المؤلفون: Cioarca-Nedelcu, Ruxandra, Atanasiu, Valeriu, Stoian, Irina

المصدر: Journal of Medicine and Life

مصطلحات موضوعية: Liver Cirrhosis, O2-∙ – superoxide anion, TLR4 – toll-like receptor 4, steatohepatitis, ROS – reactive oxygen species, HSC – hepatic stellate cells, Review, JNK – Janus Kinase, H2O2 – hydrogen peroxide, PPARalpha – peroxisome proliferator-activated receptor-alpha, SREBP-1 – sterol regulatory element-binding protein 1, KC – Kupffer cells, CD14 – cluster of differentiation, CYP2E1 – cytochrome P450 2E1, A(2)C – 2-(2-methoxy ethoxy) ethyl 8-(cis-2-n-octylcyclopropyl), LPS – lipopolysaccharides, steatosis, oxidative stress, ER – endoplasmic reticulum, GSH – glutathione, MAA – malondialdehyde-acetaldehyde compounds, Humans, DNA – deoxyribonucleic acid, AMPK – adenosine monophosphate-activated protein kinase, Liver Diseases, Alcoholic, ADH – alcohol dehydrogenase, NADPH – reduced nicotinamide adenine dinucleotide phosphate, Ethanol, cirrhosis, NAD+ – nicotinamide adenine dinucleotide, ALDH2 – aldehyde dehydrogenase 2, NADH – reduced nicotinamide adenine dinucleotide, Fatty Liver, OH – hydroxyl radical, Liver, HER – hydroxyethyl radical, NADP+ – nicotinamide adenine dinucleotide phosphate, TNFalpha – tumor necrosis factor-alpha

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::0628a91d0b63c00b579082571aeb3494Test
http://europepmc.org/articles/PMC8742892Test

المؤلفون: Farah Khashab, May Al-Maghrebi, Nora Al-Kandari, Farah Al-Saleh, Fatemah Fadel

المصدر: Saudi Journal of Biological Sciences, Vol 27, Iss 8, Pp 2174-2184 (2020)
Saudi Journal of Biological Sciences

مصطلحات موضوعية: 0106 biological sciences, 0301 basic medicine, O2, molecular oxygen, PERK, pancreatic ER kinase, NADP, nicotinamide adenine dinucleotide phosphate, PCC, protein carbonyl content, DMSO, dimethyl sulfoxide, ST, seminiferous tubule, medicine.disease_cause, 01 natural sciences, ATF, activating transcription factor, eIF2α1, eukaryotic initiation factor 2α1, PVDF, polyvinylidene difluoride, chemistry.chemical_compound, DNA, deoxyribonucleic acid, PCR, polymerase chain reaction, UPR, unfolded protein response, ECL, electrochemiluminescence, TOS, testicular oxidative stress, ASK1, PARP, poly ADP-ribose polymerase, lcsh:QH301-705.5, ANOVA, analysis of variance, ATM, ataxia telangiectasia mutated, NADPH oxidase, RT, reverse transcription, biology, Chemistry, ELISA, enzyme-linked immunosorbent assay, BTB, blood-testis barrier, i.p., intraperitoneal, NOX, NADPH oxidase, JNK, c-Jun N-terminal Kinase, OS, oxidative stress, H2O2, hydrogen peroxide, IAP, inhibitors of apoptosis, p-, phosphorylated, RIPA, radioimmunoprecipitation assay, Germ cell apoptosis, General Agricultural and Biological Sciences, ER stress, kDa, kilodalton, phox, phagocyte oxidase, DNA damage, mRNA, messenger ribonucleic acid, H2AX, histone variant, IRE1, inositol requiring kinase 1, DAPI, diamidino phenylindole, CHOP, CCAAT-enhancer-binding protein homologous protein, TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labeling, Article, DDR, DNA damage response, Testicular ischemia Reperfusion Injury, ER, endoplasmic reticulum, Superoxide dismutase, Andrology, cDNA, complementary DNA, 03 medical and health sciences, ROS, reactive oxygen species, SOD, superoxide dismutase, GCA, germ cell apoptosis, medicine, IF, immunofluorescence, MDA, malondialdehyde, GRP78, glucose-related protein 78, medicine.disease, O2−, superoxide anion, Chk, checkpoint kinase, 8-OHdG, 8-hydroxy-2′-deoxyguanosine, 030104 developmental biology, lcsh:Biology (General), Oxidative stress, TRAF-2, tumor-necrosis-factor receptor-associated factor 2, SDS-PAGE, sodium dodecyl sulfate polyacrylamide gel electrophoresis, Apocynin, H&E, hematoxylin and eosin, RNA, ribonucleic acid, γ-H2AX, 139 serine-phosphorylated histone variant, Unfolded protein response, biology.protein, ASK1, apoptosis signaling kinase 1, BSA, bovine serum albumin, gDNA, genomic DNA, SD, standard deviation, Reperfusion injury, 010606 plant biology & botany

