المؤلفون: Khalil, Antoine A, Smits, Daan, Haughton, Peter D, Koorman, Thijs, Jansen, Karin A, Verhagen, Mathijs P, van der Net, Mirjam, van Zwieten, Kitty, Enserink, Lotte, Jansen, Lisa, El-Gammal, Abdelrahman G, Visser, Daan, Pasolli, Milena, Tak, Max, Westland, Denise, van Diest, Paul J, Moelans, Cathy B, Roukens, M Guy, Tavares, Sandra, Fortier, Anne-Marie, Park, Morag, Fodde, Riccardo, Gloerich, Martijn, Zwartkruis, Fried J T, Derksen, Patrick Wb, de Rooij, Johan

المساهمون: CMM Groep Khalil, Cancer, Pathologie Groep Derksen, CMM Groep Gloerich, Experimentele Afd. Cardiologie 2, CMM Groep Maurice, CMM Groep Kalkhoven, Pathologie, Pathologie Groep Van Diest, CMM Groep Coffer, CMM Groep Bos

مصطلحات موضوعية: Adaptor Proteins, Signal Transducing/metabolism, Animals, Breast Neoplasms/metabolism, Cell Line, Tumor, Collagen Type I/metabolism, Female, Gene Expression Regulation, Neoplastic, Humans, Mechanotransduction, Cellular, Mice, Neoplasm Invasiveness, Organoids/metabolism, Transcription Factors/metabolism, YAP-Signaling Proteins/metabolism, Journal Article

وصف الملف: application/pdf

العلاقة: https://dspace.library.uu.nl/handle/1874/453227Test

الإتاحة: https://dspace.library.uu.nl/handle/1874/453227Test

المؤلفون: Yetkin-Arik, B, Jansen, S A, Varderidou-Minasian, S, Westendorp, B, Skarp, K-P, Altelaar, M, Lindemans, C A, Lorenowicz, M J

المساهمون: Pathobiologie, Cell Biology, Metabolism and Cancer, Afd Biomol.Mass Spect. and Proteomics, Cell Biology, Metabolism & Cancer - Cancer

مصطلحات موضوعية: Apoptosis/drug effects, Busulfan/pharmacology, Cell Proliferation/drug effects, Coculture Techniques, Graft vs Host Disease/therapy, Humans, Intestinal Mucosa/drug effects, Mesenchymal Stem Cell Transplantation/methods, Mesenchymal Stem Cells/metabolism, Organoids/metabolism, Regeneration/drug effects

وصف الملف: application/pdf

العلاقة: https://dspace.library.uu.nl/handle/1874/451868Test

الإتاحة: https://dspace.library.uu.nl/handle/1874/451868Test

المؤلفون: McDonald, Andrew, Wijnholds, Jan

المصدر: McDonald , A & Wijnholds , J 2024 , ' Retinal Ciliopathies and Potential Gene Therapies : A Focus on Human iPSC-Derived Organoid Models ' , International Journal of Molecular Sciences , vol. 25 , no. 5 , 2887 . https://doi.org/10.3390/ijms25052887Test

مصطلحات موضوعية: Animals, Humans, Induced Pluripotent Stem Cells/metabolism, Retina/metabolism, Retinal Degeneration/metabolism, Genetic Therapy, Organoids/metabolism, Ciliopathies/metabolism, Eye Proteins/metabolism

وصف الملف: application/pdf

العلاقة: https://pure.knaw.nl/portal/en/publications/c56c4883-06a4-47d5-9142-aee59e555f15Test

الإتاحة: https://doi.org/10.3390/ijms25052887Test
https://doi.org/20.500.11755/c56c4883-06a4-47d5-9142-aee59e555f15Test
https://pure.knaw.nl/portal/en/publications/c56c4883-06a4-47d5-9142-aee59e555f15Test
https://hdl.handle.net/20.500.11755/c56c4883-06a4-47d5-9142-aee59e555f15Test
https://pure.knaw.nl/ws/files/1323719596/McDonald2024.pdfTest

المؤلفون: Millen, Rosemary, De Kort, Willem W.B., Koomen, Mandy, van Son, Gijs J.F., Gobits, Roán, Penning de Vries, Bas, Begthel, Harry, Zandvliet, Maurice, Doornaert, Patricia, Raaijmakers, Cornelis P.J., Geurts, Maarten H., Elias, Sjoerd G., van Es, Robert J.J., de Bree, Remco, Devriese, Lot A., Willems, Stefan M., Kranenburg, Onno, Driehuis, Else, Clevers, Hans

