المؤلفون: Anna Liao, Gary Probst, Pamela S. Keim, Kang Hu, Roy K. Hom, David A. Quincy, Michael S. Dappen, Grace T. Kwong, Jenifer Smith, Martin L. Neitzel, Ying-zi Xu, Elizabeth F. Brigham, Kevin P. Quinn, Frédérique Bard, Minghua Sun, Jing Wu, John-Michael Sauer, Dora Kholodenko, Hongbin Zhang, William Wallace, Matthew N. Mattson, Patricia Sacayon, Jacek Jagodzinski, Hing L. Sham, Brian T. Peterson, Simeon Bowers, Jennifer Marugg, Guriqbal S. Basi, Lee H. Latimer, Susanna S. Hemphill, Darren B. Dressen, Karina Wong, Kevin Tanaka, Michael P. Bova, Pamela Santiago, Daniel K. Ness, Anh P. Truong, Wes Zmolek, Lany Ruslim, Christopher Willits, Michael K. Lee, Andrei W. Konradi, Xiaocong M. Ye, Lam Nguyen, Chris M. Semko, Ted A. Yednock, Ruth N. Motter, Albert W. Garofalo, Erich Goldbach, Pearl Tanaka, Danielle L. Aubele

المصدر: Journal of Medicinal Chemistry. 56:5261-5274

مصطلحات موضوعية: Trifluoromethyl, biology, Stereochemistry, Quinoline, In vitro, chemistry.chemical_compound, chemistry, In vivo, Drug Discovery, biology.protein, medicine, Molecular Medicine, Structure–activity relationship, Chirality (chemistry), Amyloid precursor protein secretase, Semagacestat, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::c5b61686f688dd0abd9c5edac66d7201Test
https://doi.org/10.1021/jm301741tTest

المؤلفون: Jay Tung, Guriqbal S. Basi, David Davis, Ivan Lieberburg, Russell J. Caccavello, Michael Power, Pamela S. Keim, Donald A. Walker, Kirsten L. Jacobson-Croak, Normand Frigon, Robin Barbour, Susanna Suomensaari, Hua Tan, Lisa McConlogue, John P. Anderson, Gwen Tatsuno, Harry F. Dovey, Shuwen Wang, Minhtam Doan, Dale Schenk, Peter Seubert, Jun Zhao, Nancy Jewett, Jin Hong, Sukanto Sinha, Varghese John, J. Knops

المصدر: Nature. 402:537-540

مصطلحات موضوعية: Multidisciplinary, Beta-secretase 1, biology, Alpha secretase, Biochemistry, biology.protein, Amyloid precursor protein, P3 peptide, Verubecestat, Cleavage (embryo), Amyloid precursor protein secretase, Enzyme assay

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::ec9dacb1af91145ab653388836691c6eTest
https://doi.org/10.1038/990114Test

المؤلفون: Gary, Probst, Danielle L, Aubele, Simeon, Bowers, Darren, Dressen, Albert W, Garofalo, Roy K, Hom, Andrei W, Konradi, Jennifer L, Marugg, Matthew N, Mattson, Martin L, Neitzel, Chris M, Semko, Hing L, Sham, Jenifer, Smith, Minghua, Sun, Anh P, Truong, Xiaocong M, Ye, Ying-Zi, Xu, Michael S, Dappen, Jacek J, Jagodzinski, Pamela S, Keim, Brian, Peterson, Lee H, Latimer, David, Quincy, Jing, Wu, Erich, Goldbach, Daniel K, Ness, Kevin P, Quinn, John-Michael, Sauer, Karina, Wong, Hongbin, Zhang, Wes, Zmolek, Elizabeth F, Brigham, Dora, Kholodenko, Kang, Hu, Grace T, Kwong, Michael, Lee, Anna, Liao, Ruth N, Motter, Patricia, Sacayon, Pamela, Santiago, Christopher, Willits, Frédérique, Bard, Michael P, Bova, Susanna S, Hemphill, Lam, Nguyen, Lany, Ruslim, Kevin, Tanaka, Pearl, Tanaka, William, Wallace, Ted A, Yednock, Guriqbal S, Basi

المصدر: Journal of medicinal chemistry. 56(13)