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25b9b9c3762cf95184a4b635e3a70e69Test
http://www.sciencedirect.com/science/article/pii/S1319562X20301364Test

المؤلفون: Zhonggui He, Yixin Sun, Gang Wang, Linlin Cao, Yang Wang, Qikun Jiang, Jin Sun, Dongyang Zhao

المصدر: Acta Pharmaceutica Sinica B, Vol 10, Iss 8, Pp 1382-1396 (2020)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: HIF-1α, hypoxia-inducible factor-1α, H2O, water, 3O2, molecular oxygen, medicine.medical_treatment, Photodynamic therapy, Review, MDR1, multidrug resistance 1, 0302 clinical medicine, DC, dendritic cells, polycyclic compounds, General Pharmacology, Toxicology and Pharmaceutics, Hypoxia, Cancer, 0303 health sciences, Oxygen supply, Ce6, chlorin e6, DDS, drug delivery system, CeO2, cerium oxide, HIF, hypoxia-inducible factor, PDT, photodynamic therapy, H2O2, hydrogen peroxide, 030220 oncology & carcinogenesis, APCs, antigen-presenting cells, medicine.symptom, therapeutics, PFC, perfluorocarbon, PS, photosensitizers, PFH, perfluoroethane, Tumor cells, NMR - Nuclear magnetic resonance, TAM, tumor-associated macrophages, 03 medical and health sciences, ROS, reactive oxygen species, AQ4N, banoxantrone, O2.−, superoxide anion, medicine, NMR, nuclear magnetic resonance, EPR, enhanced permeability and retention, MB, methylene blue, CaO2, calcium dioxide, 030304 developmental biology, Tumor hypoxia, OH., hydroxyl radical, business.industry, lcsh:RM1-950, Mn-CDs, magnetofluorescent manganese-carbon dots, Nanomedicine delivery systems, Hypoxia (medical), Hb - Hemoglobin, DOX, doxorubicin, eye diseases, Oxygen, FDA, U.S. Food and Drug Administration, MDSC, myeloid derived suppressive cells, lcsh:Therapeutics. Pharmacology, TPZ, tirapazamine, RBCs, red blood cells, Cancer research, MnO2, manganese dioxide, business, H2O2 - Hydrogen peroxide, HSA, human serum albumin, Hb, hemoglobin

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55dbc5e9669afc312da6e54f6cee2e96Test
https://doi.org/10.1016/j.apsb.2020.01.004Test

المؤلفون: Karol Svik, Ružena Sotníková, Barbara Kaprinay, Lukáš Slovák, Dominika Michalikova, Vladimir Knezl, Boris Lipták, Zdenka Gasparova

المصدر: Saudi Pharmaceutical Journal, Vol 27, Iss 8, Pp 1196-1202 (2019)
Saudi Pharmaceutical Journal : SPJ

