المؤلفون: Morozko, Eva L, Smith-Geater, Charlene, Monteys, Alejandro Mas, Pradhan, Subrata, Lim, Ryan G, Langfelder, Peter, Kachemov, Marketta, Kulkarni, Jayesh A, Zaifman, Josh, Hill, Austin, Stocksdale, Jennifer T, Cullis, Pieter R, Wu, Jie, Ochaba, Joseph, Miramontes, Ricardo, Chakraborty, Anirban, Hazra, Tapas K, Lau, Alice, St-cyrc, Sophie, Orellana, Iliana, Kopan, Lexi, Wang, Keona Q, Yeung, Sylvia, Leavitt, Blair R, Reidling, Jack C, Yang, X William, Steffan, Joan S, Davidson, Beverly L, Sarkar, Partha S, Thompson, Leslie M

المصدر: Proceedings of the National Academy of Sciences of the United States of America. 118(32)

مصطلحات موضوعية: Biological Sciences, Biomedical and Clinical Sciences, Clinical Sciences, Genetics

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/3qr022tsTest

المؤلفون: Morozko, Eva L, Smith-Geater, Charlene, Monteys, Alejandro Mas, Pradhan, Subrata, Lim, Ryan G, Langfelder, Peter, Kachemov, Marketta, Kulkarni, Jayesh A, Zaifman, Josh, Hill, Austin, Stocksdale, Jennifer T, Cullis, Pieter R, Wu, Jie, Ochaba, Joseph, Miramontes, Ricardo, Chakraborty, Anirban, Hazra, Tapas K, Lau, Alice, St-cyr, Sophie, Orellana, Iliana, Kopan, Lexi, Wang, Keona Q, Yeung, Sylvia, Leavitt, Blair R, Reidling, Jack C, Yang, X William, Steffan, Joan S, Davidson, Beverly L, Sarkar, Partha S, Thompson, Leslie M

المصدر: Proceedings of the National Academy of Sciences of the United States of America. 118(4)

مصطلحات موضوعية: Biochemistry and Cell Biology, Genetics, Biological Sciences, Neurosciences, Huntington's Disease, Brain Disorders, Neurodegenerative, Stem Cell Research, Rare Diseases, Underpinning research, 1.1 Normal biological development and functioning, 2.1 Biological and endogenous factors, Aetiology, Neurological, Animals, Cell Differentiation, DNA, DNA Damage, DNA Repair, DNA Repair Enzymes, Disease Models, Animal, Female, Humans, Huntingtin Protein, Huntington Disease, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Neurons, Phosphotransferases (Alcohol Group Acceptor), Pluripotent Stem Cells, Primary Cell Culture, Protein Inhibitors of Activated STAT, Protein Processing, Post-Translational, RNA, Small Interfering, Small Ubiquitin-Related Modifier Proteins, Sumoylation, Transcription, Genetic, DNA damage repair, SUMO, PIAS, Huntington's disease, PNKP

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/6np4540mTest

المؤلفون: Crapser, Joshua D, Ochaba, Joseph, Soni, Neelakshi, Reidling, Jack C, Thompson, Leslie M, Green, Kim N

المصدر: Brain. 143(1)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Clinical Sciences, Brain Disorders, Rare Diseases, Prevention, Neurodegenerative, Neurosciences, Huntington's Disease, Aetiology, 2.1 Biological and endogenous factors, Neurological, Aminopyridines, Animals, Astrocytes, Chondroitin Sulfate Proteoglycans, Cytokines, Disease Models, Animal, Down-Regulation, Extracellular Matrix, Hand Strength, Humans, Huntingtin Protein, Huntington Disease, Inflammation, Mice, Mice, Transgenic, Microglia, Neostriatum, Neurites, Pyrroles, RNA, Messenger, Receptors, Granulocyte-Macrophage Colony-Stimulating Factor, Recognition, Psychology, Synapses, Transcriptome, microglia, Huntington's disease, CSF1R, extracellular matrix, perineuronal nets, Medical and Health Sciences, Psychology and Cognitive Sciences, Neurology & Neurosurgery, Biomedical and clinical sciences, Health sciences, Psychology

