المؤلفون: Sunshine, Sara, Puschnik, Andreas, Replogle, Joseph, Laurie, Matthew, Liu, Jamin, Zha, Beth, Nuñez, James, Byrum, Janie, McMorrow, Aidan, Frieman, Matthew, Winkler, Juliane, Qiu, Xiaojie, Rosenberg, Oren, Leonetti, Manuel, Weissman, Jonathan, DeRisi, Joseph, Hein, Marco, Ye, Chun

المصدر: Nature Communications. 14(1)

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/4f4875ddTest

المؤلفون: Samelson, Avi J, Tran, Quang Dinh, Robinot, Rémy, Carrau, Lucia, Rezelj, Veronica V, Kain, Alice Mac, Chen, Merissa, Ramadoss, Gokul N, Guo, Xiaoyan, Lim, Shion A, Lui, Irene, Nuñez, James K, Rockwood, Sarah J, Wang, Jianhui, Liu, Na, Carlson-Stevermer, Jared, Oki, Jennifer, Maures, Travis, Holden, Kevin, Weissman, Jonathan S, Wells, James A, Conklin, Bruce R, TenOever, Benjamin R, Chakrabarti, Lisa A, Vignuzzi, Marco, Tian, Ruilin, Kampmann, Martin

المصدر: Nature Cell Biology. 24(1)

مصطلحات موضوعية: Biochemistry and Cell Biology, Biological Sciences, Pneumonia, Emerging Infectious Diseases, Cancer, Biodefense, Vaccine Related, Infectious Diseases, Prevention, Lung, 2.1 Biological and endogenous factors, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, Aetiology, Infection, Good Health and Well Being, Angiotensin-Converting Enzyme 2, Antiviral Agents, COVID-19, Cell Line, Epithelial Cells, Humans, Membrane Glycoproteins, SARS-CoV-2, Transcription Factors, COVID-19 Drug Treatment, Medical and Health Sciences, Developmental Biology, Biochemistry and cell biology

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/9m5387j8Test

المؤلفون: Nuñez, James K, Chen, Jin, Pommier, Greg C, Cogan, J Zachery, Replogle, Joseph M, Adriaens, Carmen, Ramadoss, Gokul N, Shi, Quanming, Hung, King L, Samelson, Avi J, Pogson, Angela N, Kim, James YS, Chung, Amanda, Leonetti, Manuel D, Chang, Howard Y, Kampmann, Martin, Bernstein, Bradley E, Hovestadt, Volker, Gilbert, Luke A, Weissman, Jonathan S

المصدر: Cell. 184(9)

مصطلحات موضوعية: Biological Sciences, Genetics, Human Genome, Biotechnology, Stem Cell Research, Underpinning research, 1.1 Normal biological development and functioning, Generic health relevance, CRISPR-Cas Systems, Cell Differentiation, Cellular Reprogramming, CpG Islands, DNA Methylation, Epigenesis, Genetic, Epigenome, Gene Editing, Gene Silencing, Histone Code, Humans, Induced Pluripotent Stem Cells, Neurons, Protein Processing, Post-Translational, CRISPR, DNA methylation, cell therapy, dCas9, epigenetics, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/4ph8w0v1Test
https://escholarship.org/content/qt4ph8w0v1/qt4ph8w0v1.pdfTest

المؤلفون: Chen, Jin, Brunner, Andreas-David, Cogan, J Zachery, Nuñez, James K, Fields, Alexander P, Adamson, Britt, Itzhak, Daniel N, Li, Jason Y, Mann, Matthias, Leonetti, Manuel D, Weissman, Jonathan S

المصدر: Science. 367(6482)

مصطلحات موضوعية: Biochemistry and Cell Biology, Biological Sciences, Genetics, Prevention, Biodefense, Vaccine Related, Human Genome, Biotechnology, 1.1 Normal biological development and functioning, Underpinning research, Generic health relevance, CRISPR-Cas Systems, Humans, Open Reading Frames, Operon, Peptides, Protein Biosynthesis, RNA, Messenger, Ribosomes, Transcriptome, General Science & Technology

