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1دورية أكاديمية
المؤلفون: von Fallois, Moritz, Kosyna, Friederike Katharina, Mandl, Markus, Landesman, Yosef, Dunst, Jürgen, Depping, Reinhard
المصدر: http://lobid.org/resources/99370674181806441Test#!, 147(7):2025-2033.
مصطلحات موضوعية: Gene Expression Regulation, Neoplastic [MeSH], Carcinoma, Hepatocellular/metabolism [MeSH], Hypoxia, Karyopherins/metabolism [MeSH], HIF, Nuclear transport, Apoptosis [MeSH], Receptors, Cytoplasmic and Nuclear/metabolism [MeSH], CRM1, Osteosarcoma/metabolism [MeSH], Tumor Cells, Cultured [MeSH], Liver Neoplasms/pathology [MeSH], Liver Neoplasms/metabolism [MeSH], Triazoles/pharmacology [MeSH], Hypoxia-Inducible Factor 1, alpha Subunit/genetics [MeSH], Hepatocellular/radiotherapy [MeSH], Osteosarcoma/drug therapy [MeSH], Osteosarcoma/radiotherapy [MeSH], Bone Neoplasms/radiotherapy [MeSH], Cell Proliferation [MeSH], Selinexor, Karyopherins/antagonists, Karyopherins/genetics [MeSH], Original Article – Cancer Research, Humans [MeSH]
العلاقة: https://repository.publisso.de/resource/frl:6449896Test; https://doi.org/10.1007/s00432-021-03626-2Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8164574Test/
الإتاحة: https://doi.org/10.1007/s00432-021-03626-2Test
https://repository.publisso.de/resource/frl:6449896Test
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8164574Test/ -
2دورية أكاديمية
المساهمون: Wang, Wei (author.), Mak, King Lun Kingston (thesis advisor.), Chinese University of Hong Kong Graduate School. Division of Biomedical Sciences. (degree granting institution.)
مصطلحات موضوعية: Osteosarcoma, Metastasis, Osteosarcoma--etiology, Osteosarcoma--metabolism, Neoplasm Metatasis
وصف الملف: electronic resource; remote; 1 online resource (ii-xiv, 192 leaves) : illustrations (some color); computer; online resource
العلاقة: cuhk:2188635; local: ETD920200717; local: AAI13855778; local: 991039750280103407; https://julac.hosted.exlibrisgroup.com/primo-explore/search?query=addsrcrid,exact,991039750280103407,AND&tab=default_tab&search_scope=All&vid=CUHK&mode=advanced&lang=en_USTest; https://repository.lib.cuhk.edu.hk/en/item/cuhk-2188635Test
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3دورية أكاديمية
المساهمون: Won-Il Choi, Bu-Nam Jeon, Chae-Ok Yun, Pyung-Hwan Kim, Sung-Eun Kim, Kang-Yell Choi, Se Hoon Kim, Man-Wook Hur, Yun, Chae Ok, Jeon, Bu Nam, Choi, Won Il, Hur, Man Wook, Kim, Se Hoon, Kim, Pyung Hwan
المصدر: T200900100.pdf
مصطلحات موضوعية: Blotting, Western, Bone Neoplasms/genetics, Bone Neoplasms/metabolism, Bone Neoplasms/pathology, Cell Cycle, Cell Proliferation, Chromatin Immunoprecipitation, Colony-Forming Units Assay, Cyclin-Dependent Kinase Inhibitor p21/antagonists & inhibitors, Cyclin-Dependent Kinase Inhibitor p21/genetics, Cyclin-Dependent Kinase Inhibitor p21/metabolism, DNA-Binding Proteins/physiology, Electrophoretic Mobility Shift Assay, Flow Cytometry, Gene Expression Regulation, Neoplastic, HeLa Cells, Humans, Immunoprecipitation, Mutagenesis, Site-Directed, Osteosarcoma/genetics, Osteosarcoma/metabolism, Osteosarcoma/pathology, Promoter Regions, Genetic, RNA, Small Interfering/pharmacology, Sp1 Transcription Factor/genetics
وصف الملف: 12633~12644
