بيانات النشر: | Associação Brasileira de Transplante de Órgãos, 2007. |
| سنة النشر: | 2007 |
| المجموعة: | LCC:Specialties of internal medicine LCC:Special situations and conditions LCC:Surgery |
| مصطلحات موضوعية: | Mesenchymal Stem Cell Transplantation, Renal Insufficiency, Acute, Renal Insufficiency, Chronic, Specialties of internal medicine, RC581-951, Special situations and conditions, RC952-1245, Surgery, RD1-811 |
| الوصف: | Mesenchymal stem cell (MSC) therapy is a promising new therapy for kidney diseases. Many authors have been demonstrated that the MSC treatment leads to N improvement of the renal function in acute damaged models. However, the way it works still remains elusive. Purpose: To evaluate whether the renal protection provided by MSC administration seen in acute and chronic renal remnant damaged models involves modulation of the inflammation. Methods: MSC were attained from bone marrow of male Wistar rats. Female Wistar were subjected to ischemia-reperfusion damage by clamping renal pedicles for 1 hour. After a 6h reperfusion, 2.105 MSC were administrated i.v. in the chronic model. The nephrectomy models 5/6 were treated with 1.106 MSC administered i.v. after two weeks. Results: After a 24h reperfusion, MSC-treated animals presented a significant improvement of the renal function associated to decreased levels of IL-1β, IL-6 and TNF-α gene expression. Interestingly, the IL-4 mRNA expression increased in parallel. Furthermore, a higher expression of PCNA and an increase in the Bcl2/Bad ratio were seen in kidney tissues of MSC-treated animals. In the remnant model, this modulation in the cytokine pattern was sustained, despite a lack of amelioration of the renal dysfunction. Moreover, the expressions of TGF-β, MMP-9, TIMP-1 and Smad7 were not altered, although PAI-1 was significantly decreased. Conclusion: MSC therapy can indeed modulate the inflammatory response following acute and chronic renal injuries, accelerating the tubular repair; however, long-term outcomes seem not to be halted by this therapy. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Spanish; Castilian Portuguese |
| تدمد: | 2764-1589 |
| العلاقة: | https://bjt.emnuvens.com.br/revista/article/view/330Test; https://doaj.org/toc/2764-1589Test |
| DOI: | 10.53855/bjt.v10i2.330 |
| الوصول الحر: | https://doaj.org/article/62cc65576e8541a9bd38a725b21dee24Test |
| رقم الانضمام: | edsdoj.62cc65576e8541a9bd38a725b21dee24 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 27641589 |
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| DOI: | 10.53855/bjt.v10i2.330 |