دورية أكاديمية
Modulation of hormonal signaling in the brain by steroid receptor coactivators.
| العنوان: | Modulation of hormonal signaling in the brain by steroid receptor coactivators. |
|---|---|
| المؤلفون: | Charlier, Thierry, Balthazart, Jacques |
| المصدر: | Reviews in the Neurosciences, 16 (4), 339-57 (2005) |
| بيانات النشر: | Freund Publishing House Ltd |
| سنة النشر: | 2005 |
| المجموعة: | University of Liège: ORBi (Open Repository and Bibliography) |
| مصطلحات موضوعية: | Animals, Gene Expression Regulation, Histone Acetyltransferases, Nuclear Receptor Coactivator 2/genetics/metabolism, Preoptic Area/cytology/metabolism, Receptors, Steroid/genetics/metabolism, Sexual Behavior, Animal/physiology, Signal Transduction/physiology, Steroids/metabolism, Trans-Activators/genetics/metabolism, Transcription Factors/genetics/metabolism, Social & behavioral sciences, psychology, Neurosciences & behavior, Sciences sociales & comportementales, psychologie, Neurosciences & comportement |
| الوصف: | peer reviewed ; Nuclear receptors, such as estrogen, glucocorticoid or thyroid hormone receptors, have been shown to play a critical role in brain development and physiology. The activity of these receptors is modulated by the interaction with several proteins and, in particular, coactivators are required to enhance their transcriptional activity. The steroid receptor coactivators (SRC-1, -2 and -3) are currently the best characterized coactivators and we review here the current knowledge on the distribution and function of these proteins in the brain. Knock-out models and antisense techniques have demonstrated the requirement for SRC-1 and -2 in the brain, focusing mainly on steroid and thyroid hormone-dependent development and behavior. The precise function of SRC-3 in the brain is currently unknown but its presence throughout the brain suggests an important function. Although the molecular biology of SRCs is relatively well known, the in vivo control of their expression, post-translational modifications and time- and cell-specific interactions with the different nuclear receptors remain elusive. A complete understanding of hormone action on brain and behavior will not be attained until a better knowledge of coactivator physiology is achieved. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0334-1763 2191-0200 |
| العلاقة: | urn:issn:0334-1763; urn:issn:2191-0200; https://orbi.uliege.be/handle/2268/13898Test; info:hdl:2268/13898; scopus-id:2-s2.0-31844456915; info:pmid:16519010 |
| DOI: | 10.1515/REVNEURO.2005.16.4.339 |
| الإتاحة: | https://doi.org/10.1515/REVNEURO.2005.16.4.339Test https://orbi.uliege.be/handle/2268/13898Test |
| حقوق: | restricted access ; http://purl.org/coar/access_right/c_16ecTest ; info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.76816B6B |
| قاعدة البيانات: | BASE |
| تدمد: | 03341763 21910200 |
|---|---|
| DOI: | 10.1515/REVNEURO.2005.16.4.339 |