مصطلحات موضوعية: Male, Time Factors, Gene Expression, Rats, Sprague-Dawley, Mice, Structure-Activity Relationship, Dogs, Drug Stability, Basic Helix-Loop-Helix Transcription Factors, Animals, Humans, RNA, Messenger, Enzyme Inhibitors, Homeodomain Proteins, Sulfonamides, Amyloid beta-Peptides, Dose-Response Relationship, Drug, Molecular Structure, Receptors, Notch, Rats, Models, Chemical, Area Under Curve, Drug Design, Microsomes, Liver, Quinolines, Pyrazoles, Transcription Factor HES-1, Amyloid Precursor Protein Secretases, Heterocyclic Compounds, 3-Ring

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::109e2b6e92821a752624dca210f7b056Test
https://pubmed.ncbi.nlm.nih.gov/23713656Test

المؤلفون: Guriqbal S. Basi, Hongbin Zhang, Pamela S. Keim, Michael A. Pleiss, Martin L. Neitzel, Erich Goldbach, Semko Christopher M, David A. Quincy, Albert W. Garofalo, Andrei W. Konradi, John-Michael Sauer, Matthew N. Mattson, Hing L. Sham, Elizabeth F. Brigham

المصدر: Bioorganicmedicinal chemistry letters. 20(7)

مصطلحات موضوعية: Models, Molecular, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Pyrazole, Crystallography, X-Ray, Biochemistry, Rats, Sprague-Dawley, chemistry.chemical_compound, Inhibitory Concentration 50, Structure-Activity Relationship, Alzheimer Disease, Drug Discovery, Structure–activity relationship, Potency, Animals, Humans, γ secretase, Molecular Biology, chemistry.chemical_classification, Sulfonamides, Organic Chemistry, Metabolic stability, Combinatorial chemistry, In vitro, Rats, chemistry, Molecular Medicine, Pyrazoles, Pharmacophore, Amyloid Precursor Protein Secretases, Tricyclic

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0bbae13a02ac5307da21f3ab0837c81Test
https://pubmed.ncbi.nlm.nih.gov/20206516Test

المؤلفون: Anh P, Truong, Danielle L, Aubele, Gary D, Probst, Martin L, Neitzel, Chris M, Semko, Simeon, Bowers, Darren, Dressen, Roy K, Hom, Andrei W, Konradi, Hing L, Sham, Albert W, Garofalo, Pamela S, Keim, Jing, Wu, Michael S, Dappen, Karina, Wong, Erich, Goldbach, Kevin P, Quinn, John-Michael, Sauer, Elizabeth F, Brigham, William, Wallace, Lan, Nguyen, Susanna S, Hemphill, Michael P, Bova, Frédérique, Bard, Ted A, Yednock, Guriqbal, Basi

المصدر: Bioorganicmedicinal chemistry letters. 19(17)

مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Administration, Oral, Pyrazole, Biochemistry, Chemical synthesis, chemistry.chemical_compound, Mice, Structure-Activity Relationship, In vivo, Oral administration, Drug Discovery, Amyloid precursor protein, medicine, Structure–activity relationship, Animals, Protease Inhibitors, Molecular Biology, Sulfonamides, biology, Chemistry, Organic Chemistry, Sulfonamide (medicine), Enzyme inhibitor, Drug Design, biology.protein, Quinolines, Molecular Medicine, Pyrazoles, Amyloid Precursor Protein Secretases, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c351bc65695ea36d488b1e5c084234dTest
https://pubmed.ncbi.nlm.nih.gov/19660943Test

المؤلفون: Frederick Esch, Nikolaos K. Robakis, Kumar Sambamurti, Pamela S. Keim, John P. Anderson, Ivan Lieberburg

المصدر: Neuroscience Letters. 128:126-128

مصطلحات موضوعية: Neurons, biology, medicine.diagnostic_test, General Neuroscience, Proteolysis, P3 peptide, Cleavage (embryo), medicine.disease, PC12 Cells, Carboxypeptidase, Amyloid beta-Protein Precursor, chemistry.chemical_compound, chemistry, Biochemistry, Alzheimer Disease, Cell culture, mental disorders, Chromatography, Gel, biology.protein, Amyloid precursor protein, medicine, Animals, Cyanogen bromide, Alzheimer's disease

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4696f12e642b072b81445be79c19fc8aTest
https://doi.org/10.1016/0304-3940Test(91)90775-o

المؤلفون: Jeffrey P. Shapiros, Pamela S. Keim, John H. Law

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://www.ars.usda.gov/SP2UserFiles/person/5083/structuralTest studies.pdf.