العلاقة: JOURNAL OF BIOLOGICAL CHEMISTRY; J01258; OAK-2009-00086; https://ir.ymlib.yonsei.ac.kr/handle/22282913/103426Test; T200900100; JOURNAL OF BIOLOGICAL CHEMISTRY, Vol.284(19) : 12633-12644, 2009; 37333
الإتاحة: https://doi.org/10.1074/jbc.M809794200Test
https://ir.ymlib.yonsei.ac.kr/handle/22282913/103426Test -
4دورية أكاديمية
المساهمون: Ji-Hak Jeong, Hiroo Nakajima, Junji Magae, Chiharu Furukawa, Keiko Taki, Kensuke Otsuka, Masanori Tomita, In-Seon Lee, Cheorl-Ho Kim, Hyeun-Wook Chang, Kwan-Sik Min, Kwang-Kyun Park, Kwan-Kyu Park, Young-Chae Chang, Park, Kwang Kyun
مصطلحات موضوعية: Adenosine Triphosphate/metabolism, Alkenes/pharmacology, Antibiotics, Antineoplastic/pharmacology, Ataxia Telangiectasia Mutated Proteins, Blotting, Western, Bone Neoplasms/genetics, Bone Neoplasms/metabolism, Bone Neoplasms/pathology, Cell Cycle Proteins/genetics, Cell Cycle Proteins/metabolism, Cell Line, Tumor, Cell Respiration/drug effects, Checkpoint Kinase 1, Comet Assay, DNA Breaks, Double-Stranded, DNA-Binding Proteins/genetics, DNA-Binding Proteins/metabolism, Electrophoretic Mobility Shift Assay, Fluorescent Antibody Technique, Humans, Mitochondria/drug effects, Mitochondria/metabolism, Osteosarcoma/genetics, Osteosarcoma/metabolism, Osteosarcoma/pathology, Phenols/pharmacology
وصف الملف: 2797~2803
العلاقة: INTERNATIONAL JOURNAL OF CANCER; J01092; OAK-2009-01972; https://ir.ymlib.yonsei.ac.kr/handle/22282913/105312Test; T200903705; INTERNATIONAL JOURNAL OF CANCER, Vol.124(12) : 2797-2803, 2009
الإتاحة: https://doi.org/10.1002/ijc.24259Test
https://ir.ymlib.yonsei.ac.kr/handle/22282913/105312Test -
5دورية أكاديمية
المؤلفون: Han, Ilkyu, Lee, Mi Ra, Nam, Kwang Woo, Oh, Joo Han, Moon, Kyung Chul, Kim, Han-Soo
المساهمون: 한일규, 이미라, 남광우, 오주한, 문경철, 김한수
مصطلحات موضوعية: Blotting, Western, Bone Neoplasms/*metabolism/*mortality, Cell Line, Tumor, Child, Preschool, Immunohistochemistry, Intramolecular Oxidoreductases/*metabolism, Macrophage Migration-Inhibitory Factors/*metabolism, Multivariate Analysis, Neoplasm Invasiveness, Neovascularization, Pathologic/metabolism, Osteosarcoma/*metabolism/*mortality, Prognosis, Survival Analysis, Vascular Endothelial Growth Factor A/metabolism
العلاقة: Clin Orthop Relat Res. 2008;466(9):2107-2113; 1528-1132 (Electronic); http://www.springerlink.com/content/n61082156w10376l/fulltext.pdfTest; http://hdl.handle.net/10371/67438Test
الإتاحة: https://doi.org/10.1007/s11999-008-0333-1Test
http://hdl.handle.net/10371/67438Test
http://www.springerlink.com/content/n61082156w10376l/fulltext.pdfTest -
6
المؤلفون: Roberta Mazzone, Piero Picci, Katia Scotlandi, Michela Pasello, Patrizia Nanni, Giordano Nicoletti, Maria Cristina Manara, Antonello Mai, Clara Guerzoni, Camilla Cristalli, Pier Luigi Lollini, Lorena Landuzzi, Sergio Valente, Giulia Stazi, Paola B. Arimondo, Clemens Zwergel