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/96m1n5z5Test

المؤلفون: Baskin, David, Buehler, Jim, Carter, Deirdre, Connelly, Brandon, Cummings, John, Davies, Evelyn, Elliott, John, Etherington, Kelley, Fulton, Brie, Jelinski, John, Kievit, Kenneth, Larson, Jennifer, Malvania, Kushal, Mulholland, Brendan, Nunez, James, Palladino, Carl, Philliber, Jeff, Robertson, Samantha, Saadeh, Joseph, Salvini, Karen, Santos, Bernadette, Sossikian, Leana, Tanouye, Patricia, Xu, Suying

وصف الملف: application/pdf

العلاقة: qt9pv896tj; https://escholarship.org/uc/item/9pv896tjTest

الإتاحة: https://escholarship.org/uc/item/9pv896tjTest

المؤلفون: Adamson, Britt, Norman, Thomas M, Jost, Marco, Cho, Min Y, Nuñez, James K, Chen, Yuwen, Villalta, Jacqueline E, Gilbert, Luke A, Horlbeck, Max A, Hein, Marco Y, Pak, Ryan A, Gray, Andrew N, Gross, Carol A, Dixit, Atray, Parnas, Oren, Regev, Aviv, Weissman, Jonathan S

المصدر: Cell. 167(7)

مصطلحات موضوعية: Biochemistry and Cell Biology, Bioinformatics and Computational Biology, Genetics, Biological Sciences, Human Genome, Vaccine Related, Biotechnology, Underpinning research, 2.1 Biological and endogenous factors, 1.1 Normal biological development and functioning, Aetiology, Animals, Clustered Regularly Interspaced Short Palindromic Repeats, Endoribonucleases, Feedback, Humans, Models, Molecular, Protein Serine-Threonine Kinases, RNA, Guide, Kinetoplastida, Sequence Analysis, RNA, Single-Cell Analysis, Transcription, Genetic, Unfolded Protein Response, CRIPSRi, CRISPR, Single-cell RNA-seq, cell-to-cell heterogeneity, genome-scale screening, single-cell genomics, unfolded protein response, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/9961h6m4Test

المؤلفون: Samelson, Avi, J, Tran, Quang Dinh, Robinot, Rémy, Carrau, Lucia, Rezelj, Veronica, V, Kain, Alice Mac, Chen, Merissa, Ramadoss, Gokul, N, Guo, Xiaoyan, Lim, Shion, A, Lui, Irene, Nuñez, James, K, Rockwood, Sarah, J, Wang, Jianhui, Liu, Na, Carlson-Stevermer, Jared, Oki, Jennifer, Maures, Travis, Holden, Kevin, Weissman, Jonathan, S, Wells, James, A, Conklin, Bruce, R, Tenoever, Benjamin, R, Chakrabarti, Lisa, A, Vignuzzi, Marco, Tian, Ruilin, Kampmann, Martin

المساهمون: University of California San Francisco (UC San Francisco), University of California (UC), Chan Zuckerberg BioHub San Francisco, CA, Populations virales et Pathogenèse - Viral Populations and Pathogenesis, Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), École Doctorale Bio Sorbonne Paris Cité Paris (ED562 - BioSPC), Université Sorbonne Paris Cité (USPC)-Université Paris Cité (UPCité), Virus et Immunité - Virus and immunity (CNRS-UMR3569), NYU Langone Health New York, Gladstone Institutes San Francisco, Genentech, Inc., Genentech, Inc. San Francisco, Howard Hughes Medical Institute (HHMI), Southern University of Science and Technology (SUSTech), Synthego Redwood City, CA, Whitehead Institute, Massachusetts Institute of Technology (MIT), A.J.S. is supported by NIH grant F32AG063487. G.N.R. is supported by the NSF Graduate Research Fellowship Program (GRFP) and UCSF Discovery Fellowship. S.A.L. was a Merck Fellow of the Helen Hay Whitney Foundation. I.L. was supported by an NSF GRFP award. M.K. is a Chan Zuckerberg Biohub Investigator., We thank members of the Kampmann, Vignuzzi and Conklin laboratories, as well as V. Ramani, D. Ruggero, M. Ott and her laboratory and other members of the UCSF QBI Coronavirus Research Group (QCRG) for helpful discussions. We thank K. Leng for feedback on the manuscript. We acknowledge the Gladstone Stem Cell Core for help with cardiomyocyte production.

