المؤلفون: Jeremy D. S. Marshall, Dielle E. Whitecross, Paul Mellor, Deborah H. Anderson

المصدر: Biomolecules; Volume 9; Issue 1; Pages: 29

مصطلحات موضوعية: PI3K (phosphatidylinositol 3-kinase), cancer, mutations, p85α subunit, PTEN (phosphatase and tensin homologue deleted on chromosome 10), Rab5

جغرافية الموضوع: agris

وصف الملف: application/pdf

العلاقة: https://dx.doi.orgTest/10.3390/biom9010029

الإتاحة: https://doi.orgTest/10.3390/biom9010029

المؤلفون: Agne, Kazlauskaite, Chandana, Kondapalli, Robert, Gourlay, David G, Campbell, Maria Stella, Ritorto, Kay, Hofmann, Dario R, Alessi, Axel, Knebel, Matthias, Trost, Miratul M K, Muqit

المصدر: Biochemical Journal

مصطلحات موضوعية: CCCP, carbonyl cyanide m-chlorophenylhydrazone, HOIL1, haem-oxidized IRP2 (iron-regulatory protein 2) ubiquitin ligase 1, IKK, IκB (inhibitor of nuclear factor κB) kinase, Ubiquitin-Protein Ligases, Molecular Sequence Data, MBP, maltose-binding protein, ISG15, interferon-induced 17 kDa protein, Accelerated Publication, Nedd8, neural-precursor-cell-expressed developmentally down-regulated 8, HEK, human embryonic kidney, PINK1, PTEN (phosphatase and tensin homologue deleted on chromosome 10)-induced putative kinase 1, NUAK1, NUAK family SNF1-like kinase 1, ubiquitin, Serine, Humans, Amino Acid Sequence, TcPINK1, Tribolium castaneum PINK1, Parkin, PD, Parkinson’s disease, TCEP, tris-(2-carboxyethyl)phosphine, phosphorylation, SUMO, small ubiquitin-related modifier, HRP, horseradish peroxidase, GSK3β, glycogen synthase kinase-3β, PTEN (phosphatase and tensin homologue deleted on chromosome 10)-induced putative kinase 1 (PINK1), nervous system diseases, HEK293 Cells, CDK2, cyclin-dependent kinase 2, PLK1, Polo-like kinase 1, Ni-NTA, Ni2+-nitrilotriacetate, Parkinson’s disease, MLK1, mixed lineage kinase 1, SILAC, stable isotope labelling by amino acids in cell culture, Ubl, ubiquitin-like, OTU1, OTU (ovarian tumour) domain-containing protein 1, Protein Kinases

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::aa0af3494e76422dd3bf8afa4806b227Test
http://europepmc.org/articles/PMC4000136Test

المؤلفون: Deborah H. Anderson, Paul Mellor, Jeremy D. S. Marshall, Dielle E. Whitecross

المصدر: Biomolecules
Biomolecules, Vol 9, Iss 1, p 29 (2019)

مصطلحات موضوعية: Cell signaling, Protein subunit, Phosphatase, lcsh:QR1-502, Review, GTPase, Biochemistry, lcsh:Microbiology, 03 medical and health sciences, 0302 clinical medicine, Rab5, Protein Domains, Neoplasms, cancer, Humans, PTEN, Tensin, Molecular Biology, PI3K/AKT/mTOR pathway, rab5 GTP-Binding Proteins, 030304 developmental biology, 0303 health sciences, biology, PTEN Phosphohydrolase, breakpoint cluster region, p85α subunit, PTEN (phosphatase and tensin homologue deleted on chromosome 10), PI3K (phosphatidylinositol 3-kinase), mutations, 3. Good health, Cell biology, Class Ia Phosphatidylinositol 3-Kinase, Protein Subunits, 030220 oncology & carcinogenesis, Mutation, biology.protein

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16f5f4c43a1b7bbdb00b0ac38a634eedTest
https://doi.orgTest/10.3390/biom9010029

المؤلفون: Xiaoqun Catherine Zhang, Antonella Piccini, Nicholas K. Tonks, Michael P. Myers, Linda Van Aelst