المساهمون: MKA/BT Onderzoek, Pathologie Groep Brosens, Epi Kanker Team C, MS Radiotherapie, Cancer, Klinische Fysica RT, JC onderzoeksprogramma Kanker, DHS 3D Lab, MS Hoofd-Hals Chirurgische Oncologie, MS Medische Oncologie, Pathologie Pathologen staf, Lab Translational Oncology, Regenerative Medicine and Stem Cells, CMM, Hubrecht Institute with UMC

مصطلحات موضوعية: Antineoplastic Agents/pharmacology, Biomarkers/metabolism, Carcinoma, Squamous Cell/drug therapy, Head and Neck Neoplasms/drug therapy, Humans, Organoids/metabolism, Protein-Arginine N-Methyltransferases/metabolism, CRISPR, Foundational research, targeted therapy, head and neck cancer, organoids, patient-derived models, personalised medicine, radiotherapy, cancer, 3D models, General Medicine, Journal Article

وصف الملف: application/pdf

العلاقة: https://dspace.library.uu.nl/handle/1874/449149Test

الإتاحة: https://dspace.library.uu.nl/handle/1874/449149Test

المؤلفون: Jelinsky, Scott A, Derksen, Merel, Bauman, Eric, Verissimo, Carla S, van Dooremalen, Wies T M, Roos, Jamie Lee, Higuera Barón, Celia, Caballero-Franco, Celia, Johnson, Bryce G, Rooks, Michelle G, Pott, Johanna, Oldenburg, Bas, Vries, Robert G J, Boj, Sylvia F, Kasaian, Marion T, Pourfarzad, Farzin, Rosadini, Charles V

المساهمون: MS MDL 1, Infection & Immunity

مصطلحات موضوعية: Cytokines/metabolism, Epithelial Cells/metabolism, Humans, Inflammatory Bowel Diseases/pathology, Intestinal Mucosa/pathology, Intestines/physiology, Organoids/metabolism, Tumor Necrosis Factor-alpha/pharmacology, barrier function, cell differentiation, organoids, tofacitinib, Gastroenterology, Immunology and Allergy, Journal Article

وصف الملف: application/pdf

العلاقة: https://dspace.library.uu.nl/handle/1874/447481Test

الإتاحة: https://dspace.library.uu.nl/handle/1874/447481Test

المؤلفون: Escudero, Mélanie, Vaysse, Laurence, Eke, Gozde, Peyrou, Marion, Villarroya, Francesc, Bonnel, Sophie, Boyer, Louisa, Vieu, Christophe, Chaput, Benoit, Yao, Xi, Deschaseaux, Frédéric, Parny, Mélissa, Raymond-Letron, Isabelle, Dani, Christian, Carrière, Audrey, Malaquin, Laurent, Casteilla, Louis

المساهمون: Geroscience and rejuvenation research center (RESTORE), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Équipe Ingénierie pour les sciences du vivant (LAAS-ELIA), Laboratoire d'analyse et d'architecture des systèmes (LAAS), Université Toulouse Capitole (UT Capitole), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université Toulouse Capitole (UT Capitole), Université de Toulouse (UT), University of Barcelona, Service Instrumentation Conception Caractérisation (LAAS-I2C), Service Chirurgie maxillo-faciale et plastique de la face CHU Toulouse, Pôle Céphalique CHU Toulouse, Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Institut de Biologie Valrose (IBV), Université Nice Sophia Antipolis (1965 - 2019) (UNS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UniCA), ANR-18-CE18-0006,hiPSC-Adipospheres,Un modèle 3D d'adipocytes beiges dérivés de cellules iPS humaines pour le criblage de molécules et pour la thérapie cellulaire de l'obésité(2018), ANR-18-EURE-0003,CARE,Toulouse Graudate School of Cancer Ageing and REjuvenation(2018), European Project: 760927,H2020-HoliFAB project

المصدر: ISSN: 2198-3844 ; Advanced Science ; https://ut3-toulouseinp.hal.science/hal-04266619Test ; Advanced Science, 2023, 10 (31), pp.e2301499. ⟨10.1002/advs.202301499⟩ ; https://onlinelibrary.wiley.com/doi/10.1002/advs.202301499Test.

