المؤلفون: Jyothishmathi Swaminathan, Shinji Maegawa, Shavali Shaik, Ajay Sharma, Javiera Bravo-Alegria, Lei Guo, Lin Xu, Arif Harmanci, Vidya Gopalakrishnan

المصدر: Frontiers in Oncology, Vol 12 (2022)

مصطلحات موضوعية: REST (RE-1 silencing transcription factor), PRC2 (Polycomb repressive complex 2), Mll4 (KMT2D), G9a/Glp complex, KDM7A, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fonc.2022.855167/fullTest; https://doaj.org/toc/2234-943XTest

الوصول الحر: https://doaj.org/article/adbcf35e4afc4f71ab1fa836a5a1653cTest

المؤلفون: Serena Buontempo, Pasquale Laise, James M. Hughes, Sebastiano Trattaro, Vivek Das, Chantal Rencurel, Giuseppe Testa

المصدر: Frontiers in Neuroscience, Vol 16 (2022)

مصطلحات موضوعية: EZH2 (enhancer of zeste homolog 2), H3K27me3 – histone H3 tri-methylated at Lysine 27, neuronal differentiation, PRC2 (Polycomb repressive complex 2), corticogenesis, epigenetics, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fnins.2022.814144/fullTest; https://doaj.org/toc/1662-453XTest

الوصول الحر: https://doaj.org/article/364545fc5725480b9422d154b7645c28Test

المؤلفون: Elisa Del Savio, Roberta Maestro

المصدر: Cells; Volume 11; Issue 17; Pages: 2626

مصطلحات موضوعية: epithelioid sarcoma, soft tissue sarcoma, SMARCB1, SWI/SNF, PRC2 (Polycomb Repressive Complex 2), tazemetostat

وصف الملف: application/pdf

العلاقة: Cellular Pathology; https://dx.doi.org/10.3390/cells11172626Test

الإتاحة: https://doi.org/10.3390/cells11172626Test

المؤلفون: Jian Liu, Qi Lv, Yinan Zhang, Yao Xing, Dong Dong, Yue Liu, Lihong Hu, Hongzhi Qiao

المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 9, Pp 2880-2899 (2021)

مصطلحات موضوعية: PMSF, phenylmethanesulfonyl fluoride, MPO, myeloperoxidase, ATG7, autophagy-related protein 7, DMSO, dimethyl sulfoxide, CETSA, cellular thermal shift assay, 0302 clinical medicine, EZH2, enhancer of zeste homolog 2, General Pharmacology, Toxicology and Pharmaceutics, M-CSF, macrophage colony stimulating factor, 0303 health sciences, Chemistry, BMDMs, bone marrow-derived macrophages, EZH2, Inflammasome, ELISA, enzyme-linked immunosorbent assay, Colitis, PMA, phorbol myristate acetate, Ulcerative colitis, ChIP, chromatin immunoprecipitation, 030220 oncology & carcinogenesis, Histone methyltransferase, LPS, lipopolysaccharide, Original Article, DAI, disease activity index, medicine.drug, AIM2, absent in melanoma 2, ATP, adenosine triphosphate, ECL, enhanced chemiluminescent, 3-MC, 3-methylcholanthrene, ATG5, RM1-950, macromolecular substances, SIP, solvent-induced protein precipitation, Lonicerin, 03 medical and health sciences, CHX, cycloheximide, FBS, fetal bovine serum, PAMPs, pathogen-associated molecular patterns, DSS, dextran sulfate sodium, Autophagy, medicine, Epigenetics, TEM, transmission electron microscopy, 030304 developmental biology, EDTA, ethylenediaminetetraacetic acid, RMSF, root mean-square fluctuation, RMSD, root mean-square deviation, MDP, muramyldipeptide, medicine.disease, NLRP3 inflammasome, ATG5, autophagy-related protein 5, MSU, monosodium urate crystals, UC, ulcerative colitis, 5-ASA, 5-aminosalicylic acid, DTT, dithiothreitol, DAMPs, damage-associated molecular patterns, H&E, hematoxylin and eosin, Cancer research, Therapeutics. Pharmacology, NLRP3, nucleotide-binding domain-like receptors family pyrin domain containing 3, PRC2, polycomb repressive complex 2

