المؤلفون: Marjolijn Woutersen, Andre Muller, Nicole H.P. Cnubben, Marja E.J. Pronk, Wout Slob, Minne B. Heringa, Betty C. Hakkert

مصطلحات موضوعية: Philosophy, Rebuttal, Kinetically derived maximum dose, General Medicine, Religious studies, Dose selection, Toxicology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35e1e5e573e5e99ddb25193d036a35d5Test
http://hdl.handle.net/10029/624487Test

المؤلفون: Minne B. Heringa, Betty C. Hakkert, Marja E.J. Pronk, Nicole H.P. Cnubben, Andre Muller, Wout Slob, Marjolijn Woutersen

مصطلحات موضوعية: Hazard and risk assessment, Top dose selection, Computer science, 010501 environmental sciences, Hazard analysis, Toxicology, 030226 pharmacology & pharmacy, 01 natural sciences, 3Rs, 03 medical and health sciences, 0302 clinical medicine, media_common.cataloged_instance, Kinetically derived maximum dose, European union, KMD, Risk management, Selection (genetic algorithm), 0105 earth and related environmental sciences, media_common, business.industry, General Medicine, Classification, Inflection point, Risk analysis (engineering), Toxicity, Maximum dose, business, Dose selection

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21eb0dd1c55dfd4532f1e2cc54198c59Test
http://hdl.handle.net/10029/624063Test

المؤلفون: Jochem Louisse, Ans Punt, Sandra Coecke, Minne B. Heringa, Martin Alewijn, Ad A. C. M. Peijnenburg, Nicole H.P. Cnubben

المصدر: Toxicology in Vitro 63 (2020)
Toxicology in Vitro, 63

مصطلحات موضوعية: 0301 basic medicine, Novel Foods & Agrochains, Metabolic Clearance Rate, BU Toxicologie, Hepatic clearance, Pharmacology, Biology, Novel Foods & Agroketens, Toxicology, 03 medical and health sciences, 0302 clinical medicine, BU Authenticity & Bioassays, In vivo, Metabolic clearance rate, Animals, Humans, Life Science, Toxicokinetics, BU Toxicology, Novel Foods & Agrochains, Cells, Cultured, Chemical risk, VLAG, BU Toxicology, General Medicine, In vitro, Rats, BU Authenticiteit & Bioassays, 030104 developmental biology, BU Toxicologie, Novel Foods & Agroketens, 030220 oncology & carcinogenesis, Hepatocytes

وصف الملف: application/pdf; application/octet-stream

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc493365c123cee9c9ac961f5078a1edTest
http://hdl.handle.net/10029/623605Test

المؤلفون: Andre Muller, Marja E.J. Pronk, Betty C. Hakkert, Nicole H.P. Cnubben, Marjolijn Woutersen

المصدر: Regulatory toxicology and pharmacology : RTP. 114

مصطلحات موضوعية: medicine.medical_specialty, Toxicity studies, 010501 environmental sciences, Hazard analysis, Endocrine Disruptors, Toxicology, 030226 pharmacology & pharmacy, 01 natural sciences, Hazardous Substances, Low dosing, 03 medical and health sciences, 0302 clinical medicine, Toxicity Tests, medicine, Incident management (ITSM), Humans, Dosing, European Union, Intensive care medicine, Risk management, 0105 earth and related environmental sciences, Risk Management, business.industry, Human health, General Medicine, Classification, Regulatory impact, Hazard, Toxicity, Risk assessment, business, Health impact assessment

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f39b12444ad9f7cc82863829e7093560Test
https://pubmed.ncbi.nlm.nih.gov/32679052Test

المؤلفون: Betty C. Hakkert, Nicole H.P. Cnubben, Minne B. Heringa, Wout Slob, Marjolijn Woutersen, Andre Muller, Marja E.J. Pronk

المصدر: Regulatory Toxicology and Pharmacology. 116:104730

مصطلحات موضوعية: Philosophy, Rebuttal, MEDLINE, General Medicine, Toxicology, Classics

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00f96ef3af92c7eb1396df928d6d2e62Test
https://doi.org/10.1016/j.yrtph.2020.104730Test

المؤلفون: Leo L.P. van Stee, René B.H. Braakman, Karen Smet, Nicole H.P. Cnubben, J.J.P. Bogaards, Jeffrey R. Kelsey

المصدر: Regulatory Toxicology and Pharmacology. 110:104512

مصطلحات موضوعية: Male, Methyl Ethers, Metabolite, Administration, Oral, Alcohol, Ether, Acetates, 010501 environmental sciences, Toxicology, 030226 pharmacology & pharmacy, 01 natural sciences, Rats, Sprague-Dawley, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Animals, 0105 earth and related environmental sciences, Triethylene glycol, Chromatography, Ethylene oxide, Diethylene glycol, General Medicine, Glycol ethers, chemistry, Solvents, Ethylene Glycols, Ethylene glycol

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63ecd696e2d6b2d1a72615c88b4b9cbbTest
https://doi.org/10.1016/j.yrtph.2019.104512Test

