Association of Preoperative Plasma Levels of Vascular Endothelial Growth Factor and Soluble Vascular Cell Adhesion Molecule-1 With Lymph Node Status and Biochemical Progression After Radical Prostatectomy
| العنوان: | Association of Preoperative Plasma Levels of Vascular Endothelial Growth Factor and Soluble Vascular Cell Adhesion Molecule-1 With Lymph Node Status and Biochemical Progression After Radical Prostatectomy |
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| المؤلفون: | Dolores J. Lamb, Thomas M. Wheeler, Nina V. Shah, Shahrokh F. Shariat, Kevin M. Slawin, Veronica A. Anwuri |
| المصدر: | Journal of Clinical Oncology. 22:1655-1663 |
| بيانات النشر: | American Society of Clinical Oncology (ASCO), 2004. |
| سنة النشر: | 2004 |
| مصطلحات موضوعية: | Adult, Male, Vascular Endothelial Growth Factor A, Cancer Research, medicine.medical_specialty, Pathology, Angiogenesis, medicine.medical_treatment, Urology, Vascular Cell Adhesion Molecule-1, Bone Neoplasms, Sensitivity and Specificity, Metastasis, Cohort Studies, Prostate cancer, chemistry.chemical_compound, Predictive Value of Tests, Biomarkers, Tumor, medicine, Humans, Aged, Neoplasm Staging, Aged, 80 and over, Prostatectomy, Neovascularization, Pathologic, business.industry, Prostatic Neoplasms, Cancer, Middle Aged, medicine.disease, Vascular endothelial growth factor, Vascular endothelial growth factor A, Oncology, chemistry, Case-Control Studies, Disease Progression, business, Soluble Vascular Cell Adhesion Molecule 1 |
| الوصف: | Purpose Angiogenesis is a critical process for cancer progression. We tested whether elevated circulating levels of the angiogenesis-related markers vascular endothelial growth factor (VEGF) and/or soluble vascular cell adhesion molecule-1 (sVCAM-1) are associated with prostate cancer diagnosis, stage, progression, and metastasis. Patients and Methods Plasma levels of VEGF and sVCAM-1 were measured on frozen, archival plasma obtained preoperatively from 215 consecutive patients who underwent radical prostatectomy for clinically localized disease, nine men with untreated prostate cancer metastatic to bones, and 40 healthy men without cancer. Results Plasma levels of both VEGF and sVCAM-1 were highest in patients with bone metastases (P < .001). VEGF levels were higher in patients with clinically localized disease than in healthy controls (P < .001). VEGF levels were elevated in patients with biopsy and final Gleason sum ≥ 7 (P = .036 and P = .020, respectively) and extraprostatic extension (P = .047). Higher preoperative VEGF was independently associated with metastases to lymph nodes (P < .001). Both VEGF and sVCAM-1 were independently associated with biochemical progression after adjustment for the effects of standard preoperative features (P = .014 and P = .039, respectively). VEGF remained independently associated with biochemical progression after adjustment for standard postoperative features (P = .019). Conclusion Plasma levels of VEGF increased incrementally from healthy controls to patients with clinically localized disease to patients with lymph node and skeletal metastases. Higher preoperative VEGF was independently associated with metastases to lymph nodes and biochemical progression after surgery in both pre- and postoperative models. Plasma sVCAM-1 was elevated in men with bone metastases and was associated with biochemical progression in a preoperative model. |
| تدمد: | 1527-7755 0732-183X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::742d7610732a521fc3281582b68dc2ebTest https://doi.org/10.1200/jco.2004.09.142Test |
| رقم الانضمام: | edsair.doi.dedup.....742d7610732a521fc3281582b68dc2eb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15277755 0732183X |
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