دورية أكاديمية
Characteristics of COVID-19 and Impact of Disease Activity in Patients with Adult-Onset Still’s Disease
| العنوان: | Characteristics of COVID-19 and Impact of Disease Activity in Patients with Adult-Onset Still’s Disease |
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| المؤلفون: | Xinyue Hong, Xiaoming Wang, Ningqi Dai, Yue Sun, Honglei Liu, Xiaobing Cheng, Junna Ye, Hui Shi, Qiongyi Hu, Jianfen Meng, Zhuochao Zhou, Chengde Yang, Jialin Teng, Yutong Su, Huihui Chi |
| المصدر: | Rheumatology and Therapy, Vol 11, Iss 1, Pp 201-212 (2024) |
| بيانات النشر: | Adis, Springer Healthcare, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Diseases of the musculoskeletal system |
| مصطلحات موضوعية: | Adult-onset Still’s disease, COVID-19, Glucocorticoids, JAK inhibitors, Diseases of the musculoskeletal system, RC925-935 |
| الوصف: | Abstract Introduction This study aimed to characterize the morbidity, hospitalization, and mortality rates among patients with adult-onset Still’s disease (AOSD) affected by coronavirus disease 2019 (COVID-19) and explore the impact of COVID-19 on the disease activity of AOSD. Methods Data on the clinical and demographic characteristics, COVID-19-related symptoms, and outcomes were retrospectively collected. Patients were stratified according to COVID-19 severity and associations between risk factors and outcomes were analyzed using multivariate logistic regression. The disease activity of patients with AOSD flares after COVID-19 was described. Results A total of 188 patients with AOSD were followed up, of whom 75.5% (n = 142) had a confirmed or highly suspected COVID-19. Patients on medium or high-dose oral glucocorticoids or Janus kinase (JAK) inhibitors were at increased risk of developing moderate to severe COVID-19. Six patients suffered flares of AOSD following COVID-19 in a short period; however, the relapse rate was not statistically increased compared with patients without COVID-19. Conclusion Patients with AOSD receiving medium or high-dose glucocorticoid therapy or JAK inhibitors had worse COVID-19 outcomes. Further work is needed to explore risk factors affecting COVID-19 outcomes and the impact of COVID-19 on disease activity in AOSD. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2198-6576 2198-6584 |
| العلاقة: | https://doaj.org/toc/2198-6576Test; https://doaj.org/toc/2198-6584Test |
| DOI: | 10.1007/s40744-023-00632-3 |
| الوصول الحر: | https://doaj.org/article/8862997af6e1413699d67e8e37cfda58Test |
| رقم الانضمام: | edsdoj.8862997af6e1413699d67e8e37cfda58 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 21986576 21986584 |
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| DOI: | 10.1007/s40744-023-00632-3 |