المساهمون: Istituto Ortopedico Rizzoli [Bologna, Italy], Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Centre National de la Recherche Scientifique (CNRS), Department of Medicinal Chemistry and Technologies, Institut Pasteur, Fondation Cenci Bolognetti - Istituto Pasteur Italia, Fondazione Cenci Bolognetti, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], This work was funded by AIRC (IG 18451 to K. Scotlandi, IG 19162 to A. Mai), the Italian Ministry of Health (TRANSCAN_ project TORPEDO_ER-2015-23604059 to K. Scotlandi), Progetto Ateneo Sapienza (to A. Mai), PRIN 2016 (prot 20152TE5PK to A. Mai), and the NIH (R01GM114306 to A. Mai)., The authors thank Cristina Ghinelli for editing the manuscript., Manara, Maria Cristina, Valente, Sergio, Cristalli, Camilla, Nicoletti, Giordano, Landuzzi, Lorena, Zwergel, Clemen, Mazzone, Roberta, Stazi, Giulia, Arimondo, Paola B, Pasello, Michela, Guerzoni, Clara, Picci, Piero, Nanni, Patrizia, Lollini, Pier-Luigi, Mai, Antonello, Scotlandi, Katia
المصدر: Molecular Cancer Therapeutics
Molecular Cancer Therapeutics, American Association for Cancer Research, 2018, 17 (9), pp.1881-1892. ⟨10.1158/1535-7163.MCT-17-0818⟩مصطلحات موضوعية: 0301 basic medicine, Male, patient-derived xenograft (PDX), MESH: Osteosarcoma/genetics, MESH: Antineoplastic Combined Chemotherapy Protocols/therapeutic use, Cellular differentiation, DNA Methyltransferase Inhibitor, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, chemotherapy, MESH: Mice, Knockout, 0302 clinical medicine, MESH: Osteosarcoma/drug therapy, Antineoplastic Combined Chemotherapy Protocols, MESH: Aminoquinolines/administration & dosage, MESH: Animals, MESH: Quinolines/chemistry, Enzyme Inhibitors, MESH: DNA (Cytosine-5-)-Methyltransferase 1/metabolism, Mice, Knockout, DNA methylation, Chemistry, 3. Good health, Tumor Burden, MESH: Benzamides/pharmacology, Gene Expression Regulation, Neoplastic, 030220 oncology & carcinogenesis, Benzamides, oncology, Aminoquinolines, Quinolines, MESH: Cisplatin/administration & dosage, MESH: Bone Neoplasms/metabolism, Osteosarcoma, MESH: Doxorubicin/administration & dosage, epigenetic, MESH: Bone Neoplasms/genetics, medicine.drug, DNA (Cytosine-5-)-Methyltransferase 1, musculoskeletal diseases, MESH: Aminoquinolines/pharmacology, MESH: Cell Line, Tumor, DNA damage, MESH: Gene Expression Regulation, Neoplastic/drug effects, MESH: Tumor Burden/genetics, MESH: Xenograft Model Antitumor Assays, Bone Neoplasms, [SDV.CAN]Life Sciences [q-bio]/Cancer, 03 medical and health sciences, Cell Line, Tumor, osteosarcoma, medicine, Animals, Humans, Doxorubicin, MESH: DNA (Cytosine-5-)-Methyltransferase 1/antagonists & inhibitors, MESH: Enzyme Inhibitors/chemistry, Cisplatin, MESH: Humans, Nucleoside inhibitor, medicine.disease, MESH: Enzyme Inhibitors/pharmacology, Xenograft Model Antitumor Assays, MESH: Male, MESH: Enzyme Inhibitors/administration & dosage, MESH: Bone Neoplasms/drug therapy, 030104 developmental biology, MESH: Osteosarcoma/metabolism, Cancer research, cancer research, MESH: DNA (Cytosine-5-)-Methyltransferase 1/genetics, MESH: Benzamides/administration & dosage, MESH: Tumor Burden/drug effects
وصف الملف: STAMPA
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e55d5482d55dc2ed43ad6818ec4cbf60Test
https://hal.archives-ouvertes.fr/hal-02383680Test -
7
المؤلفون: Stephen P. Jackson, Mareike Herzog, Alejandra Bruna, Luca Pellegrini, Violeta Serra, Mark J. O'Connor, Zhongwu Lai, Chloé Lescale, Jacqueline J.L. Jacobs, Fengtang Yang, Jonathan Lam, Matylda Sczaniecka-Clift, Abigail Shea, Carlos Caldas, Matthias Ostermaier, Gabriel Balmus, Julia Coates, Wenming Wei, Inge de Krijger, Yaron Galanty, Mukerrem Demir, Ludovic Deriano, Petra Beli, Domenic Pilger, Harveer Dev, Rimma Belotserkovskaya, Alistair Martin, Beiyuan Fu, Ting-Wei Will Chiang, Qian Wu
