المؤلفون: Gastaldi, Giacomo Gianni Giuseppe, Rocha Gomes, Diana Bianca, Schneiter, Philippe, Montet, Xavier Cédric Rodolphe, Tappy, Luc, Clement, Sophie, Negro, Francesco

المصدر: ISSN: 1932-6203 ; PLOS ONE, vol. 14, no. 6 (2019) e0217751.

مصطلحات موضوعية: info:eu-repo/classification/ddc/616, info:eu-repo/classification/ddc/616.07, info:eu-repo/classification/ddc/616.0757, Adenine Nucleotides/pharmacology, Animals, Biological Transport/drug effects, Cyclic AMP/metabolism, Cyclooxygenase Inhibitors, Lymphocyte Activation, Lymphocytes/immunology/metabolism, Phytohemagglutinins/pharmacology, Prostaglandins E/metabolism, Swine, Uridine/metabolism

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/31170218; https://archive-ouverte.unige.ch/unige:123540Test; unige:123540

الإتاحة: https://doi.org/10.1371/journal.pone.0217751Test
https://archive-ouverte.unige.ch/unige:123540Test

المؤلفون: Tabrizi, Sarah J, Leavitt, Blair R, Rosser, Anne, Kordasiewicz, Holly B, Czech, Christian, Swayze, Eric E, Norris, Daniel A, Baumann, Tiffany, Gerlach, Irene, Schobel, Scott A, Paz, Erika, Smith, Anne V, Landwehrmeyer, G Bernhard, Bennett, C Frank, Lane, Roger M, Teams, Phase 1–2a IONIS-HTTRx Study Site, McColgan, Peter, Hensman, Davina, Ghosh, Rhia, Flower, Michael, Libri, Vincenzo, Saunders, Edwina, Raymond, Lynn, Wild, Edward J, Decolongon, Joji, Li, Tuan, Fathinia, Panteha, Lang, Christina, Lewerenz, Jan, Lindenberg, Katrin, Ludolph, Albert C, Schneider, Ariane, Trautmann, Sonja, Uhl, Stefanie, Saft, Carsten, Weydt, Patrick, Kaminski, Barbara, Kaminski, Daniela, Hoffmann, Rainer, von Hein, Sarah M, Muhlack, Siegfried, Gold, Ralf, Collins, Lucy, Mason, Sarah, Scott, Kirsten, Barker, Roger A, Stoker, Tom, Greenland, Julia, Andresen, Katie, Shanmugam, Mohan, Abdelghani, Mowafak, Turgut, Tolga, Peeren, Siofra, Colaco, Olga, Owens, Rebecca, Subin, Sujamole, Blair, Nick F, Spruth, Eike Jakob, Beckmann, Janna, Krug, Henriette, Langenfurth, Anika, Crossley, Diana, Akhtar, Nasreen, Gavin, Jennie, De Souza, Jenny, Massey, Thomas, McLauchlan, Duncan, Craufurd, David, Cousins, Rebecca, Shastin, Dmitri, Peall, Kathryn, Bhatt, Harsh, Davison, Andrew, Bagshawe, Joanne, Gunning, Belinda, Hamandi, Khalid, Priller, Josef, Rickards, Hugh

المصدر: The New England journal of medicine 380(24), 2307-2316 (2019). doi:10.1056/NEJMoa1900907

مصطلحات موضوعية: info:eu-repo/classification/ddc/610, Adult, Dose-Response Relationship, Drug, Female, Humans, Huntingtin Protein: antagonists & inhibitors, Huntingtin Protein: cerebrospinal fluid, Huntingtin Protein: genetics, Huntington Disease: drug therapy, Injections, Spinal, Male, Middle Aged, Mutation, Nucleotides: chemical synthesis, Nucleotides: pharmacology, Oligonucleotides: cerebrospinal fluid, Oligonucleotides: therapeutic use, HTT protein, human, HTT(RX), Huntingtin Protein, Nucleotides, Oligonucleotides

جغرافية الموضوع: DE

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/pmid:31059641; info:eu-repo/semantics/altIdentifier/issn/0028-4793; info:eu-repo/semantics/altIdentifier/issn/1533-4406; https://pub.dzne.de/record/140752Test; https://pub.dzne.de/search?p=id:%22DZNE-2020-07074%22Test

