المؤلفون: Deschamps, Anthea, Velly, Lionel, Jouve, Elisabeth, Guilhaumou, Romain, Gattacceca, Florence

المساهمون: Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes (IPC), Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut de Neurosciences des Systèmes (INS), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Pharmacologie Clinique Hôpital de la Timone - APHM, Assistance Publique - Hôpitaux de Marseille (APHM)-Hôpital de la Timone CHU - APHM (TIMONE), Assistance Publique - Hôpitaux de Marseille (APHM), Centre d'Investigation Clinique Hôpital de la Conception - APHM (CIC), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Institut Paoli-Calmettes (IPC), Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital de la Conception CHU - APHM (LA CONCEPTION), Hôpital de la Timone CHU - APHM (TIMONE), Méthodes computationnelles pour la prise en charge thérapeutique en oncologie : Optimisation des stratégies par modélisation mécaniste et statistique (COMPO), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre de Recherche en Cancérologie de Marseille (CRCM), Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-Institut Paoli-Calmettes (IPC)

المصدر: PAGE. Abstracts of the Annual Meeting of the Population Approach Group in Europe. ISSN 1871-6032 ; PAGE 2023 - 31th Annual Meeting of the Population Approach Group in Europe ; https://hal.science/hal-04353098Test ; PAGE 2023 - 31th Annual Meeting of the Population Approach Group in Europe, Jun 2023, La Corogne, Spain. pp.10667 ; https://www.page-meeting.org/default.asp?keuze=search&orderby=&keywordTitle=&keywordContent=&keywordAuthor=&keywordNumber=&meeting=48Test

مصطلحات موضوعية: PK Pharmacokinetics, Cefotaxime, Population model, Inter-individual variability, Therapeutic drug monitoring TDM, [INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation, [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology

جغرافية الموضوع: La Corogne, Spain

العلاقة: hal-04353098; https://hal.science/hal-04353098Test; https://hal.science/hal-04353098/documentTest; https://hal.science/hal-04353098/file/poster_anthea_deschamps.pdfTest

الإتاحة: https://hal.science/hal-04353098Test
https://hal.science/hal-04353098/documentTest
https://hal.science/hal-04353098/file/poster_anthea_deschamps.pdfTest

المؤلفون: Shengtao Yuan, Han Luwei, Dezhen Peng, Zhiqiang Wang, Hongzhi Du, Li Sun, Zhang Xian, Zhao Liwen, Danyu Du, Ligong Lu, Meixiao Zhan, Zhibo Zhang, Yong Li

المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 6, Pp 1526-1540 (2021)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: BCRP, breast cancer resistance protein, Metabolite, OATP, organic anion transporting polypeptide, IC50, half maximal inhibitory concentration, Preclinical efficacy, Papp, apparent permeability coefficient, chemistry.chemical_compound, 0302 clinical medicine, LC–MS/MS, liquid chromatography–tandem mass spectrometry, Medicine, PDX, patient-derived tumor xenograft, General Pharmacology, Toxicology and Pharmaceutics, AML, acute myeloid leukemia, MDR1, multidrug resistance protein 1, media_common, 0303 health sciences, α-KG, α-ketoglutaric acid, mIDH2 inhibitor, 2-Hydroxyglutarate, ADME, absorption, distribution, metabolism and excretion, 030220 oncology & carcinogenesis, Differentiation, CYP, cytochrome P450, Original Article, Drug, 2-HG, 2-hydroxyglutaric acid, Mutant isocitrate dehydrogenase 2 (mIDH2), media_common.quotation_subject, CDX, cell-line-derived xenograft, RM1-950, IDH2, Acute myeloid leukaemia, 03 medical and health sciences, mIDH2, mutant isocitrate dehydrogenase, Pharmacokinetics, SH1573, AUC, area under the cure, AG-221, enasidenib, Tumor metabolism, Carcinogen, 030304 developmental biology, PD, pharamacodynamics, business.industry, OCT, organ cation transporter, Clinical trial, chemistry, Cell culture, Pharmacodynamics, Cancer research, OAT, organic anion transporter, PK, pharmacokinetics, Therapeutics. Pharmacology, business, EPO, erythropoietin