المساهمون: Dev, Harveer [0000-0003-2874-6894], Yang, Fengtang [0000-0002-3573-2354], Balmus, Gabriel [0000-0003-2872-4468], Serra, Violeta [0000-0001-6620-1065], Beli, Petra [0000-0001-9507-9820], Pellegrini, Luca [0000-0002-9300-497X], Deriano, Ludovic [0000-0002-9673-9525], Jacobs, Jacqueline JL [0000-0002-7704-4795], Jackson, Stephen P [0000-0001-9317-7937], Apollo - University of Cambridge Repository, Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge [UK] (CAM), Department of Biochemistry [Cambridge], Cambridge University Hospitals - NHS (CUH), Intégrité du génome, immunité et cancer - Genome integrity, Immunity and Cancer, Institut Pasteur [Paris] (IP), Netherlands Cancer Institute (NKI), Antoni van Leeuwenhoek Hospital, Cancer Research UK Cambridge Institute [Cambridge, Royaume-Uni] (CRUK), Institute of Molecular Biology (IMB), Johannes Gutenberg - Universität Mainz = Johannes Gutenberg University (JGU), Wellcome Trust Sanger Institute [Hinxton, UK], AstraZeneca US [Waltham, USA], AstraZeneca [Cambridge, UK], The Wellcome Trust Sanger Institute [Cambridge], Vall d'Hebron Institute of Oncology [Barcelone] (VHIO), Vall d'Hebron University Hospital [Barcelona], The SPJ lab is largely funded by a Cancer Research UK (CRUK) Program Grant, C6/A18796, and a Wellcome Trust (WT) Investigator Award, 206388/Z/17/Z. Core infrastructure funding was provided by CRUK grant C6946/A24843 and WT grant WT203144. S.P.J. receives a salary from the University of Cambridge. H.D. is funded by WT Clinical Fellowship 206721/Z/17/Z. TWC was supported by a Cambridge International Scholarship. D.P. is funded by Cancer Research UK studentship C6/A21454. The P.B. lab is supported by the Emmy Noether Program (BE 5342/1-1) from the German Research Foundation and a Marie Curie Career Integration Grant from the European Commission (630763). The L.P. lab is funded by the WT (investigator award 104641/Z/14/Z) and the Medical Research Council (project grant MR/N000161/1). The C.C. lab was supported with funding from CRUK. The J.J. lab was supported by the European Research Council grant ERC-StG 311565, The Dutch Cancer Society (KWF) grant KWF 10999, and the Netherlands Organization for Scientific Research (NWO) as part of the National Roadmap Large-scale Research Facilities of the Netherlands, Proteins@Work (project no. 184.032.201 to the Proteomics Facility of the Netherlands Cancer Institute). The L.D. lab is funded by the Institut Pasteur, the Institut National du Cancer (no. PLBIO16-181) and the European Research Council (starting grant agreement no. 310917). W.W. is part of the Pasteur–Paris University (PPU) International PhD program and this project received funding from the CNBG company, China. Q.W. is funded by the Wellcome Trust (200814/Z/16/Z ). The V.S. lab work was funded by the Instituto de Salud Carlos III (ISCIII), an initiative of the Spanish Ministry of Economy and Innovation partially supported by European Regional Development FEDER Funds (PI17-01080 to VS), the European Research Area-NET, Transcan-2 (AC15/00063), a non-commercial research agreement