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/2m13143kTest
https://escholarship.org/content/qt2m13143k/qt2m13143k.pdfTest

المؤلفون: Ochaba, Joseph, Fote, Gianna, Kachemov, Marketta, Thein, Soe, Yeung, Sylvia Y, Lau, Alice L, Hernandez, Sarah, Lim, Ryan G, Casale, Malcolm, Neel, Michael J, Monuki, Edwin S, Reidling, Jack, Housman, David E, Thompson, Leslie M, Steffan, Joan S

المصدر: Proceedings of the National Academy of Sciences of the United States of America. 116(22)

مصطلحات موضوعية: Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Biological Sciences, Huntington's Disease, Neurosciences, Rare Diseases, Neurodegenerative, Brain Disorders, Orphan Drug, Aetiology, 2.1 Biological and endogenous factors, Neurological, Animals, Autophagy, Corpus Striatum, Disease Models, Animal, Disease Progression, Huntingtin Protein, Huntington Disease, I-kappa B Kinase, Male, Mice, Mice, Knockout, Microglia, Phosphorylation, huntingtin, autophagy, Huntington's disease, neurodegeneration, I kappa B kinase, Huntington’s disease, IκB kinase

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/08v4h5j5Test

المؤلفون: Villar-Pazos, Sabrina, Thomas, Laurel, Yang, Yunhan, Chen, Kun, Lyles, Jenea B., Deitch, Bradley J., Ochaba, Joseph, Ling, Karen, Powers, Berit, Gingras, Sebastien, Kordasiewicz, Holly B., Grubisha, Melanie J., Huang, Yanhua H., Thomas, Gary

المساهمون: U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke, U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases, NORD (National Organization for Rare Disorders) PACS1 Syndrome Research Foundation

المصدر: Nature Communications ; volume 14, issue 1 ; ISSN 2041-1723

مصطلحات موضوعية: General Physics and Astronomy, General Biochemistry, Genetics and Molecular Biology, General Chemistry, Multidisciplinary

الإتاحة: https://doi.org/10.1038/s41467-023-42176-8Test
https://www.nature.com/articles/s41467-023-42176-8.pdfTest
https://www.nature.com/articles/s41467-023-42176-8Test

المؤلفون: Morozko, Eva L, Ochaba, Joseph, Hernandez, Sarah J, Lau, Alice, Sanchez, Isabella, Orellana, Iliana, Kopan, Lexi, Crapser, Joshua, Duong, Janet H, Overman, Julia, Yeung, Silvia, Steffan, Joan S, Reidling, Jack, Thompson, Leslie M

المصدر: Journal of Huntington's Disease, vol Preprint, iss Preprint

مصطلحات موضوعية: Biomedical and Clinical Sciences, Clinical Sciences, Rare Diseases, Neurosciences, Brain Disorders, Neurodegenerative, Acquired Cognitive Impairment, Huntington's Disease, Neurological, Animals, Brain, Disease Models, Animal, Electrophoresis, Agar Gel, Electrophoresis, Polyacrylamide Gel, Exons, Humans, Huntingtin Protein, Huntington Disease, Longitudinal Studies, Mice, Mice, Inbred Strains, Mice, Transgenic, Protein Aggregation, Pathological, Specimen Handling, Huntingtin, protein homeostasis, conformer, protein aggregates, aggregation, Huntington's disease, Huntington’s disease

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/06r291hwTest

المؤلفون: Wang, Bo, Zeng, Li, Merillat, Sean A, Fischer, Svetlana, Ochaba, Joseph, Thompson, Leslie M, Barmada, Sami J, Scaglione, Kenneth M, Paulson, Henry L

المصدر: Neurobiology of Disease. 109(Pt A)

