المؤلفون: Jules Dichamp, Geraldine Cellière, Ahmed Ghallab, Reham Hassan, Noemie Boissier, Ute Hofmann, Joerg Reinders, Selahaddin Sezgin, Sebastian Zühlke, Jan G. Hengstler, Dirk Drasdo

المصدر: Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)

مصطلحات موضوعية: APAP, in vitro to in vivo extrapolation, acetaminophen, drug toxicity, digital twin, multi-scale, Biotechnology, TP248.13-248.65

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fbioe.2023.1049564/fullTest; https://doaj.org/toc/2296-4185Test

الوصول الحر: https://doaj.org/article/282f59c4609f49c39d335abcc09bf519Test

المؤلفون: Jules Dichamp, Geraldine Cellière, Ahmed Ghallab, Reham Hassan, Noemie Boissier, Ute Hofmann, Joerg Reinders, Selahaddin Sezgin, Sebastian Zühlke, Jan G. Hengstler, Dirk Drasdo

مصطلحات موضوعية: Biotechnology, Biological Engineering, Genetic Engineering, Biomarkers, Biomaterials, Biomechanical Engineering, Biomedical Engineering not elsewhere classified, Synthetic Biology, Agricultural Marine Biotechnology, Bioremediation, Bioprocessing, Bioproduction and Bioproducts, Industrial Biotechnology Diagnostics (incl. Biosensors), Industrial Microbiology (incl. Biofeedstocks), Industrial Molecular Engineering of Nucleic Acids and Proteins, Industrial Biotechnology not elsewhere classified, Medical Biotechnology Diagnostics (incl. Biosensors), Medical Molecular Engineering of Nucleic Acids and Proteins, Regenerative Medicine (incl. Stem Cells and Tissue Engineering), Medical Biotechnology not elsewhere classified, APAP, in vitro to in vivo extrapolation, acetaminophen, drug toxicity, digital twin, multi-scale, modeling, metabolism

العلاقة: https://figshare.com/articles/dataset/Table1_In_vitro_to_in_vivo_acetaminophen_hepatotoxicity_extrapolation_using_classical_schemes_pharmacodynamic_models_and_a_multiscale_spatial-temporal_liver_twin_XLSX/21993893Test

الإتاحة: https://doi.org/10.3389/fbioe.2023.1049564.s003Test
https://figshare.com/articles/dataset/Table1_In_vitro_to_in_vivo_acetaminophen_hepatotoxicity_extrapolation_using_classical_schemes_pharmacodynamic_models_and_a_multiscale_spatial-temporal_liver_twin_XLSX/21993893Test

المؤلفون: Jules Dichamp, Geraldine Cellière, Ahmed Ghallab, Reham Hassan, Noemie Boissier, Ute Hofmann, Joerg Reinders, Selahaddin Sezgin, Sebastian Zühlke, Jan G. Hengstler, Dirk Drasdo

مصطلحات موضوعية: Biotechnology, Biological Engineering, Genetic Engineering, Biomarkers, Biomaterials, Biomechanical Engineering, Biomedical Engineering not elsewhere classified, Synthetic Biology, Agricultural Marine Biotechnology, Bioremediation, Bioprocessing, Bioproduction and Bioproducts, Industrial Biotechnology Diagnostics (incl. Biosensors), Industrial Microbiology (incl. Biofeedstocks), Industrial Molecular Engineering of Nucleic Acids and Proteins, Industrial Biotechnology not elsewhere classified, Medical Biotechnology Diagnostics (incl. Biosensors), Medical Molecular Engineering of Nucleic Acids and Proteins, Regenerative Medicine (incl. Stem Cells and Tissue Engineering), Medical Biotechnology not elsewhere classified, APAP, in vitro to in vivo extrapolation, acetaminophen, drug toxicity, digital twin, multi-scale, modeling, metabolism

العلاقة: https://figshare.com/articles/dataset/DataSheet1_In_vitro_to_in_vivo_acetaminophen_hepatotoxicity_extrapolation_using_classical_schemes_pharmacodynamic_models_and_a_multiscale_spatial-temporal_liver_twin_ZIP/21993884Test

الإتاحة: https://doi.org/10.3389/fbioe.2023.1049564.s001Test
https://figshare.com/articles/dataset/DataSheet1_In_vitro_to_in_vivo_acetaminophen_hepatotoxicity_extrapolation_using_classical_schemes_pharmacodynamic_models_and_a_multiscale_spatial-temporal_liver_twin_ZIP/21993884Test