with AstraZeneca UK, and structural funds from the Agència de Gestió d’Ajuts Universitaris i de Recerca (AGAUR, 2017 SGR 540) and the Orozco Family. V.S. received a salary and travel support to C.C.’s lab from ISCIII (CP14/00228, MV15/00041) and the FERO Foundation., The authors thank all S.P.J. laboratory members for support and advice, and Cambridge colleagues N. Lawrence for OMX super-resolution microscopy support and R. Butler for help with computational image analyses and programming. The authors also thank S. Selivanova and S. Hough for help with plasmid amplification, sample preparation and tissue culture maintenance, K. Dry for extensive editorial assistance, F. Muñoz-Martinez for assistance with CRISPR–Cas9 knockout generation, L. Radu for assistance with protein purification, C. Lord (Institute of Cancer Research, London) for SUM149PT cells, D. Durocher (University of Toronto, Canada) for U2OS LacSceIII cells, F. Alt (Harvard University, USA) for CH12F3 cells and 53bp1 knockout CH12F3 cell clones, T. Honjo (Kyoto University, Japan) for permission to use the CH12F3 cell line, and J. Serrat in the Jacobs lab for technical assistance, Institut Pasteur [Paris], Johannes Gutenberg - Universität Mainz (JGU)
المصدر: Nature Cell Biology
Nature Cell Biology, 2018, 20 (8), pp.954-965. ⟨10.1038/s41556-018-0140-1⟩
Nature cell biology
Nature Cell Biology, Nature Publishing Group, 2018, 20 (8), pp.954-965. ⟨10.1038/s41556-018-0140-1⟩مصطلحات موضوعية: MESH: DNA Breaks, Double-Stranded, RAD51, Cell Cycle Proteins, Poly (ADP-Ribose) Polymerase Inhibitor, MESH: Recombinational DNA Repair, Mice, MESH: Animals, DNA Breaks, Double-Stranded, skin and connective tissue diseases, Cancer, Telomere-binding protein, Ovarian Neoplasms, MESH: Breast Neoplasms / metabolism, MESH: Telomere-Binding Proteins / metabolism, 3. Good health, Cell biology, MESH: HEK293 Cells, MESH: Proteins / genetics, MESH: Telomere-Binding Proteins / genetics, MESH: Tumor Suppressor p53-Binding Protein 1 / metabolism, MESH: Xenograft Model Antitumor Assays, Telomere-Binding Proteins, MESH: Ovarian Neoplasms / drug therapy, Bone Neoplasms, MESH: Ovarian Neoplasms / metabolism, Article, 03 medical and health sciences, MESH: Cell Cycle Proteins, MESH: Bone Neoplasms / metabolism, Humans, MESH: Osteosarcoma / metabolism, [SDV.GEN]Life Sciences [q-bio]/Genetics, MESH: Humans, MESH: Tumor Suppressor p53-Binding Protein 1 / genetics, Dose-Response Relationship, Drug, HEK 293 cells, Proteins, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, DNA, MESH: BRCA1 Protein / deficiency, 030104 developmental biology, Multiprotein Complexes, MESH: Mad2 Proteins / metabolism, MESH: Breast Neoplasms / genetics, MESH: Bone Neoplasms / drug therapy, Cisplatin, Homologous recombination, MESH: Osteosarcoma / genetics, MESH: Female, 0301 basic medicine, DNA End-Joining Repair, MESH: Proteins / metabolism, MESH: Dose-Response Relationship, Drug, chemistry.chemical_compound, MESH: Osteosarcoma / pathology, MESH: Breast Neoplasms / pathology, Homologous Recombination, Polymerase, MESH: Breast Neoplasms / drug therapy, Osteosarcoma, biology, Chemistry, BRCA1 Protein, DNA damage and repair, MESH: Poly(ADP-ribose) Polymerase Inhibitors / pharmacology, MESH: Bone