مصطلحات موضوعية: Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Biological Sciences, Neurosciences, Huntington's Disease, Brain Disorders, Rare Diseases, Neurodegenerative, Aetiology, 2.1 Biological and endogenous factors, Neurological, Animals, Corpus Striatum, Disease Models, Animal, Gene Knock-In Techniques, HEK293 Cells, Humans, Huntingtin Protein, Huntington Disease, Inclusion Bodies, Male, Mice, Inbred C57BL, Mice, Knockout, Neurons, Primary Cell Culture, Ubiquitin-Conjugating Enzymes, Huntington's disease, Huntingtin, Ubiquitination, Ubiquitin-conjugating enzyme, Ube2W, Protein misfolding, Neurodegeneration, Clinical Sciences, Neurology & Neurosurgery, Biochemistry and cell biology

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/46d143pjTest

المؤلفون: Ochaba, Joseph, Morozko, Eva L, O'Rourke, Jacqueline G, Thompson, Leslie M

المصدر: Journal of Visualized Experiments. 2018(132)

مصطلحات موضوعية: Biochemistry and Cell Biology, Biological Sciences, Brain Disorders, Neurosciences, Neurodegenerative, Huntington's Disease, Rare Diseases, Aetiology, 2.1 Biological and endogenous factors, Underpinning research, 1.1 Normal biological development and functioning, Neurological, Animals, Dose Fractionation, Radiation, Humans, Huntingtin Protein, Huntington Disease, Mice, Models, Biological, Biochemistry, Issue 132, Huntington's disease, aggregation, huntingtin, protein fractionation, insoluble, proteostasis, Psychology, Cognitive Sciences, Biochemistry and cell biology

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/9rp644p1Test

المؤلفون: Reidling, Jack C, Relaño-Ginés, Aroa, Holley, Sandra M, Ochaba, Joseph, Moore, Cindy, Fury, Brian, Lau, Alice, Tran, Andrew H, Yeung, Sylvia, Salamati, Delaram, Zhu, Chunni, Hatami, Asa, Cepeda, Carlos, Barry, Joshua A, Kamdjou, Talia, King, Alvin, Coleal-Bergum, Dane, Franich, Nicholas R, LaFerla, Frank M, Steffan, Joan S, Blurton-Jones, Mathew, Meshul, Charles K, Bauer, Gerhard, Levine, Michael S, Chesselet, Marie-Francoise, Thompson, Leslie M

المصدر: Stem Cell Reports. 10(1)

مصطلحات موضوعية: Biochemistry and Cell Biology, Biological Sciences, Regenerative Medicine, Orphan Drug, Stem Cell Research, Stem Cell Research - Nonembryonic - Human, Huntington's Disease, Neurodegenerative, Brain Disorders, Transplantation, Rare Diseases, Neurosciences, 5.2 Cellular and gene therapies, Aetiology, Development of treatments and therapeutic interventions, 2.1 Biological and endogenous factors, Neurological, Animals, Cell Line, Cognition, Disease Models, Animal, Heterografts, Human Embryonic Stem Cells, Humans, Huntington Disease, Mice, Motor Activity, Neural Stem Cells, Recovery of Function, Huntington's disease, Q140 mice, R6/2 mice, embryonic stem cells, neural stem cell, transplantation, Clinical Sciences, Biochemistry and cell biology

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/5hr4z9wwTest

المؤلفون: Franich, Nicholas R, Basso, Manuela, André, Emily A, Ochaba, Joseph, Kumar, Amit, Thein, Soe, Fote, Gianna, Kachemov, Marketta, Lau, Alice L, Yeung, Sylvia Y, Osmand, Alexander, Zeitlin, Scott O, Ratan, Rajiv R, Thompson, Leslie M, Steffan, Joan S

المصدر: Journal of Huntington's Disease, vol Preprint, iss Preprint

مصطلحات موضوعية: Biomedical and Clinical Sciences, Neurosciences, Aging, Rare Diseases, Neurodegenerative, Orphan Drug, Huntington's Disease, Brain Disorders, 2.1 Biological and endogenous factors, Aetiology, Neurological, Animals, Cerebellum, Cerebral Cortex, Corpus Striatum, Disease Models, Animal, Disease Progression, Female, Gene Knock-In Techniques, Homozygote, Huntingtin Protein, Huntington Disease, Male, Mice, Inbred C57BL, Mutant Proteins, Autophagy, Huntingtin, Huntington's disease, neurodegeneration, Huntington’s disease, neurodegeneration

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/0t58t5wkTest