المؤلفون: Noemie Boissier, Dirk Drasdo, Irene E. Vignon-Clementel

المساهمون: Modelling and Analysis for Medical and Biological Applications (MAMBA), Inria de Paris, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire Jacques-Louis Lions (LJLL (UMR_7598)), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Leibniz Research Centre for Working Environment and Human Factors [Dortmund] (IFADO), Technische Universität Dortmund [Dortmund] (TU), SImulations en Médecine, BIOtechnologie et ToXicologie de systèmes multicellulaires (SIMBIOTX ), Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), This work has been supported by the German Ministry of Education and Research through LiSym (Grant No. 031L0045, BMBF) and the French Ministry of Research through the grants iFlow (ANR-13-TECS-0006) and iLite (ANR-16-RHUS-0005), ANR-13-TECS-0006,iFLOW,Estimation intraopératoire de la fonction hépatique par caméra fluorescente proche-infrarouge lors de chirurgies du foie(2013), ANR-16-RHUS-0005,iLite,iLite(2016), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)

المصدر: International Journal for Numerical Methods in Biomedical Engineering
International Journal for Numerical Methods in Biomedical Engineering, John Wiley and Sons, 2021, 37 (2), ⟨10.1002/cnm.3422⟩
International Journal for Numerical Methods in Biomedical Engineering, 2021, 37 (2), ⟨10.1002/cnm.3422⟩

مصطلحات موضوعية: Convection, Fåhræus–Lindqvist effect, Computer science, 0206 medical engineering, Flow (psychology), Biomedical Engineering, 02 engineering and technology, 030204 cardiovascular system & hematology, Signal, Microcirculation, [SPI.MECA.MEFL]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Fluids mechanics [physics.class-ph], 03 medical and health sciences, 0302 clinical medicine, Computer Simulation, [PHYS.MECA.BIOM]Physics [physics]/Mechanics [physics]/Biomechanics [physics.med-ph], Molecular Biology, Fahraeus-Lindqvist effect, Computer simulation, Applied Mathematics, Hemodynamics, Models, Cardiovascular, Convection-reaction, Blood flow, 020601 biomedical engineering, [INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation, Plasma skimming, Numerical scheme for networks, Computational Theory and Mathematics, Modeling and Simulation, Detoxifying organ, Focus (optics), Biological system, Software, Blood Flow Velocity

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a31db22650b4d683f6635a8abf68dab3Test
https://hal.inria.fr/hal-03135175Test

المؤلفون: Georgia Guenther, Brigitte Begher-Tibbe, Adrian Friebel, Amruta Damle-Vartak, Nachiket Vartak, Florian Joly, Fabian Geisler, Simone Jörs, Jörns Fickel, Dirk Drasdo, Gudrun Wibbelt, Jan G. Hengstler, Ahmed Ghallab, Heribert Hofer, Stefan Hoehme, Irene E. Vignon-Clementel, Kasimir Wansing, Christian Hedberg, Marie Rosselin, Noemie Boissier, Peter L.M. Jansen

المصدر: Hepatology, 73(4):1531-1550

مصطلحات موضوعية: 0301 basic medicine, mouse livers, Gastroenterology and Hepatology, Bone canaliculus, digestive system, Bile flow, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Gastroenterologi, medicine, small-molecule flux, Fluorescein, Hepatology, Chemistry, imaging, 500 Naturwissenschaften und Mathematik::570 Biowissenschaften, Biologie::570 Biowissenschaften, Biologie, ddc, Interlobular bile ducts, 030104 developmental biology, medicine.anatomical_structure, Hepatocyte, Biophysics, Diffusive flux, 030211 gastroenterology & hepatology, Correlative imaging, Concentration gradient

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0edd02a9eaecd90ddb1de1d8de94aeddTest

المؤلفون: Noemie Boissier, Amruta Damle-Vartak, Florian Joly, Jörns Fickel, Brigitte Begher-Tibbe, Georgia Guenther, Fabian Geisler, Simone Jörs, Gudrun Wibbelt, Marie Rosselin, Kasimir Wansing, Christian Hedberg, Peter L.M. Jansen, Adrian Friebel, Nachiket Vartak, Dirk Drasdo, Irene E. Vignon-Clementel, Ahmed Ghallab, Heribert Hofer, Stefan Hoehme, Jan G. Hengstler

مصطلحات موضوعية: Chemistry, Organ function, Bone canaliculus, digestive system, Bile flow, Interlobular bile ducts, chemistry.chemical_compound, Membrane, medicine.anatomical_structure, Hepatocyte, medicine, Biophysics, Fluorescein, Concentration gradient

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::d1ab98e4fa7fe5ddda5d83b1f7f93eadTest
https://doi.org/10.1101/778803Test