التفاصيل البيبلوغرافية
| العنوان: |
Sarcoma treatment in the era of molecular medicine |
| المؤلفون: |
Grünewald, T.G.P. (Thomas G. P.), Alonso-Roldán, M.M. (Marta María), Avnet, S. (Sofia), Banito, A. (Ana), Burdach, S. (Stefan), Cidre-Aranaz, F. (Florencia), Di-Pompo, G. (Gemma), Distel, M. (Martin), Dorado-Garcia, H. (Heathcliff), Garcia-Castro, J. (Javier), González-González, L. (Laura), Grigoriadis, A.E. (Agamemnon), Kasan, M. (Merve), Koelsche, C. (Christian), Krumbholz, M. (Manuela), Lecanda, F. (Fernando), Lemma, S. (Silvia), Longo, D.L. (Dario L.), Madrigal-Esquivel, C. (Claudia), Morales-Molina, Á. (Álvaro), Musa, J. (Julian), Ohmura, S. (Shunya), Ory, B. (Benjamin), Pereira-Silva, M. (Miguel), Perut, F. (Francesca), Rodríguez, R. (René), Seeling, C. (Carolin), Al-Shaaili, N. (Nada), Shaabani, S. (Shabnam), Shiavone, K. (Kristina), Sinha, S. (Snehadri), Tomazou, E.M. (Eleni M.), Trautmann, M. (Marcel), Vela, M. (Maria), Versleijen-Jonkers, Y.M.H. (Yvonne M. H.), Visgauss, J. (Julia), Zalacain, M. (Marta), Schober, S.J. (Sebastian J.), Lissat, A. (Andrej), English, W.R. (William R.), Baldini, N. (Nicola), Heymann, D. (Dominique) |
| بيانات النشر: |
MDPI AG |
| سنة النشر: |
2020 |
| المجموعة: |
dadun - Depósito Académico Digital Universidad de Navarra |
| مصطلحات موضوعية: |
Cancer stem cells, Cell dormancy, Chorioallantoic membrane (CAM) models, Circulating tumor cells (CTCs), Epigenomic alterations, Extracellular vesicles (EVs), Genomic alterations, Immunotherapy, Oncolytic viruses, Orthotopic xenografts, Patient-derived xenografts (PDXs), Pediatric tumors, Precision medicine, Sarcomas, Tumor microenvironment (TME) |
| الوصف: |
Sarcomas are heterogeneous and clinically challenging soft tissue and bone cancers. Although constituting only 1% of all human malignancies, sarcomas represent the second most common type of solid tumors in children and adolescents and comprise an important group of secondary malignancies. More than 100 histological subtypes have been characterized to date, and many more are being discovered due to molecular profiling. Owing to their mostly aggressive biological behavior, relative rarity, and occurrence at virtually every anatomical site, many sarcoma subtypes are in particular difficult-to-treat categories. Current multimodal treatment concepts combine surgery, polychemotherapy (with/without local hyperthermia), irradiation, immunotherapy, and/or targeted therapeutics. Recent scientific advancements have enabled a more precise molecular characterization of sarcoma subtypes and revealed novel therapeutic targets and prognostic/predictive biomarkers. This review aims at providing a comprehensive overview of the latest advances in the molecular biology of sarcomas and their effects on clinical oncology; it is meant for a broad readership ranging from novices to experts in the field of sarcoma. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
https://hdl.handle.net/10171/66462Test |
| الإتاحة: |
https://hdl.handle.net/10171/66462Test |
| حقوق: |
info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edsbas.CF741945 |
| قاعدة البيانات: |
BASE |
