نتائج البحث - "Oligonucleotides, Antisense/genetics"

1

Silencing of ceramide synthase 2 in hepatocytes modulates plasma ceramide biomarkers predictive of cardiovascular death

المؤلفون: Christer S. Ejsing, Sandra F Gallego, Anthony H. Futerman, Richard R. Sprenger, Ole N. Jensen, Nanna Albæk, Steffen Schmidt, Marie W. Lindholm, Charlotte Øverup, Yael Pewzner-Jung, Sergey Kovalchuk, Iris D. Zelnik

المصدر: Mol Ther
Schmidt, S, Gallego, S F, Zelnik, I D, Kovalchuk, S, Albæk, N, Sprenger, R R, Øverup, C, Pewzner-Jung, Y, Futerman, A H, Lindholm, M W, Jensen, O N & Ejsing, C S 2022, ' Silencing of ceramide synthase 2 in hepatocytes modulates plasma ceramide biomarkers predictive of cardiovascular death ', Molecular Therapy, vol. 30, no. 4, pp. 1661-1674 . https://doi.org/10.1016/j.ymthe.2021.08.021Test

مصطلحات موضوعية: Oligonucleotides, Antisense/genetics, Research & Experimental Medicine, Proteomics, DISEASE, PCSK9, Plasma, chemistry.chemical_compound, 0302 clinical medicine, cardiovascular disease, Drug Discovery, Medicine, Genetics & Heredity, chemistry.chemical_classification, 0303 health sciences, CHOLESTEROL, Ceramide synthase 2, 3. Good health, Medicine, Research & Experimental, Cardiovascular Diseases, Molecular Medicine, ceramide synthase 2, Oxidoreductases, Life Sciences & Biomedicine, Ceramide, government.form_of_government, INHIBITION, liver, Ceramides, ANTISENSE OLIGONUCLEOTIDES, DELIVERY, 03 medical and health sciences, proteomics, Oxidoreductases/antagonists & inhibitors, Lipidomics, Cardiovascular Diseases/genetics, Genetics, Mus musculus, Humans, Gene silencing, Gene Silencing, Molecular Biology, 030304 developmental biology, Pharmacology, Antisense therapy, Science & Technology, sphingolipids, business.industry, ceramide biomarkers, antisense therapy, Oligonucleotides, Antisense, Sphingolipid, REDUCTION, MICE, Enzyme, Biotechnology & Applied Microbiology, chemistry, Hepatocytes, Commentary, Cancer research, government, RNA, lipidomics, LIPIDOME, business, Biomarkers, 030217 neurology & neurosurgery

وصف الملف: application/pdf; Print-Electronic

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8b0e637383248c3671fcfcbf8c482c6Test
https://doi.org/10.1016/j.ymthe.2021.08.021Test

2

Clinical advances of RNA therapeutics for treatment of neurological and neuromuscular diseases

المؤلفون: Anja Holm, Stine N. Hansen, Henrik Klitgaard, Sakari Kauppinen

المصدر: Holm, A, Hansen, S N, Klitgaard, H & Kauppinen, S 2022, ' Clinical advances of RNA therapeutics for treatment of neurological and neuromuscular diseases ', RNA Biology, vol. 19, no. 1, pp. 594-608 . https://doi.org/10.1080/15476286.2022.2066334Test

مصطلحات موضوعية: RNA, Small Interfering/genetics, Amyloid Neuropathies, Familial, Oligonucleotides, Antisense/genetics, Amyotrophic Lateral Sclerosis, Amyotrophic Lateral Sclerosis/genetics, Cell Biology, Neuromuscular Diseases, Neuromuscular Diseases/drug therapy, Oligonucleotides, Antisense, United States, Quality of Life, Animals, RNA, Messenger, RNA, Small Interfering, Molecular Biology

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea210bd5f94a483d8b7e4fb573343f21Test
https://pubmed.ncbi.nlm.nih.gov/35482908Test

3

AON-Mediated Exon Skipping to Bypass Protein Truncation in Retinal Dystrophies Due to the Recurrent CEP290 c.4723A > T Mutation. Fact or Fiction?

المؤلفون: Imad Ghazi, Isabelle Perrault, Nicolas Goudin, Jean-Michel Rozet, Josseline Kaplan, Sabine Defoort-Dhellemmes, Iris Barny, Christel Michel, Xavier Gérard

المصدر: Genes, Vol 10, Iss 5, p 368 (2019)
Genes, vol. 10, no. 5

مصطلحات موضوعية: 0301 basic medicine, lcsh:QH426-470, 030105 genetics & heredity, Biology, spontaneous nonsense correction, medicine.disease_cause, 03 medical and health sciences, chemistry.chemical_compound, Exon, Genetics, medicine, Leber congenital amaurosis and allied retinal ciliopathies, Genetics (clinical), Flanders founder c.4723A >, Mutation, Cilium, Retinal, medicine.disease, Molecular biology, Exon skipping, Cilia elongation, Ciliopathy, Antigens, Neoplasm/genetics, Antigens, Neoplasm/metabolism, Cell Cycle Proteins/genetics, Cell Cycle Proteins/metabolism, Codon, Nonsense, Cytoskeletal Proteins/genetics, Cytoskeletal Proteins/metabolism, Exons/genetics, Eye Abnormalities/genetics, Eye Diseases, Hereditary/genetics, Humans, Male, Neoplasm Proteins/genetics, Oligonucleotides, Antisense/genetics, RNA Splicing, Retina/metabolism, Retinal Dystrophies/genetics, Retinal Dystrophies/physiopathology, AON-mediated exon skipping, CEP290, Flanders founder c.4723A > Leber congenital amaurosis and allied retinal ciliopathies, T nonsense mutation, lcsh:Genetics, 030104 developmental biology, chemistry, RNA splicing, Retinal Dystrophies