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1989ebe7a9db18d2c8b52de1673685c1Test
http://www.sciencedirect.com/science/article/pii/S2211383521000769Test

المؤلفون: Yi Guo, Mingshi Yang, Li Zhang, Changzhi Shi, Dongmei Cun, Hriday Bera

المصدر: Acta Pharmaceutica Sinica. B
Guo, Y, Bera, H, Shi, C, Zhang, L, Cun, D & Yang, M 2021, ' Pharmaceutical strategies to extend pulmonary exposure of inhaled medicines ', Acta Pharmaceutica Sinica B, vol. 11, no. 8, pp. 2565-2584 . https://doi.org/10.1016/j.apsb.2021.05.015Test
Acta Pharmaceutica Sinica B, Vol 11, Iss 8, Pp 2565-2584 (2021)

مصطلحات موضوعية: PLA, polylactic acid, MPP, mucus-penetrating particles, PLGA, poly(lactic-co-glycolic acid), Review, CS, chitosan, Pulmonary exposure, MW, molecular weight, PVA, polyvinyl alcohol, 0302 clinical medicine, Inhaled sustained release formulations, BALF, bronchoalveolar lavage fluid, General Pharmacology, Toxicology and Pharmaceutics, Patient compliance, COPD, chronic obstructive pulmonary diseases, HA, hyaluronic acid, DPIs, dry powder inhalers, 0303 health sciences, DPPC, dipalmitoylphosphatidylcholine, FDA, US food and drug administration, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Obstructive Pulmonary Diseases, API, active pharmaceutical ingredient, NLCs, nanostructured lipid carriers, Clearance, medicine.medical_specialty, LABA, long-acting β2-adrenoceptor agonist, RM1-950, IL-5, interleukin-5, PCL, poly-ε-caprolactone, 03 medical and health sciences, LPPs, large porous particles, medicine, FDKP, fumaryl diketopiperazine, Intensive care medicine, Pharmaceutical strategies, Systemic diseases, Da, aerodynamic diameters, 030304 developmental biology, Asthma, PEG, polyethylene glycol, Lung, PVA - Polyvinyl alcohol, business.industry, DSPC, 1,2-distearoyl-sn-glycero-3-phosphocholine, Therapeutic effect, Drug administration, Pulmonary clearance pathways, MP, mucoadhesive particles, medicine.disease, Pulmonary drug delivery, SLNs, solid lipid nanoparticles, PDD, pulmonary drug delivery, Tmax, time of maximum concentration, ALIS, amikacin liposomal inhalation suspension, Mn, number-average molecular weight, MDIs, metered dose inhalers, Pulmonary safety, IL-4, interleukin-4, MCE, mucociliary escalator, PK, pharmacokinetics, Therapeutics. Pharmacology, ELF, epithelial lining fluid, business, Local lung diseases

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35ad93be5bd1dd39fb79dc4d37488c35Test
http://europepmc.org/articles/PMC8424368Test

المؤلفون: Martin J. Loessner, Mathias Schmelcher, Noël Stierlin, Léa V. Zinsli

المصدر: Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 315-329 (2021)
Computational and Structural Biotechnology Journal, 19

مصطلحات موضوعية: HAP, Homo-amino-acid polymer, NMR, Nuclear magnetic resonance, EPO, Erythropoietin, ANN, Artificial neural network, ELP, Elastin-like polypeptide, APC, Antigen-presenting cell, Review, SVM, Support vector machine, Ig, Immunoglobulin, Biochemistry, Epitope, chemistry.chemical_compound, 0302 clinical medicine, Structural Biology, BCR, B cell receptor, IL, Interleukin, PAMP, Pathogen-associated molecular pattern, LPS, Lipopolysaccharide, ADA, Anti-drug antibody, 0303 health sciences, Protein therapeutics, TCR, T cell receptor, Immunogenicity, Protein therapeutic, Anti-drug-antibody, T cell epitope, B cell epitope, GLK, Gelatin-like protein, PBMC, Peripheral blood mononuclear cell, RNN, Recurrent artificial neural network, ABR, Antigen-binding region, DC, Dendritic cell, Computer Science Applications, HLA, Human leukocyte antigen, PD, Pharmacodynamics, TAP, Transporter associated with antigen processing, PEG, Polyethylene glycol, 030220 oncology & carcinogenesis, TLR, Toll-like receptor, Biotechnology, PRR, Pattern recognition receptor, ER, Endoplasmatic reticulum, Glycosylation, Reductive methylation, Biophysics, HMM, Hidden Markov model, Mutagenesis (molecular biology technique), CDR, Complementarity determining region, Computational biology, Biology, PAS, Polypeptide composed of proline, alanine, and/or serine, PSA, Sialic acid polymers, 03 medical and health sciences, CRISPR, Clustered regularly interspaced short palindromic repeats, Genetics, PK, Pharmacokinetics, Deimmunization, ComputingMethodologies_COMPUTERGRAPHICS, 030304 developmental biology, MHC, Major histocompatibility complex, Bab, Binding antibody, XTEN, “Xtended” recombinant polypeptide, Nab, Neutralizing antibody, chemistry, PEGylation, TP248.13-248.65