المصدر: Biochemical Journal

مصطلحات موضوعية: PTEN, phosphatase and tensin homologue deleted on chromosome 10, Dendritic Spines, Phosphatase, PDZ domain, Molecular Sequence Data, Biochemistry, Hippocampus, Green fluorescent protein, 03 medical and health sciences, chemistry.chemical_compound, HEK, human embryonic kidney, 0302 clinical medicine, Organ Culture Techniques, DsRed, Discosoma red fluorescent protein, Phosphoprotein Phosphatases, Tensin, PTEN, Animals, Phosphatidylinositol, Amino Acid Sequence, Molecular Biology, 030304 developmental biology, GFP, green fluorescent protein, 0303 health sciences, organotypic hippocampal slice culture, spine density, biology, NMDA, N-methyl-D-aspartate, protein phosphatase, PTEN Phosphohydrolase, Cell Biology, Protein phosphatase 2, Molecular biology, phosphatase and tensin homologue deleted on chromosome 10 (PTEN), Rats, Enzyme Activation, chemistry, Animals, Newborn, DTT, dithiothreitol, 030220 oncology & carcinogenesis, Lipid phosphatase activity, biology.protein, Phosphorylation, two-photon laser-scanning microscopy, PTP, protein tyrosine phosphatase, PI3K, phosphoinositide 3-kinase, Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e03d25e1b10e0fe5a6eb98b3725ea48Test
http://europepmc.org/articles/PMC3365644Test

المؤلفون: Hirohide Matsuura, Ryohei Miyazaki, Kenji Sunagawa, Jiro Ikeda, Kotaro Takeda, Aya Kamiharaguchi, Toru Hashimoto, Toshihiro Ichiki, Eriko Narabayashi

المصدر: Clinical Science (London, England : 1979)

مصطلحات موضوعية: BP, blood pressure, Vascular Endothelial Growth Factor A, donepezil, (RS)-2-[(1-benzyl-4-piperidyl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one, Angiogenesis, interleukin-1β, Interleukin-1beta, Hindlimb, PDGF, platelet-derived growth factor, Neovascularization, chemistry.chemical_compound, angiogenesis, Mice, Phosphatidylinositol 3-Kinases, bFGF, basic fibroblast growth factor, Piperidines, Ischemia, Donepezil, Phosphorylation, hindlimb ischaemia, Cells, Cultured, DMEM, Dulbecco's modified Eagle's medium, HR, heart rate, Neovascularization, Pathologic, General Medicine, HPF, high-power field, Acetylcholinesterase, VEGF, vascular endothelial growth factor, qRT–PCR, quantitative reverse transcription–PCR, Vascular endothelial growth factor, Acetylcholinesterase inhibitor, TNFα, tumour necrosis factor α, JNK, c-Jun N-terminal kinase, Indans, LPS, lipopolysaccharide, AD, Alzheimer's disease, medicine.symptom, NF-κB, nuclear factor κB, PI3K, phosphoinositide 3-kinase, medicine.drug, Research Article, PTEN, phosphatase and tensin homologue deleted on chromosome 10, medicine.medical_specialty, PBMC, peripheral blood mononuclear cell, medicine.drug_class, Morpholines, Neovascularization, Physiologic, S9, Biology, CNS, central nervous system, ERK, extracellular-signal-regulated kinase, FBS, fetal bovine serum, Internal medicine, mental disorders, medicine, Animals, ACh, acetylcholine, nAChR, nicotinic ACh receptor, Acetylcholine, IL, interleukin, mAChR, muscarinic ACh receptor, Mice, Inbred C57BL, Endocrinology, chemistry, COPD, chronic obstructive pulmonary disease, Chromones, Cholinergic, Cholinesterase Inhibitors, Proto-Oncogene Proteins c-akt, acetylcholinesterase inhibitor, MAPK, mitogen-activated protein kinase

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3ce33e50427ec3ddd356728c79c185dTest
http://europepmc.org/articles/PMC3359057Test