Neoplasms / genetics, DNA-Binding Proteins, MESH: Bone Neoplasms / pathology, Mad2 Proteins, Female, MESH: Ovarian Neoplasms / genetics, Tumor Suppressor p53-Binding Protein 1, MESH: Cisplatin / pharmacology, MESH: Cell Line, Tumor, Lymphocytes, Null, [SDV.CAN]Life Sciences [q-bio]/Cancer, Breast Neoplasms, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, MESH: BRCA1 Protein / genetics, Poly(ADP-ribose) Polymerase Inhibitors, Cell Line, Tumor, MESH: Drug Resistance, Neoplasm* / genetics, MESH: Mad2 Proteins / genetics, MESH: Ovarian Neoplasms / pathology, Animals, MESH: Mice, MESH: Osteosarcoma / drug therapy, Oligonucleotide, Protective Devices, Recombinational DNA Repair, Cell Biology, MESH: Multiprotein Complexes, Xenograft Model Antitumor Assays, HEK293 Cells, Drug Resistance, Neoplasm, biology.protein, MESH: DNA End-Joining Repair, MESH: DNA-Binding Proteins
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94c03882fb1aad0056e71d15c34e8ed4Test
https://www.repository.cam.ac.uk/handle/1810/282947Test -
8دورية أكاديمية
المساهمون: Hwal Suh, Dong-Wook Han, Jong-Chul Park, Dong Hee Lee, Woo Suk Lee, Chang Dong Han, Park, Jong Chul, Suh, Hwal, Han, Chang Dong
مصطلحات موضوعية: Alkaline Phosphatase/metabolism, Analysis of Variance, Animals, Biological Factors/chemistry, Biological Factors/pharmacology, Bone Neoplasms/metabolism, Bone Substitutes/chemistry, Bone Substitutes/pharmacology, Cattle, Cell Adhesion/drug effects, Collagen/chemistry, Collagen/pharmacology, Osteoblasts/cytology, Osteoblasts/drug effects, Osteoblasts/enzymology, Osteosarcoma/metabolism, Rabbits, Rats, Sprague-Dawley, Tumor Cells, Cultured/metabolism, Carbonate apatite, Type I atelocollagen, Bone inducing agent, Osteoblast attachment, Osteoblast proliferation, Alkaline phosphatase activity
وصف الملف: 459~466
العلاقة: ARTIFICIAL ORGANS; J00246; OAK-2001-01288; https://ir.ymlib.yonsei.ac.kr/handle/22282913/143168Test; T200103829; ARTIFICIAL ORGANS, Vol.25(6) : 459-466, 2001
الإتاحة: https://doi.org/10.1046/j.1525-1594.2001.025006459.xTest
https://ir.ymlib.yonsei.ac.kr/handle/22282913/143168Test -
9دورية أكاديمية
المؤلفون: Manara, Maria Cristina, Valente, Sergio, Cristalli, Camilla, Nicoletti, Giordano, Landuzzi, Lorena, Zwergel, Clemens, Mazzone, Roberta, Stazi, Giulia, Arimondo, Paola, Pasello, Michela, Guerzoni, Clara, Picci, Piero, Nanni, Patrizia, Lollini, Pier-Luigi, Mai, Antonello, Scotlandi, Katia
المساهمون: Istituto Ortopedico Rizzoli Bologna, Italy, Università degli Studi di Roma "La Sapienza" = Sapienza University Rome (UNIROMA), Centre National de la Recherche Scientifique (CNRS), Department of Medicinal Chemistry and Technologies, Institut Pasteur, Fondation Cenci Bolognetti - Istituto Pasteur Italia, Fondazione Cenci Bolognetti, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Università degli Studi di Roma "La Sapienza" = Sapienza University Rome (UNIROMA), This work was funded by AIRC (IG 18451 to K. Scotlandi, IG 19162 to A. Mai), the Italian Ministry of Health (TRANSCAN_ project TORPEDO_ER-2015-23604059 to K. Scotlandi), Progetto Ateneo Sapienza (to A. Mai), PRIN 2016 (prot 20152TE5PK to A. Mai), and the NIH (R01GM114306 to A. Mai)., The authors thank Cristina Ghinelli for editing the manuscript.
