المؤلفون: Olsen, Jessica M., Åslund, Alice, Bokhari, Muhammad Hamza, Hutchinson, Dana S., Bengtsson, Tore

المصدر: Molecular Metabolism. 30:240-249

مصطلحات موضوعية: Glucose clearance, Brown adipose tissue, GLUT1, Akt, PI3K alpha, Insulin, Thermogenesis

وصف الملف: print

الوصول الحر: https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-177617Test
https://doi.org/10.1016/j.molmet.2019.10.004Test

المؤلفون: Chang DY, Ma WL, Lu YS

المصدر: Therapeutics and Clinical Risk Management, Vol Volume 17, Pp 193-207 (2021)

مصطلحات موضوعية: hr+/her2− advanced/metastatic breast cancer, pik3ca mutation test, alpelisib pi3k alpha-selective inhibitor, prognosis, survival benefit, toxicity management., Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

العلاقة: https://www.dovepress.com/role-of-alpelisib-in-the-treatment-of-pik3ca-mutated-breast-cancer-pat-peer-reviewed-article-TCRMTest; https://doaj.org/toc/1178-203XTest

الوصول الحر: https://doaj.org/article/f9bbf567c77d45949e2cc7fdf4e7b24aTest

المؤلفون: Ros, Susana, Wright, Alan J, D'Santos, Paula, Hu, De-En, Hesketh, Richard L, Lubling, Yaniv, Georgopoulou, Dimitra, Lerda, Giulia, Couturier, Dominique-Laurent, Razavi, Pedram, Pelossof, Rapahel, Batra, Ankita S, Mannion, Elizabeth, Lewis, David Y, Martin, Alistair, Baird, Richard D, Oliveira, Mafalda, de Boo, Leonora W, Linn, Sabine C, Scaltriti, Maurizio, Rueda, Oscar M, Bruna, Alejandra, Caldas, Carlos, Brindle, Kevin M

مصطلحات موضوعية: FDG-PET, FOXM1, MRI, PI3K alpha inhibition, biomarker, breast cancer, hexokinase 2, hyperpolarized [1-(13)C]pyruvate, lactate dehydrogenase, treatment response, Animals, Antineoplastic Combined Chemotherapy Protocols, Breast Neoplasms, Cell Line, Tumor, Class I Phosphatidylinositol 3-Kinases, Drug Resistance, Neoplasm, Female, Forkhead Box Protein M1, Fulvestrant, Humans, Imidazoles, MCF-7 Cells, Magnetic Resonance Imaging, Mice, Inbred NOD, Knockout, SCID, Oxazepines

وصف الملف: Print-Electronic; application/pdf

العلاقة: https://doi.org/10.17863/CAM.55683Test; https://doi.org/10.17863/CAM.62058Test; https://www.repository.cam.ac.uk/handle/1810/309812Test

الإتاحة: https://doi.org/10.17863/CAM.56911Test
https://doi.org/10.17863/CAM.55683Test
https://doi.org/10.17863/CAM.62058Test
https://www.repository.cam.ac.uk/handle/1810/309812Test

المؤلفون: Yen-Shen Lu, Wei-Li Diana Ma, Dwan-Ying Chang

المصدر: Therapeutics and Clinical Risk Management

مصطلحات موضوعية: Oncology, medicine.medical_specialty, medicine.medical_treatment, Buparlisib, Review, 030204 cardiovascular system & hematology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Breast cancer, Internal medicine, medicine, survival benefit, Pharmacology (medical), alpelisib PI3K alpha-selective inhibitor, 030212 general & internal medicine, General Pharmacology, Toxicology and Pharmaceutics, Adverse effect, PI3K/AKT/mTOR pathway, Chemical Health and Safety, business.industry, Cancer, General Medicine, HR+/HER2− advanced/metastatic breast cancer, medicine.disease, Clinical trial, chemistry, Tolerability, PIK3CA mutation test, Hormone therapy, prognosis, business, Safety Research, toxicity management

