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1دورية أكاديمية
المؤلفون: Kudtarkar, Parul, Melton, Rebecca, Mummey, Hannah, Benaglio, Paola, Okino, Mei-Lin, Gaulton, Kyle, Elgamal, Ruth
المصدر: Diabetes. 72(11)
وصف الملف: application/pdf
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2دورية أكاديمية
المؤلفون: Wang, Gaowei, Chiou, Joshua, Zeng, Chun, Miller, Michael, Matta, Ileana, Han, Jee Yun, Kadakia, Nikita, Okino, Mei-Lin, Beebe, Elisha, Mallick, Medhavi, Camunas-Soler, Joan, dos Santos, Theodore, Dai, Xiao-Qing, Ellis, Cara, Hang, Yan, Kim, Seung K, MacDonald, Patrick E, Kandeel, Fouad R, Preissl, Sebastian, Gaulton, Kyle J, Sander, Maike
المصدر: Nature Genetics. 55(6)
مصطلحات موضوعية: Biochemistry and Cell Biology, Genetics, Biological Sciences, Diabetes, Aetiology, 2.1 Biological and endogenous factors, Metabolic and endocrine, Humans, Diabetes Mellitus, Type 2, Multiomics, Insulin-Secreting Cells, Gene Expression Regulation, Chromatin, Medical and Health Sciences, Developmental Biology, Agricultural biotechnology, Bioinformatics and computational biology
وصف الملف: application/pdf
الوصول الحر: https://escholarship.org/uc/item/169684xzTest
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3دورية أكاديمية
المؤلفون: Benaglio, Paola, Newsome, Jacklyn, Han, Jee Yun, Chiou, Joshua, Aylward, Anthony, Corban, Sierra, Miller, Michael, Okino, Mei-Lin, Kaur, Jaspreet, Preissl, Sebastian, Gorkin, David U, Gaulton, Kyle J
المصدر: PLOS Genetics. 19(6)
مصطلحات موضوعية: Biological Sciences, Genetics, Human Genome, 1.1 Normal biological development and functioning, Aetiology, 2.1 Biological and endogenous factors, Underpinning research, Metabolic and endocrine, Humans, Chromatin, Chromatin Immunoprecipitation Sequencing, Multifactorial Inheritance, Leukocytes, Mononuclear, Quantitative Trait Loci, Developmental Biology
وصف الملف: application/pdf
الوصول الحر: https://escholarship.org/uc/item/2bd0392cTest
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4دورية أكاديمية
المؤلفون: Benaglio, Paola, Zhu, Han, Okino, Mei-Lin, Yan, Jian, Elgamal, Ruth, Nariai, Naoki, Beebe, Elisha, Korgaonkar, Katha, Qiu, Yunjiang, Donovan, Margaret KR, Chiou, Joshua, Wang, Gaowei, Newsome, Jacklyn, Kaur, Jaspreet, Miller, Michael, Preissl, Sebastian, Corban, Sierra, Aylward, Anthony, Taipale, Jussi, Ren, Bing, Frazer, Kelly A, Sander, Maike, Gaulton, Kyle J
المصدر: Cell Genomics. 2(12)
مصطلحات موضوعية: Biochemistry and Cell Biology, Genetics, Biological Sciences, Diabetes, Autoimmune Disease, Prevention, Human Genome, Pediatric, 2.1 Biological and endogenous factors, Aetiology, Metabolic and endocrine, 3D chromatin interactions, CRISPR screen, accessible chromatin, beta cell, functional genomics, gene expression, high-throughput reporter assay, human genetics, proinflammatory cytokines, type 1 diabetes
وصف الملف: application/pdf
الوصول الحر: https://escholarship.org/uc/item/8wv9b80nTest
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5دورية أكاديمية
المؤلفون: Chiou, Joshua, Geusz, Ryan J, Okino, Mei-Lin, Han, Jee Yun, Miller, Michael, Melton, Rebecca, Beebe, Elisha, Benaglio, Paola, Huang, Serina, Korgaonkar, Katha, Heller, Sandra, Kleger, Alexander, Preissl, Sebastian, Gorkin, David U, Sander, Maike, Gaulton, Kyle J
المصدر: Nature. 594(7863)