المصدر: ISSN: 1465-7392.

مصطلحات موضوعية: [SDV]Life Sciences [q-bio]

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/35027731; pasteur-04133563; https://pasteur.hal.science/pasteur-04133563Test; https://pasteur.hal.science/pasteur-04133563/documentTest; https://pasteur.hal.science/pasteur-04133563/file/samelson_kampmann_nihms-1759623.pdfTest; PUBMED: 35027731; PUBMEDCENTRAL: PMC8820466

الإتاحة: https://doi.org/10.1038/s41556-021-00821-8Test
https://pasteur.hal.science/pasteur-04133563Test
https://pasteur.hal.science/pasteur-04133563/documentTest
https://pasteur.hal.science/pasteur-04133563/file/samelson_kampmann_nihms-1759623.pdfTest

المؤلفون: Nuñez, James K, Chen, Jin, Pommier, Greg C, Cogan, J Zachery, Replogle, Joseph M, Adriaens, Carmen, Ramadoss, Gokul N, Shi, Quanming, Hung, King L, Samelson, Avi J, Pogson, Angela N, Kim, James YS, Chung, Amanda, Leonetti, Manuel D, Chang, Howard Y, Kampmann, Martin, Bernstein, Bradley E, Hovestadt, Volker, Gilbert, Luke A, Weissman, Jonathan S

المساهمون: Whitehead Institute for Biomedical Research

المصدر: PMC

وصف الملف: application/octet-stream

العلاقة: http://dx.doi.org/10.1016/J.CELL.2021.03.025Test; Cell; https://hdl.handle.net/1721.1/142534.2Test; Nuñez, James K, Chen, Jin, Pommier, Greg C, Cogan, J Zachery, Replogle, Joseph M et al. 2021. "Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing." Cell, 184 (9).

الإتاحة: https://doi.org/10.1016/J.CELL.2021.03.025Test
https://hdl.handle.net/1721.1/142534.2Test

المؤلفون: Baskin, David, Buehler, Jim, Carter, Deirdre, Connelly, Brandon, Cummings, John, Davies, Evelyn, Elliot, John, Etherington, Kelley, Fulton, Brie, Jelinski, John, Kievit, Ken, Larson, Jennifer, Mulholland, Brendan, Nunez, James, Palladino, Carl, Philliber, Jeff, Robertson, Samantha, Saadeh, Joseph, Salvini, Karen, Santos, Bernadette, Sossikian, Leana, Tanouye, Amy, Torkelson, Mike, Xu, Suying

وصف الملف: application/pdf

العلاقة: qt2rb2w57h; https://escholarship.org/uc/item/2rb2w57hTest; https://escholarship.org/content/qt2rb2w57h/qt2rb2w57h.pdfTest

الإتاحة: https://escholarship.org/uc/item/2rb2w57hTest
https://escholarship.org/content/qt2rb2w57h/qt2rb2w57h.pdfTest

المؤلفون: Nuñez, James K, Harrington, Lucas B, Kranzusch, Philip J, Engelman, Alan N, Doudna, Jennifer A

المصدر: Nature. 527(7579)

مصطلحات موضوعية: Biological Sciences, Genetics, Adaptive Immunity, Bacteriophage M13, Base Sequence, CRISPR-Associated Proteins, Catalytic Domain, Clustered Regularly Interspaced Short Palindromic Repeats, Crystallography, X-Ray, DNA, Viral, Escherichia coli, Integrases, Models, Molecular, Virus Integration, General Science & Technology

الوصول الحر: https://escholarship.org/uc/item/618388d8Test