Treatment According to Molecular Profiling in Relapsed/Refractory Cancer Patients: A Review Focusing on Latest Profiling Studies
| العنوان: | Treatment According to Molecular Profiling in Relapsed/Refractory Cancer Patients: A Review Focusing on Latest Profiling Studies |
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| المؤلفون: | Kai Zimmer, Gilbert Spizzo, Guenther Gastl, Mohamed E. Salem, Andreas Seeber, Florian Kocher |
| المصدر: | Computational and Structural Biotechnology Journal, Vol 17, Iss, Pp 447-453 (2019) Computational and Structural Biotechnology Journal |
| بيانات النشر: | Elsevier, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Oncology, IHC, Immunohistochemistry, medicine.medical_treatment, Druggability, PIK3CA, Phosphatidylinositol-4,5-bisphosphate-3-kinase catalytic subunit alpha, Review Article, Biochemistry, Targeted therapy, law.invention, Molecular profiling, DNA, Deoxyribonucleic acid, 0302 clinical medicine, Randomized controlled trial, Structural Biology, law, MEK, Mitogen-activated protein kinase, Medicine, Profiling (information science), mTOR, Mammalian target of Rapamycin, 0303 health sciences, ASCO, American Society of Clinical Oncology, Precision oncology, CISH, Chromogenic in-situ hybridization, Computer Science Applications, 030220 oncology & carcinogenesis, HER2, Human epidermal growth factor receptor 2, MP, Molecular profile, FGFR, Fibroblast growth factor receptor, Abl, Abelson murine leukemia viral oncogene homolog 1, Biotechnology, FISH, Fluorescence in-situ hybridization, medicine.medical_specialty, CGH, Comparative genomic hybridization, lcsh:Biotechnology, Biophysics, 03 medical and health sciences, NCI, National Cancer Institute, CR, Complete response, PFS, Progression-free survival, RAF, Rapidly growing fibrosarcoma - protein, Internal medicine, lcsh:TP248.13-248.65, WES, Whole-exome sequencing, Genetics, In patient, RNA, Ribonucleic acid, 030304 developmental biology, R/R, Refractory/Relapsed, PTEN, Phosphatase and tensin homolog, business.industry, Bcr, Breakpoint cluster region, SD, Stable Disease, MSI, Microsatellite Instability, Personalized medicine, FDA, Food and Drug Administration, NGS, Next generation sequencing, OS, Overall Survival, PR, Partial Response, HR, Hazard Ratio, Relapsed refractory, TTF, Time to treatment failure, Molecular targets, PCR, Polymerase chain reaction, business, ORR, Overall response rate, Metastatic cancer |
| الوصف: | In this review we aim to summarize studies investigating the impact of a molecular profiling (MP)-guided treatment approach in heavily pretreated cancer patients. In summary, many independent single- and multicenter studies showed a significant benefit of MP-guided treatment regarding response rates and survival. However, in the only randomized trial conducted so far, no benefit of MP-guided targeted therapy was observed. Notably, various profiling approaches were conducted in the respective studies: some studies used a single analytic approach (i.e. next-generation sequencing), others applied multiple analytic methods to perform comprehensive molecular profiling. It seems that multiplatform profiling analyses, detected an increased number of druggable molecular targets or signaling pathway alterations and that a higher proportion of patients was treated according to the molecular cancer profile. Even though no randomized study has shown a benefit of molecular profiling so far, many studies indicate that MP-guided treatment can be beneficial in patients with relapsed and/or refractory cancer. Currently ongoing large randomized trials (i.e. NCI-MATCH, TAPUR) will add evidence to the role of profiling-guided cancer treatment. Keywords: Molecular profiling, Personalized medicine, Precision oncology, Metastatic cancer |
| اللغة: | English |
| تدمد: | 2001-0370 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26ff7f01c70be92f61c5fc4a1e4362beTest http://www.sciencedirect.com/science/article/pii/S2001037018303088Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....26ff7f01c70be92f61c5fc4a1e4362be |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20010370 |
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