دورية أكاديمية

Oral Potentially Malignant Disorders and Candida in Oral Tongue Squamous Cell Carcinoma Patients

التفاصيل البيبلوغرافية
العنوان: Oral Potentially Malignant Disorders and Candida in Oral Tongue Squamous Cell Carcinoma Patients
المؤلفون: Orvokki Saraneva, Jussi Furuholm, Jaana Hagström, Timo Sorsa, Ville Rita, Taina Tervahartiala, Hannamari Välimaa, Hellevi Ruokonen
المصدر: Dentistry Journal, Vol 11, Iss 7, p 170 (2023)
بيانات النشر: MDPI AG, 2023.
سنة النشر: 2023
المجموعة: LCC:Dentistry
مصطلحات موضوعية: oral tongue squamous cell carcinoma, Candida, lichen planus, lichenoid reaction, Dentistry, RK1-715
الوصف: This retrospective study addressed the role of oral potentially malignant disorders and the presence of intraepithelial Candida hyphae in the carcinogenesis of the oral tongue squamous cell carcinoma and its association with smoking, alcohol consumption, and oral inflammatory burden. The medical records of 183 subjects diagnosed with oral tongue squamous cell carcinoma at the Helsinki University Hospital were investigated. Preceding oral lichen planus, lichenoid reaction, and leukoplakia diagnosis were recorded. Further, the data on Candida hyphae in histological samples as an indicator of oral candidiasis, oral inflammatory burden, smoking, and alcohol consumption were recorded and analyzed. The histopathological diagnosis of oral lichen planus/lichenoid reaction (p < 0.001) and the presence of Candida hyphae (p = 0.005) were associated significantly with female gender. Oral lichen planus/lichenoid reaction patients were less often smokers than patients without these lesions. Candida hyphae were more often recorded in patients without alcohol use (p = 0.012). Oral lichen planus/lichenoid reaction and Candida hyphae in histological samples were associated with female gender and lower levels of typical risk factors, such as alcohol use and smoking, in oral tongue squamous cell carcinoma patients. Therefore, these patients should be well monitored despite a potential lack of the classical risk factors of oral carcinoma.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2304-6767
العلاقة: https://www.mdpi.com/2304-6767/11/7/170Test; https://doaj.org/toc/2304-6767Test
DOI: 10.3390/dj11070170
الوصول الحر: https://doaj.org/article/ede0a8fd992b4637853273aad0310004Test
رقم الانضمام: edsdoj.0a8fd992b4637853273aad0310004
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:23046767
DOI:10.3390/dj11070170