المصدر: ISSN: 1535-7163.
مصطلحات موضوعية: MESH: Aminoquinolines/administration & dosage, MESH: Aminoquinolines/pharmacology, MESH: Cisplatin/administration & dosage, MESH: DNA (Cytosine-5-)-Methyltransferase 1/antagonists & inhibitors, MESH: DNA (Cytosine-5-)-Methyltransferase 1/genetics, MESH: DNA (Cytosine-5-)-Methyltransferase 1/metabolism, MESH: Doxorubicin/administration & dosage, MESH: Enzyme Inhibitors/administration & dosage, MESH: Enzyme Inhibitors/chemistry, MESH: Enzyme Inhibitors/pharmacology, MESH: Gene Expression Regulation, Neoplastic/drug effects, MESH: Humans, MESH: Animals, MESH: Male, MESH: Mice, Knockout, MESH: Osteosarcoma/drug therapy, MESH: Osteosarcoma/genetics, MESH: Osteosarcoma/metabolism, MESH: Quinolines/chemistry, MESH: Tumor Burden/drug effects, MESH: Tumor Burden/genetics, MESH: Xenograft Model Antitumor Assays, MESH: Antineoplastic Combined Chemotherapy Protocols/therapeutic use, MESH: Benzamides/administration & dosage, MESH: Benzamides/pharmacology, MESH: Bone Neoplasms/drug therapy, MESH: Bone Neoplasms/genetics, MESH: Bone Neoplasms/metabolism
العلاقة: info:eu-repo/semantics/altIdentifier/pmid/2995920; hal-02383680; https://hal.science/hal-02383680Test; PUBMED: 2995920
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10دورية أكاديمية
المؤلفون: Dev, Harveer, Chiang, Ting-Wei Will, Lescale, Chloé, de Krijger, Inge, Martin, Alistair, Pilger, Domenic, Coates, Julia, Sczaniecka-Clift, Matylda, Wei, Wenming, Ostermaier, Matthias, Herzog, Mareike, Lam, Jonathan, Shea, Abigail, Demir, Mukerrem, Wu, Qian, Yang, Fengtang, Fu, Beiyuan, Lai, Zhongwu, Balmus, Gabriel, Belotserkovskaya, Rimma, Serra, Violeta, O’connor, Mark, Bruna, Alejandra, Beli, Petra, Pellegrini, Luca, Caldas, Carlos, Deriano, Ludovic, Jacobs, Jacqueline, Galanty, Yaron, Jackson, Stephen, T.
المساهمون: Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge UK (CAM), Department of Biochemistry Cambridge, Cambridge University Hospitals - NHS (CUH), Intégrité du génome, immunité et cancer - Genome integrity, Immunity and Cancer, Institut Pasteur Paris (IP), Netherlands Cancer Institute (NKI), Antoni van Leeuwenhoek Hospital, Cancer Research UK Cambridge Institute Cambridge, Royaume-Uni (CRUK), Institute of Molecular Biology Mainz, Germany (IMB), Johannes Gutenberg - Universität Mainz = Johannes Gutenberg University (JGU), Wellcome Trust Sanger Institute Hinxton, UK, AstraZeneca US Waltham, USA, AstraZeneca Cambridge, UK, The Wellcome Trust Sanger Institute Cambridge, Vall d'Hebron Institute of Oncology Barcelone (VHIO), Vall d'Hebron University Hospital Barcelona, The SPJ lab is largely funded by a Cancer Research UK (CRUK) Program Grant, C6/A18796, and a Wellcome Trust (WT) Investigator Award, 206388/Z/17/Z. Core infrastructure funding was provided by CRUK grant C6946/A24843 and WT grant WT203144. S.P.J. receives a salary from the University of Cambridge. H.D. is funded by WT Clinical Fellowship 206721/Z/17/Z. TWC was supported by a Cambridge International Scholarship. D.P. is funded by Cancer Research UK studentship C6/A21454. The P.B. lab is supported by the Emmy Noether Program (BE 5342/1-1) from the German Research Foundation and a Marie Curie Career Integration Grant from the European Commission (630763). The L.P. lab is funded by the WT (investigator award 104641/Z/14/Z) and the Medical Research Council (project grant MR/N000161/1). The C.C. lab was supported with funding from