الإتاحة: https://doi.org/10.1056/NEJMoa1900907Test
https://pub.dzne.de/record/140752Test
https://pub.dzne.de/search?p=id:%22DZNE-2020-07074%22Test

المؤلفون: Xavier Montet, Diana Gomes, Luc Tappy, Giacomo Gastaldi, Francesco Negro, Sophie Clément, Philippe Schneiter

المصدر: PLOS ONE, Vol. 14, No 6 (2019) P. e0217751
PLoS ONE, Vol 14, Iss 6, p e0217751 (2019)
PloS one, vol. 14, no. 6, pp. e0217751
PLoS ONE

مصطلحات موضوعية: Male, Chronic Hepatitis, Swine, medicine.medical_treatment, Hepacivirus, Pharmacology, ddc:616.07, Lymphocyte Activation, Biochemistry, Chronic Liver Disease, Endocrinology, 0302 clinical medicine, Lymphocytes/immunology/metabolism, Insulin, Uridine/metabolism, ddc:616, Organic Compounds, Liver Diseases, Phytohemagglutinins/pharmacology, Type 2 Diabetes, Adipose Tissue, Physical Sciences, Cytokines, Medicine, 030211 gastroenterology & hepatology, Adenine Nucleotides/pharmacology, Endocrine Disorders, Science, Carbohydrates, Gastroenterology and Hepatology, Antiviral Agents, Microbiology, 03 medical and health sciences, Thinness, Diabetes Mellitus, Humans, Cyclooxygenase Inhibitors, Flaviviruses, Biological Transport/drug effects, Organisms, Chemical Compounds, Biology and Life Sciences, medicine.disease, Hormones, Glucose, Biological Tissue, 030104 developmental biology, chemistry, RNA viruses, 0301 basic medicine, Sofosbuvir, Adipose tissue, Type 2 diabetes, medicine.disease_cause, chemistry.chemical_compound, Glucose Metabolism, Medicine and Health Sciences, Cyclic AMP/metabolism, Adult, Antiviral Agents/therapeutic use, Cytokines/blood, Diabetes Mellitus/pathology, Female, Glucose/metabolism, Hepatitis C, Chronic/blood, Hepatitis C, Chronic/drug therapy, Insulin Resistance, Middle Aged, Thinness/complications, Young Adult, Pathology and laboratory medicine, Multidisciplinary, Hepatitis C virus, Antimicrobials, Monosaccharides, Drugs, Medical microbiology, Antivirals, Chemistry, Viruses, Carbohydrate Metabolism, Pathogens, Anatomy, Prostaglandins E/metabolism, Research Article, medicine.drug, Ledipasvir, ddc:616.0757, Insulin resistance, Microbial Control, Virology, medicine, Animals, Diabetic Endocrinology, business.industry, Ribavirin, Organic Chemistry, Viral pathogens, Hepatitis C, Chronic, Hepatitis viruses, Microbial pathogens, Metabolism, Metabolic Disorders, business

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a407c62b8f3a34827e4bf95b5c3edf0bTest
https://archive-ouverte.unige.ch/unige:123540Test

المؤلفون: Kuhlmann, F.M., Robinson, J.I., Bluemling, G.R., Ronet, C., Fasel, N., Beverley, S.M.

المصدر: Proceedings of the National Academy of Sciences of the United States of America, vol. 114, no. 5, pp. E811-E819

مصطلحات موضوعية: Animals, Antiviral Agents/pharmacology, Capsid Proteins/genetics, Capsid Proteins/metabolism, Leishmania braziliensis/virology, Leishmania guyanensis/virology, Leishmaniasis/parasitology, Leishmaniavirus/drug effects, Leishmaniavirus/genetics, Leishmaniavirus/metabolism, Mice, Inbred C57BL, Nucleosides/pharmacology, Nucleotides/pharmacology, chemotherapy, endobiont virus, trypanosomatid protozoan parasite, viral segregation, virulence

وصف الملف: application/pdf

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/28096399; info:eu-repo/semantics/altIdentifier/eissn/1091-6490; info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_9466129FAB720; https://serval.unil.ch/notice/serval:BIB_9466129FAB72Test; urn:issn:0027-8424; https://serval.unil.ch/resource/serval:BIB_9466129FAB72.P001/REF.pdfTest; http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_9466129FAB720Test