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85d1b3289409a8e17d29649a47b30231Test
https://www.mdpi.com/2073-4425/10/5/368Test

4

Allele-Selective Inhibition of Mutant Huntingtin with 2-Thio- and C5- Triazolylphenyl-Deoxythymidine-Modified Antisense Oligonucleotides

المؤلفون: Andrew T. Watt, Michael E. Østergaard, Pawan Kumar, Pawan K. Sharma, Punit P. Seth, Josh G. Nichols, Poul Nielsen

المصدر: Østergaard, M E, Kumar, P, Nichols, J, Watt, A, Sharma, P K, Nielsen, P & Seth, P P 2015, ' Allele-Selective Inhibition of Mutant Huntingtin with 2-Thio-and C5-Triazolylphenyl-Deoxythymidine-Modified Antisense Oligonucleotides ', Nucleic Acid Therapeutics, vol. 25, no. 5, pp. 266-274 . https://doi.org/10.1089/nat.2015.0547Test

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b13b9c3fad6a832bc3a891027d83f039Test
https://pubmed.ncbi.nlm.nih.gov/26222265Test

5

In Vivo Antisense Oligodeoxynucleotide Mapping Reveals Masked Regulatory Elements in an mRNA Dormant in Mouse Oocytes

المؤلفون: Jean-Dominique Vassalli, Béatrice Conne, Dominique Belin, Joachim Huarte, Pascale Gubler, Andre Stutz

المصدر: Molecular and Cellular Biology, Vol. 17, No 4 (1997) pp. 1759-1767

مصطلحات موضوعية: Protein Biosynthesis/drug effects, Untranslated region, Tissue Plasminogen Activator/biosynthesis/genetics, Polyadenylation, Molecular Sequence Data, Gene Expression Regulation/drug effects, RNA, Messenger/ genetics/metabolism, Biology, Oligonucleotides, Antisense/ genetics/pharmacology, Mice, Meiosis/drug effects/genetics, Protein biosynthesis, Animals, Gene silencing, Coding region, RNA, Messenger, Molecular Biology, ddc:616, Regulation of gene expression, Messenger RNA, Base Sequence, Translation (biology), Cell Biology, Oligonucleotides, Antisense, Molecular biology, Oocytes/drug effects/growth & development/ metabolism, Meiosis, Gene Expression Regulation, Protein Biosynthesis, Tissue Plasminogen Activator, Oocytes, Female, Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1955c163514b54683b079aabe8a592ecTest
https://doi.org/10.1128/mcb.17.4.1759Test

6

دورية أكاديمية

Growth factor-dependent inhibition of normal hematopoiesis by N-ras antisense oligodeoxynucleotides.

المؤلفون: Skorski T, Szczylik C, Ratajczak MZ, Malaguarnera L, Gewirtz AM, CALABRETTA, Bruno

المساهمون: Skorski, T, Szczylik, C, Ratajczak, Mz, Malaguarnera, L, Gewirtz, Am, Calabretta, Bruno

مصطلحات موضوعية: Growth Substances/pharmacology, Hematopoiesis/drug effect, Oligonucleotides Antisense/genetics

وصف الملف: STAMPA

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/1371302; info:eu-repo/semantics/altIdentifier/wos/WOS:A1992HF64000013; volume:175; firstpage:743; lastpage:750; journal:JOURNAL OF EXPERIMENTAL MEDICINE; http://hdl.handle.net/11380/811724Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-0026522525

الإتاحة: http://hdl.handle.net/11380/811724Test

View record in BASE

7

مراجعة

PNA - peptide nucleic acids. On the way towards gene therapeutic drugs / PNA - peptidnukleinsyrer. På vej mod genterapeutiske laegemidler

المؤلفون: Nielsen, P E

المصدر: Ugeskrift for Laeger. 160(36):5171

View record in SveMed+

8

Phospholamban antisense oligonucleotides improve cardiac function in murine cardiomyopathy

المساهمون: Hubrecht Institute for Developmental Biology and Stem Cell Research, Cardiovascular Centre (CVC), Restoring Organ Function by Means of Regenerative Medicine (REGENERATE)

المصدر: Nature Communications, 12(1). Nature Publishing Group
Nature Communications, 12(1):5180. Nature Publishing Group
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications

مصطلحات موضوعية: Male, Oligonucleotides, Antisense/genetics, Cardiomyopathy, Oligonucleotides, General Physics and Astronomy, Inbred C57BL, Mice, Myocytes, Cardiac, Myocardial infarction, Multidisciplinary, Inbred Lew, Dilated cardiomyopathy, Myocytes, Cardiac/metabolism, Phospholamban, Cardiac/metabolism, Female, Cardiomyopathies, Cardiac function curve, endocrine system, Calcium/metabolism, Science, Ischemia, Cardiomyopathies/genetics, Drug development, Article, General Biochemistry, Genetics and Molecular Biology, Heart Failure/genetics, Downregulation and upregulation, medicine, Animals, Humans, Heart Failure, Myocytes, Calcium-Binding Proteins/genetics, business.industry, Calcium-Binding Proteins, General Chemistry, Genetic Therapy, Translational research, Oligonucleotides, Antisense, medicine.disease, Rats, Mice, Inbred C57BL, Rats, Inbred Lew, Heart failure, Cancer research, Antisense/genetics, Calcium, business