وصف الملف: application/pdf

العلاقة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.518.8328Test; http://www.ars.usda.gov/SP2UserFiles/person/5083/structuralTest studies.pdf

الإتاحة: http://www.ars.usda.gov/SP2UserFiles/person/5083/structuralTest studies.pdf

المؤلفون: Ted Yednock, Chris M. Semko, Hing L. Sham, Darren B. Dressen, Gary Probst, John-Michael Sauer, Albert W. Garofalo, Kevin P. Quinn, Michael P. Bova, Jing Wu, Michael S. Dappen, Simeon Bowers, Martin L. Neitzel, Pamela S. Keim, Karina Wong, Guriqbal S. Basi, Roy K. Hom, Erich Goldbach, Anh P. Truong, Andrei W. Konradi, Susanna S. Hemphill, William A Wallace, Lan K. Nguyen, Elizabeth F. Brigham, Danielle L. Aubele, Frederique Bard

المصدر: Bioorganic & Medicinal Chemistry Letters. 20:7553

مصطلحات موضوعية: chemistry.chemical_classification, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Pyrazole, Biochemistry, Sulfonamide, chemistry.chemical_compound, chemistry, Design synthesis, Drug Discovery, Molecular Medicine, Structure–activity relationship, γ secretase, Molecular Biology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::49d496068a972d5629e4dba9b9fa5644Test
https://doi.org/10.1016/j.bmcl.2010.10.090Test

المؤلفون: Albert W. Garofalo, Stephen B. Freedman, Balazs Szoke, Ferdie Soriano, Lee H. Latimer, George Shopp, Ruth N. Motter, Terence Hui, Kevin P. Quinn, Jenifer Smith, Jeanne Baker, Mei Yu, Michael K. Lee, Michael P. Bova, Pamela S. Keim, Elizabeth F. Brigham, John A Tucker, Andrei W. Konradi, Guriqbal S. Basi, Pearl Tang, Jon Hawkinson, Xiao-Hua Chen, Matthew N. Mattson, Kang Hu, Danielle L. Aubele, Martin L. Neitzel, Jennifer Marugg, Daniel K. Ness, Rose Lawler-Herbold, Christopher M Semko, Dora Kholodenko, Ying-zi Xu, Paul Shapiro, Kevin Tanaka, Michael S. Dappen, Tovah Eichenbaum, James L Miller, Lany Ruslim, Jing Wu, Robin Barbour, Linda Mutter, Jacek Jagodzinski, Erich Goldbach, Xiacong Michael Ye, Dale Schenk, Scott McCauley, Susanna S. Hemphill, John Michael Sauer, Anna Liao, Huifang Ni, Lan K. Nguyen, Michael A Pleiss

المصدر: Alzheimer's Research & Therapy

مصطلحات موضوعية: Genetically modified mouse, biology, business.industry, Research, Cognitive Neuroscience, Transgene, Clinical Neurology, Notch signaling pathway, P3 peptide, Pharmacology, Bioinformatics, Neurology, In vivo, Toxicity, Amyloid precursor protein, biology.protein, Medicine, Neurology (clinical), business, Gamma secretase

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57cfce5191b5c22ca3906348025bc9baTest
https://doi.org/10.1186/alzrt60Test

المؤلفون: Russell W. Blacher, Donald McClure, Eric C. Beattie, Tilman Oltersdorf, Frederick Esch, Pamela S. Keim, Alan R. Culwell, Pamela J. Ward

المصدر: Science (New York, N.Y.). 248(4959)

مصطلحات موضوعية: medicine.medical_specialty, Amyloid, Amyloid beta, BACE1-AS, Molecular Sequence Data, Transfection, Amyloid beta-Protein Precursor, Internal medicine, mental disorders, medicine, Amyloid precursor protein, Humans, Senile plaques, Amino Acid Sequence, Protein Precursors, Multidisciplinary, biology, P3 peptide, medicine.disease, Peptide Fragments, Cell biology, Biochemistry of Alzheimer's disease, Endocrinology, Alpha secretase, biology.protein, Alzheimer's disease, Protein Processing, Post-Translational

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61d919fa82f1eaa7e414e53db86a5011Test
https://pubmed.ncbi.nlm.nih.gov/2111583Test