مصطلحات موضوعية: 0301 basic medicine, Rutin, OGTT, oral glucose tolerance test, Atorvastatin, Pharmaceutical Science, Morris water navigation task, Pharmacology, chemistry.chemical_compound, 0302 clinical medicine, Blood serum, HTG, hypertriacylglycerolemic, HTG-HFFD-A, hypertriacylglycerolemic rat with high-fat-high-fructose diet with atorvastatin, Aorta, NOS, NO synthase, medicine.diagnostic_test, PXR, pregnane X receptor, eNOS, endothelial NO synthase, Glc, glucose, HFFD, high-fat-high-fructose diet, TG, triacylglycerols, Metabolic syndrome, IRS-1, insulin receptor substrate 1, ANOVA, one-way analysis of variance, cAMP, cyclic adenosine monophosphate, HMG-CoA, β-hydroxy β-methylglutaryl-CoA, MetS, metabolic syndrome, lipids (amino acids, peptides, and proteins), HTG-HFFD, hypertriacylglycerolemic rat with high-fat-high-fructose diet, medicine.drug, O2¯, superoxide anion, GLUT-4, glucose transporter 4, SEM, standard error of the mean, Article, 03 medical and health sciences, Spatial memory, ROS, reactive oxygen species, medicine.artery, HTG-HFFD-R, hypertriacylglycerolemic rat with high-fat-high-fructose diet with rutin, medicine, PKC, proteinkinase C, LDL-cholesterol, low density lipoprotein cholesterol, AD, Alzheimer disease, ACh, acetylcholine, business.industry, lcsh:RM1-950, nutritional and metabolic diseases, medicine.disease, MWM, Morris water maze, 030104 developmental biology, lcsh:Therapeutics. Pharmacology, Dyslipidemia, chemistry, HDL-cholesterol, high density lipoprotein cholesterol, Lipid profile, business, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c0a4581c4c56fe26a14d56f42bc91e9Test
http://www.sciencedirect.com/science/article/pii/S1319016419301318Test

المؤلفون: Kaori Harata, Hidehiko Kikuchi, Futoshi Kuribayashi, Harishkumar Madhyastha

المصدر: Biochemistry and Biophysics Reports, Vol 25, Iss, Pp 100891-(2021)
Biochemistry and Biophysics Reports

مصطلحات موضوعية: 0301 basic medicine, PMA, phorbol 12-myristate 13-acetate, Ellagic acid, Biophysics, Retinoic acid, Monoblast, ATRA, all-trans retinoic acid, U937, gp91-phox, Biochemistry, lcsh:Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Histone H3, 0302 clinical medicine, H3K9, Lys-9 residues of histone H3, Gene expression, lcsh:QD415-436, lcsh:QH301-705.5, U937 cell, Superoxide, All-trans retinoic acid, H3K14, Lys-14 residues of histone H3, O2−, superoxide anion, Urolithin, ChIP, chromatin immunoprecipitation, Urolithin A, 030104 developmental biology, chemistry, lcsh:Biology (General), 030220 oncology & carcinogenesis, Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cbc4996b9bad56399a9ba6666d74e36Test
http://www.sciencedirect.com/science/article/pii/S2405580820302016Test

المؤلفون: Swarnmala Samal, Mukesh Meena

المصدر: Toxicology Reports
Toxicology Reports, Vol 6, Iss, Pp 745-758 (2019)

مصطلحات موضوعية: HSTs, host specific toxins, Health, Toxicology and Mutagenesis, Alternariol, 010501 environmental sciences, ALT, alternuene, Toxicology, CDCs, conditionally dispensable chromosomes, 01 natural sciences, chemistry.chemical_compound, 0302 clinical medicine, GPX, guaiacol peroxidase, GSH, glutathione, GR, glutathione reductase, PCD, programmed cell death, ˙OH, hydroxyl radical, DHT, dihydrotentoxin, HR, hypersensitive response, biology, SMs, secondary metabolites, food and beverages, Plant physiology, Alternaria, AOH, alternariol, Biochemistry, H2O2, hydrogen peroxide, APX, ascorbate peroxidase, 1O2, singlet oxygen, UGT, UDP-Glucuronosyltransferases, Membrane permeability, Host-specific toxins, DHAR, dehydroascorbate reductase, TeA, tenuazonic acid, Article, 03 medical and health sciences, ROS, reactive oxygen species, lcsh:RA1190-1270, SOD, superoxide dismutase, PKS, polyketide synthase gene, otorhinolaryngologic diseases, Tenuazonic acid, Pathogenicity, O2˙ˉ, superoxide anion, Mycotoxin, lcsh:Toxicology. Poisons, 0105 earth and related environmental sciences, ComputingMethodologies_COMPUTERGRAPHICS, ATX, alterotoxin, NO, nitric oxide, Secondary metabolites, NRPS, nonribosomal peptide synthetase, Curvularin, Alternaria species, biology.organism_classification, TEN, tentoxin, MDHAR, monodehydroascorbate reductase, chemistry, Tentoxin, AME, alternariol 9-monomethyl ether, AA, ascorbic acid, CAT, catalase, nHSTs, non-host specific toxins, Non-host-specific toxins, 030217 neurology & neurosurgery, REMI, restriction enzyme-mediated integration