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b197d7e1bd61447a9d7a45da0a56387Test
https://doi.org/10.1016/j.apsb.2021.03.011Test

المؤلفون: Xiaohui Pan, Bo Yang, Hongjie Guo, Shuyuan Cheng, Xi Chen, Ling Ding, Qiaojun He, Wenxin Zhang

المصدر: Acta Pharmaceutica Sinica B, Vol 10, Iss 5, Pp 723-733 (2020)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: TIM-3, T cell immunoglobulin and mucin domain 3, H3K27me3, tri-methylation of lysine 27 on histone H3, MDSCs, myeloid-derived suppressor cells, medicine.medical_treatment, Review, TAA, tumor-associated antigen, DC, dendritic cell, 0302 clinical medicine, EZH2, enhancer of zeste homolog 2, LAG-3, lymphocyte activation gene-3, CTLA-4, cytotoxic T lymphocyte antigen 4, Medicine, BETi, bromodomain and extra-terminal motif inhibitors, General Pharmacology, Toxicology and Pharmaceutics, FOXP3, forkhead box P3, HDACi, histone deacetylase inhibitor, Cancer, 0303 health sciences, ACE1, angiotensin converting enzyme, CLL, chronic lymphocytic leukemia, biology, IDO, indoleamine 2,3-dioxygenase, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Tregs, regulatory T cells, PD-L1/PD-1 blockade, CCL22 (MDC), macrophage-derived chemokine, Immunotherapy, TET2, ten-eleven translocation 2, CTLs, cytotoxic T lymphocytes, FDA, U. S. Food and Drug Administration, PD-L1, programmed cell death ligand 1, T cell, CTA, cancer testis antigen, Immune cycle, TIL, tumor infiltrating lymphocytes, Epigenetic regulation, OS, overall survival, 03 medical and health sciences, Immune system, Antigen, PD-L1, TH-1, T helper type 1, DNMT1, DNA methyltransferase 1, MHC, major histocompatibility complex, CX3CL1, C-X3-C motif chemokine ligand 1, IFN-γ, interferon-gamma, 030304 developmental biology, business.industry, lcsh:RM1-950, biochemical phenomena, metabolism, and nutrition, medicine.disease, CXCL, CXC chemokine ligand, Blockade, lcsh:Therapeutics. Pharmacology, APC, antigen-presenting cell, UHRF1, ubiquitin-like PHD and RING finger domain-containing 1, 5-AzaC, 5-azacitidine, ACP1, human red cell acid phosphatase, biology.protein, Cancer research, bacteria, DNMTi, DNA methyltransferase inhibitors, PD-1, programmed cell death 1, business, PRC2, polycomb repressive complex 2

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1ca7b0479f6fea7a89a3e1eb06905c5Test
https://doi.org/10.1016/j.apsb.2019.09.006Test

المؤلفون: Jyothishmathi Swaminathan, Shinji Maegawa, Shavali Shaik, Ajay Sharma, Javiera Bravo-Alegria, Lei Guo, Lin Xu, Arif Harmanci, Vidya Gopalakrishnan

مصطلحات موضوعية: Cancer, Cancer Cell Biology, Cancer Diagnosis, Cancer Genetics, Cancer Therapy (excl. Chemotherapy and Radiation Therapy), Chemotherapy, Haematological Tumours, Molecular Targets, Radiation Therapy, Solid Tumours, Oncology and Carcinogenesis not elsewhere classified, REST (RE-1 silencing transcription factor), PRC2 (Polycomb repressive complex 2), Mll4 (KMT2D), G9a/Glp complex, KDM7A

العلاقة: https://figshare.com/articles/dataset/DataSheet_1_Cross-Talk_Between_Histone_Methyltransferases_and_Demethylases_Regulate_REST_Transcription_During_Neurogenesis_docx/19720921Test

الإتاحة: https://doi.org/10.3389/fonc.2022.855167.s001Test
https://figshare.com/articles/dataset/DataSheet_1_Cross-Talk_Between_Histone_Methyltransferases_and_Demethylases_Regulate_REST_Transcription_During_Neurogenesis_docx/19720921Test

