Could Aberrant Migration Explain Metachronous Germ Cell Tumors?
| العنوان: | Could Aberrant Migration Explain Metachronous Germ Cell Tumors? |
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| المؤلفون: | Olivia Chapuis, Pierre Kubicek, Aude Fléchon, Cécile Faure-Conter, Julien Jacquemus, Tanguy Fenouil, Cécile Dumesnil |
| المصدر: | Cancer Investigation. :1-7 |
| بيانات النشر: | Informa UK Limited, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, endocrine system, Cancer Research, Extragonadal, Adolescent, Biology, Mediastinal Neoplasms, Young Adult, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Germinoma, urogenital system, Embryogenesis, Disease Management, Neoplasms, Second Primary, General Medicine, Neoplasms, Germ Cell and Embryonal, medicine.disease, Combined Modality Therapy, Seminoma, Checkpoint Kinase 2, Transformation (genetics), 030104 developmental biology, Oncology, Drug Resistance, Neoplasm, 030220 oncology & carcinogenesis, Cancer research, Germ cell tumors, MutL Protein Homolog 1, Pinealoma |
| الوصف: | Extragonadal germ cell tumors (GCTs) are thought to arise as a result of local transformation of primordial gonadal cells (PGCs) that become misplaced during embryogenesis. With the exception of bilateral testis tumors, metachronous GCT (i.e., occurring at a site classically described for primary GCTs) are rare events.The clinical, radiological, and molecular data (if available) of patients with metachronous GCT were analyzed.Three Caucasian males were identified: case 1 presented with a pineal germinoma 19 years after a mediastinal seminoma that had been treated with chemotherapy, case 2 presented with a pineal non-seminomatous GCT (NSGCT) that occurred three years after a mediastinal seminoma treated with chemotherapy, and case 3 presented with a mediastinal seminoma concomitant with a suprasellar germinoma that occurred two years after a stage I testicular NSGCT treated exclusively with surgery. None of these patients had a positive family history or disorder of sex development. Molecular data were available for cases 2 and 3. In case 2, aThese rare cases should alert clinicians of the possibility of multiple GCTs that should not be considered to be relapses. The underlying physiopathology is unknown, but multiple PGC mismigrations is a likely cause. Initial treatment with cisplatin may select chemo-resistant clones, thereby making the subsequent treatment more of a challenge. |
| تدمد: | 1532-4192 0735-7907 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8056e3f3ab5f40b6e331384c3be93eeaTest https://doi.org/10.1080/07357907.2020.1828447Test |
| رقم الانضمام: | edsair.doi.dedup.....8056e3f3ab5f40b6e331384c3be93eea |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15324192 07357907 |
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