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d0873a9ff416d69f6ee1410ec388383Test
http://europepmc.org/articles/PMC7943556Test

المؤلفون: M. Mounayar, E. Kefaloyianni, B. Smith, Z. Solhjou, O. H. Maarouf, J. Azzi, L. Chabtini, P. Fiorina, M. Kraus, R. Briddell, W. Fodor, A. Herrlich, R. Abdi

المساهمون: M. Mounayar, E. Kefaloyianni, B. Smith, Z. Solhjou, O.H. Maarouf, J. Azzi, L. Chabtini, P. Fiorina, M. Krau, R. Briddell, W. Fodor, A. Herrlich, R. Abdi

مصطلحات موضوعية: Cell signaling, Immunosuppression, Immunotherapy, Interferon gamma, Mesenchymal stem cell, PI3K alpha, STAT1, T cell, Down-Regulation, Human, Interferon-gamma, Mesenchymal Stromal Cell, Phosphatidylinositol 3-Kinase, STAT1 Transcription Factor, STAT3 Transcription Factor, Up-Regulation, Cell Differentiation, Cell Biology, Developmental Biology, Molecular Medicine, Medicine (all), Settore MED/13 - Endocrinologia

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/25753288; info:eu-repo/semantics/altIdentifier/wos/WOS:000354882500018; volume:33; issue:6; firstpage:1892; lastpage:1901; numberofpages:10; journal:STEM CELLS; http://hdl.handle.net/2434/499134Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84929791799

الإتاحة: https://doi.org/10.1002/stem.1986Test
http://hdl.handle.net/2434/499134Test

المؤلفون: De-En Hu, David Y. Lewis, Giulia Lerda, Carlos Caldas, Dominique-Laurent Couturier, Susana Ros, Alan J. Wright, Alejandra Bruna, Paula D'Santos, Maurizio Scaltriti, Yaniv Lubling, Richard L. Hesketh, Dimitra Georgopoulou, Rapahel Pelossof, Alistair Martin, Ankita Sati Batra, Oscar M. Rueda, Kevin M. Brindle, Leonora W. de Boo, Sabine C. Linn, Mafalda Oliveira, Pedram Razavi, Richard D. Baird, Elizabeth Mannion

المساهمون: Institut Català de la Salut, [Ros S, Wright AJ, D'Santos P, Hu DE, Hesketh RL, Lubling Y] Cancer Research UK Cambridge Institute and Department of Oncology, Li Ka Shing Centre, University of Cambridge, Cambridge, UK. Cancer Research UK Cambridge Cancer Centre, Cambridge, UK. [Oliveira M] Servei d’Oncologia Mèdica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus

المصدر: Scientia
Cancer Cell

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, PI3K alpha inhibition, Neoplasms::Neoplasms by Site::Breast Neoplasms [DISEASES], Estrogen receptor, Medicaments antineoplàstics - Ús terapèutic, Mice, SCID, chemistry.chemical_compound, Phosphatidylinositol 3-Kinases, 0302 clinical medicine, Mama - Càncer, Mice, Inbred NOD, Antineoplastic Combined Chemotherapy Protocols, Medicine, Other subheadings::/therapeutic use [Other subheadings], FDG-PET, Fulvestrant, Mice, Knockout, neoplasias::neoplasias por localización::neoplasias de la mama [ENFERMEDADES], medicine.diagnostic_test, Imidazoles, Glucose analog, Magnetic Resonance Imaging, hexokinase 2, Oncology, Receptors, Estrogen, Positron emission tomography, 030220 oncology & carcinogenesis, MCF-7 Cells, Biomarker (medicine), biomarker, Female, medicine.drug, MRI, Class I Phosphatidylinositol 3-Kinases, Breast Neoplasms, Article, 03 medical and health sciences, Breast cancer, breast cancer, Lactate dehydrogenase, Cell Line, Tumor, Animals, Humans, Lactic Acid, terapéutica::protocolos clínicos::protocolos antineoplásicos::protocolos de quimioterapia antineoplásica combinada [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], hyperpolarized [1-(13)C]pyruvate, Protein Kinase Inhibitors, Fluorodeoxyglucose, Oncogene, business.industry, Otros calificadores::/uso terapéutico [Otros calificadores], hyperpolarized [1-13C]pyruvate, Forkhead Box Protein M1, FOXM1, treatment response, lactate dehydrogenase, Therapeutics::Clinical Protocols::Antineoplastic Protocols::Antineoplastic Combined Chemotherapy Protocols [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], medicine.disease, Xenograft Model Antitumor Assays, Oxazepines, Tamoxifen, 030104 developmental biology, chemistry, Drug Resistance, Neoplasm, Cancer research, business