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::487c975b3848480f404e9814d65eba01Test
http://europepmc.org/articles/PMC6684332Test

المؤلفون: Reinaldo Marín, Flor H. Pujol, Deliana Rojas, Luis Sobrevia

المصدر: Biochimica et Biophysica Acta. Molecular Basis of Disease

مصطلحات موضوعية: TNF-α, tumour necrosis factor-alpha, Placenta, TMPRSS2, transmembrane serine protease type 2, HIF-1α, hypoxia-inducible factor 1 alpha, Ang 1–7, angiotensin 1-7, IL-8, interleukin 8, TNF, tumour necrosis factor, HIF-2α, hypoxia-inducible factor 2 alpha, AT1, angiotensin receptor 1, Pre-Eclampsia, Pregnancy, reproductive and urinary physiology, COVID-19, coronavirus disease 2019, loPE, late-onset preeclampsia, PlGF, placental growth factor, VEGF, vascular endothelial growth factor, IL-6, interleukin 6, sFlt-1, soluble fms-like tyrosine kinase-1, H2O2, hydrogen peroxide, Molecular Medicine, Female, 1O2, singlet oxygen, Human, ACE, angiotensin-converting enzyme, NADH, nicotinamide adenine dinucleotide reduced form, CTB, cytotrophoblast, ACE2, angiotensin-converting enzyme 2, SARS-CoV-2, severe acute respiratory syndrome coronavirus 2, Article, ROS, reactive oxygen species, •OH, hydroxyl radicals, SOD, superoxide dismutase, •O2−, superoxide anion, Animals, Humans, STB, syncytiotrophoblast, Molecular Biology, Ang II, angiotensin II, eoPE, early-onset preeclampsia, NF-κB, nuclear transcription factor-kappa B, SARS-CoV-2, COVID-19, RAS, renin-angiotensin system, NADPH, nicotinamide adenine dinucleotide phosphate, Preeclampsia, ONOO−, peroxynitrite, Oxidative Stress, NO•, nitric oxide, IL-10, interleukin 10, ADAM17, a disintegrin and metalloprotease 17, CAT, catalase

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f69415503fb233c3dd8f144a7755885Test
http://europepmc.org/articles/PMC8668602Test

المؤلفون: Konstantinos Filis, Fragiska Sigala, Sven Zukunft, Beate Fisslthaler, Janina Wittig, Ralf P. Brandes, Andreas Papapetropoulos, Matthias S. Leisegang, Sofia Iris Bibli, Andrea Kapasakalidi, Jiong Hu, Ingrid Fleming, Diamantis I. Tsilimigras, Georgios Zografos

