دورية أكاديمية
Sandostatin, a new analogue of somatostatin, reduces the metabolic changes induced by the nocturnal interruption of continuous subcutaneous insulin infusion in type 1 (insulin-dependent) diabetic patients.
| العنوان: | Sandostatin, a new analogue of somatostatin, reduces the metabolic changes induced by the nocturnal interruption of continuous subcutaneous insulin infusion in type 1 (insulin-dependent) diabetic patients. |
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| المؤلفون: | Scheen, André, Gillet, J., Rosenthaler, J., Guiot, J., Henrivaux, P., Jandrain, Bernard, Lefebvre, Pierre |
| المصدر: | Diabetologia, 32 (11), 801-9 (1989) |
| بيانات النشر: | Springer Verlag |
| سنة النشر: | 1989 |
| المجموعة: | University of Liège: ORBi (Open Repository and Bibliography) |
| مصطلحات موضوعية: | 3-Hydroxybutyric Acid, Adult, Blood Glucose/metabolism, C-Peptide/blood, Diabetes Mellitus, Type 1/drug therapy/physiopathology, Diabetic Neuropathies/physiopathology, Drug Administration Schedule, Fatty Acids, Nonesterified/blood, Female, Glucagon/blood, Glycerol/blood, Growth Hormone/blood, Humans, Hydroxybutyrates/blood, Insulin/blood, Insulin Infusion Systems, Male, Octreotide/blood/therapeutic use, Human health sciences, Endocrinology, metabolism & nutrition, Pharmacy, pharmacology & toxicology, Sciences de la santé humaine, Endocrinologie, métabolisme & nutrition, Pharmacie, pharmacologie & toxicologie |
| الوصف: | peer reviewed ; With the aim of assessing a new somatostatin analogue to prevent the metabolic changes induced by a 6-h nocturnal arrest of an insulin pump, nine C-peptide negative Type 1 (insulin-dependent) diabetic patients were submitted blindly to two interruptions (from 23.00 to 05.00 hours) of their continuous s.c. insulin infusion, once after a single s.c. injection at 23.00 hours of 50 micrograms SMS 201-995 (Sandostatin, Sandoz) and once after 0.9% NaCl. Plasma SMS 201-995 levels peaked at 24.00 hours and then declined with an elimination half-life averaging 144 +/- 15 min. Plasma glucagon and growth hormone levels were significantly reduced after SMS 201-995 whereas the progressive fall in plasma-free insulin levels from 23.00 to 05.00 hours was unaffected. In the control test, blood glucose levels tended to decrease slightly from 23.00 to 02.00 hours and then increased markedly from 02.00 to 05.00 hours (+5.3 +/- 1.5 mmol/l) while after SMS 201-995 they decreased significantly from 23.00 to 02.00 hours (-2.6 +/- 0.5 mmol/l), resulting in values below 3 mmol/l in seven subjects, but showed a secondary increase until 05.00 hours (+3.5 +/- 1.5 mmol vs 23.00 h; p less than 0.05 vs 0.9% NaCl). While the rises in plasma non-esterified fatty acid and glycerol levels were not reduced by SMS 201-995, the increase in plasma 3-hydroxbutyrate levels, although similar from 23.00 to 02.00 hours, was significantly reduced from 02.00 to 05.00 hours (+77 +/- 20 vs +124 +/- 31 mumols.l-1.h-1; p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS) |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0012-186X 1432-0428 |
| العلاقة: | urn:issn:0012-186X; urn:issn:1432-0428; https://orbi.uliege.be/handle/2268/14054Test; info:hdl:2268/14054; scopus-id:2-s2.0-0024463483; info:pmid:2687064 |
| DOI: | 10.1007/BF00264911 |
| الإتاحة: | https://doi.org/10.1007/BF00264911Test https://orbi.uliege.be/handle/2268/14054Test |
| رقم الانضمام: | edsbas.4046014D |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 0012186X 14320428 |
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| DOI: | 10.1007/BF00264911 |