المؤلفون: Charles N. Zawatsky, Joshua K. Park, Jasmina Abdalla, George Kunos, Malliga R. Iyer, Resat Cinar

المصدر: Frontiers in Endocrinology, Vol 12 (2021)

مصطلحات موضوعية: endocannabinoids, skin fibrosis, bleomycin, ATP-binding cassette transporters, P-gp (P-glycoprotein), peripheral CB1R antagonist, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fendo.2021.744857/fullTest; https://doaj.org/toc/1664-2392Test

الوصول الحر: https://doaj.org/article/073151024c6a4eedbf2545e7f496978bTest

المساهمون: So Hee Park, Myung Ji Kim, Hyun Ho Jung, Won Seok Chang, Hyun Seok Choi, Itay Rachmilevitch, Eyal Zadicario, Jin Woo Chang, Kim, Myung Ji

مصطلحات موضوعية: AU = arbitrary unit, BBB = blood-brain barrier, BBBD = disruption of the BBB, GBM = glioblastoma, GRE = gradient echo, MB = microbubble, MRgFUS = MR-guided focused ultrasound, P-gp = P-glycoprotein 1, TMZ = temozolomide, blood-brain barrier, focused ultrasound, glioblastoma, magnetic resonance imaging, oncology, surgical technique

العلاقة: JOURNAL OF NEUROSURGERY; J01636; OAK-2021-05704; OAK-2022-05359; https://ir.ymlib.yonsei.ac.kr/handle/22282913/184985Test; https://thejns.org/view/journals/j-neurosurg/134/2/article-p475.xmlTest; T202006026; JOURNAL OF NEUROSURGERY, Vol.134(2) : 475-483, 2021-02

الإتاحة: https://doi.org/10.3171/2019.10.JNS192206Test
https://ir.ymlib.yonsei.ac.kr/handle/22282913/184985Test
https://thejns.org/view/journals/j-neurosurg/134/2/article-p475.xmlTest

المؤلفون: Liang Han, Chen Jiang

المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 8, Pp 2306-2325 (2021)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: PSMA, prostate-specific membrane antigen, Gd, gadolinium, BACE1, β-secretase 1, MMP9, metalloproteinase-9, PLGA, poly(lactic-co-glycolic acid), Disease, Review, Aβ, amyloid beta, ICAM-1, intercellular adhesion molecule-1, KCa, calcium-dependent potassium channels, PD, Parkinson's disease, LDL, low density lipoprotein, PEG, polyethyleneglycol, Epilepsy, 0302 clinical medicine, P-gp, P-glycoprotein, Medicine, LRP1, LDLR-related protein 1, General Pharmacology, Toxicology and Pharmaceutics, BBB, blood–brain barrier, siRNA, short interfering RNA, 0303 health sciences, ZO1, zona occludens 1, LAT1, L-type amino acid transporter 1, LDLR, LDL receptor, RBC, red blood cell, AMT, alpha-methyl-l-tryptophan, DTPA-Gd, Gd-diethyltriaminepentaacetic acid, RAGE, receptor for advanced glycosylation end products, VEGF, vascular endothelial growth factor, Drug delivery systems, KATP, ATP-sensitive potassium channels, medicine.anatomical_structure, TJ, tight junction, 030220 oncology & carcinogenesis, Drug delivery, cardiovascular system, AD, Alzheimer's disease, Brain diseases, RMT, receptor-mediated transcytosis, Traumatic brain injury, Brain tumor, BDNF, brain derived neurotrophic factor, Brain-targeting, TfR, transferrin receptor, RM1-950, Blood–brain barrier, TBI, traumatic brain injury, MFSD2A, major facilitator superfamily domain-containing protein 2a, 03 medical and health sciences, ROS, reactive oxygen species, EPR, enhanced permeability and retention, NPs, nanoparticles, 030304 developmental biology, CMT, carrier-mediated transportation, PEG-PLGA, polyethyleneglycol-poly(lactic-co-glycolic acid), business.industry, LFA-1, lymphocyte function associated antigen-1, GLUT1, glucose transporter-1, medicine.disease, tPA, tissue plasminogen activator, Brain targeting, BTB, blood–brain tumor barrier, nervous system, Nanoparticles, Nasal administration, Therapeutics. Pharmacology, business, Neuroscience, MRI, magnetic resonance imaging