المصدر: Redox Biology, Vol 28, Iss, Pp-(2020)
Redox Biology

مصطلحات موضوعية: 0301 basic medicine, (DPPP), Diphenyl-1-pyrenylphosphine, (DHE), Dihydroethidium, Clinical Biochemistry, (O2•-), Superoxide anion, Biochemistry, (IL-1β), Interleukin-1β, (ROS), Reactive oxygen species, Lipid peroxidation, Mice, chemistry.chemical_compound, 0302 clinical medicine, (KLF2), Krüppel-like factor 2, Hydrogen Sulfide, lcsh:QH301-705.5, Regulation of gene expression, chemistry.chemical_classification, (NO), Nitric oxide, lcsh:R5-920, Chemistry, (H2Sn), H2S-related sulfane sulfur compounds, Plaque, Atherosclerotic, Cell biology, Endothelial stem cell, (H2S), Hydrogen sulfide, (Prx), Peroxiredoxin, KLF2, (H2O2), Hydrogen peroxide, Phosphorylation, lcsh:Medicine (General), Oxidation-Reduction, Research Paper, Kruppel-Like Transcription Factors, 03 medical and health sciences, (CSE), Cystathionine γ lyase, (TBARS), Thiobarbituric acid reactive substances, parasitic diseases, Human Umbilical Vein Endothelial Cells, Animals, Humans, ddc:610, Transcription factor, Reactive oxygen species, (3′UTR), 3′Untranslated region, (siRNA), Small interfering RNA, Organic Chemistry, HEK 293 cells, Cystathionine gamma-Lyase, Endothelial Cells, MicroRNAs, HEK293 Cells, 030104 developmental biology, Gene Expression Regulation, lcsh:Biology (General), Lipid Peroxidation, Stress, Mechanical, (eNOS), Endothelial nitric oxide synthase, 030217 neurology & neurosurgery, (LC-MS/MS), Liquid chromatography - tandem mass spectrometry, Peroxiredoxin VI

وصف الملف: application/octet-stream

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2721769dfb88e312bc0265a9420acc7eTest
http://www.sciencedirect.com/science/article/pii/S2213231719312261Test

المؤلفون: F. Tuccillo, Joseph L. Evans, Antonella Borrelli, Franco M. Buonaguro, Ira D. Goldfine, P. Bonelli, Aldo Mancini