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2b060b2e425bd30db0f56bcb62081cfTest
https://hdl.handle.net/11351/6311Test

المؤلفون: Ros Dominguez, Susana, Wright, Alan J, Brindle, Kevin M

مصطلحات موضوعية: raw data, imaging, biomarker, FOXM1, PI3K alpha inhibitor, breast cancer, resistance, early detection, MRI

وصف الملف: Excel MATLAB Vivoquant 3.0 software; application/zip

العلاقة: https://doi.org/10.1016/j.ccell.2020.08.016Test; https://www.repository.cam.ac.uk/handle/1810/309812Test; https://www.repository.cam.ac.uk/handle/1810/311219Test

الإتاحة: https://doi.org/10.17863/CAM.55683Test
https://doi.org/10.1016/j.ccell.2020.08.016Test
https://www.repository.cam.ac.uk/handle/1810/311219Test

المؤلفون: Louisa J Phillipson, David H Segal, Tracy L Nero, Michael W Parker, Soo San Wan, Melanie de Silva, Mark Guthridge, Andrew H Wei, Christopher J Burns

مصطلحات موضوعية: Organic chemistry not elsewhere classified, Science & Technology, Life Sciences & Biomedicine, Physical Sciences, Biochemistry & Molecular Biology, Chemistry, Medicinal, Organic, Pharmacology & Pharmacy, Pyrazolo[1,5-a] pyrimidine, CDK9 selectivity, CDK7, PI3K alpha, FLT3, Molecular modelling, ACUTE MYELOID-LEUKEMIA, PI3-KINASE P110-ALPHA INHIBITORS, CHRONIC LYMPHOCYTIC-LEUKEMIA, DEPENDENT KINASE INHIBITORS, BIOLOGICAL EVALUATION, P-TEFB, DRUG TARGET, PHASE-I, MCL-1, FLAVOPIRIDOL, PI3Kα, Pyrazolo[1,5-a]pyrimidine, Organic Chemistry

العلاقة: http://hdl.handle.net/10536/DRO/DU:30132334Test; https://figshare.com/articles/journal_contribution/Discovery_and_SAR_of_novel_pyrazolo_1_5-a_pyrimidines_as_inhibitors_of_CDK9/20729347Test

الإتاحة: http://hdl.handle.net/10536/DRO/DU:30132334Test
https://figshare.com/articles/journal_contribution/Discovery_and_SAR_of_novel_pyrazolo_1_5-a_pyrimidines_as_inhibitors_of_CDK9/20729347Test

المؤلفون: Yang, Kai-Chien

المصدر: All Theses and Dissertations (ETDs)

مصطلحات موضوعية: Physiology, Cellular biology, Cardiac Hypertrophy, Cardiac PI3K&alpha, Signaling, Electrophysiology, Heart Failure, K+ Channels, Next generation sequencing

وصف الملف: application/pdf

العلاقة: https://openscholarship.wustl.edu/etd/669Test; https://openscholarship.wustl.edu/cgi/viewcontent.cgi?article=1668&context=etdTest

الإتاحة: https://openscholarship.wustl.edu/etd/669Test
https://openscholarship.wustl.edu/cgi/viewcontent.cgi?article=1668&context=etdTest