مصطلحات موضوعية: Biological Sciences, Biomedical and Clinical Sciences, Genetics, Epidemiology, Health Sciences, Autoimmune Disease, Prevention, Biotechnology, Human Genome, Diabetes, Pediatric, Aetiology, 2.1 Biological and endogenous factors, Metabolic and endocrine, Generic health relevance, Good Health and Well Being, Chromatin, Cystic Fibrosis Transmembrane Conductance Regulator, Diabetes Mellitus, Type 1, Epigenomics, Female, Gene Expression Regulation, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Immunity, Male, Pancreatic Ducts, Single-Cell Analysis, General Science & Technology
وصف الملف: application/pdf
الوصول الحر: https://escholarship.org/uc/item/3jx3t5qdTest
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6دورية أكاديمية
المؤلفون: Aylward, Anthony, Okino, Mei-Lin, Benaglio, Paola, Chiou, Joshua, Beebe, Elisha, Padilla, Jose Andres, Diep, Sharlene, Gaulton, Kyle J
المصدر: PLoS genetics. 17(5)
مصطلحات موضوعية: Developmental Biology, Genetics
وصف الملف: application/pdf
الوصول الحر: https://escholarship.org/uc/item/4tg2s1qcTest
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7دورية أكاديمية
المؤلفون: Chiou, Joshua, Zeng, Chun, Cheng, Zhang, Han, Jee Yun, Schlichting, Michael, Miller, Michael, Mendez, Robert, Huang, Serina, Wang, Jinzhao, Sui, Yinghui, Deogaygay, Allison, Okino, Mei-Lin, Qiu, Yunjiang, Sun, Ying, Kudtarkar, Parul, Fang, Rongxin, Preissl, Sebastian, Sander, Maike, Gorkin, David U, Gaulton, Kyle J
المصدر: Nature Genetics. 53(4)
مصطلحات موضوعية: Human Genome, Genetics, Stem Cell Research, Diabetes, 2.1 Biological and endogenous factors, Aetiology, Underpinning research, 1.1 Normal biological development and functioning, Metabolic and endocrine, Blood Glucose, Cell Differentiation, Chromatin, Diabetes Mellitus, Type 2, Epigenomics, Fasting, Gene Expression Profiling, Genome-Wide Association Study, Glucagon-Secreting Cells, High-Throughput Nucleotide Sequencing, Human Embryonic Stem Cells, Humans, Insulin-Secreting Cells, KCNQ1 Potassium Channel, Multigene Family, Pancreatic Polypeptide-Secreting Cells, Polymorphism, Genetic, Single-Cell Analysis, Somatostatin-Secreting Cells, Transcription Factors, Biological Sciences, Medical and Health Sciences, Developmental Biology
وصف الملف: application/pdf
الوصول الحر: https://escholarship.org/uc/item/8hv4s46nTest
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8دورية أكاديمية
المؤلفون: Greenwald, William W, Chiou, Joshua, Yan, Jian, Qiu, Yunjiang, Dai, Ning, Wang, Allen, Nariai, Naoki, Aylward, Anthony, Han, Jee Yun, Kadakia, Nikita, Regue, Laura, Okino, Mei-Lin, Drees, Frauke, Kramer, Dana, Vinckier, Nicholas, Minichiello, Liliana, Gorkin, David, Avruch, Joseph, Frazer, Kelly A, Sander, Maike, Ren, Bing, Gaulton, Kyle J
المصدر: Nature communications. 10(1)
مصطلحات موضوعية: Islets of Langerhans, Cell Nucleus, Chromatin, Animals, Mice, Inbred C57BL, Mice, Knockout, Humans, Mice, Diabetes Mellitus, Type 2, Genetic Predisposition to Disease, Insulin, Glucose, RNA-Binding Proteins, Gene Expression Profiling, Chromatin Assembly and Disassembly, Molecular Conformation, Quantitative Trait Loci, Adult, Middle Aged, Female, Male, Gene Regulatory Networks, Enhancer Elements, Genetic, Genetics, Diabetes, Biotechnology, Human Genome, 2.1 Biological and endogenous factors, Metabolic and endocrine
وصف الملف: application/pdf
الوصول الحر: https://escholarship.org/uc/item/9mf3h56qTest
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9دورية أكاديمية
المؤلفون: Benaglio, Paola, Zhu, Han, Okino, Mei Lin, Yan, Jian, Elgamal, Ruth, Nariai, Naoki, Beebe, Elisha, Korgaonkar, Katha, Qiu, Yunjiang, Donovan, Margaret K.R., Chiou, Joshua, Wang, Gaowei, Newsome, Jacklyn, Kaur, Jaspreet, Miller, Michael, Preissl, Sebastian, Corban, Sierra, Aylward, Anthony, Taipale, Jussi, Ren, Bing, Frazer, Kelly A., Sander, Maike, Gaulton, Kyle J.