وصف الملف: application/application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bc6eb34d6710e1da9ae4b3df006a799Test
https://doi.org/10.1016/j.csbj.2020.12.024Test

المؤلفون: Adeola Shobo, Nicholas James, Daniel Dai, Alexander Röntgen, Corbin Black, Jean-Robert Kwizera, Mark A. Hancock, Khanh Huy Bui, Gerhard Multhaup

المساهمون: Apollo - University of Cambridge Repository

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: Male, AUC, area-under the curve, sD-AIP, scrambled version of D-AIP (EFRKFTGG), Mice, Transgenic, CHCA, α-cyano-4-hydroxy cinnamic acid, AD, Alzheimer’s disease, Biochemistry, D-AIP, AIP (RGTFEGKF) synthesized using D-amino acids, 03 medical and health sciences, Mice, 0302 clinical medicine, APP, amyloid precursor protein, Alzheimer Disease, amyloid-beta42 peptide, Cmax, maximum concentration reached, ThT, thioflavin T, CL/F, apparent total clearance from plasma after oral administration, Animals, IS, internal standard, Tmax, time at which maximum concentration is reached, TEM, transmission electron microscopy, Molecular Biology, AIP, Aβ42-oligomer interacting peptide, L-AIP, AIP (RGTFEGKF) synthesized using L-amino acids, 030304 developmental biology, 0303 health sciences, Amyloid beta-Peptides, t½, elimination half-life, anti-amyloid, Brain, amyloid-beta42-oligomer interacting peptide (AIP), Cell Biology, MSI, mass spectrometry imaging, Peptide Fragments, 3. Good health, Aβ, amyloid-beta, BBB, blood brain barrier, PK, pharmacokinetics, Female, MRT, mean residence time, Vd, apparent volume of distribution, amyloid-beta oligomers, 030217 neurology & neurosurgery, Research Article

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a29a2223836effe65f042554ddc2330dTest
https://www.repository.cam.ac.uk/handle/1810/334182Test

المؤلفون: Hillel Galitzer, Constantin Itin, William D. Fraser, Jonathan Tang, Gregory Burshtein, Phillip Schwartz

المصدر: International Journal of Pharmaceutics: X, Vol 3, Iss, Pp 100097-(2021)
International Journal of Pharmaceutics: X

مصطلحات موضوعية: Proteolysis, Cmax, Pharmaceutical Science, Peptide, Pharmacology, Pharmacy and materia medica, Pharmacokinetics, Teriparatide, medicine, PTH, parathyroid hormone, Salcaprozate sodium, SNAC, salcaprozate sodium, chemistry.chemical_classification, Gastrointestinal tract, medicine.diagnostic_test, Kunitz STI protease inhibitor, GIT, gastrointestinal tract, hPTH(1–34), teriparatide, RS1-441, Oral delivery, chemistry, Permeation enhancer, Drug delivery, SBTI, soybean trypsin inhibitor, PK, pharmacokinetics, Soybean trypsin inhibitor, SNAC, Research Paper, medicine.drug

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39d2bd80762af53fd310511b4c6664b0Test
http://www.sciencedirect.com/science/article/pii/S2590156721000268Test

المؤلفون: Liu, Xiaodong, Weaver, Roni, Hottenstein, Charles, Szapacs, Matthew, Abberley, Lee, Chen, Lingsing, Wang, Xun

المساهمون: Translational Medicine Department, QPS, One Innovation Way, Suite 200, Newark, DE 19711, USA, GlaxoSmithKline DMPK, 709 Swedeland Rd, King of Prussia, PA 19406

المصدر: ISSN: 1948-593X ; Journal of Bioanalysis & Biomedicine ; https://hal.science/hal-04020930Test ; Journal of Bioanalysis & Biomedicine, 2014, 06, ⟨10.4172/1948-593x.1000110⟩.