المؤلفون: Julie Guillermet-Guibert, Alexander Gray, Bart Vanhaesebroeck, Inma M. Berenjeno, Stewart Fleming, Wayne Pearce

المصدر: Biochemical Journal

مصطلحات موضوعية: Male, Lymphoma, PDK1, phosphoinositide-dependent kinase 1, FRET, Förster resonance energy transfer, phosphoinositide 3-kinase (PI3K), Biochemistry, kinase isoform, Mice, Phosphatidylinositol 3-Kinases, Prostate cancer, 0302 clinical medicine, Tensin, Phosphoinositide-3 Kinase Inhibitors, p, phosphorylated, 0303 health sciences, biology, phosphatase and tensin homologue deleted on chromosome 10 (PTEN), Isoenzymes, Cell Transformation, Neoplastic, mTORC, mTOR complex, 030220 oncology & carcinogenesis, Lipid phosphatase activity, shRNA, short hairpin RNA, PI3K, phosphoinositide 3-kinase, Research Article, PTEN, phosphatase and tensin homologue deleted on chromosome 10, tumour suppressor, Class I Phosphatidylinositol 3-Kinases, lipid signalling, mTOR, mammalian target of rapamycin, P110α, TCA, trichloroacetic acid, 03 medical and health sciences, FBS, fetal bovine serum, medicine, cancer, Animals, PTEN, Thyroid Neoplasms, Molecular Biology, PI3K/AKT/mTOR pathway, 030304 developmental biology, PTEN Phosphohydrolase, Prostatic Neoplasms, Cancer, Cell Biology, PIN, prostatic intra-epithelial neoplasia, medicine.disease, MEF, mouse embryonic fibroblast, WT, wild-type, P110δ, Cancer research, biology.protein, Proto-Oncogene Proteins c-akt, FOX, forkhead box

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0e5c2f41f43fae0efd40ae37e1b37e9Test
https://doi.orgTest/10.1042/bj20111741

المؤلفون: Samantha Giordano, Jisun Lee, Jianhua Zhang

المصدر: Biochemical Journal

مصطلحات موضوعية: ULK, unc (unco-ordinated family member)-51-like kinase, Transcription, Genetic, Protein Deglycase DJ-1, BNIP, Bcl-2/adenovirus E18 19-kDa-interacting protein, Review Article, Biochemistry, IκB, inhibitor of nuclear factor κB, DNM1L, 0302 clinical medicine, mitochondrion, Rubicon, RUN domain- and cysteine-rich domain-containing beclin-1-interacting protein, NOS, nitric oxide synthase, FIP200, focal adhesion kinase family-interacting protein of 200 kDa, GFP, green fluorescent protein, 0303 health sciences, TOR Serine-Threonine Kinases, ECH, enoyl-CoA hydratase, Intracellular Signaling Peptides and Proteins, BAG, Bcl-2-associated athanogene, ALS, amyotrophic lateral sclerosis, LRRK2, leucine-rich repeat kinase 2, Cell biology, Keap1, Kelch-like ECH-associated protein 1, Cardiovascular Diseases, TNFα, tumour necrosis factor α, VDAC, voltage-dependent anion channel, UCP, uncoupling protein, NGF, nerve growth factor, mTOR, mammalian target of rapamycin, PE, phosphatidylethanolamine, Nitric Oxide, 03 medical and health sciences, Humans, AMPK, 5′-AMP-activated protein kinase, Vps34, vacuolar protein sorting 34, IKKβ, IκB kinase β, Molecular Biology, Drp1, dynamin-related protein 1, PINK1, PTEN (phosphatase and tensin homologue deleted on chromosome 10)-induced kinase 1, ATG, AuTophaGy-related, RLS, reactive lipid species, redox signalling, Hydrogen Peroxide, HIF-1, hypoxia-inducible factor 1, siRNA, small interfering RNA, tfLC3, tandem fluorescently tagged LC3, Reactive Oxygen Species, Protein Kinases, 3-MA, 3-methyladenine, 030217 neurology & neurosurgery, Mitochondrial Turnover, HNE, 4-hydroxynonenal, Mitochondrion, Tzb, trastuzumab, medicine.disease_cause, Nrf2, nuclear factor-erythroid 2-related factor 2, RFP, red fluorescent protein, Neoplasms, Mitophagy, oxidative stress, nitrative stress, NAC, N-acetyl-L-cysteine, Oncogene Proteins, neurodegeneration, TOR, target of rapamycin, Parkinson Disease, NOX, NADPH oxidase, Reactive Nitrogen Species, Mitochondria, NF-κB, nuclear factor κB, TAC, transverse aortic constriction, Oxidation-Reduction, PI3K, phosphoinositide 3-kinase, Signal Transduction, autophagy, Programmed cell death, IP3, inositol 1,4,5-trisphosphate, TIGAR, TP53 (tumour protein 53)-induced glycolysis and apoptosis regulator, LAMP, lysosome-associated membrane protein, PINK1, JNK1, c-Jun N-terminal kinase 1, Biology, ER, endoplasmic reticulum, RNS, reactive nitrogen species, ROS, reactive oxygen species, mETC, mitochondrial electron-transport chain, SOD, superoxide dismutase, BNIP3L, BNIP3-like, medicine, Animals, 030304 developmental biology, EM, electron microscopy, Autophagy, Cell Biology, NBR1, neighbour of BRCA1 (breast cancer early-onset 1), GABARAP, GABAA (γ-aminobutyric acid type A)-receptor-associated protein, LC3, light chain 3, mtDNA, mitochondrial DNA, PI3P, phosphatidylinositol 3-phosphate, Lysosomes, Oxidative stress