المساهمون: Department of Pathology, Biosciences, Doctoral Programme in Integrative Life Science, Jussi Taipale / Principal Investigator
مصطلحات موضوعية: 3D chromatin interactions, accessible chromatin, beta cell, CRISPR screen, functional genomics, gene expression, high-throughput reporter assay, human genetics, proinflammatory cytokines, type 1 diabetes, General medicine, internal medicine and other clinical medicine, Biomedicine
وصف الملف: application/pdf
العلاقة: The work performed in this study was supported by NIH grants DK122607 and DK120429 to K.J.G. and M.S.; DK112155 to M.S., K.F., K.J.G., and B.R.; and DK105541 to M.S., K.F., and B.R. The work performed in this study was supported by NIH grants DK122607 and DK120429 to K.J.G. and M.S.; DK112155 to M.S. K.F. K.J.G. and B.R.; and DK105541 to M.S. K.F. and B.R. K.J.G. and M.S. conceived of and supervised the study. K.J.G. P.B. H.Z. M.O. and M.S. wrote the manuscript. J.T. and B.R. supervised the design and generation of SNP-SELEX data. K.F. supervised the design of SNP-SELEX and analyses of genomic data. S.P. supervised generation of single-cell data. P.B. performed statistical data analysis of genomic, CRISPR-KO screen, and genetic data; H.Z. performed the CRISPR-KO screen and interpreted the results; M.O. and M.M. performed genomic assays. J.Y. performed the SNP-SELEX assay. P.B. M.O. R.E. E.B. K.K. A.A. J.C. G.W. and J.N. performed bulk and single-cell data analysis. M.O. R.E. J.K. and S.C. performed functional validation experiments. P.B. N.N. Y.Q. A.A. and M.K.D. performed design and analysis of SNP-SELEX data. All authors contributed to and approved of the final version of the manuscript. K.J.G. is a consultant of Genentech and holds stock in Neurocrine Biosciences. B.R. is a consultant of Arima Genomics and a co-founder of Epigenome Technologies. P.B. is an employee of Shoreline Bioscience. N.N. is an employee of Guardant Health. E.B. is an employee and shareholder of Aetion. K.K. is an employee of Cartography Bio. Y.Q. is an employee of Sana Biotechnology. M.D. is an employee and shareholder of Seer. J.C. is an employee and shareholder of Pfizer.; Benaglio , P , Zhu , H , Okino , M L , Yan , J , Elgamal , R , Nariai , N , Beebe , E , Korgaonkar , K , Qiu , Y , Donovan , M K R , Chiou , J , Wang , G , Newsome , J , Kaur , J , Miller , M , Preissl , S , Corban , S , Aylward , A , Taipale , J , Ren , B , Frazer , K A , Sander , M & Gaulton , K J 2022 , ' Type 1 diabetes risk genes mediate pancreatic beta cell survival in response to proinflammatory cytokines ' , Cell genomics , vol. 2 , no. 12 , 100214 . https://doi.org/10.1016/j.xgen.2022.100214Test; http://hdl.handle.net/10138/354977Test; c6a62712-0c8b-4078-9442-a6813e9052b5; 85143868567
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10دورية أكاديمية
المؤلفون: Elgamal, Ruth M., Kudtarkar, Parul, Melton, Rebecca L., Mummey, Hannah M., Benaglio, Paola, Okino, Mei-Lin, Gaulton, Kyle J.
المصدر: Diabetes; Nov2023, Vol. 72 Issue 11, p1719-1728, 10p
مصطلحات موضوعية: ISLANDS of Langerhans, GENE expression, TYPE 1 diabetes, TYPE 2 diabetes, RNA sequencing