مصطلحات موضوعية: stromal vascular fraction, adipose-derived stroma/stem cells (ASC), beige and brown adipocytes, guided-assembly, hydrogels, microtissues, organoid morphogenesis, MESH: Adipogenesis, MESH: Adipose Tissue, White / metabolism, MESH: Diabetes Mellitus, Type 2* / metabolism, MESH: Humans, MESH: Obesity / metabolism, MESH: Organoids / metabolism, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, [SDV.BC]Life Sciences [q-bio]/Cellular Biology

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/37731092; info:eu-repo/grantAgreement//760927/EU/HoliFAB/H2020-HoliFAB project; hal-04266619; https://ut3-toulouseinp.hal.science/hal-04266619Test; https://ut3-toulouseinp.hal.science/hal-04266619v2/documentTest; https://ut3-toulouseinp.hal.science/hal-04266619v2/file/Escudero_2023.pdfTest; PUBMED: 37731092; PUBMEDCENTRAL: PMC10625054

الإتاحة: https://doi.org/10.1002/advs.202301499Test
https://ut3-toulouseinp.hal.science/hal-04266619Test
https://ut3-toulouseinp.hal.science/hal-04266619v2/documentTest
https://ut3-toulouseinp.hal.science/hal-04266619v2/file/Escudero_2023.pdfTest

المؤلفون: Lassé, Moritz, El Saghir, Jamal, Berthier, Celine C, Eddy, Sean, Fischer, Matthew, Laufer, Sandra D, Kylies, Dominik, Hutzfeldt, Arvid, Bonin, Léna Lydie, Dumoulin, Bernhard, Menon, Rajasree, Vega-Warner, Virginia, Eichinger, Felix, Alakwaa, Fadhl, Fermin, Damian, Billing, Anja M, Minakawa, Akihiro, McCown, Phillip J, Rose, Michael P, Godfrey, Bradley, Meister, Elisabeth, Wiech, Thorsten, Noriega, Mercedes, Chrysopoulou, Maria, Brandts, Paul, Ju, Wenjun, Reinhard, Linda, Hoxha, Elion, Grahammer, Florian, Lindenmeyer, Maja T, Huber, Tobias B, Schlüter, Hartmut, Thiel, Steffen, Mariani, Laura H, Puelles, Victor G, Braun, Fabian, Kretzler, Matthias, Demir, Fatih, Harder, Jennifer L, Rinschen, Markus M

المصدر: Lassé , M , El Saghir , J , Berthier , C C , Eddy , S , Fischer , M , Laufer , S D , Kylies , D , Hutzfeldt , A , Bonin , L L , Dumoulin , B , Menon , R , Vega-Warner , V , Eichinger , F , Alakwaa , F , Fermin , D , Billing , A M , Minakawa , A , McCown , P J , Rose , M P , Godfrey , B , Meister , E , Wiech , T , Noriega , M , ....

مصطلحات موضوعية: Humans, Tumor Necrosis Factor-alpha/metabolism, Proteome/metabolism, Kidney, Kidney Diseases/genetics, Organoids/metabolism

العلاقة: https://pure.au.dk/portal/da/publications/an-integrated-organoid-omics-map-extends-modeling-potential-of-kidney-diseaseTest(6f91bf5c-d3bc-4338-98bc-961b6a0f2809).html

الإتاحة: https://doi.org/10.1038/s41467-023-39740-7Test
https://pure.au.dk/portal/da/publications/an-integrated-organoid-omics-map-extends-modeling-potential-of-kidney-diseaseTest(6f91bf5c-d3bc-4338-98bc-961b6a0f2809).html

المؤلفون: Mertens, Sander, Huismans, Maarten A, Verissimo, Carla S, Ponsioen, Bas, Overmeer, Rene, Proost, Natalie, van Tellingen, Olaf, van de Ven, Marieke, Begthel, Harry, Boj, Sylvia F, Clevers, Hans, Roodhart, Jeanine M L, Bos, Johannes L, Snippert, Hugo J G

المصدر: Mertens , S , Huismans , M A , Verissimo , C S , Ponsioen , B , Overmeer , R , Proost , N , van Tellingen , O , van de Ven , M , Begthel , H , Boj , S F , Clevers , H , Roodhart , J M L , Bos , J L & Snippert , H J G 2023 , ' Drug-repurposing screen on patient-derived organoids identifies therapy-induced vulnerability in KRAS-mutant colon cancer ' , Cell Reports , vol. 42 , no. 4 , pp. 112324 . https://doi.org/10.1016/j.celrep.2023.112324Test