المصدر: Redox Biology, Vol 15, Iss C, Pp 467-479 (2018)
Redox Biology

مصطلحات موضوعية: Cirrhosis, HCC, Hepatocellular carcinoma, MnSOD, Manganese superoxide dismutase, Review Article, ecSOD, Extracellular Cu/ZnSOD, Biochemistry, Antioxidants, GIT, Gastrointestinal tract, 0302 clinical medicine, Fibrosis, MS, Metabolic syndrome, GLP-1, Glucagon-like peptide-1, LPS, Lipopolysaccharide, lcsh:QH301-705.5, Interventions, DASH, Drug-associated steatohepatitis, SSAO, Semicarbazide-sensitive amine oxidase, NKT, Natural killer T, Liver Neoplasms, NAFLD, Non-alcoholic fatty liver disease, PAMPs, Pathogen-associated molecular patterns (PAMPs), LPL, Lipoprotein lipase, PNPLA3, Patatin-like phospholipase 3, 030211 gastroenterology & hepatology, SCD1, Stearoyl-coenzyme A desaturase 1, AST, Aspartate aminotransferase, PGC-1α, Coactivator peroxisome proliferator-activated receptor-γ-1α, INT-747, Obeticholic acid (OCA), lcsh:Medicine (General), NADH, Nicotinamide adenine dinucleotide, LPB, Lipopolysaccharide-binding protein, Carcinoma, Hepatocellular, FIAF, Fasting-induced adipose factor, CS + WR, Cold storage and warm reperfusion, GF, Germ-free, FADH, Flavin adenine dinucleotide, NO, Nitric oxide, digestive system, CCR2/CCR5, C-C chemokine receptor types 2 and 5, 03 medical and health sciences, Manganese superoxide dismutase, Humans, CD14, Cluster of differentiation 14, NASH, Non-alcoholic steatohepatitis, Probiotics, nutritional and metabolic diseases, medicine.disease, VLX103, Venlafaxine-103, digestive system diseases, PIVENS, Pioglitazone versus Vitamin E versus Placebo, 030104 developmental biology, chemistry, PASH, PNPLA3-associated steatohepatitis, FXR, Farnesoid X receptor, CASH, Chemotherapy-associated steatohepatitis, LOXL, Lysyl oxidase and lysyl oxidase-like, Steatohepatitis, Reactive Oxygen Species, Mkt, Market, ROS, Reactive oxygen species, TZDs, Thiazolidinediones, 0301 basic medicine, ETC, Respiratory electron transport chain, Clinical Biochemistry, VAP-1, Vascular adhesion protein-1, PXS-4728A, SSAO/VAP-1 inhibitor BI 1467335, HVPG, Hepatic venous pressure gradient, •OH, Hydroxyl free radicals, HPC, Primary hepatic carcinoma, Chronic liver disease, SOD, Superoxide dismutase, FGF21, Fibroblast growth factor 21, aa, Amino acid, chemistry.chemical_compound, BASH, Both alcoholic and non-alcoholic liver disease, Non-alcoholic Fatty Liver Disease, H2, Molecular hydrogen, lcsh:R5-920, NAS, NAFLD activity score, medicine.diagnostic_test, NN2211, Liraglutide, O2, Molecular oxygen, Fatty liver, Elafibranor, Obeticholic acid, Drugs, ER, Estrogen receptor, IL-10, Interleukin-10, Liver, Liver biopsy, JNK, c-Jun N-terminal kinase, ASK1, Apoptosis signal- regulating kinase 1, Cu/ZnSOD, Copper/zinc superoxide dismutase, RG-125 AZD4076, N-acetylgalactosamine (GalNAc)-conjugated anti-miR-103/107 oligonucleotide, TLR, Toll-like receptor, H. pilory, Helicobacter pylori, HSCs, Hepatic stellate cells, PPAR, Peroxisome proliferator-activated receptor, medicine, ATP, Adenosine 5c-triphosphate, IL-6, Interleukin-6, MDA, Malondialdehyde, γgt, Gamma-glutamyl transferase, business.industry, Organic Chemistry, ALT, Alanine aminotransferase, TNF, Tumor necrosis factor, NF-κB, Nuclear factor kappa, O2·–, Superoxide anion, FGF19, Fibroblast growth factor 19, Gastrointestinal Microbiome, DPP-4 inhibitor, Dipeptidyl peptidase 4 inhibitor, FDA, Food and drug administration, Oxidative Stress, CVC, Cenicriviroc, lcsh:Biology (General), FFA, Free fatty acids, Cancer research, NAP, H. pylori-induced neutrophil-activating protein, Saroglitazar-ZYH1, [(S)-α-ethoxy-4-{2-[2-methyl-5-(4-methylthio) phenyl)]-1H-pyrrol-1-yl]-ethoxy})-benzenepropanoic acid magnesium salt], business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2419fc2467afc0fef89a4f91dd16f4cTest
http://www.sciencedirect.com/science/article/pii/S2213231717309291Test

المؤلفون: Xiong Li, Boqun Li, Yongping Yang, Xiaoming Zhang, Yuansheng Wu

المصدر: Plant Diversity
Plant Diversity, Vol 40, Iss 1, Pp 19-27 (2018)

مصطلحات موضوعية: 0106 biological sciences, Antioxidant, medicine.medical_treatment, Plant Science, Vacuole, FW, fresh weight, 010501 environmental sciences, 01 natural sciences, GST, glutathione S-transferase, DW, dry weight, Cd, cadmium, PCs, phytochelatins, lcsh:Botany, GSH, glutathione, GR, glutathione reductase, Osmotic pressure, lcsh:QH301-705.5, Antioxidant system, chemistry.chemical_classification, HM, heavy metal, Cadmium, food and beverages, Phytochelatin, Zn, zinc, lcsh:QK1-989, Amino acid, Biochemistry, POD, peroxidase, APX, ascorbate peroxidase, H2O2, hydrogen peroxide, Detoxification, O2-, superoxide anion, chemistry.chemical_element, DHAR, dehydroascorbate reductase, TCA, trichloroacetic acid, Article, ROS, reactive oxygen species, SOD, superoxide dismutase, medicine, Turnip, Hyperaccumulator, Ecology, Evolution, Behavior and Systematics, 0105 earth and related environmental sciences, MDA, malondialdehyde, Reactive oxygen species, lcsh:Biology (General), chemistry, Ni, nickel, AsA, ascorbic acid, CAT, catalase, 010606 plant biology & botany

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d10b3b44efc4772302ac003bec9fed71Test
https://doi.org/10.1016/j.pld.2017.12.005Test