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a05eff9f72ac70fe48cb5ed9a111b5bTest
http://www.sciencedirect.com/science/article/pii/S2211383520308522Test

المؤلفون: Ying Han, Xintong Zhang, Wei Huang, Zhonggao Gao, Mingji Jin

المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 7, Pp 1789-1812 (2021)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: SLC, solute carrier, Bioavailability, AMI, amiodarone, MPA, mycophenolic acid, TLCA, taurolithocholate, ASP, amisulpride, RA, rheumatoid arthritis, Review, NRs, nitroreductases, MDR1, multidrug resistance gene 1, NaGC, sodium glycholate, MATEs, multidrug and toxin extrusion proteins, NMEs, new molecular entities, 0302 clinical medicine, HFD, high fat diet, P-gp, P-glycoprotein, ACS, amphipathic chitosan derivative, Medicine, General Pharmacology, Toxicology and Pharmaceutics, LCA, lithocholic acid, 0303 health sciences, Gastrointestinal tract, IBD, inflammatory bowel disease, pKa, dissociation constant, RBC, red blood cell, FA, folate, OATs, organic anion transporters, 030220 oncology & carcinogenesis, MKC, monoketocholic acid, the GI tract, the gastrointestinal tract, AQP4, aquaporin 4, OCTNs, organic zwitterion/cation, T2D, type 2 diabetes, Gut microbiota, RM1-950, WHO, World Health Organization, 03 medical and health sciences, EcN, Escherichia coli Nissle 1917, Drug Transport Process, BDEPT, the bacteria-directed enzyme prodrug therapy, BCS, biopharmaceutics classification system, NEC, necrotizing enterocolitis, DRPs, digoxin reduction products, NaDC, sodium deoxycholate, Probiotics, CPP, cell-penetrating peptide, OCTs, organic cation transporters, TDCA, taurodeoxycholate, cgr operon, cardiac glycoside reductase operon, RA - Rheumatoid arthritis, DCA, deoxycholic acid, AA, ascorbic acid, BBR, berberine, Personalized medicine, BDDCS, the biopharmaceutics drug disposition classification system, SSZ, sulfasalazine, UDC, ursodeoxycholic acid, PPIs, proton pump inhibitors, BCRP, breast cancer resistance protein, CS, chitosan, Gut flora, Bioinformatics, PD, Parkinson's disease, SLN, solid lipid nanoparticle, SGLT-1, sodium-coupled glucose transporter 1, Oral administration, MRP2, multidrug resistance-associated protein 2, FAO, Food and Agriculture Organization of the United Nations, SVCT-1/2, the sodium-dependent vitamin C transporter-1/2, an OTC drug, an over-the-counter drug, CA, cholic acid, biology, ABC, ATP-binding cassette, T1DM, type 1 diabetes mellitus, NSAIDs, non-steroidal anti-inflammatory drugs, AR, azoreductase, GCDC, glycochenodeoxycholate, Drug delivery, GL, glycyrrhizic acid, PT, pectin, LPS, lipopolysaccharide, TME, the tumor microenvironment, T1D, type 1 diabetes, TCDC, taurochenodeoxycholate, Oral drugs, MDR1a, multidrug resistance protein-1a, SCFAs, short-chain fatty acids, CDCA, chenodeoxycholic acid, 030304 developmental biology, business.industry, dhBBR, dihydroberberine, biology.organism_classification, HTC, hematocrit, PWSDs, poorly water-soluble drugs, Colon-specific drug delivery system, stomatognathic diseases, SP, sulfapyridine, 5-ASA, 5-aminosalicylic acid, BSH, bile salt hydrolase, TCA, taurocholate, Therapeutics. Pharmacology, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d001e27a816f9de7d75ff16dd2143ecTest
http://www.sciencedirect.com/science/article/pii/S2211383520307279Test