مصطلحات موضوعية: Humans, Proto-Oncogene Proteins p21(ras)/metabolism, Colorectal Neoplasms/drug therapy, Vinorelbine/pharmacology, Drug Repositioning, Cell Line, Tumor, Colonic Neoplasms/drug therapy, Antineoplastic Agents/pharmacology, Organoids/metabolism

العلاقة: https://pure.knaw.nl/portal/en/publications/0e9a4b35-b114-42f9-a362-1cc8de9626cfTest

الإتاحة: https://doi.org/10.1016/j.celrep.2023.112324Test
https://doi.org/20.500.11755/0e9a4b35-b114-42f9-a362-1cc8de9626cfTest
https://pure.knaw.nl/portal/en/publications/0e9a4b35-b114-42f9-a362-1cc8de9626cfTest
https://hdl.handle.net/20.500.11755/0e9a4b35-b114-42f9-a362-1cc8de9626cfTest

المؤلفون: Rüland, Laura, Andreatta, Francesco, Massalini, Simone, Chuva de Sousa Lopes, Susana, Clevers, Hans, Hendriks, Delilah, Artegiani, Benedetta

المصدر: Rüland , L , Andreatta , F , Massalini , S , Chuva de Sousa Lopes , S , Clevers , H , Hendriks , D & Artegiani , B 2023 , ' Organoid models of fibrolamellar carcinoma mutations reveal hepatocyte transdifferentiation through cooperative BAP1 and PRKAR2A loss ' , Nature Communications , vol. 14 , no. 1 , pp. 2377 . https://doi.org/10.1038/s41467-023-37951-6Test

مصطلحات موضوعية: Humans, Liver Neoplasms/metabolism, Cell Transdifferentiation/genetics, Carcinoma, Hepatocellular/metabolism, Mutation, Hepatocytes/metabolism, Organoids/metabolism, HSP40 Heat-Shock Proteins/metabolism, Tumor Suppressor Proteins/genetics, Ubiquitin Thiolesterase/genetics, Cyclic AMP-Dependent Protein Kinase RIIalpha Subunit/genetics

العلاقة: https://pure.knaw.nl/portal/en/publications/9c906605-9400-4449-884a-c3f63d5a8045Test

الإتاحة: https://doi.org/10.1038/s41467-023-37951-6Test
https://doi.org/20.500.11755/9c906605-9400-4449-884a-c3f63d5a8045Test
https://pure.knaw.nl/portal/en/publications/9c906605-9400-4449-884a-c3f63d5a8045Test
https://hdl.handle.net/20.500.11755/9c906605-9400-4449-884a-c3f63d5a8045Test

المؤلفون: Yousef Yengej, Fjodor A, Jansen, Jitske, Ammerlaan, Carola M E, Dilmen, Emre, Pou Casellas, Carla, Masereeuw, Rosalinde, Hoenderop, Joost G, Smeets, Bart, Rookmaaker, Maarten B, Verhaar, Marianne C, Clevers, Hans

المصدر: Yousef Yengej , F A , Jansen , J , Ammerlaan , C M E , Dilmen , E , Pou Casellas , C , Masereeuw , R , Hoenderop , J G , Smeets , B , Rookmaaker , M B , Verhaar , M C & Clevers , H 2023 , ' Tubuloid culture enables long-term expansion of functional human kidney tubule epithelium from iPSC-derived organoids ' , Proceedings of the National Academy of Sciences of the United States of America , vol. 120 , no. 6 , pp. e2216836120 . https://doi.org/10.1073/pnas.2216836120Test

مصطلحات موضوعية: Humans, Induced Pluripotent Stem Cells/metabolism, Kidney/metabolism, Epithelium, Organoids/metabolism, Kidney Tubules, Cell Differentiation

العلاقة: https://pure.knaw.nl/portal/en/publications/e2c6717c-81b4-4d53-8459-4896fece3632Test

الإتاحة: https://doi.org/10.1073/pnas.2216836120Test
https://doi.org/20.500.11755/e2c6717c-81b4-4d53-8459-4896fece3632Test
https://pure.knaw.nl/portal/en/publications/e2c6717c-81b4-4d53-8459-4896fece3632Test
https://hdl.handle.net/20.500.11755/e2c6717c-81b4-4d53-8459-4896fece3632Test