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44e98ea4264830de72cbbef88db3977bTest
https://doi.orgTest/10.1042/bj20111451

المؤلفون: Woo-Jeong Lee, Sharada Kolekar, Christina M. Buchanan, Peter R. Shepherd, Stephen M. F. Jamieson, Jack U. Flanagan, Jackie D. Kendall, William A. Denny, Ripudaman Singh, James M. J. Dickson, Bruce C. Baguley, Gordon W. Rewcastle

المصدر: Biochemical Journal

مصطلحات موضوعية: PTEN, phosphatase and tensin homologue deleted on chromosome 10, PKB, protein kinase B, medicine.medical_treatment, TGI, tumour growth inhibition, BID, twice daily dosing, p110α E545K mutation, mTOR, mammalian target of rapamycin, ERK, extracellular-signal-regulated kinase, Biochemistry, Mice, Tumor Cells, Cultured, medicine, Animals, Humans, Protein Isoforms, Tensin, PTEN, Tissue Distribution, Enzyme Inhibitors, pan-phosphoinositide 3kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitor NVP-BEZ235, phosphoinositide 3-kinase α (PI3Kα), Molecular Biology, Protein kinase B, PI3K/AKT/mTOR pathway, Phosphoinositide-3 Kinase Inhibitors, Homeodomain Proteins, Mice, Knockout, Phosphoinositide 3-kinase, biology, QD, once daily dosing, Growth factor, PIK3CA, Neoplasms, Experimental, Cell Biology, phosphoinositide 4-kinase (PI4K), PIK3CA H1047R mutation, PI4K, phosphoinositide 4-kinase, Cell biology, Class Ia Phosphatidylinositol 3-Kinase, P110δ, biology.protein, Signal transduction, Proto-Oncogene Proteins c-akt, PI3K, phosphoinositide 3-kinase, Research Article, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd1a7d1444366d807c36dc5923f61ac0Test
https://doi.orgTest/10.1042/bj20110502