المؤلفون: Weiguo Zhong, Yuanjin Zhang, Shengbo Huang, Bingyi Yao, Xin Wang, Wenxia Chen

المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 7, Pp 1697-1707 (2021)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: PSCs, pluripotent stem cells, SLC, solute carrier, BCRP, breast cancer resistance protein, Abcg2, OATP, organic anion transporting polypeptide, Review, Papp, apparent permeability coefficient, 0302 clinical medicine, P-gp, P-glycoprotein, General Pharmacology, Toxicology and Pharmaceutics, Induced pluripotent stem cell, P-glycoprotein, OCT, organic cation transporter, OCTN, carnitine/organic cation transporter, 0303 health sciences, biology, Multidrug resistance-associated protein 2, MCT, monocarboxylate transporter protein, iPSCs, induced pluripotent stem cells, Phenotype, Cell biology, medicine.anatomical_structure, 3D organoid, ER, efflux ratio, 030220 oncology & carcinogenesis, Lgr5+, leucine-rich-repeat-containing G-protein-coupled receptor 5 positive, Caco-2 cell monolayer, PMAT, plasma membrane monoamine transporter, TMDs, transmembrane domains, Drug transporter, RM1-950, TEER, transepithelial electrical resistance, 03 medical and health sciences, ASCs, adult somatic stem cells, MRP2, multidrug resistance protein 2, Organoid, medicine, DDI, drug–drug interactions, NBD, nucleotide-binding domain, 030304 developmental biology, EGF, epidermal growth factor, PEPT, peptide transporter protein, Rh123, rhodamine 123, BMP, bone morphogenetic protein, ESCs, embryonic stem cells, Small intestine, FGF, fibroblast growth factor, cMOAT, canalicular multispecific organic anion transporter, CDF, 5(6)-carboxy-2′,7′-dichlorofluorescein, Cell culture, biology.protein, Therapeutics. Pharmacology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dd5440f02c300c8abab983b55b9cddaTest
https://doi.org/10.1016/j.apsb.2020.12.002Test

المؤلفون: Samuel A. Sprowls, W. Pentz, Manish Ranjan, A. Gabriele, Brooke N. Kielkowski, Jeffrey S Carpenter, Pushkar Saralkar, Rashi I. Mehta, Paul R. Lockman, Ross Fladeland, Peng Wang, Tasneem Arsiwala, Chris E. Adkins, Kathryn E Blethen, Ali R. Rezai, Umer Najib

المصدر: Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 7, Pp 676-691 (2021)

مصطلحات موضوعية: 0301 basic medicine, DAMP, Damage associated molecular pattern, Cancer Research, MRI, Magnetic resonance imaging, Focused ultrasound, medicine.medical_treatment, GBM, Glioblastoma, Ultrasonic Therapy, Review Article, 0302 clinical medicine, Drug Delivery Systems, Tumor Microenvironment, Medicine, Neoplasm Metastasis, RC254-282, Blood-brain barrier, VEGF, Vascular Endothelial Growth Factor, CNS, Central nervous system, Brain Neoplasms, ABC, ATP-binding cassette, Ultrasound, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, BCRP, Breast cancer resistant protein, ABCG2, BBB, Blood-brain barrier, medicine.anatomical_structure, HIFU, High intensity focused ultrasound, Treatment Outcome, Ultrasonic Waves, 030220 oncology & carcinogenesis, Drug delivery, cardiovascular system, P-gp, P-glycoprotein, ABCB1, Central nervous system, Blood–brain barrier, Permeability, LIFU, Low-intensity focused ultrasound, 03 medical and health sciences, DCE, Dynamic contrast enhancement, HLA, Human Leukocyte antigen, Blood-tumor barrier, Animals, Humans, FUS, Focused ultrasound, Chemotherapy, Tumor microenvironment, MRP, Multi-drug resistant protein, ABCC1, business.industry, Blood tumor barrier, TNF, Tumor necrosis factor, Biological Transport, AUC, Area under the curve, Disease Models, Animal, 030104 developmental biology, Biological Variation, Population, BTB, Blood-tumor barrier, Cancer research, Disruption, High-Intensity Focused Ultrasound Ablation, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14bce52dd68e77db39bf5423f5169f36Test
http://europepmc.org/articles/PMC8208897Test

