المؤلفون: Miller, Duncan C, Reuillon, Tristan, Molyneux, Lauren, Blackburn, Timothy, Cook, Simon J, Edwards, Noel, Endicott, Jane A, Golding, Bernard T, Griffin, Roger J, Hardcastle, Ian, Harnor, Suzannah J, Heptinstall, Amy, Lochhead, Pamela, Martin, Mathew P, Martin, Nick C, Myers, Stephanie, Newell, David R, Noble, Richard A, Phillips, Nicole, Rigoreau, Laurent, Thomas, Huw, Tucker, Julie A, Wang, Lan-Zhen, Waring, Michael J, Wong, Ai-Ching, Wedge, Stephen R, Noble, Martin E, Cano, Celine

مصطلحات موضوعية: Chemistry

وصف الملف: application/pdf

العلاقة: http://sure.sunderland.ac.uk/id/eprint/14709/8/acs.jmedchem.1c01756.pdfTest; Miller, Duncan C , Reuillon, Tristan , Molyneux, Lauren , Blackburn, Timothy , Cook, Simon J , Edwards, Noel , Endicott, Jane A , Golding, Bernard T , Griffin, Roger J , Hardcastle, Ian , Harnor, Suzannah J , Heptinstall, Amy , Lochhead, Pamela , Martin, Mathew P , Martin, Nick C , Myers, Stephanie , Newell, David R , Noble, Richard A , Phillips, Nicole , Rigoreau, Laurent , Thomas, Huw , Tucker, Julie A , Wang, Lan-Zhen , Waring, Michael J , Wong, Ai-Ching , Wedge, Stephen R , Noble, Martin E and Cano, Celine (2022) Parallel Optimisation of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor. Journal of Medicinal Chemistry, 65 (9). pp. 6513-6540. ISSN 0022-2623

الإتاحة: http://sure.sunderland.ac.uk/id/eprint/14709Test/
http://sure.sunderland.ac.uk/id/eprint/14709/8/acs.jmedchem.1c01756.pdfTest

المؤلفون: Anscombe, Elizabeth, Meschini, Elisa, Mora-Vidal, Regina, Martin, Mathew P., Staunton, David, Geitmann, Matthis, Danielson, U. Helena, Stanley, Will A., Wang, Lan Z., Reuillon, Tristan, Golding, Bernard T., Cano, Celine, Newell, David R., Noble, Martin E. M., Wedge, Stephen R., Endicott, Jane A., Griffin, Roger J.

المصدر: Chemistry and Biology. 22(9):1159-1164

وصف الملف: electronic

الوصول الحر: https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-268711Test
https://doi.org/10.1016/j.chembiol.2015.07.018Test
https://uu.diva-portal.org/smash/get/diva2:878807/FULLTEXT01.pdfTest

المؤلفون: Matheson, Christopher J., Coxon, Christopher R., Bayliss, Richard, Boxall, Kathy, Carbain, Benoit, Fry, Andrew M., Hardcastle, Ian R., Harnor, Suzannah J., Mas-Droux, Corine, Newell, David R., Richards, Mark W., Sivaprakasam, Mangaleswaran, Turner, David, Griffin, Roger J., Golding, Bernard T., Cano, Céline

المساهمون: Cancer Research UK

المصدر: RSC Medicinal Chemistry ; volume 11, issue 6, page 707-731 ; ISSN 2632-8682

الإتاحة: https://doi.org/10.1039/d0md00074dTest
http://pubs.rsc.org/en/content/articlepdf/2020/MD/D0MD00074DTest

المؤلفون: Matheson, Elizabeth C., Thomas, Huw, Case, Marian, Blair, Helen, Jackson, Rosanna K., Masic, D., Veal, Gareth, Halsey, Chris, Newell, David R., Vormoor, Josef, Irving, Julie A.E.

وصف الملف: text

العلاقة: http://eprints.gla.ac.uk/177202/1/177202.pdfTest; Matheson, E. C. et al. (2019) Glucocorticoids and selumetinib are highly synergistic in RAS pathway-mutated childhood acute lymphoblastic leukemia through upregulation of BIM. Haematologica , 104(9), pp. 1804-1811. (doi:10.3324/haematol.2017.185975 ) (PMID:30655370) (PMCID:PMC6717586)

الإتاحة: https://doi.org/10.3324/haematol.2017.185975Test
http://eprints.gla.ac.uk/177202Test/
http://eprints.gla.ac.uk/177202/1/177202.pdfTest

المؤلفون: Tucker, Julie Ann, Myers, Stephanie M., Miller, Duncan C., Molyneux, Lauren, Arasta, Mercedes, Bawn, Ruth H., Blackburn, Timothy J., Cook, Simon J., Edwards, Noel, Endicott, Jane A., Golding, Bernard T., Griffin, Roger J., Hammonds, Tim, Hardcastle, Ian R., Harnor, Suzannah J., Heptinstall, Amy B., Lochhead, Pamela A., Martin, Mathew P., Martin, Nick C., Newell, David R., Owen, Paul J., Pang, Leon C., Reuillon, Tristan, Rigoreau, Laurent J.M., Thomas, Huw D., Wang, Lan-Zhen, Wong, Ai-Ching, Noble, Martin E.M., Wedge, Stephen R., Cano, Celine