المؤلفون: Serena Buontempo, Pasquale Laise, James M. Hughes, Sebastiano Trattaro, Vivek Das, Chantal Rencurel, Giuseppe Testa

مصطلحات موضوعية: Neuroscience, Biological Engineering, Developmental Biology, Stem Cells, Artificial Intelligence and Image Processing, Endocrinology, Radiology and Organ Imaging, Autonomic Nervous System, Cellular Nervous System, Central Nervous System, Sensory Systems, Clinical Nursing: Tertiary (Rehabilitative), Decision Making, Rehabilitation Engineering, Biomedical Engineering not elsewhere classified, Signal Processing, Neurogenetics, Image Processing, EZH2 (enhancer of zeste homolog 2), H3K27me3 – histone H3 tri-methylated at Lysine 27, neuronal differentiation, PRC2 (Polycomb repressive complex 2), corticogenesis, epigenetics, transcriptomics, Prdm13

العلاقة: https://figshare.com/articles/dataset/Data_Sheet_1_EZH2-Mediated_H3K27me3_Targets_Transcriptional_Circuits_of_Neuronal_Differentiation_zip/19752301Test

الإتاحة: https://doi.org/10.3389/fnins.2022.814144.s001Test
https://figshare.com/articles/dataset/Data_Sheet_1_EZH2-Mediated_H3K27me3_Targets_Transcriptional_Circuits_of_Neuronal_Differentiation_zip/19752301Test

المؤلفون: Daniel S. Ziemianowicz, Daniel J. Saltzberg, D. Alex Crowder, Christoph U. Schräder, Andrej Sali, Troy J. Pells, Morgan Hepburn, David C. Schriemer

المصدر: Molecular & Cellular Proteomics : MCP

مصطلحات موضوعية: Models, Molecular, Proteomics, HPC, high-performance computing, FDR, false discovery rate, Computer science, Protein Conformation, Distributed computing, PMI, Python modeling interface, Spec#, SLURM, simple Linux utility for resource management, cryo-electron microscopy, Biochemistry, Data type, Mass Spectrometry, Analytical Chemistry, 03 medical and health sciences, 0302 clinical medicine, Resource (project management), integrative modeling, crosslinking, HX-MS, hydrogen exchange mass spectrometry, PRC2, Polycomb repressive complex 2, Molecular Biology, IMP, integrative modeling platform, 030304 developmental biology, computer.programming_language, Structure (mathematical logic), 0303 health sciences, Technological Innovation and Resources, Polycomb Repressive Complex 2, Cryo-EM, cryoelectron microscopy, Supercomputer, XL-MS, cross-linking mass spectrometry, hydrogen-deuterium exchange, Structural biology, Bundle, structural mass spectrometry, computer, 030217 neurology & neurosurgery, Software

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f59d88f6161e32bbbe5a3291a6c1d235Test
http://europepmc.org/articles/PMC8452774Test