المؤلفون: Hossam M. Abdallah, Ahmed M. Al-Abd, Riham Salah El-Dine, Ali M. El-Halawany

المصدر: Journal of Advanced Research, Vol 6, Iss 1, Pp 45-62 (2015)

مصطلحات موضوعية: Multidrug resistance (MDR), Multidrug resistance-associated protein 1 (MRP1), Natural products, P-gp (P-glycoprotein), Medicine (General), R5-920, Science (General), Q1-390

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2090123214001416Test; https://doaj.org/toc/2090-1232Test; https://doaj.org/toc/2090-1224Test

الوصول الحر: https://doaj.org/article/7a2dacfc11664f2491bfd50132a5683bTest

المؤلفون: Jia Meng, Yan Zhao, Guangying Shao, Shun Zhang, Zemei Ge, Baoxue Yang, Xiaoqiang Geng, Shuyuan Wang, Yue Xu, Min Li, Jinzhao He, Runtao Li, Guangping Chen, Hong Zhou, Jianhua Ran

المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 1, Pp 181-202 (2021)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: AQP1, aquaporin 1, Fa, fraction absorbance, BCRP, breast cancer resistance protein, medicine.medical_treatment, IC50, half maximal inhibitory concentration, Urine, DMF, N,N-dimethylformamide, Pharmacology, Urea transporter inhibitor, chemistry.chemical_compound, CCK-8, cell counting kit-8, HDL-C and LDL-C, high- and low-density lipoprotein, PBS, phosphate buffered saline, Pharmacokinetics, Oral administration, P-gp, P-glycoprotein, medicine, Diuretic, IMCD, inner medulla collecting duct, General Pharmacology, Toxicology and Pharmaceutics, UT, urea transporter, GFR, glomerular filtration rate, lcsh:RM1-950, Transporter, CMC-Na, carboxymethylcellulose sodium, medicine.disease, Structure optimization, r.t., room temperature, Papp, apparent permeability, lcsh:Therapeutics. Pharmacology, chemistry, Toxicity, Urea, Original Article, Hyponatremia, THF, tetrahydrofuran

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b07691ffc571a4d2e747924feb8f8ea3Test
https://doi.org/10.1016/j.apsb.2020.06.001Test

المؤلفون: Vigneshwaran Namasivayam, Jens Pahnke, Katja Silbermann, Michael Wiese, Sven Marcel Stefan

المصدر: Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 3269-3283 (2021)