المؤلفون: Bart Vanhaesebroeck, Larissa S. Moniz

المصدر: Biochemical Journal

مصطلحات موضوعية: medicine.medical_treatment, PDK1, phosphoinositide-dependent kinase 1, AKT2, phosphoinositide 3-kinase (PI3K), Biochemistry, Targeted therapy, PRAS40, proline-rich Akt substrate of 40 kDa, FOXO, forkhead box O, NDRG1, N-Myc downstream-regulated gene 1, qRT-PCR, quantitative reverse transcription–PCR, protein kinase inhibitor, Kinase, mammalian target of rapamycin (mTOR), N-Myc downstream-regulated gene 1 (NDRG1), HRP, horseradish peroxidase, N-Myc, neuroblastoma-derived Myc, mTORC, mTOR complex, shRNA, short hairpin RNA, Female, PI3K, phosphoinositide 3-kinase, Research Article, PTEN, phosphatase and tensin homologue deleted on chromosome 10, PH, pleckstrin homology, Breast Neoplasms, MTS, 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium, SGK, serum- and glucocorticoid-regulated kinase, mTOR, mammalian target of rapamycin, Protein Serine-Threonine Kinases, Biology, TBST, Tris-buffered saline-Tween, Immediate early protein, Immediate-Early Proteins, HEK, human embryonic kidney, FBS, fetal bovine serum, GSK3, glycogen synthase kinase 3, medicine, Animals, Humans, Protein Kinase Inhibitors, Molecular Biology, Protein kinase B, GI50, growth inhibition by 50%, Cancer, Cell Biology, medicine.disease, signal transduction inhibitor, Drug Resistance, Neoplasm, Cancer cell, SGK1, Cancer research, Proto-Oncogene Proteins c-akt

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56af178bf350810955ab7ec16195ac68Test
https://doi.orgTest/10.1042/bj20130617

المؤلفون: Chen, H, Handel, Ngeow, Huhn, Yang, Heindl, Berbers, Hegazy, A, Kionke, Yehia, Sack, Blaser, Rensing-Ehl, Reifenberger, Keith, J, Travis, S, Merkenschlager, Keiss, Wittekind, Walker, L, Ehl, Aretz, Dustin, Eng, Powrie, F, Uhlig, H

المصدر: The Journal of Allergy and Clinical Immunology

مصطلحات موضوعية: Male, PTEN, Immunological Synapses, TMRE, Tetramethylrhodamine-ethylester, T-Lymphocytes, Regulatory, SHIP, Src homology domain 2–containing inositol phosphatase, CS, Cowden syndrome, PI3K, Phosphoinositide 3-kinase, Phosphoprotein Phosphatases, Immunology and Allergy, phosphatases, Child, Cells, Cultured, MALT, Mucosa-associated lymphoid tissue, Membrane Potential, Mitochondrial, B-Lymphocytes, autoimmunity, phosphoinositide 3-kinase, Nuclear Proteins, PHLPP, PH domain leucine-rich repeat protein phosphatase, Forkhead Transcription Factors, POD, Peroxidase, Regulatory T cells, Middle Aged, IC50, Inhibitory concentration of 50%, FACS, Fluorescence-activated cell sorting, FOXP3, Forkhead box P3, Protein Transport, CTLA-4, Cytotoxic T lymphocyte–associated antigen 4, Protein Binding, Signal Transduction, Adult, FITC, Fluorescein isothiocyanate, PH domain leucine-rich repeat protein phosphatase, HRM, High Resolution DNA Melting, Adolescent, APC, Allophycocyanin, ICAM-1, Intercellular adhesion molecule 1, Immunology, NHERF1, Na+/H+-exchanger 3 regulatory factor, chemical and pharmacologic phenomena, mTORC1, PTEN/AKT/mTOR complex 1, DLG1, Scaffold protein discs, large homolog 1, PerCP, Peridinin-chlorophyll-protein complex, PP2A, Protein phosphatase 2A, immunologic synapse, Young Adult, Immune Deficiencies, Infection, and Systemic Immune Disorders, Humans, Aged, PTEN, Phosphatase and tensin homologue deleted on chromosome 10, Hyperplasia, PTEN Phosphohydrolase, mTOR, Mammalian target of rapamycin, PE, Phycoerythrin, PHTS, PTEN hamartoma tumor syndrome, Lymphocyte Subsets, TCR, T-cell receptor, Tmem, Memory T, iTreg, In vitro induced regulatory T, Mutation, PHTS, Hamartoma Syndrome, Multiple

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::7d641d886c66f79f3802609a220ac434Test