المؤلفون: Yitian Zhou, Magnus Ingelman-Sundberg, Volker M. Lauschke

المصدر: Pharmacology & Therapeutics

مصطلحات موضوعية: 0301 basic medicine, SJS, Stevens-Johnson syndrome, DNMTs, DNA methyltransferases, PTMs, Posttranslational modifications, Epigenesis, Genetic, TAB-Seq, TET-assisted bisulfite sequencing, MAF, Minor allele frequencies, SCAR, Severe cutaneous adverse reaction, 0302 clinical medicine, ChIP, Chromatin immunoprecipitation, CFTR, Cystic fibrosis transmembrane conductance regulator, Medicine, eQTL, Quantitative trait locus, Pharmacology (medical), Biomarker discovery, PRC2, Polycomb repressive complex 2, 5hmC, 5-hydroxymethylcytosine, UM, Ultrarapid metabolism, education.field_of_study, MS, Multiple sclerosis, High-Throughput Nucleotide Sequencing, TEN, Toxic epidermal necrolysis, Biobank, CPIC, Clinical Pharmacogenetics Implementation Consortium, 3. Good health, PM, Poor metabolism, 030220 oncology & carcinogenesis, GST, Glutathione-S-transferase, SNVs, Single nucleotide variations, DIHS, Drug-induced hypersensitivity syndrome, Drug-Related Side Effects and Adverse Reactions, 5fC, 5- Formylcytosine, Population, MEDLINE, 5caC, 5- Carboxylcytosine, DPWG, Dutch Pharmacogenetics Working Group, Article, 03 medical and health sciences, HDACs, Histone deacetylases, RA, Retinoic acid, ABC-HSS, Abacavir hypersensitivity syndrome, Animals, Humans, Pharmacokinetics, MPE, Maculopapular exanthema, education, Pharmacology, oxBS-seq, Oxidative bisulfite sequencing, business.industry, DILI, Drug-induced liver injury, CNVs, Copy number variations, DRESS, Drug rash with eosinophilia and systemic symptoms, Data science, CAT, Catalase, GPCR, G-protein coupled receptor, 030104 developmental biology, ALL, Acute lymphoblastic leukemia, Biological Variation, Population, Pharmacogenetics, Pharmacogenomics, Genomic Profile, Personalized medicine, DHR, Drug hypersensitivity reactions, business, Biomarkers

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c77b497b32c4399ec51c1cb33968c9cTest
https://doi.org/10.1016/j.pharmthera.2019.01.002Test

المؤلفون: Gwen Lomberk, Adebowale O. Bamidele, Mary R. Sagstetter, Manuel Bonfim Braga Neto, Olga F. Sarmento, Subra Kugathasan, Raul Urrutia, Michelle Gonzalez, William A. Faubion, Phyllis A. Svingen

المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 1, Pp 55-71 (2019)
Cellular and Molecular Gastroenterology and Hepatology

مصطلحات موضوعية: Male, 0301 basic medicine, Cell Separation, T-Lymphocytes, Regulatory, Regulatory T Cells, Jurkat Cells, 0302 clinical medicine, EZH2, enhancer of zeste homolog 2, co-IP, co-immunoprecipitation, Phosphorylation, Original Research, IBD, inflammatory bowel disease, Janus kinase 1, biology, Chemistry, EZH2, Polycomb Repressive Complex 2, Gastroenterology, FOXP3, Forkhead Transcription Factors, H3K27me3, trimethylated histone H3 at lysine 27, hemic and immune systems, C232, cysteine 232, Middle Aged, Proinflammatory Cytokine, 3. Good health, Chromatin, Intestines, STAT, signal transducer and activator of transcription, medicine.anatomical_structure, Female, Epigenetics, 030211 gastroenterology & hepatology, ChIP, chromatin-immunoprecipitation, JAK, Janus kinase, Co-Repressor Proteins, Protein Binding, Signal Transduction, Crohn’s Disease, Adult, STAT3 Transcription Factor, PMA, phorbol 12-myristate 13-acetate, PBMC, peripheral blood mononuclear cell, Regulatory T cell, PBS, phosphate-buffered saline, SUZ12, suppressor of zeste, Treg, regulatory T cell, chemical and pharmacologic phenomena, macromolecular substances, Proinflammatory cytokine, 03 medical and health sciences, EED, embryonic ectoderm development, CD, Crohn’s disease, medicine, Animals, Humans, LZ, leucine zipper, Enhancer of Zeste Homolog 2 Protein, lcsh:RC799-869, Phosphotyrosine, Interleukin 6, Th, T helper, Transcription factor, Janus Kinases, Cell Nucleus, Inflammation, FOXP3, forkhead domain-containing X-chromosome–encoded protein, Hepatology, Interleukin-6, PLA, proximity ligation assay, Inflammatory Bowel Diseases, WT, wild-type, IL, interleukin, Mice, Inbred C57BL, 030104 developmental biology, Mutation, IPEX, immune dysregulation, polyendocrinopathy, enteropathy, X-linked, biology.protein, Cancer research, lcsh:Diseases of the digestive system. Gastroenterology, FCS, fetal calf serum, PRC2, polycomb repressive complex 2

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f12e433b1850cff302bda788632ed012Test
http://www.sciencedirect.com/science/article/pii/S2352345X18301267Test