دورية أكاديمية
Systemic Inflammation Rapidly Induces Reversible Atrial Electrical Remodeling: The Role of Interleukin-6–Mediated Changes in Connexin Expression
| العنوان: | Systemic Inflammation Rapidly Induces Reversible Atrial Electrical Remodeling: The Role of Interleukin-6–Mediated Changes in Connexin Expression |
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| المؤلفون: | Lazzerini P. E., Laghi-Pasini F., Acampa M., Srivastava U., Bertolozzi I., Giabbani B., Finizola F., Vanni F., Dokollari A., Natale M., Cevenini G., Selvi E., Migliacci N., Maccherini M., Boutjdir M., Capecchi P. L. |
| المساهمون: | Lazzerini, P. E., Laghi-Pasini, F., Acampa, M., Srivastava, U., Bertolozzi, I., Giabbani, B., Finizola, F., Vanni, F., Dokollari, A., Natale, M., Cevenini, G., Selvi, E., Migliacci, N., Maccherini, M., Boutjdir, M., Capecchi, P. L. |
| سنة النشر: | 2019 |
| المجموعة: | Università degli Studi di Siena: USiena air |
| مصطلحات موضوعية: | atrial electrical remodeling, atrial fibrillation, connexin, interleukin-6, P-wave indice, systemic inflammation |
| الوصف: | Background: Systemic inflammation is a strong predictor of atrial fibrillation. A key role for electrical remodeling is increasingly recognized, and experimental data suggest that inflammatory cytokines can directly affect connexins resulting in gap-junction dysfunction. We hypothesized that systemic inflammation, regardless of its origin, promotes atrial electric remodeling invivo, as a result of cytokine-mediated changes in connexin expression. Methods and Results: Fifty-four patients with different inflammatory diseases and elevated C-reactive protein were prospectively enrolled, and electrocardiographic P-wave dispersion indices, cytokine levels (interleukin-6, tumor necrosis factor-α, interleukin-1, interleukin-10), and connexin expression (connexin 40, connexin 43) were measured during active disease and after reducing C-reactive protein by >75%. Moreover, peripheral blood mononuclear cells and atrial tissue specimens from an additional sample of 12 patients undergoing cardiac surgery were evaluated for atrial and circulating mRNA levels of connexins. Finally, invitro effects of interleukin-6 on connexin expression were studied in HL-1 mouse atrial myocytes. In patients with active inflammatory diseases, P-wave dispersion indices were increased but rapidly decreased within days when C-reactive protein normalizes and interleukin-6 levels decline. In inflammatory disease patients, both P-wave dispersion indices and interleukin-6 changes were inversely associated with circulating connexin levels, and a positive correlation between connexin expression in peripheral blood mononuclear cells and atrial tissue was demonstrated. Moreover, interleukin-6 significantly reduced connexin expression in HL-1 cells. Conclusions: Our data suggest that regardless of specific etiology and organ localization, systemic inflammation, via interleukin-6 elevation, rapidly induces atrial electrical remodeling by down-regulating cardiac connexins. Although transient, these changes may significantly increase the risk for atrial ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/31423933; info:eu-repo/semantics/altIdentifier/wos/WOS:000484585100002; volume:8; issue:16; firstpage:1; lastpage:17; numberofpages:17; journal:JOURNAL OF THE AMERICAN HEART ASSOCIATION. CARDIOVASCULAR AND CEREBROVASCULAR DISEASE; http://hdl.handle.net/11365/1087494Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85072144939 |
| DOI: | 10.1161/JAHA.118.011006 |
| الإتاحة: | https://doi.org/10.1161/JAHA.118.011006Test http://hdl.handle.net/11365/1087494Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.EA1955ED |
| قاعدة البيانات: | BASE |
| DOI: | 10.1161/JAHA.118.011006 |
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