CRUK. The J.J. lab was supported by the European Research Council grant ERC-StG 311565, The Dutch Cancer Society (KWF) grant KWF 10999, and the Netherlands Organization for Scientific Research (NWO) as part of the National Roadmap Large-scale Research Facilities of the Netherlands, Proteins@Work (project no. 184.032.201 to the Proteomics Facility of the Netherlands Cancer Institute). The L.D. lab is funded by the Institut Pasteur, the Institut National du Cancer (no. PLBIO16-181) and the European Research Council (starting grant agreement no. 310917). W.W. is part of the Pasteur–Paris University (PPU) International PhD program and this project received funding from the CNBG company, China. Q.W. is funded by the Wellcome Trust (200814/Z/16/Z ). The V.S. lab work was funded by the Instituto de Salud Carlos III (ISCIII), an initiative of the Spanish Ministry of Economy and Innovation partially supported by European Regional Development FEDER Funds (PI17-01080 to VS), the European Research Area-NET, Transcan-2 (AC15/00063), a non-commercial research agreement with AstraZeneca UK, and structural funds from the Agència de Gestió d’Ajuts Universitaris i de Recerca (AGAUR, 2017 SGR 540) and the Orozco Family. V.S. received a salary and travel support to C.C.’s lab from ISCIII (CP14/00228, MV15/00041) and the FERO Foundation., The authors thank all S.P.J. laboratory members for support and advice, and Cambridge colleagues N. Lawrence for OMX super-resolution microscopy support and R. Butler for help with computational image analyses and programming. The authors also thank S. Selivanova and S. Hough for help with plasmid amplification, sample preparation and tissue culture maintenance, K. Dry for extensive editorial assistance, F. Muñoz-Martinez for assistance with CRISPR–Cas9 knockout generation, L. Radu for assistance with protein purification, C. Lord (Institute of Cancer Research, London) for SUM149PT cells, D. Durocher (University of Toronto, Canada) for U2OS LacSceIII cells, F. Alt (Harvard University, USA) for CH12F3 cells and 53bp1 knockout CH12F3 cell clones, T. Honjo (Kyoto University, Japan) for permission to use the CH12F3 cell line, and J. Serrat in the Jacobs lab for technical assistance
المصدر: ISSN: 1465-7392.
مصطلحات موضوعية: DNA damage and repair, Cancer, MESH: Animals, MESH: BRCA1 Protein / deficiency, MESH: Drug Resistance, Neoplasm* / genetics, MESH: Female, MESH: BRCA1 Protein / genetics, MESH: HEK293 Cells, MESH: Humans, MESH: Mad2 Proteins / genetics, MESH: Mad2 Proteins / metabolism, MESH: Mice, MESH: Multiprotein Complexes, MESH: Osteosarcoma / drug therapy, MESH: Breast Neoplasms / pathology, MESH: Osteosarcoma / genetics, MESH: Osteosarcoma / metabolism, MESH: Osteosarcoma / pathology, MESH: Bone Neoplasms / drug therapy, MESH: Ovarian Neoplasms / drug therapy, MESH: Ovarian Neoplasms / genetics, MESH: Ovarian Neoplasms / metabolism, MESH: Ovarian Neoplasms / pathology, MESH: Poly(ADP-ribose) Polymerase Inhibitors / pharmacology, MESH: Proteins / genetics, MESH: Cell Cycle Proteins, MESH: Proteins / metabolism, MESH: Recombinational DNA Repair, MESH: Telomere-Binding Proteins / genetics
العلاقة: info:eu-repo/semantics/altIdentifier/pmid/30022119; pasteur-02757608; https://pasteur.hal.science/pasteur-02757608Test; PUBMED: 30022119; PUBMEDCENTRAL: PMC6145444
الإتاحة: https://doi.org/10.1038/s41556-018-0140-1Test
https://pasteur.hal.science/pasteur-02757608Test