مصطلحات موضوعية: SMILES, simplified molecular input line entry specification, Scaffold, MOE, molecular operating environment, ABCG2 (BCRP), Computer science, Well-studied ABC transporters, IC50, half-maximal inhibition concentration, Multidrug resistance (MDR), Biophysics, Pattern analysis, ATP-binding cassette transporter, MRP1, multidrug resistance-associated protein 1 (ABCC1), Computational biology, C@PA, computer-aided pattern analysis, SEM, standard error of the mean, Biochemistry, 03 medical and health sciences, 0302 clinical medicine, F1–5, pharmacophore features 1–5, Under-studied ABC transporters (e.g., ABCA7), MDR, multidrug resistance, Structural Biology, Pattern analysis (C@PA), Genetics, Statistical analysis, ABC transporter, ATP-binding cassette transporter, P-gp, P-glycoprotein (ABCB1), Fragmentation (cell biology), Tc, Tanimotto coefficient, ComputingMethodologies_COMPUTERGRAPHICS, calcein AM, calcein acetoxymethyl, ABCC1 (MRP1), 030304 developmental biology, 0303 health sciences, Pan-ABC inhibition / antagonism / blockage (PANABC), BCRP, breast cancer resistance protein (ABCG2), ATP, adenosine-triphosphate, Robustness (evolution), Triple / multitarget / broad-spectrum / promiscuous inhibitor / antagonist, Multitarget fingerprints, Computer Science Applications, ABCB1 (P-gp), 030220 oncology & carcinogenesis, Alzheimer's disease (AD), Hit rate, Substructure, TP248.13-248.65, Research Article, Biotechnology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d40715d0bceb0276ecc21ab6730bd845Test
https://doi.org/10.1016/j.csbj.2021.05.018Test

المؤلفون: Weimin Li, Hui Deng

المصدر: Acta Pharmaceutica Sinica B, Vol 10, Iss 4, Pp 582-602 (2020)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: HFD, high-fat diet, Monoacylglycerol lipases, THL, tetrahydrolipstatin, AA, arachidonic acid, SDS-PAGE, sodium dodecyl sulphate polyacrylamide gel electrophoresis, Review, Pharmacology, PD, Parkinson's disease, chemistry.chemical_compound, OCT2, organic cation transporter 2, 0302 clinical medicine, Neuroinflammation, MAGL, monoacylglycerol lipase, P-gp, P-glycoprotein, PA, phosphatidic acid, General Pharmacology, Toxicology and Pharmaceutics, Cancer, 0303 health sciences, ABPP, activity-based protein profiling, Drug discovery, FP-Rh, fluorophosphonate-rhodamine, Chemistry, CC-ABPP, click chemistry activity-based protein profiling, Serine hydrolase, Metabolic syndrome, Endocannabinoid system, PGs, prostaglandins, NHS, N-hydroxysuccinimidyl, Arachidonic acid, 030220 oncology & carcinogenesis, AD, Alzheimer's disease, FFAs, free fatty acids, 2-Arachidaoylglycerol, 2-AG, 2-arachidonoyl glycerol, ABHD6 and ABHD12, α/β-hydrolase 6 and 12, FP, fluorophosphonate, PGE2, prostaglandin, CNS, central nervous system, PK, pharmacokinetic, PET, positron emission tomography, MS, multiple sclerosis, EAE, encephalomyelitis, 03 medical and health sciences, SAR, structure–activity relationship, 7-HCA, 7-hydroxycoumarinyl arachidonate, PLA2G7, phospholipase A2 group VII, SBDD, structure-based drug design, 2-OG, 2-oleoylglycerol, CB1R and CB2R, cannabinoid receptors, cPLA2, cytosolic phospholipase A2, BCRP, breast cancer resistant protein, 030304 developmental biology, MAGs, monoglycerides, EI, enzyme–inhibitor complex, FQ, fit quality, AEA, anandamide, lcsh:RM1-950, 4-NPA, 4-nitrophenylacetate, HFIP, hexafluoroisopropyl, Lipid metabolism, NAM, N-arachidonoyl maleimide, CFA, complete Freund's adjuvant, ABP, activity-based probes, LFD, low-fat diet, Monoacylglycerol lipase, FAAH, amide hydrolase, CYP, cytochrome P450 proteins, LC–MS, liquid chromatographic mass spectrometry, lcsh:Therapeutics. Pharmacology, Eicosanoid, DTT, dithiothreitol, DAGLs, diacylglycerol lipases, COX, cyclooxygenases, DAG, diacylglycerol

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e4fa27f8e67a62d3e620239e37ab9daTest
https://doi.org/10.1016/j.apsb.2019.10.006Test