وصف الملف: text

العلاقة: https://eprints.whiterose.ac.uk/148098/1/ERK5LeadIDPaper_EurJMedChem_2019_04_29.docxTest; Tucker, Julie Ann orcid.org/0000-0002-6119-676X , Myers, Stephanie M., Miller, Duncan C. et al. (27 more authors) (2019) Identification of a novel orally bioavailable ERK5 inhibitor with selectivity over p38α and BRD4. European Journal of Medicinal Chemistry. pp. 530-543. ISSN 0223-5234

الإتاحة: https://doi.org/10.1016/j.ejmech.2019.05.057Test
https://eprints.whiterose.ac.uk/148098Test/
https://eprints.whiterose.ac.uk/148098/1/ERK5LeadIDPaper_EurJMedChem_2019_04_29.docxTest

المؤلفون: Chen, Lindi, Pastorino, Fabio, Berry, Philip, Bonner, Jennifer, Kirk, Calum, Wood, Katrina M., Thomas, Huw D., Zhao, Yan, Daga, Antonio, Veal, Gareth J., Lunec, John, Newell, David R., Ponzoni, Mirco, Tweddle, Deborah A.

المساهمون: Cancer Research UK, Neuroblastoma UK, Sparks, Children's Cancer and Leukaemia Group

المصدر: International Journal of Cancer ; volume 144, issue 12, page 3146-3159 ; ISSN 0020-7136 1097-0215

الإتاحة: https://doi.org/10.1002/ijc.32058Test

المؤلفون: Drummond, Catherine J, Esfandiari, Arman, Liu, Junfeng, Lu, Xiaohong, Hutton, Claire, Jackson, Jennifer, Bennaceur, Karim, Xu, Qing, Makimanejavali, Aditya Rao, DEL BELLO, FABIO, PIERGENTILI, Alessandro, Newell, David R, Hardcastle, Ian R, Griffin, Roger J, Lunec, John

المساهمون: Drummond, Catherine J, Esfandiari, Arman, Liu, Junfeng, Lu, Xiaohong, Hutton, Claire, Jackson, Jennifer, Bennaceur, Karim, Xu, Qing, Makimanejavali, Aditya Rao, DEL BELLO, Fabio, Piergentili, Alessandro, Newell, David R, Hardcastle, Ian R, Griffin, Roger J, Lunec, John

وصف الملف: STAMPA

العلاقة: info:eu-repo/semantics/altIdentifier/wos/WOS:000385402300104; volume:7; firstpage:46203; lastpage:46218; numberofpages:16; journal:ONCOTARGET; http://hdl.handle.net/11581/394236Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84979910691; http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&pathTest[]=10073&path[]=32713

الإتاحة: https://doi.org/10.18632/oncotarget.10073Test
http://hdl.handle.net/11581/394236Test
http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&pathTest[]=10073&path[]=32713

المؤلفون: Coxon, Christopher R., Anscombe, Elizabeth, Harnor, Suzannah J., Martin, Mathew P., Carbain, Benoit, Golding, Bernard T., Hardcastle, Ian R., Harlow, Lisa K., Korolchuk, Svitlana, Matheson, Christopher J., Newell, David R., Noble, Martin E. M., Sivaprakasam, Mangaleswaran, Tudhope, Susan J., Turner, David M., Wang, Lan Z., Wedge, Stephen R., Wong, Christopher, Griffin, Roger J., Endicott, Jane A., Cano, Céline

المساهمون: Medical Research Council, Cancer Research UK

المصدر: Journal of Medicinal Chemistry ; volume 60, issue 5, page 1746-1767 ; ISSN 0022-2623 1520-4804

الإتاحة: https://doi.org/10.1021/acs.jmedchem.6b01254Test

المؤلفون: Miller, Duncan C., Reuillon, Tristan, Molyneux, Lauren, Blackburn, Timothy J., Cook, Simon, Edwards, Noel, Endicott, Jane A., Golding, Bernard T., Griffin, Roger J., Hardcastle, Ian R., Heptinstall, Amy B., Lochhead, Pamela, Martin, Mathew P., Martin, Nick, Myers, Stephanie M., Newell, David R., Noble, Richard, Rigoreau, Laurent J.M., Thomas, Huw, Tucker, Julie Ann, Wang, Lan-Zhen, Waring, Michael J., Wong, Ai-Ching, Wedge, Stephen, Noble, Martin, Cano, Celine

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::643876374a98b92971005d5d769a4162Test
https://eprints.whiterose.ac.uk/185363/3/acs.jmedchem.1c01756.pdfTest

المؤلفون: Lochhead, Pamela A., Clark, Jonathan, Wang, Lan-Zhen, Gilmour, Lesley, Squires, Matthew, Gilley, Rebecca, Foxton, Caroline, Newell, David R., Wedge, Stephen R., Cook, Simon J.

وصف الملف: text

العلاقة: http://eprints.gla.ac.uk/118756/1/118756.pdfTest; Lochhead, P. A., Clark, J., Wang, L.-Z., Gilmour, L. , Squires, M., Gilley, R., Foxton, C., Newell, D. R., Wedge, S. R. and Cook, S. J. (2016) Tumor cells with KRAS or BRAF mutations orERK5/MAPK7 amplification are not addicted to ERK5 activity for cell proliferation. Cell Cycle , 15(4), pp. 506-518. (doi:10.1080/15384101.2015.1120915 ) (PMID:26959608)

الإتاحة: https://doi.org/10.1080/15384101.2015.1120915Test
http://eprints.gla.ac.uk/118756Test/
http://eprints.gla.ac.uk/118756/1/118756.pdfTest