الإتاحة: https://doi.org/10.1073/pnas.1619114114Test
https://serval.unil.ch/notice/serval:BIB_9466129FAB72Test
https://serval.unil.ch/resource/serval:BIB_9466129FAB72.P001/REF.pdfTest
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_9466129FAB720Test

المؤلفون: Chabes, Andrei, Stillman, Bruce

المصدر: Proceedings of the National Academy of Sciences of the United States of America. 104(4):1183-8

مصطلحات موضوعية: Alleles, Cell Cycle/*drug effects, Chromatin/metabolism, DNA Damage, DNA, Fungal/drug effects, Nucleotides/*pharmacology, Promoter Regions (Genetics), Saccharomyces cerevisiae/*cytology/genetics

وصف الملف: print

الوصول الحر: https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-6636Test
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=17227840&dopt=CitationTest

المؤلفون: Pradeepkumar, Pushpangadan I, Amirkhanov, Nariman V, Chattopadhyaya, Jyoti

المصدر: Org Biomol Chem. 1(1):81-92

مصطلحات موضوعية: Base Sequence, Cytidine/*chemistry, Deoxyribonuclease I/chemistry, Dose-Response Relationship, Drug, Electrophoresis, Polyacrylamide Gel, Endonucleases/*pharmacology, Ethers, Cyclic/*chemistry, Exonucleases/chemistry/*pharmacology, Humans, Kinetics, Models, Chemical, Molecular Sequence Data, Nucleic Acid Conformation, Nucleotides/pharmacology, Oligonucleotides, Antisense/*pharmacology, Protein Binding, RNA/chemistry, Research Support, Non-U.S. Gov't, Ribonuclease H, Calf Thymus/*chemistry, Temperature

وصف الملف: print

الوصول الحر: https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-73474Test
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=12929393&dopt=CitationTest

المؤلفون: Amiable, Claire, Paoletti, Julie, Haouz, Ahmed, Padilla, André, Labesse, Gilles, Kaminski, Pierre-Alexandre, Pochet, Sylvie

المساهمون: Université Paris Descartes - Paris 5 (UPD5), Chimie et Biocatalyse, Institut Pasteur Paris (IP)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS), Cristallographie (Plateforme) - Crystallography (Platform), Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS), Centre de Biochimie Structurale Montpellier (CBS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), This work was supported by grants from the Fondation pour la Recherche Médicale (DCM20111223063 to S. Pochet), Institut Pasteur, CNRS, INSERM and the French Infrastructure for Integrated Structural Biology (FRISBI, ANR-10-INSB-05-01)., ANR-10-INBS-0005,FRISBI,Infrastructure Française pour la Biologie Structurale Intégrée(2010)

المصدر: ISSN: 0223-5234.

مصطلحات موضوعية: Cancer, Cross-coupling reaction, Crystal structure, DNPH1, Inhibitor, Nucleoside analogues, MESH: Animals, MESH: Antineoplastic Agents/chemical synthesis, MESH: Enzyme Inhibitors/chemistry, MESH: Enzyme Inhibitors/metabolism, MESH: Enzyme Inhibitors/pharmacology, MESH: Humans, MESH: Molecular Docking Simulation, MESH: Molecular Targeted Therapy, MESH: N-Glycosyl Hydrolases/antagonists & inhibitors, MESH: N-Glycosyl Hydrolases/chemistry, MESH: N-Glycosyl Hydrolases/metabolism, MESH: Nuclear Proteins/antagonists & inhibitors, MESH: Antineoplastic Agents/chemistry, MESH: Nuclear Proteins/chemistry, MESH: Nuclear Proteins/metabolism, MESH: Protein Conformation, MESH: Proto-Oncogene Proteins/antagonists & inhibitors, MESH: Proto-Oncogene Proteins/chemistry, MESH: Proto-Oncogene Proteins/metabolism, MESH: Purine Nucleotides/chemical synthesis, MESH: Purine Nucleotides/chemistry, MESH: Purine Nucleotides/metabolism, MESH: Purine Nucleotides/pharmacology, MESH: Antineoplastic Agents/metabolism

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/25108359; pasteur-01483767; https://pasteur.hal.science/pasteur-01483767Test; PUBMED: 25108359

الإتاحة: https://doi.org/10.1016/j.ejmech.2014.07.110Test
https://pasteur.hal.science/pasteur-01483767Test

