التفاصيل البيبلوغرافية
العنوان:
Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features
المؤلفون:
Dustin J. Flanagan , Raheleh Amirkhah , David F. Vincent , Nuray Gundaz , Pauline Gentaz , Patrizia Cammareri , Aoife J. McCooey , Amy M. B. McCorry , Natalie C. Fisher , Hayley L. Davis , Rachel A. Ridgway , Jeroen Lohuis , Joshua D. G. Leach , Rene Jackstadt , Kathryn Gilroy , Elisa Mariella , Colin Nixon , William Clark , Ann Hedley , Elke K. Markert , Douglas Strathdee , Laurent Bartholin , Keara L. Redmond , Emma M. Kerr , Daniel B. Longley , Fiona Ginty , Sanghee Cho , Helen G. Coleman , Maurice B. Loughrey , Alberto Bardelli , Timothy S. Maughan , Andrew D. Campbell , Mark Lawler , Simon J. Leedham , Simon T. Barry , Gareth J. Inman , Jacco van Rheenen , Philip D. Dunne , Owen J. Sansom
المصدر:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
بيانات النشر:
Nature Portfolio, 2022.
سنة النشر:
2022
المجموعة:
LCC:Science
مصطلحات موضوعية:
Science
الوصف:
It remains critical to identify colorectal cancers (CRC) that will disseminate as early as possible. Here, the authors identify CRC tumours that are aggressive and prone to early dissemination, characterised by epithelial TGFβ and growth-factor signalling - which could be targeted with MEK/EGFR inhibitors.
نوع الوثيقة:
article
وصف الملف:
electronic resource
اللغة:
English
تدمد:
2041-1723
العلاقة:
https://doaj.org/toc/2041-1723Test
DOI:
10.1038/s41467-022-35134-3
الوصول الحر:
https://doaj.org/article/685f337608c24440b7e084866104173aTest
رقم الانضمام:
edsdoj.685f337608c24440b7e084866104173a
قاعدة البيانات:
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