التفاصيل البيبلوغرافية
العنوان:
Stages, scaffolds and strings in the spatial organisation of non-homologous end joining: Insights from X-ray diffraction and Cryo-EM
المؤلفون:
Shikang Liang , Tom L. Blundell , Amanda K. Chaplin , Aleš Hnízda , Antonia Kefala Stavridi , Robert Appleby
المساهمون:
Liang, Shikang [0000-0002-6930-7882], Blundell, Tom [0000-0002-2708-8992], Apollo - University of Cambridge Repository
المصدر:
Progress in Biophysics and Molecular Biology
بيانات النشر:
Elsevier BV, 2021.
سنة النشر:
2021
مصطلحات موضوعية:
Materials science , DNA End-Joining Repair , Spatial organisation , DNA Repair , Cryo-electron microscopy , DNA repair , Double-strand breaks , 030303 biophysics , Biophysics , KBM, Ku-binding motif , Computational biology , Article , 03 medical and health sciences , chemistry.chemical_compound , DNA-PK, DNA-dependent protein kinase , PAXX, Paralog of XRCC4 and XLF , XLF, XRCC4-Like Factor , Stages , Strings , Humans , DSB, double-strand break , DNA Breaks, Double-Stranded , Orchestration (computing) , vWA, von Willebrand factor type A , cryo-EM, cryo-electron microscopy , PTIP, Pax transcription-activation-domain interacting protein , Molecular Biology , NHEJ , Cryo-EM , IR, ionising radiation , Scaffolds , 0303 health sciences , 53BP1, p53-binding protein 1 , Cryoelectron Microscopy , X-ray diffraction , Non-homologous end joining , enzymes and coenzymes (carbohydrates) , chemistry , DNA-PKcs, DNA-PK catalytic subunit , NHEJ, non-homologous end joining , X-ray crystallography , PNKP, polynucleotide kinase , APLF, aprataxin and PNKP-like factor , BRCT, BRCA1 C-Terminus domain , lncRNA, long noncoding RNA , HR, homologous recombination , DNA , CTR, C-terminal region
الوصف:
Non-homologous end joining (NHEJ) is the preferred pathway for the repair of DNA double-strand breaks in humans. Here we describe three structural aspects of the repair pathway: stages, scaffolds and strings. We discuss the orchestration of DNA repair to guarantee robust and efficient NHEJ. We focus on structural studies over the past two decades, not only using X-ray diffraction, but also increasingly exploiting cryo-EM to investigate the macromolecular assemblies.
وصف الملف:
application/pdf
الوصول الحر:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca43e6e448ffae277c09ed2c9f19bd34Test https://www.repository.cam.ac.uk/handle/1810/316479Test
حقوق:
OPEN
رقم الانضمام:
edsair.doi.dedup.....ca43e6e448ffae277c09ed2c9f19bd34
قاعدة البيانات:
OpenAIRE