مصطلحات موضوعية: Gyrolab Bioanalysis Biotinylation Linker Spacer Freeze-thaw Immunoassay BSA: Bovine Serum Albumin HABA: 4'-Hydroxyazo-Benzene-2-Carboxylic Acid IQ: Installation Qualification LIMS: Laboratory Information Management System MRD: Minimum Required Dilution OQ: Operational Qualification PBS: Phosphate-Buffered Saline PBST: Phosphate-Buffered Saline With 0.01% Tween-20 PEG: Polyethylene Glycol PK: Pharmacokinetics PMT: Photomultiplier-Tube PQ: Performance Qualification TK: Toxicokinetics Xiaodong F Liu, QPS, One Innovation Way, Suite 200, Gyrolab, Bioanalysis, Biotinylation, Linker, Spacer, Freeze-thaw, Immunoassay BSA: Bovine Serum Albumin, HABA: 4'-Hydroxyazo-Benzene-2-Carboxylic Acid, IQ: Installation Qualification, LIMS: Laboratory Information Management System, MRD: Minimum Required Dilution, OQ: Operational Qualification, PBS: Phosphate-Buffered Saline, PBST: Phosphate-Buffered Saline With 0.01% Tween-20, PEG: Polyethylene Glycol, PK: Pharmacokinetics, PMT: Photomultiplier-Tube, PQ: Performance Qualification, TK: Toxicokinetics Xiaodong F Liu, [SDV]Life Sciences [q-bio]

العلاقة: hal-04020930; https://hal.science/hal-04020930Test; https://hal.science/hal-04020930/documentTest; https://hal.science/hal-04020930/file/assessing-effects-of-freezethaw-on-biotinylated-macromolecules-using-gyrolab-1948-593X.1000110.pdfTest

الإتاحة: https://doi.org/10.4172/1948-593x.1000110Test
https://hal.science/hal-04020930Test
https://hal.science/hal-04020930/documentTest
https://hal.science/hal-04020930/file/assessing-effects-of-freezethaw-on-biotinylated-macromolecules-using-gyrolab-1948-593X.1000110.pdfTest

المؤلفون: Zhuowei Liu, Yuxi Wang, Chengjian Zhao, Yang Zhang, Manyu Zhao, Jinliang Yang, Yuqin Yao, Peng Li, Chen Zhengxia, Xiaoxin Chen, Chaofeng Long

المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 10, Iss 8, Pp 1453-1475 (2020)

مصطلحات موضوعية: LC–MS, liquid chromatography mass spectrometry, RSD, relative standard deviation, Carboxamide, IC50, half maximal inhibitory concentration, Fibroblast growth factor, TGI, tumor growth inhibition rate, PDGF, platelet-derived growth factor, CE, collision energy, 0302 clinical medicine, RTKs, receptor tyrosine kinases, RE, values and relative error, Vdss, volume of distribution at steady state, PDX, patient-derived tumor xenograft, General Pharmacology, Toxicology and Pharmaceutics, PDB, protein data bank, EC, vascular endothelial cell, 0303 health sciences, Tumor, biology, Chemistry, ERKs, extracellular signal-regulated kinases, VEGF, vascular endothelial growth factor, HBVPs, human brain vascular pericytes, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Anti-angiogenesis therapy, Original Article, i.v., intravenous injection, FGFRs, fibroblast growth factor receptors, Platelet-derived growth factor receptor, IHC, immunohistochemistry, VEGFRs, vascular endothelial growth factor receptors, PM, pericyte medium, HUVECs, human umbilical vein endothelial cells, medicine.drug_class, p.o., per os, CL, systemic clearance, PDGFRs, platelet-derived growth factor receptors, Pharmacokinetic, LLOQ, lower limit of quantification, Cmax, maximum plasma concentration, 03 medical and health sciences, Drug synthesis, Pharmacokinetics, Growth factor receptor, PD, pharmacodynamics, medicine, ECM, endothelial cell medium, Fibroblast, NMR, nuclear magnetic resonance, 030304 developmental biology, ULOQ, up limit of quantitation, ATCC, American Type Culture Collection, Tmax, time the maximum concentration occurred, lcsh:RM1-950, AUC, area under the plasma concentration–time curve, TLC, thin-layer chromatography, In vitro, FGF, fibroblast growth factor, QC, quality control, lcsh:Therapeutics. Pharmacology, Pharmacodynamics, biology.protein, Cancer research, PK, pharmacokinetics, Multi-angiokinase inhibitor, MsOH, methane sulfonic acid, MRM, multiple reaction monitoring