المؤلفون: Choy, EHY, Pang, SF, Poon, AMS

مصطلحات موضوعية: Adenine Nucleotides - Pharmacology, Animals, Binding, Competitive, Blood Glucose - Metabolism, Deoxyglucose - Pharmacology, Guanine Nucleotides - Pharmacology, Hepatocytes - Drug Effects - Metabolism, Hyperglycemia - Metabolism, Hypoglycemia - Metabolism, Insulin - Pharmacology, Kinetics, Melatonin - Analogs & Derivatives - Metabolism - Pharmacology, Mice, Receptors, Cell Surface - Classification - Drug Effects - Metabolism, Cytoplasmic And Nuclear - Classification - Drug Effects - Metabolism, Melatonin

العلاقة: Biological Signals and Receptors; http://www.scopus.com/mlt/select.url?eid=2-s2.0-0035200294&selection=ref&src=s&origin=recordpageTest; Biological Signals And Receptors, 2001, v. 10 n. 6, p. 367-379; 379; WOS:000172784600003; eid_2-s2.0-0035200294; 367; http://hdl.handle.net/10722/171696Test; 10

الإتاحة: http://hdl.handle.net/10722/171696Test

المؤلفون: Bar, Isabelle, Guns, Pieter-Jan D F, Metallo, Jessica, Cammarata, Dorothée, Wilkin, Françoise, Boeynaems, Jean-Marie, Bult, Hidde, Robaye, Bernard

المصدر: Molecular pharmacology, 74 (3

مصطلحات موضوعية: Sciences bio-médicales et agricoles, Animals, Aorta -- drug effects, Aorta -- metabolism, Cytokines -- biosynthesis, Endothelial Cells -- drug effects, Endothelial Cells -- metabolism, Extracellular Signal-Regulated MAP Kinases -- metabolism, Gene Deletion, Gene Expression Regulation -- drug effects, Inositol Phosphates -- biosynthesis, Lipopolysaccharides -- pharmacology, MAP Kinase Signaling System -- drug effects, Macrophages, Peritoneal -- drug effects, Peritoneal -- enzymology, Peritoneal -- metabolism, Mice, Knockout, Muscle Contraction -- drug effects, Muscle Relaxation -- drug effects, Muscle, Smooth, Vascular -- cytology, Myocytes, Smooth Muscle -- drug effects, Smooth Muscle -- metabolism, Nucleotides -- pharmacology, Phenylephrine -- pharmacology, RNA

وصف الملف: No full-text files

العلاقة: uri/info:doi/10.1124/mol.108.046904; uri/info:pii/mol.108.046904; uri/info:pmid/18523137; uri/info:scp/50449096581; http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/50313Test

الإتاحة: http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/50313Test

المؤلفون: Ben Addi, Abduelhakem, Lefort, Anne, Hua, Xiaoyang, Libert, Frédérick, Communi, Didier, Ledent, Catherine, Macours, Pascale, Tilley, Stephen L, Boeynaems, Jean-Marie, Robaye, Bernard

المصدر: European Journal of Immunology, 38 (6

مصطلحات موضوعية: Sciences bio-médicales et agricoles, Acetamides -- pharmacology, Adenine Nucleotides -- pharmacology, Adenosine -- pharmacology, Adenosine-5'-(N-ethylcarboxamide) -- pharmacology, Animals, Antigens, Surface -- metabolism, Arginase -- genetics, Arginase -- metabolism, Cyclic AMP -- metabolism, Cytokines -- metabolism, Dendritic Cells -- drug effects, Dendritic Cells -- metabolism, Gene Expression -- drug effects, Gene Expression Profiling, Interleukin-12 -- metabolism, Lipopolysaccharides -- pharmacology, Mice, Inbred C57BL, Knockout, Nitrites -- metabolism, Purines -- pharmacology, Receptor, Adenosine A2A -- agonists, Adenosine A2A -- antagonists & inhibitors, Adenosine A2A -- genetics, Adenosine A2B -- genetics, Adenosine A2B -- physiology, Receptors

وصف الملف: 1 full-text file(s): application/pdf

العلاقة: uri/info:doi/10.1002/eji.200737781; uri/info:pmid/18465770; uri/info:scp/49649091999; https://dipot.ulb.ac.be/dspace/bitstream/2013/50312/3/50312.pdfTest; http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/50312Test

الإتاحة: http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/50312Test
https://dipot.ulb.ac.be/dspace/bitstream/2013/50312/3/50312.pdfTest