المؤلفون: Diana Wouters, Niels-Christian Ganderup, Nicole H.P. Cnubben, Theo Rispens, C. Frieke Kuper, M. Hart, André Penninks, Gerrit Jan Wolbink, Lucien A. Aarden, Geertje van Mierlo

المساهمون: Landsteiner Laboratory

المصدر: Journal of immunotoxicology, 11(1), 62-71. Informa Healthcare

مصطلحات موضوعية: musculoskeletal diseases, Metabolic Clearance Rate, Swine, medicine.drug_class, Injections, Subcutaneous, Immunology, Drug Evaluation, Preclinical, Pharmacology, Antibodies, Monoclonal, Humanized, Toxicology, Monoclonal antibody, Pharmacokinetics, medicine, Adalimumab, Animals, Humans, Dosing, Tumor Necrosis Factor-alpha, business.industry, Immunogenicity, Area under the curve, Antibodies, Monoclonal, Infliximab, Antibody Formation, Toxicity, Feasibility Studies, Swine, Miniature, Female, business, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f039b5fcb2f751fc499c8a4629990545Test
https://doi.org/10.3109/1547691x.2013.796023Test

المؤلفون: Anne-Marie Zuurmond, Nicole H.P. Cnubben, Jolanda H. M. van Bilsen, Benno van El, Robert Doornbos, Jacqueline Bastiaans, A. Koudijs, Jeroen DeGroot, Babs C.T. van Manen-Vernooij, André H. Penninks

المصدر: Regulatory Toxicology and Pharmacology. 59:461-470

مصطلحات موضوعية: Male, musculoskeletal diseases, medicine.drug_class, Drug Evaluation, Preclinical, Cmax, Arthritis, Pharmacology, Toxicology, Random Allocation, Pharmacokinetics, Animals, Medicine, Cells, Cultured, Anakinra, Dose-Response Relationship, Drug, business.industry, Receptors, Interleukin-1, General Medicine, medicine.disease, Receptor antagonist, Arthritis, Experimental, Rats, Disease Models, Animal, Interleukin 1 Receptor Antagonist Protein, Treatment Outcome, Interleukin 1 receptor antagonist, Rats, Inbred Lew, Rheumatoid arthritis, business, Ex vivo, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ce1d59e059e01509c0195cb80ad3242Test
https://doi.org/10.1016/j.yrtph.2011.01.014Test

المؤلفون: Suzan Wopereis, Henk F. J. Hendriks, Age K. Smilde, Nicole H.P. Cnubben, Elwin Verheij, T. van Vliet, B. van Ommen, Carina M. Rubingh, M. J. van Erk, J. van der Greef

المساهمون: Biosystems Data Analysis (SILS, FNWI)

المصدر: Chemometrics and Intelligent Laboratory Systems, 106(1), 108-114. Elsevier B.V
Chemometrics and Intelligent Laboratory Systems, 1, 106, 108-114

مصطلحات موضوعية: Placebo treatment, Word error rate, NPLS-DA, Overweight, Multi-way analysis, Analytical Chemistry, Treatment and control groups, Life, Statistics, medicine, Interpretability, Intervention trial, QS - Quality & Safety MSB - Microbiology and Systems Biology PHS - Pharmacokinetics & Human Studies, Spectroscopy, Nutrition, business.industry, Process Chemistry and Technology, Multilevel model, Multilevel modeling, Intervention studies, Computer Science Applications, EELS - Earth, Environmental and Life Sciences, medicine.symptom, business, Software

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b88a59e5487c3b94ea287e139ea142eTest
https://doi.org/10.1016/j.chemolab.2010.06.003Test

المؤلفون: Linette Pellis, Suzan Wopereis, Marjan van Erk, H.F.J. Hendriks, Carina M. Rubingh, Teake Kooistra, Nicole H.P. Cnubben, Ben van Ommen, G.C.M. Bakker

المساهمون: TNO Kwaliteit van Leven

المصدر: American Journal of Clinical Nutrition, 4, 91, 1044-1059

مصطلحات موضوعية: metabolic disorder, Male, obesity, antioxidant, double blind procedure, Anti-Inflammatory Agents, Medicine (miscellaneous), Adipose tissue, medicine.disease_cause, Antioxidants, Nutrigenomics, lipid metabolism, middle aged, mononuclear cell, oxidative stress, pathophysiology, chemistry.chemical_classification, C reactive protein, Cross-Over Studies, Nutrition and Dietetics, adult, drug effect, article, clinical trial, methodology, Blood proteins, adipose tissue, female, C-Reactive Protein, Liver, Adiponectin, medicine.symptom, antiinflammatory agent, vascular endothelium, Polyunsaturated fatty acid, medicine.medical_specialty, crossover procedure, Diet therapy, Inflammation, Physiological Sciences, Biology, Young Adult, Double-Blind Method, Metabolic Diseases, blood, Internal medicine, medicine, Humans, controlled study, human, controlled clinical trial, Overweight, Ascorbic acid, Diet, Endocrinology, diet therapy, chemistry, randomized controlled trial, Leukocytes, Mononuclear, Endothelium, Vascular, metabolism, Oxidative stress

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b332b34df0ec6336fd4ca7becc591688Test
https://doi.org/10.3945/ajcn.2009.28822Test