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a6380c470a4be26e380966eab21f579Test
http://europepmc.org/articles/PMC7488503Test

المؤلفون: Chunlin Zhuang, Fen-Er Chen, Ge Meng, KaiJun Jin, Erik De Clercq, Christophe Pannecouque, Minjie Liu

المصدر: Acta Pharmaceutica Sinica B, Vol 10, Iss 2, Pp 344-357 (2020)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: Molecular model, Mutant, MD, molecular dynamic, BP-DATA, biphenyl-substituted diaryltriazine, SI, selectivity index, RPV, rilpivirine, chemistry.chemical_compound, 0302 clinical medicine, NNRTI, non-nucleoside reverse transcriptase inhibitor, EFV, efavirenz, Side chain, HEPT, 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine, General Pharmacology, Toxicology and Pharmaceutics, chemistry.chemical_classification, 0303 health sciences, NP-DATAs, NVP, nevirapine, NNIBP, non-nucleoside inhibitor binding pocket, HIV, human immunodeficiency virus, NP-DATA, naphthyl diaryltriazine, 030220 oncology & carcinogenesis, RT, reverse transcriptase, Lead compound, Original article, Stereochemistry, ETR, etravirine, Molecular modeling, RMSD, root-mean square deviation, BP-DATAs, 03 medical and health sciences, EC50, the concentration causing 50% inhibition of antiviral activity, SAR, structure–activity relationship, Potency, TSAO, tert-butyldimethylsilyl-spiroaminooxathioledioxide, Positional adaptability, 030304 developmental biology, DAPY, diarylpyrimidine, lcsh:RM1-950, WT, wild-type, Reverse transcriptase, AIDS, acquired immunodeficiency syndrome, DATA, diaryltriazine, Enzyme, CC50, 50% cytotoxicity concentration, lcsh:Therapeutics. Pharmacology, chemistry, HIV-1, NNRTIs, PK, pharmacokinetics, Nucleoside

وصف الملف: Print-Electronic

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::669bcf19e6301aee51c948cba93b6a27Test
http://www.sciencedirect.com/science/article/pii/S2211383519301832Test

المؤلفون: Tien Nguyen, Andrea Nguyen, Vivian Laquer, Nicholas Squittieri

المصدر: JAAD International
JAAD International, Vol 6, Iss, Pp 13-19 (2022)

مصطلحات موضوعية: medicine.medical_specialty, Population, BSA, body surface area, Dermatology, corticosteroids, Pharmacokinetics, Psoriasis, Internal medicine, medicine, min, Minimum, Adverse effect, education, LSR, local skin reaction, CST, cosyntropin stimulation test, Body surface area, education.field_of_study, Halobetasol Propionate, EOS, end of study, HPA, hypothalamic-pituitary-adrenal, business.industry, psoriasis, medicine.disease, Discontinuation, HBP, halobetasol propionate, max, Maximum, RL1-803, Lotion, adolescent, PK, pharmacokinetics, Original Article, adrenal suppression, halobetasol propionate, pharmacology, business, AE, adverse event, IGA, Investigator Global Assessment

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21b54bac107c6d89ed7973f987bbb9a7Test
https://pubmed.ncbi.nlm.nih.gov/34870246Test